专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4267174A Immune-stimulating and cancerostatic 1-acyl-2-cyanoaziridines 失效
标题翻译：免疫刺激和癌性1-酰基-2-氰基氮丙啶
公开(公告)号：US4267174A
公开(公告)日：1981-05-12
申请号：US916389
申请日：1978-06-16
申请人： Herbert Berger , Rudi Gall , Wolfgang Kampe , Uwe Bicker , Rolf Kuhn
发明人： Herbert Berger , Rudi Gall , Wolfgang Kampe , Uwe Bicker , Rolf Kuhn
IPC分类号： C07D499/64 , A61K31/396 , A61K31/43 , A61K31/495 , A61P31/00 , A61P35/00 , A61P37/04 , C07D203/00 , C07D203/18 , C07D203/24 , C07D231/16 , C07D231/20 , C07D231/22 , C07D307/68 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/06 , C07D487/04 , C07D499/04 , C07F9/564 , F42B3/087 , A61K31/395
CPC分类号： C07D307/68 , C07D203/18 , C07D203/24 , C07D231/16 , C07D231/20 , C07D231/22 , C07F9/564 , Y10S514/885
摘要： 1-Acyl-2-cyanoaziridines of the formula ##STR1## wherein R is an acyl radical of a carboxylic, sulphonic, sulphinic, sulphenic, phosphonic or phosphoric acid,exhibit immune-stimulating and cancerostatic activities.
摘要翻译：其中R是羧酸，磺酸，亚磺酸，磺酸，膦酸或磷酸的酰基的式“IMAGE”的1-酰基-2-氰基氮丙啶表现出免疫刺激和癌症活性。

2. 发明授权

US4282212A Immune-stimulating 1-(N-acylcarbamoyl)-2-cyanoaziridines 失效
标题翻译：免疫刺激1-（N-酰基氨基甲酰基）-2-氰基氮丙啶
公开(公告)号：US4282212A
公开(公告)日：1981-08-04
申请号：US838426
申请日：1977-09-30
申请人： Herbert Berger , Rudi Gall , Wolfgang Kampe , Uwe Bicker , Gottfried Hebold
发明人： Herbert Berger , Rudi Gall , Wolfgang Kampe , Uwe Bicker , Gottfried Hebold
IPC分类号： C07D203/12 , C07D203/06 , C07D203/08 , C07D203/18 , C07D203/20 , C07D203/24 , C07D237/24 , C07D317/68 , C07D333/38 , C07D409/12 , C07D417/12 , C07F9/22 , C07F9/24 , C07F9/564 , A61K31/395
CPC分类号： C07C265/16 , C07D203/06 , C07D203/20 , C07D203/24 , C07D237/24 , C07D317/68 , C07D333/38 , C07F9/564
摘要： 1-(N-Acyl-carbamoyl)-2-cyanoaziridines of the formula ##STR1## wherein X is oxygen or sulphur,Z is hydrogen or an organic radical, andY is a carbonyl, sulphonyl, sulphinyl, sulphenyl, phosphoryl or phosphonyl radical,and salts thereof, exhibit immune-stimulating and cancerostatic activities.
摘要翻译：其中X是氧或硫，Z是氢或有机基团，Y是羰基，磺酰基，亚磺酰基，磺酰基，磷酰基或膦酰基的1-（N-酰基 - 氨基甲酰基）-2-氰基氮丙啶及其盐具有免疫刺激和癌症活性。

