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1. 发明申请

US20090182204A1 Body composition, circulation, and vital signs monitor and method 审中-公开
标题翻译：身体组成，循环和生命体征监测和方法
公开(公告)号：US20090182204A1
公开(公告)日：2009-07-16
申请号：US12317538
申请日：2008-12-24
申请人： Herbert J. Semler , Philip Benz , Gary Mills , James McNames
发明人： Herbert J. Semler , Philip Benz , Gary Mills , James McNames
IPC分类号： A61B5/02 , A61B5/0402 , A61B5/0476 , A61B5/053
CPC分类号： A61B5/04085 , A61B5/04325 , A61B5/053 , A61B5/6833 , A61B5/7275 , A61N1/3625 , A61N1/39 , A61N1/3937 , G16H40/63 , G16H40/67 , G16H50/20 , G16H50/30
摘要： The invented non-invasive vital signs monitor is in a flexible, nominally flat planar form having integral gel electrodes, a sticky-back rear surface, an internal flex circuit capable of sensing, recording and playing out several minutes of the most recently acquired ECG waveform data and a front surface that includes an outplay port. The invented non-invasive body composition ‘risk’ monitor includes a measurement device for monitoring one or more variables including body fluid mass, dehydration, respiratory rate, blood pressure, bio-impedance, cardiography such as cardiac output, and body conformation parameters. The risk monitor may be provided in a lightweight carrying case into which the vital signs monitor plugs. Finally, a lightweight portable probe or transducer containing a transmissive or reflective electro-optical emitter and receptor in the infrared spectrum is fitted on a subject's finger or toe. Associated electronics energize and monitor the probe, detect cardio-rhythmic fluctuations therefrom, and process digital data over a prescribed window to produce a non-invasive, qualitative or quantitative measure of the subject's circulation. In accordance with one embodiment of the invention, a simple tri-color LED array is used to indicate the subject's circulation as being normal, reduced, or borderline. Thus the vital signs, bio-impedance, and circulation monitors may be independent or they may be integrated into one portable, non-invasive device that can concurrently monitor and locally display or remotely convey important patient data including circulation data to a local subject or physician or to/from a remote patient medical data center via wireless telemetry for oversight, treatment and possible intervention by a remote physician.
摘要翻译：本发明的非侵入性生命体征监测器是具有整体凝胶电极，粘性后表面，能够感测，记录和播放最近采集的ECG波形数分钟的内部柔性电路的灵活的，标称平坦的平面形式数据和包括外接端口的前表面。本发明的非侵入性身体成分“风险”监测器包括用于监测一个或多个变量的测量装置，包括体液量，脱水，呼吸频率，血压，生物阻抗，心输出量等心脏检查以及身体构象参数。风险监视器可以设置在生命体征监视器插入的轻量级手提箱中。最后，将包含红外光谱中的透射或反射电光发射器和受体的轻便便携式探头或传感器安装在受试者的手指或脚趾上。相关电子设备激励和监测探针，检测心跳节奏的波动，并在规定的窗口处理数字数据，以产生对受试者循环的非侵入性，定性或定量的测量。根据本发明的一个实施例，简单的三色LED阵列用于指示受试者的循环是正常的，减少的或边界的。因此，生命体征，生物阻抗和循环监测器可以是独立的，或者它们可以被集成到一个便携式非侵入性装置中，其可以同时监测和本地显示或远程传送包括循环数据在内的重要患者数据给局部受试者或医师或者通过无线遥测器从远程病人医疗数据中心进行远程医疗数据中心，以进行远程医师的监视，治疗和可能的干预。

2. 发明申请

US20090149764A1 Circulation monitoring system and method 有权
公开(公告)号：US20090149764A1
公开(公告)日：2009-06-11
申请号：US12001505
申请日：2007-12-11
申请人： Herbert J. Semler , Philip Benz , Gary Mills , James McNames
发明人： Herbert J. Semler , Philip Benz , Gary Mills , James McNames
IPC分类号： A61B5/1455
CPC分类号： A61B5/02416 , A61B5/02007 , A61B5/14552 , A61B5/6826 , A61B5/6829 , A61B5/6838
摘要： A lightweight portable probe or transducer containing a transmissive or reflective electro-optical emitter and receptor in the infrared spectrum is fitted on a subject's finger or toe. Associated electronics energize and monitor the probe, detect cardio-rhythmic fluctuations therefrom, and process digital data over a prescribed window to produce a non-invasive, qualitative or quantitative measure of the subject's circulation. In accordance with one embodiment of the invention, a simple tri-color LED array is used to indicate the subject's circulation as being normal, reduced, or borderline.

