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1. 发明授权

US09963675B2 Compositions and methods for treating retinal diseases 有权
公开(公告)号：US09963675B2
公开(公告)日：2018-05-08
申请号：US15144628
申请日：2016-05-02
申请人： Henry Klassen , Jing Yang
发明人： Henry Klassen , Jing Yang
IPC分类号： C12N5/079 , A61K35/30 , A61K9/00 , C12N5/0797
CPC分类号： C12N5/0621 , A61K9/0019 , A61K9/0048 , A61K35/30 , C12N5/0623 , C12N2500/02 , C12N2500/38 , C12N2500/90 , C12N2509/00 , C12N2533/52
摘要： Disclosed herein are compositions and methods for treating, ameliorating or preventing a retinal disease or condition; improving a photopic (day light) vision; for improving correcting visual acuity, improving macular function, improving a visual field, or improving scotopic (night) vision by administration of retinal progenitor cells. The subject matter described herein also provides cell populations comprising retinal progenitor cells and methods of isolation thereof.

2. 发明授权

US09107897B2 Methods for isolating mammalian retinal progenitor cells 有权
标题翻译：分离哺乳动物视网膜祖细胞的方法
公开(公告)号：US09107897B2
公开(公告)日：2015-08-18
申请号：US14118223
申请日：2012-05-17
申请人： Henry Klassen , Jing Yang
发明人： Henry Klassen , Jing Yang
IPC分类号： A61K35/30 , A61K9/00 , C12N5/0797
CPC分类号： C12N5/0621 , A61K9/0019 , A61K9/0048 , A61K35/30 , C12N5/0623 , C12N2500/02 , C12N2500/38 , C12N2500/90 , C12N2509/00 , C12N2533/52
摘要： Disclosed herein are compositions and methods for treating, ameliorating or preventing a retinal disease or condition; improving a photopic (day light) vision; for improving correcting visual acuity, improving macular function, improving a visual field, or improving scotopic (night) vision by administration of retinal progenitor cells. The subject matter described herein also provides cell populations comprising retinal progenitor cells and methods of isolation thereof.
摘要翻译：本文公开了治疗，改善或预防视网膜疾病或病症的组合物和方法; 改善视力（日光）; 用于通过施用视网膜祖细胞来改善矫正视力，改善黄斑功能，改善视野或改善暗视（夜间）视力。本文所述的主题还提供了包含视网膜祖细胞的细胞群及其分离方法。

3. 发明申请

US20080213893A1 ISOLATION OF NEURAL STEM CELLS USING GANGLIOSIDES AND OTHER SURFACE MARKERS 有权
标题翻译：使用疱疹和其他表面标记分离神经干细胞
公开(公告)号：US20080213893A1
公开(公告)日：2008-09-04
申请号：US11934597
申请日：2007-11-02
申请人： Henry Klassen , Michael Schwartz , Michael J. Young
发明人： Henry Klassen , Michael Schwartz , Michael J. Young
IPC分类号： C12N5/06
CPC分类号： C12N5/0623 , A61K35/12 , C07K16/28 , C12N2503/00 , G01N33/57407 , G01N33/57484
摘要： During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included gene products as well as non-protein molecules and sugar epitopes not directly coded in the genome. Together with surface markers which were determined to be absent from the surface of hNSCs, the molecules described herein provide a means to enrich for neural stem cells, or neural progenitor subpopulations, particularly using combinatorial cell sorting strategies. These same molecules also represent targets for pharmacological manipulation of NSC populations and subpopulations, both in vivo and ex vivo. Furthermore, these molecules provide potential targets for therapeutic manipulation of other neural precursor-related cell types including malignant conditions as well as other diseases originating from, or preferentially affecting, various uncommitted or replication-competent cell types.
摘要翻译：在NSCs的生长和研究期间，鉴定出存在于多能神经干细胞和祖细胞（NSCs）表面上的一系列分子。使用许多人和鼠神经干细胞系（包括视网膜干细胞（RSCs））鉴定这些标记物。鉴定的NSC特异性标记物包括基因产物以及非直接编码在基因组中的非蛋白质分子和糖表位。与被确定为不存在于hNSC表面的表面标志物一起，本文所述的分子提供了富集神经干细胞或神经祖细胞亚群的方法，特别是使用组合细胞分选策略。这些相同的分子也代表体内和体外NSC群体和亚群体药理学操作的目标。此外，这些分子提供治疗性治疗其他神经前体相关细胞类型的潜在靶标，包括恶性疾病以及源于或优先影响各种未提及或复制的细胞类型的其他疾病。

