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1. 发明授权

US4946648A Method of sterilizing plasma or plasma fractions 失效
$Method of sterilizing plasma or plasma fractions$
标题翻译：消毒血浆或血浆级分的方法
公开(公告)号：US4946648A
公开(公告)日：1990-08-07
申请号：US241300
申请日：1988-09-07
申请人： Herbert Dichtelmuller , Wolfgang Moller , Wolfgang Stephan , Hans Schleussner
发明人： Herbert Dichtelmuller , Wolfgang Moller , Wolfgang Stephan , Hans Schleussner
IPC分类号： A61K35/16 , A61L2/00
CPC分类号： A61L2/0088 , Y10S530/83 , Y10S530/831
摘要： A method of sterilizing plasma or plasma fractions, including fractions that contain the blood-coagulating Factor VIII by treatment with .beta.-propiolactone or ultraviolet radiation. Treatment with tri-n-butyl phosphate and sodium cholate or Tween 80 is carried out either prior to or simultaneously with the .beta.-propiolactone treatment or ultraviolet radiation.
摘要翻译：一种灭菌血浆或血浆级分的方法，包括通过用β-丙内酯或紫外线辐射处理含有血液凝固因子VIII的级分。用磷酸三正丁酯和胆酸钠或吐温80处理之前或同时进行β-丙内酯处理或紫外线辐射。

2. 发明授权

US4877866A Method of producing a virus safe, storage-stable, and intravenously tolerable immunoglobulin-G preparation 失效
标题翻译：产生病毒安全，储存稳定和静脉内可耐受的免疫球蛋白-G制剂的方法
公开(公告)号：US4877866A
公开(公告)日：1989-10-31
申请号：US122092
申请日：1987-11-18
申请人： Dieter Rudnick , Norbert Kothe , Herbert Dichtelmuller , Detlef Piechaczek , Wolfgang Stephan , Hans Schleussner
发明人： Dieter Rudnick , Norbert Kothe , Herbert Dichtelmuller , Detlef Piechaczek , Wolfgang Stephan , Hans Schleussner
IPC分类号： A61K39/395 , A61K38/00 , A61L2/00 , C07K16/06
CPC分类号： A61L2/0088 , C07K16/065 , A61K38/00
摘要： A method of producing a virus-safe, storage-stable, and intravenously tolerable immunoglobulin-G preparation. The object is to make the method appropriate for industrial-scale production and economical by means of the enrichment and multistage purification of a plasma that has had the coagulation factors removed from it or of a plasma fraction or serum fraction that contains immunoglobulin G accompanied by treatment with ion exchangers and by ultrafiltration. The precipitant is eliminated, by means of diafiltration or gelfiltration, either from the plasma that has had the coagulation factors removed from it or from the plasma fraction that contains the immunoglobulin G, and the desired ion composition is established. The resulting protein solution is subjected to fractionation over an ion exchanger to separate the immunoglobulin G. The proteolytic enzymes in the resulting immunoglobulin-G solution are removed by means of affinity chromatography over a dye linked sorbent and/or are ihibited by the addition of antithrombin III. The accordingly stabilized immunoglobulin-G solution is treated, at a protein concentration of 20 to 60 g/l and a pH 6.0 to 8.0, with 0.03 to 0.07% of .beta.-propiolactone, diluted to a protein concentration of 5 to 20 g/l and subjected to ultraviolet radiation. The accordingly sterilized dilute immunoglobulin-G solution is again diafiltered or gelfiltered to remove lower molecular-weight substances. The accordingly stabilized and sterilized solution is adjusted to the desired protein content of 2 to 16% and filtered sterile.
摘要翻译：一种产生病毒安全，储存稳定和静脉内可耐受的免疫球蛋白-G制剂的方法。目的是使该方法适用于工业规模生产和经济性，这是通过从其中除去凝血因子的血浆的浓缩和多级纯化或含有伴随治疗的免疫球蛋白G的血浆级分或血清级分用离子交换剂和超滤。通过渗滤或凝胶过滤，从已经从其中除去凝血因子的血浆或来自含有免疫球蛋白G的血浆级分除去沉淀剂，并建立所需的离子组成。将得到的蛋白质溶液通过离子交换剂进行分离，以分离免疫球蛋白G.通过在染料连接的吸附剂上的亲和层析除去得到的免疫球蛋白-G溶液中的蛋白水解酶和/或通过加入抗凝血酶三，将相应稳定的免疫球蛋白-G溶液以20至60g / l的蛋白质浓度和6.0至8.0的pH 6.0至8.0处理，稀释至5至20g / l的蛋白质浓度并进行紫外线照射。将相应灭菌的稀释的免疫球蛋白-G溶液再次进行渗滤或净化，以除去较低分子量的物质。将相应稳定的和灭菌的溶液调节至2至16％的所需蛋白质含量并过滤灭菌。