3. 发明授权

US07628760B2 Circulation monitoring system and method 有权
标题翻译：循环监测系统及方法
公开(公告)号：US07628760B2
公开(公告)日：2009-12-08
申请号：US12001505
申请日：2007-12-11
申请人： Herbert J. Semler , Philip Benz , Gary Mills , James McNames
发明人： Herbert J. Semler , Philip Benz , Gary Mills , James McNames
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/02416 , A61B5/02007 , A61B5/14552 , A61B5/6826 , A61B5/6829 , A61B5/6838
摘要： A lightweight portable probe or transducer containing a transmissive or reflective electro-optical emitter and receptor in the infrared spectrum is fitted on a subject's finger or toe. Associated electronics energize and monitor the probe, detect cardio-rhythmic fluctuations therefrom, and process digital data over a prescribed window to produce a non-invasive, qualitative or quantitative measure of the subject's circulation. In accordance with one embodiment of the invention, a simple tri-color LED array is used to indicate the subject's circulation as being normal, reduced, or borderline.
摘要翻译：在红外光谱中包含透射或反射电光发射器和受体的轻便便携式探头或传感器安装在受试者的手指或脚趾上。相关电子设备激励和监测探针，检测心跳节奏的波动，并在规定的窗口处理数字数据，以产生对受试者循环的非侵入性，定性或定量的测量。根据本发明的一个实施例，简单的三色LED阵列用于指示受试者的循环是正常的，减少的或边界的。

4. 发明授权

US08529458B2 Method and apparatus for assessment of fluid responsiveness 有权
标题翻译：评估液体反应性的方法和装置
公开(公告)号：US08529458B2
公开(公告)日：2013-09-10
申请号：US12891795
申请日：2010-09-27
申请人： Sunghan Kim , Pedro Mateo Riobo Aboy , James McNames
发明人： Sunghan Kim , Pedro Mateo Riobo Aboy , James McNames
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/412 , A61B5/4848 , A61B2505/03
摘要： Methods and apparatus for determining a cardiac parameter from cardiovascular pressure signals including arterial blood pressure (ABP) and the photoplethysmographic signal to quantify the degree of amplitude modulation due to respiration and predict fluid responsiveness are disclosed. Disclosed embodiments include a method for assessing fluid responsiveness implemented in a digital computer with one or more processors comprising: (a) measuring a cardiovascular signal, and (b) computing a dynamic index predictive of fluid responsiveness from said cardiovascular signal using a nonlinear state space estimator. According to one particular embodiment, and without limitation, the nonlinear state space estimator is based on a model for cardiovascular signals such as arterial blood pressure or plethysmogram signals, and employs a marginalized particle filter to estimate a dynamic index predictive of fluid responsiveness that is substantially equivalent to a variation in pulse pressure of said cardiovascular signal.
摘要翻译：公开了用于从心血管压力信号（包括动脉血压（ABP））和光电体积描记信号确定心脏参数的方法和装置，以量化由呼吸引起的幅度调制程度并预测流体反应性。公开的实施例包括用于评估在具有一个或多个处理器的数字计算机中实现的流体响应性的方法，包括：（a）测量心血管信号，以及（b）使用非线性状态空间计算预测来自所述心血管信号的流体响应性的动态指数估计。根据一个特定实施例，非限制性地，非线性状态空间估计器基于诸如动脉血压或体积描记信号的心血管信号的模型，并且使用边缘化的粒子滤波器来估计预测流体响应性的动态指数，其基本上相当于所述心血管信号的脉压的变化。

5. 发明申请

US20110213277A1 SYSTEM, METHOD, AND APPARATUS FOR OBJECTIVE ASSESSMENT OF MOTOR SIGNS AT THE EXTREMITIES 审中-公开
标题翻译：用于目标评估电机标识的系统，方法和装置
公开(公告)号：US20110213277A1
公开(公告)日：2011-09-01
申请号：US13037287
申请日：2011-02-28
申请人： James McNames , Lars Holstrom , Joshua Booren , Edward Katz , Forest Kernan , Brent Casady , John Nutt , Craig Kinnie , Pedro Mateo Riobo Aboy
发明人： James McNames , Lars Holstrom , Joshua Booren , Edward Katz , Forest Kernan , Brent Casady , John Nutt , Craig Kinnie , Pedro Mateo Riobo Aboy
IPC分类号： A61B5/11
CPC分类号： A61B5/1124 , A61B5/4082
摘要： Disclosed embodiments include a system for objective assessment of motor signs at the extremities that comprises (a) a device for objective motor sign measurement, (b) a test protocol defining a prescribed repetitive activity, and (c) a signal processing and analysis system to generate one or more impairment metrics. According to a particular embodiment, the device for objective motor sign measurement is characterized by including means for producing a continuous measure of position of a limb or extremity during said prescribed repetitive activity during the entire movement.
摘要翻译：公开的实施例包括用于客观评估四肢运动符号的系统，其包括（a）用于客观运动符号测量的装置，（b）定义规定的重复活动的测试协议，以及（c）信号处理和分析系统，产生一个或多个损伤度量。根据具体实施例，用于目标电动机符号测量的装置的特征在于包括用于在整个运动期间在所述规定的重复活动期间产生连续测量肢体或肢体的位置的装置。