3. 发明授权

US4492659A Phospholipid compound 失效
公开(公告)号：US4492659A
公开(公告)日：1985-01-08
申请号：US395954
申请日：1982-07-07
申请人： Elmar Bosies , Rudi Gall , Gunter Weimann , Uwe Bicker , Wulf Pahlke
发明人： Elmar Bosies , Rudi Gall , Gunter Weimann , Uwe Bicker , Wulf Pahlke
IPC分类号： A61K31/66 , A61P35/00 , C07F9/09 , C07F9/10 , C07F9/02
CPC分类号： C07F9/10 , C07F9/091
摘要： The present invention provides phospholipids of the general formula: ##STR1## wherein X is a valency bond, an oxygen or sulphur atom or a sulfonyl, sulfinyl, phenylene, cycloaklylene, carbonylamino, aminocarbonyl, ureido or carbonyl group, R.sub.1 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon radical containing up to 18 carbon atoms, which is optionally substituted one or more times by halogen, alkoxy, alkylthio, alkanesulfinyl, alkanesulfonyl, carbalkoxy or phenyl, R.sub.2 is a straight-chained or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing up to 18 carbon atoms, which is optionally substituted one or more times by halogen, alkoxy, alkylthio, alkanesulphinyl, alkanesulphonyl, carbalkoxy or phenyl, Y is an oxygen atom or a --O--CO--O--, --O--CO--NH-- or --O--CS--NH-- group, R.sub.3 is a straight-chained or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, which can also be part of a cycloalkane ring system and is optionally substituted one or more times by hydroxyl, halogen, alkylthio, alkanesulphinyl, alkanesulfonyl, nitrile, alkoxycarbonyl, carboxamido optionally substituted by alkyl radicals, cycoalkyl, optionally substituted phenyl or alkoxy, which in turn is optionally substituted by phenyl, hydroxyl, alkoxy, alkylthio, alkanesulfinyl, alkanesulfonyl, optionally acylated amino, alkoxycarbonyl, nitrile or carboxamido optionally substituted by alkyl radicals, Z is an oxygen or sulfur atom, R.sub.4 is a straight-chained or branched alkylene radical containing 2 to 5 carbon atoms and R.sub.5 is a hydrogen atom or a lower alkyl radical, with the proviso that when X is a valency bond, R.sub.1 and R.sub.2 together represent an unsubstituted, straight-chained or branched, saturated or unsaturated divalent aliphatic hydrocarbon chain containing up to 18 carbon atoms, Y, R.sub.4 and R.sub.5 have the above-given meanings and Z is an oxygen atom, R.sub.3 cannot be a propylene or 2-methylpropylene chain optionally substituted by hydroxyl, alkoxy or benzyloxy and with the proviso that when X is a valency bond, R.sub.1 and R.sub.2 together signify an alkyl radical containing up to 18 carbon atoms and substituted by halogen or phenyl, Y and Z are oxygen atoms and R.sub.4 and R.sub.5 have the above-given meanings, R.sub.3 cannot be a propylene or 2-hydroxypropylene chain; and the pharmacologically acceptable salts thereof.The invention also provides pharmaceutical compositions containing such compounds, having cancerostatic action without inducing thrombocyte aggregation.

4. 发明授权

US4376731A 1-Aziridine carboxylic acid derivatives with immunostimulant activity 失效
标题翻译：具有免疫刺激活性的1-氮杂环丁烷羧酸衍生物
公开(公告)号：US4376731A
公开(公告)日：1983-03-15
申请号：US859633
申请日：1978-01-31
申请人： Elmar Bosies , Ruth Heerdt , Rudi Gall , Uwe Bicker , Anna E. Ziegler
发明人： Elmar Bosies , Ruth Heerdt , Rudi Gall , Uwe Bicker , Anna E. Ziegler
IPC分类号： C07D203/20 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/395
CPC分类号： C07D403/12 , C07D203/20 , C07D405/12 , C07D409/12
摘要： 2-Substituted-1-aziridine-carboxylic acid esters exhibiting immuno-stimulant activity and of the formula ##STR1## wherein X is a carbamoyl or alkoxycarbonyl radical, andR.sup.1 is an aliphatic hydrocarbon radical optionally substituted by halogen, alkoxy, amino, carbamoyloxy, cycloalkyl, hydroxyl, an imido or heterocyclic radical, cycloalkyl; or aryl, aralkyl, aryloxyalkyl or arylthioalkyl wherein the aryl moiety is optionally substituted by halogen, alkyl, alkoxy, hydroxyl, amino, nitro, cyano, acyl, carbalkoxy, thioalkyl, alkylsulphonyl, phenyl or trifluoromethyl. Counterparts where X is --CN and R.sup.1 is as above, except for ethyl, are also new.
摘要翻译： 2-取代的1-氮丙啶 - 羧酸酯，其具有免疫刺激活性，并且具有下式：其中X是氨基甲酰基或烷氧基羰基，R1是任选被卤素，烷氧基，氨基，氨基甲酰氧基取代的脂族烃基，环烷基，羟基，亚氨基或杂环基，环烷基; 芳基，芳烷基，芳氧基烷基或芳硫基烷基，其中芳基部分任选被卤素，烷基，烷氧基，羟基，氨基，硝基，氰基，酰基，烷氧基，硫代烷基，烷基磺酰基，苯基或三氟甲基取代。对应物，其中X为-CN和R1如上所述，除乙基以外，也是新的。