3. 发明授权

US4734279A Combination of immunoglobulins with therapeutic agents 失效
标题翻译：免疫球蛋白与治疗剂的组合
公开(公告)号：US4734279A
公开(公告)日：1988-03-29
申请号：US756672
申请日：1985-07-19
申请人： Wolfgang Stephan , Herbert Dichtelmuller , Alexander Thrun , Hans Schleussner
发明人： Wolfgang Stephan , Herbert Dichtelmuller , Alexander Thrun , Hans Schleussner
IPC分类号： A61K31/535 , A61K31/545 , A61K38/00 , A61K38/16 , A61K38/21 , A61K38/46 , A61K38/55 , A61K39/395 , A61K45/06 , A61P31/04 , A61P31/10 , A61P31/12 , A61K45/02
CPC分类号： A61K39/395 , Y10S424/804 , Y10S424/806 , Y10S435/911 , Y10S514/885
摘要： A compositon for treating diseases which comprises a therapeutically effective amount of an antibacterial, antiviral, or antimycotic agent, antitrypsin, antithrombin, interferon, or lysozyme, and an immunoenhancing amount of immunoglobulins IgG, IgM, and IgA, and a method of therapy of a mammal in need thereof are disclosed.
摘要翻译：用于治疗疾病的组合物，其包含治疗有效量的抗细菌剂，抗病毒剂或抗真菌剂，抗胰蛋白酶，抗凝血酶原，干扰素或溶菌酶，以及免疫增强量的免疫球蛋白IgG，IgM和IgA，以及治疗公开了有需要的哺乳动物。

4. 发明授权

US4460365A Polyurethane bag for blood 失效
标题翻译：聚氨酯袋为血液
公开(公告)号：US4460365A
公开(公告)日：1984-07-17
申请号：US80622
申请日：1979-10-01
申请人： Karlheinz Ganshirt , Wolfram H. Walker , Hans Schleussner
发明人： Karlheinz Ganshirt , Wolfram H. Walker , Hans Schleussner
IPC分类号： A61J1/00 , A61J1/05 , B65D30/02 , A61F1/24
CPC分类号： A61J1/10 , Y10S128/24
摘要： A bag suitable for the storage, deep-freezing and transfusion of blood and blood components formed of a calendered or extruded foil of plasticizer-free polyurethane of a thickness of about 0.1-0.5 mm, a Shore hardness A of about 60-85, temperature resistance up to about 160.degree. C. and down to about -196.degree. C. without change of properties. The bag can be used in combination with fittings and tubings of the same material to provide an overall plasticizer-free polyurethane system. The bag can be sterilized, is capable of low temperature storage, and exhibits other desirable properties without affecting the quality of its contents.
摘要翻译：一种适用于储存，深度冷冻和输血的血液和血液成分，其由厚度约0.1-0.5mm的砑光或挤出的不含增塑剂的聚氨酯薄片形成，肖氏硬度A为约60-85，温度电阻高达约160℃，低至约-196℃，而不改变性能。该袋可以与相同材料的配件和管道组合使用，以提供总体无增塑剂的聚氨酯体系。该袋可以灭菌，能够低温储存，并且表现出其它所需的性能，而不影响其内容物的质量。