6. 发明申请

US20100030119A1 METHOD AND APPARATUS FOR CONTINUOUS MEASUREMENT OF MOTOR SYMPTOMS IN PARKINSON'S DISEASE AND ESSENTIAL TREMOR WITH WEARABLE SENSORS 有权
标题翻译：用于连续测量PARKINSON'S疾病和基本TREMOR与可靠传感器的运动症状的方法和装置
公开(公告)号：US20100030119A1
公开(公告)日：2010-02-04
申请号：US12511038
申请日：2009-07-28
申请人： James McNames , Pedro Mateo Riobo Aboy , Andrew Greenberg
发明人： James McNames , Pedro Mateo Riobo Aboy , Andrew Greenberg
IPC分类号： A61B5/11
CPC分类号： A61B5/1101 , A61B5/4082
摘要： Disclosed embodiments include an apparatus for generating a plurality of movement impairment indices from one or more kinematic signals to characterize movement disorders. Additionally we disclose methods for generating a plurality of movement impairment indices from one or more kinematic signals obtained from one or more kinematic sensors, said methods implemented in a digital computer with one or more processors in order to characterize movement disorders based on spectral analysis, regularity metrics, and time-frequency analsysis.
摘要翻译：公开的实施例包括用于从一个或多个运动学信号产生多个运动损伤指数以表征运动障碍的装置。另外，我们公开了从一个或多个运动学传感器获得的一个或多个运动学信号产生多个运动损伤指标的方法，所述方法在具有一个或多个处理器的数字计算机中实现，以便基于频谱分析来表征运动障碍，规律性指标和时频分析。

7. 发明申请

US20090069647A1 METHOD, SYSTEM, AND APPARATUS FOR CARDIOVASCULAR SIGNAL ANALYSIS, MODELING, AND MONITORING 有权
标题翻译：心脏信号分析，建模与监测的方法，系统和装置
公开(公告)号：US20090069647A1
公开(公告)日：2009-03-12
申请号：US12200995
申请日：2008-08-29
申请人： James McNames , Pedro Mateo Riobo Aboy
发明人： James McNames , Pedro Mateo Riobo Aboy
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/02405 , A61B5/031 , A61B5/0816 , A61B5/14551 , A61B5/412 , A61B5/725 , G06F19/00
摘要： The present invention provides a method, system, and apparatus to monitor cardiovascular signals such as arterial blood pressure (ABP), pulse oximetry (POX), and intracranial pressure (ICP). The system can be used to calculate and monitor useful clinical information such as heart rate, respiratory rate, pulse pressure variation (PPV), harmonic phases, pulse morphology, and for artifact removal. The method uses a statistical state-space model of cardiovascular signals and a generalized Kalman filter (EKF) to simultaneously estimate and track the cardiovascular parameters of interest such as the cardiac fundamental frequency and higher harmonics, respiratory fundamental frequency and higher harmonics, cardiac component harmonic amplitudes and phases, respiratory component harmonic amplitudes and phases, and PPV.
摘要翻译：本发明提供一种监测心血管信号如血压（ABP），脉搏血氧饱和度（POX）和颅内压（ICP）的方法，系统和装置。该系统可用于计算和监测有用的临床信息，如心率，呼吸频率，脉搏压力变化（PPV），谐波相位，脉冲形态和人为因素去除。该方法使用心血管信号的统计状态空间模型和广义卡尔曼滤波器（EKF）来同时估计和跟踪感兴趣的心血管参数，例如心脏基频和高次谐波，呼吸基频和高次谐波，心脏分量谐波振幅和相位，呼吸分量谐波幅度和相位以及PPV。