5. 发明授权

US4444766A Sulfur-containing phospholipid compounds and therapeutic compositions 失效
标题翻译：含硫磷脂化合物和治疗组合物
公开(公告)号：US4444766A
公开(公告)日：1984-04-24
申请号：US311830
申请日：1981-10-16
申请人： Elmar Bosies , Rudi Gall , Gunter Weimann , Uwe Bicker , Wulf Pahlke
发明人： Elmar Bosies , Rudi Gall , Gunter Weimann , Uwe Bicker , Wulf Pahlke
IPC分类号： A61K31/661 , C07F9/09 , C07F9/10 , C07F9/165 , A61K31/095 , A61K31/66
CPC分类号： C07F9/091 , C07F9/10 , C07F9/1651
摘要： Sulfur-containing phospholipid compounds of the formula ##STR1## pharmaceutical compositions having anti-tumor activity which include said phospholipid compounds, and the method of use for combating tumors, of said phospholipid compounds.
摘要翻译：所述磷脂化合物的具有抗肿瘤活性的包含所述磷脂化合物的药物组合物和用于对抗肿瘤的方法的含硫磷脂化合物。

6. 发明授权

US3957766A Novel nitrofuran compounds and pharmaceutical compositions 失效
标题翻译：新型硝基化合物和药物组合物
公开(公告)号：US3957766A
公开(公告)日：1976-05-18
申请号：US290682
申请日：1972-09-20
申请人： Herbert Berger , Rudi Gall , Hartmut Merdes , Kurt Stach , Winfriede Sauer , Wolfgang Vomel
发明人： Herbert Berger , Rudi Gall , Hartmut Merdes , Kurt Stach , Winfriede Sauer , Wolfgang Vomel
IPC分类号： C07D487/04 , C07D295/06 , C07D295/12 , C07D471/04
CPC分类号： C07D487/04
摘要： Certain novel nitrofuran compounds of the formula: ##SPC1##WhereinHet is an aromatic heterocylic linkage;B is a bond or vinylene;Y is O or S;m is 0 or 1;X is hydrogen, lower alkyl or alkanoyl; andThe R's are variously defined;Are outstandingly effective bacteriostats and bactericides.

7. 发明授权

US4172136A 3-Nitropyrazole compounds and anti-microbial compositions 失效
标题翻译： 3-硝基吡唑化合物和抗微生物组合物
公开(公告)号：US4172136A
公开(公告)日：1979-10-23
申请号：US889594
申请日：1978-03-23
申请人： Herbert Berger , Rudi Gall , Kurt Stach, deceased , Max Thiel , Wolfgang Vomel
发明人： Herbert Berger , Rudi Gall , Kurt Stach, deceased , Max Thiel , Wolfgang Vomel
IPC分类号： C07D231/16 , C07D401/02 , C07D403/02
CPC分类号： C07D231/16
摘要： New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO-NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.
摘要翻译：新的具有下式的3-硝基吡唑化合物：其中R 1是低级烷基; R2是氢或低级烷基; R3是氰基，羧基或低级烷氧基羰基或基团-CO-NR4R5，其中R4是氢或羟基，氨基甲酰基，烷基氨基甲酰基，二烷基氨基甲酰基，硫代氨基甲酰基，脲基，硫脲基，羟基苯基，吡啶甲基或是低级烷基，烯基或环烷基取代如果需要，通过氰基，羟基，吡咯烷子基，哌啶子基，氨基，低级烷基氨基，低级二烷基氨基或低级酰基氨基取代基，R 5是氢原子或低级烷基，或者R 4和R 5一起代表低级亚烷基桥; 并且其药理学兼容的药物作为抗微生物药剂，特别是在系统性和在尿道感染中是非常有效的。