5. 发明授权

US4508833A Separation of interleukin-2 from phytohemagglutinin by dye matrix chromatography 失效
标题翻译：通过染料基质色谱分离白细胞介素-2与植物血凝素
公开(公告)号：US4508833A
公开(公告)日：1985-04-02
申请号：US449708
申请日：1982-12-14
申请人： Hans H. Sonneborn , Udo Schwulera , Hans Schleussner
发明人： Hans H. Sonneborn , Udo Schwulera , Hans Schleussner
IPC分类号： A61K38/00 , C07K14/55 , G01N33/68 , G01N31/08 , A61K37/02 , B01D15/08
CPC分类号： G01N33/6869 , C07K14/55 , A61K38/00 , Y10S436/807
摘要： Crude interleukin-2 extract is subjected to group-selective dye-ligand absorption chromatography in one or more stages of purification with a matrix-gel medium consisting of a Blue A ligand or variant thereof or of a Green A ligand in a concentration of approximately 1.5 to 3.0 mg/ml of expanded matrix at a pH of approximately 6.8 to 8.5, a temperature of approximately 4.degree. to 40.degree. C., and a flowthrough rate of approximately 10 to 100 ml/h, employing an eluent. Either PHA-free or extremely pure interleukin-2 is obtained, depending on the overall number of purification stages.
摘要翻译：使用由蓝A配体或其变体或浓度为约1.5的Green A配体组成的基质 - 凝胶介质在一个或多个纯化阶段对粗白细胞介素-2提取物进行组选择性染料 - 配体吸收色谱法使用洗脱液，pH为约6.8〜8.5，温度为约4〜40℃，流通速度为约10〜100ml /小时，为3.0mg / ml的发泡基质。取决于纯化阶段的总数，获得无PHA或极纯白细胞介素-2。

6. 发明授权

US4770856A Microtiter plate for blood typing 失效
标题翻译：用于血液分型的微量滴定板
公开(公告)号：US4770856A
公开(公告)日：1988-09-13
申请号：US114891
申请日：1987-10-29
申请人： Horst Uthemann , Dieter Merz , Hans Schleussner
发明人： Horst Uthemann , Dieter Merz , Hans Schleussner
IPC分类号： B01L3/00 , G01N33/80 , G01N21/03 , G01N33/48 , G01N33/50
CPC分类号： B01L3/5085 , G01N33/80 , Y10S422/906 , Y10S422/907 , Y10S436/809
摘要： A microtiter plate for blood typing consisting of a flat-bottomed plate of rigid transparent polystyrene having a plurality of wells, the polystyrene being surface treated by a corona and/or plasma method of applying high power electric energy at high frequency resulting in a permanently measurable negative ion-charge at the surface of the wells, and layers of substantially pure antiserums dried on the wells without any binder from a suspension or solution of the antiserums and tightly but releasably bound to the polystryene.
摘要翻译：用于血液分型的微量滴定板由具有多个孔的刚性透明聚苯乙烯的平底板组成，所述聚苯乙烯通过以高频施加高功率电能的电晕和/或等离子体方法进行表面处理，从而产生永久可测量在孔表面的负离子电荷和基本上纯的抗血清层在孔上干燥而没有任何粘合剂从抗血清的悬浮液或溶液中紧密但可释放地结合到聚苯乙烯。