8. 发明授权

US07454387B2 Method of isolating sources of variance in parametric data 失效
标题翻译：隔离参数数据方差源的方法
公开(公告)号：US07454387B2
公开(公告)日：2008-11-18
申请号：US10663218
申请日：2003-09-15
申请人： David Abercrombie , Thaddeus T. Shannon, III , James McNames
发明人： David Abercrombie , Thaddeus T. Shannon, III , James McNames
IPC分类号： G06E1/00 , G06F15/18
CPC分类号： G05B23/0254
摘要： A method of isolating sources of variance in parametric data includes steps of: (a) cleaning a data set of measurements for a plurality of parameters; (b) generating a principal component analysis basis from the cleaned data set; (c) estimating an independent component analysis model from the principal component analysis basis; (d) calculating percentages of variance for the plurality of parameters explained by each component in the estimated independent component analysis model; (e) if the calculated percentages of variance indicate that a component is a minor component, then transferring control to step (f), else transferring control to step (g); (f) removing the minor component from the principal component analysis basis and transferring control to step (c); and (g) generating as output the estimated independent component analysis model wherein no component of the independent component analysis model is a minor component.
摘要翻译：一种隔离参数数据方差源的方法包括以下步骤：（a）清洁多个参数的测量数据集; （b）从清理的数据集中生成主成分分析基础; （c）从主成分分析的基础上估计独立成分分析模型; （d）计算由估计的独立分量分析模型中的每个分量解释的多个参数的方差百分比; （e）如果计算的方差百分比表示组分是次要组分，则将控制转移到步骤（f），否则将控制转移到步骤（g）; （f）从主成分分析基础中除去次要组分，并将控制转移到步骤（c）; 和（g）生成估计的独立分量分析模型作为输出，其中独立分量分析模型的分量不是次要分量。

9. 发明申请

US20050060336A1 Method of isolating sources of variance in parametric data 失效
标题翻译：隔离参数数据方差源的方法
公开(公告)号：US20050060336A1
公开(公告)日：2005-03-17
申请号：US10663218
申请日：2003-09-15
申请人： David Abercrombie , Thaddeus Shannon , James McNames
发明人： David Abercrombie , Thaddeus Shannon , James McNames
IPC分类号： G05B23/02 , G06F17/00
CPC分类号： G05B23/0254
摘要： A method of isolating sources of variance in parametric data includes steps of: (a) cleaning a data set of measurements for a plurality of parameters; (b) generating a principal component analysis basis from the cleaned data set; (c) estimating an independent component analysis model from the principal component analysis basis; (d) calculating percentages of variance for the plurality of parameters explained by each component in the estimated independent component analysis model; (e) if the calculated percentages of variance indicate that a component is a minor component, then transferring control to step (f), else transferring control to step (g); (f) removing the minor component from the principal component analysis basis and transferring control to step (c); and (g) generating as output the estimated independent component analysis model wherein no component of the independent component analysis model is a minor component.
摘要翻译：一种隔离参数数据方差源的方法包括以下步骤：（a）清洁多个参数的测量数据集; （b）从清理的数据集中生成主成分分析基础; （c）从主成分分析的基础上估计独立成分分析模型; （d）计算由估计的独立分量分析模型中的每个分量解释的多个参数的方差百分比; （e）如果计算的方差百分比表示组分是次要组分，则将控制转移到步骤（f），否则将控制转移到步骤（g）; （f）从主成分分析基础中除去次要组分，并将控制转移到步骤（c）; 和（g）生成估计的独立分量分析模型作为输出，其中独立分量分析模型的分量不是次要分量。

10. 发明授权

US10117204B2 Wireless synchronized apparatus and system 有权
公开(公告)号：US10117204B2
公开(公告)日：2018-10-30
申请号：US14146157
申请日：2014-01-02
申请人： Andrew Greenberg , Pedro Mateo Riobo Aboy , James McNames , Sean Pearson , Gavin Gallino , Timothy Brandon
发明人： Andrew Greenberg , Pedro Mateo Riobo Aboy , James McNames , Sean Pearson , Gavin Gallino , Timothy Brandon
IPC分类号： H04W56/00 , H04L1/08 , A61B5/00 , A61B5/11
摘要： Disclosed embodiments include an apparatus that comprises (a) a kinematics sensor module including an accelerometer, a gyroscope, a magnetometer, or combinations thereof; and (b) a bidirectional wireless communication module configured for wirelessly synchronizing the sampling time instances of the kinematics sensor module with the sampling time instances of at least a second wearable apparatus including a second kinematics sensor module.

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