8. 发明授权

US4105772A 3-Nitropyrazole compounds and anti-microbial compositions 失效
标题翻译： 3-硝基吡唑化合物和抗微生物组合物
公开(公告)号：US4105772A
公开(公告)日：1978-08-08
申请号：US744215
申请日：1976-11-22
申请人： Herbert Berger , Rudi Gall , Kurt Stach, deceased , by Werner Plattner, administrator , Max Thiel , Wolfgang Vomel
发明人： Herbert Berger , Rudi Gall , Kurt Stach, deceased , by Werner Plattner, administrator , Max Thiel , Wolfgang Vomel
IPC分类号： C07D231/16 , A61K31/41 , C07D231/10
CPC分类号： C07D231/16
摘要： New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO--NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof, are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.
摘要翻译：新的具有下式的3-硝基吡唑化合物：其中R 1是低级烷基; R2是氢或低级烷基; R3是氰基，羧基或低级烷氧基羰基或基团-CO-NR4R5，其中R4是氢或羟基，氨基甲酰基，烷基氨基甲酰基，二烷基氨基甲酰基，硫代氨基甲酰基，脲基，硫脲基，羟基苯基，吡啶甲基或是低级烷基，烯基或环烷基取代如果需要，通过氰基，羟基，吡咯烷子基，哌啶子基，氨基，低级烷基氨基，低级二烷基氨基或低级酰基氨基取代基，R 5是氢原子或低级烷基，或者R 4和R 5一起代表低级亚烷基桥; 并且其药理学兼容的药物作为抗微生物剂，特别是在系统性和全球性的治疗中是非常有效的。

9. 发明授权

US4069330A Nitropyrazole compounds and anti-microbial compositions 失效
标题翻译：硝基吡唑化合物和抗微生物组合物
公开(公告)号：US4069330A
公开(公告)日：1978-01-17
申请号：US678588
申请日：1976-04-20
申请人： Herbert Berger , Rudi Gall , Max Thiel , Wolfgang Schaumann , Wolfgang Vomel
发明人： Herbert Berger , Rudi Gall , Max Thiel , Wolfgang Schaumann , Wolfgang Vomel
IPC分类号： G09F7/02 , C07D231/16 , G09F3/20 , H01B7/36 , H01R13/46 , A61K31/415
CPC分类号： H01B7/368 , C07D231/16
摘要： New nitropyrazole compounds of the formula ##STR1## wherein R.sub.1 is alkyl or hydroxyalkylR.sub.2 and R.sub.3, which may be the same or different, are alkyl orR.sub.2 and R.sub.3 together represent a 4- or 5-membered alkylene bridge which is optionally interrupted by an oxygen atom or by the grouping >N-R, in which R is an alkyl or hydroxyalkyl radical;And the pharmacologically compatible salts thereof, possess excellent anti-microbial action not only in vitro but also in vivo, especially systemically.
摘要翻译：其中R 1是烷基或羟基烷基的新的硝基吡唑化合物，其可以相同或不同，R 2和R 3可以是烷基或R 2和R 3一起代表4-或5-元亚烷基桥，其任选地被氧原子或通过NR> NR，其中R是烷基或羟烷基; 和药物相容性好的药物，不仅仅是体内，而且在体内非常有效地进行非常有效的抗微生物作用。

10. 发明授权

US3989832A Combating bacteria with nitroimidazolyl-triazolo-pyridiazine compounds 失效
标题翻译：抗菌与硝基咪唑基 - 三唑并 - 嘧啶化合物
公开(公告)号：US3989832A
公开(公告)日：1976-11-02
申请号：US600533
申请日：1975-07-31
申请人： Herbert Berger , Rudi Gall , Kurt Stach , Wolfgang Vomel , Rita Hoffmann
发明人： Herbert Berger , Rudi Gall , Kurt Stach , Wolfgang Vomel , Rita Hoffmann
IPC分类号： C07D487/04 , A01N9/00 , A01N9/22
CPC分类号： C07D487/04
摘要： Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##SPC1##Wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy;A is hydrogen, halogen, azido, cyano; lower alkyl, alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; orA is a radical of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; andR.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge;n is 0 or 1;And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.
摘要翻译：具有下式的硝基咪唑基-s-三唑并[4,3-b]哒嗪

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式