7. 发明授权

US4450078A Microfiltration device for the filtration of coagula and microaggregates from blood 失效
标题翻译：用于从血液过滤凝血酶和微团聚体的微过滤装置
公开(公告)号：US4450078A
公开(公告)日：1984-05-22
申请号：US427234
申请日：1982-09-29
申请人： Wolfram H. Walker , Karl H. Ganshirt , Hans Schleussner
发明人： Wolfram H. Walker , Karl H. Ganshirt , Hans Schleussner
IPC分类号： A61K35/14 , A61M1/22 , A61M5/165 , B01D25/04 , B01D39/16
CPC分类号： A61M5/165
摘要： A microfiltration device for the filtration of coagula and microaggregates from blood and blood components. The device contains a filter chamber with attaching nozzle, a filter cone containing truncoconical filter elements arranged in cascade with diminishing pore size and diminishing surface area, a drip chamber and a tailpiece. The filter chamber and filter cones have different tapers and are at a specific distance apart, the taper of the filter cone from inlet to outlet being greater than the taper of the filter chamber. The filter cone has up to four filter elements, and a spacer which extends into the filter element of smallest pore size and surface area and supports same. Each of the filter elements has at least two opposed ribs running from the base to the apex of the truncated cone. The spacer is constructed such that it serves simultaneously for the support of the ribs and for the support of the filter fabric of the smallest filter element. The device has a capacity of less than 100 ml. It is intended for use in transfusions of preserved blood or blood components, especially massive transfusions.
摘要翻译：用于从血液和血液成分过滤凝结物和微团聚体的微量过滤装置。该装置包括具有连接喷嘴的过滤室，包含与孔径减小和表面积减小成一列排列的截面过滤元件的过滤器锥体，滴注室和尾件。过滤室和过滤器锥体具有不同的锥度并且在特定的距离处，过滤器锥体从入口到出口的锥度大于过滤室的锥度。过滤锥体具有多达四个过滤元件，以及间隔物，其延伸到具有最小孔径和表面积的过滤元件中并且支撑相同的。每个过滤元件具有至少两个相对的肋，从基部到截锥的顶点延伸。间隔件被构造成使得其同时用于肋的支撑和用于支撑最小过滤元件的过滤织物。该装置的容量小于100毫升。它用于输血保存的血液或血液成分，特别是大量输血。

8. 发明授权

US4396717A Nutrient medium carrier system 失效
标题翻译：营养培养基载体系统
公开(公告)号：US4396717A
公开(公告)日：1983-08-02
申请号：US285647
申请日：1981-07-21
申请人： Reinhard Fiebig , Hans Schleussner
发明人： Reinhard Fiebig , Hans Schleussner
IPC分类号： C12M1/22 , C12M1/20 , C12M1/32 , C12M3/00 , C12M1/18
CPC分类号： C12M23/04 , C12M23/20 , C12M23/34 , C12M23/38 , C12M23/46 , C12M37/04
摘要： A nutrient medium carrier system comprising a sterilizable plastic nutrient medium carrier, a sterilizable plastic cover, and a sealing foil, the nutrient medium carrier having a depression to receive the nutrient medium, a surrounding beaded edge above the surface of the nutrient medium, a handle on one end, and a flat edge running around both sides and the other end, the depression being subdivided into compartments by means of ridges; the cover having a depression and a surrounding flat edge to receive the sealing foil, the cover depression gradually widening on two sides and one end to a flat edge up to the dimensions of the nutrient medium carrier, the narrow part being of such size that both side walls and one end touch the beaded edge on two sides and on the end opposite the handle, the cover having a steplike offset with locking flanges on its upper edge to hold the nutrient medium carrier, the flat edge of the carrier contacting the steplike offset of the cover, the cover on the side on which the handle of the nutrient medium carrier comes to lie being rounded off or slanted and provided with a hollow for gripping and pulling out the nutrient medium carrier from the cover.
摘要翻译：一种营养培养基载体系统，包括可灭菌的塑料营养培养基载体，可灭菌塑料盖和密封箔，所述营养培养基载体具有接收营养培养基的凹陷，营养培养基表面上方的周围串珠边缘，手柄在一端和平坦的边缘两边和另一端延伸，凹陷通过脊细分成隔间; 所述盖具有凹陷和围绕的平坦边缘以接收所述密封箔，所述盖凹陷在两侧逐渐变宽，并且一端到达平直边缘直至所述营养介质载体的尺寸，所述窄部具有如下尺寸：侧壁和一端接触两侧的珠状边缘和与手柄相对的端部，盖具有阶梯状偏移，在其上边缘具有锁定凸缘以保持营养介质载体，载体的平坦边缘接触步进偏移盖的营养介质载体的手柄侧面上的盖被倒圆或倾斜，并且设置有用于从盖上夹持和拉出营养介质载体的中空部。

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