4. 发明授权

US08241897B2 Isolation of neural stem cells using gangliosides and other surface markers 有权
标题翻译：使用神经节苷脂和其他表面标志物分离神经干细胞
公开(公告)号：US08241897B2
公开(公告)日：2012-08-14
申请号：US11934597
申请日：2007-11-02
申请人： Henry Klassen , Michael Schwartz , Michael J. Young
发明人： Henry Klassen , Michael Schwartz , Michael J. Young
IPC分类号： C12N5/0797 , C12N5/079 , C12N5/074
CPC分类号： C12N5/0623 , A61K35/12 , C07K16/28 , C12N2503/00 , G01N33/57407 , G01N33/57484
摘要： During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included gene products as well as non-protein molecules and sugar epitopes not directly coded in the genome. Together with surface markers which were determined to be absent from the surface of hNSCs, the molecules described herein provide a means to enrich for neural stem cells, or neural progenitor subpopulations, particularly using combinatorial cell sorting strategies. These same molecules also represent targets for pharmacological manipulation of NSC populations and subpopulations, both in vivo and ex vivo. Furthermore, these molecules provide potential targets for therapeutic manipulation of other neural precursor-related cell types including malignant conditions as well as other diseases originating from, or preferentially affecting, various uncommitted or replication-competent cell types.
摘要翻译：在NSCs的生长和研究期间，鉴定出存在于多能神经干细胞和祖细胞（NSCs）表面上的一系列分子。使用许多人和鼠神经干细胞系（包括视网膜干细胞（RSCs））鉴定这些标记物。鉴定的NSC特异性标记物包括基因产物以及非直接编码在基因组中的非蛋白质分子和糖表位。与被确定为不存在于hNSC表面的表面标志物一起，本文所述的分子提供了富集神经干细胞或神经祖细胞亚群的方法，特别是使用组合细胞分选策略。这些相同的分子也代表体内和体外NSC群体和亚群体药理学操作的目标。此外，这些分子提供治疗性治疗其他神经前体相关细胞类型的潜在靶标，包括恶性疾病以及源于或优先影响各种未提及或复制的细胞类型的其他疾病。

5. 发明授权

US07419825B2 Isolation of neural stem cells using gangliosides and other surface markers 有权
标题翻译：使用神经节苷脂和其他表面标志物分离神经干细胞
公开(公告)号：US07419825B2
公开(公告)日：2008-09-02
申请号：US10128009
申请日：2002-04-22
申请人： Henry Klassen , Michael Schwartz , Michael J. Young
发明人： Henry Klassen , Michael Schwartz , Michael J. Young
IPC分类号： C12N5/00 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0623 , A61K35/12 , C07K16/28 , C12N2503/00 , G01N33/57407 , G01N33/57484
摘要： During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included gene products as well as non-protein molecules and sugar epitopes not directly coded in the genome. Together with surface markers which were determined to be absent from the surface of hNSCs, the molecules described herein provide a means to enrich for neural stem cells, or neural progenitor subpopulations, particularly using combinatorial cell sorting strategies. These same molecules also represent targets for pharmacological manipulation of NSC populations and subpopulations, both in vivo and ex vivo. Furthermore, these molecules provide potential targets for therapeutic manipulation of other neural precursor-related cell types including malignant cell types as well as diseases originating from, or preferentially affecting, various uncommitted or replication-competent cell types.
摘要翻译：在NSCs的生长和研究期间，鉴定出存在于多能神经干细胞和祖细胞（NSCs）表面上的一系列分子。使用许多人和鼠神经干细胞系（包括视网膜干细胞（RSCs））鉴定这些标记物。鉴定的NSC特异性标记物包括基因产物以及非直接编码在基因组中的非蛋白质分子和糖表位。与被确定为不存在于hNSC表面的表面标志物一起，本文所述的分子提供了富集神经干细胞或神经祖细胞亚群的方法，特别是使用组合细胞分选策略。这些相同的分子也代表体内和体外NSC群体和亚群体药理学操作的目标。此外，这些分子提供潜在的目标，用于治疗其他神经前体相关细胞类型的治疗操作，包括恶性细胞类型以及源于或优先影响各种未提交或复制能力的细胞类型的疾病。

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