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1. 发明申请

US20080213893A1 ISOLATION OF NEURAL STEM CELLS USING GANGLIOSIDES AND OTHER SURFACE MARKERS 有权
标题翻译：使用疱疹和其他表面标记分离神经干细胞
公开(公告)号：US20080213893A1
公开(公告)日：2008-09-04
申请号：US11934597
申请日：2007-11-02
申请人： Henry Klassen , Michael Schwartz , Michael J. Young
发明人： Henry Klassen , Michael Schwartz , Michael J. Young
IPC分类号： C12N5/06
CPC分类号： C12N5/0623 , A61K35/12 , C07K16/28 , C12N2503/00 , G01N33/57407 , G01N33/57484
摘要： During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included gene products as well as non-protein molecules and sugar epitopes not directly coded in the genome. Together with surface markers which were determined to be absent from the surface of hNSCs, the molecules described herein provide a means to enrich for neural stem cells, or neural progenitor subpopulations, particularly using combinatorial cell sorting strategies. These same molecules also represent targets for pharmacological manipulation of NSC populations and subpopulations, both in vivo and ex vivo. Furthermore, these molecules provide potential targets for therapeutic manipulation of other neural precursor-related cell types including malignant conditions as well as other diseases originating from, or preferentially affecting, various uncommitted or replication-competent cell types.
摘要翻译：在NSCs的生长和研究期间，鉴定出存在于多能神经干细胞和祖细胞（NSCs）表面上的一系列分子。使用许多人和鼠神经干细胞系（包括视网膜干细胞（RSCs））鉴定这些标记物。鉴定的NSC特异性标记物包括基因产物以及非直接编码在基因组中的非蛋白质分子和糖表位。与被确定为不存在于hNSC表面的表面标志物一起，本文所述的分子提供了富集神经干细胞或神经祖细胞亚群的方法，特别是使用组合细胞分选策略。这些相同的分子也代表体内和体外NSC群体和亚群体药理学操作的目标。此外，这些分子提供治疗性治疗其他神经前体相关细胞类型的潜在靶标，包括恶性疾病以及源于或优先影响各种未提及或复制的细胞类型的其他疾病。

2. 发明授权

US08241897B2 Isolation of neural stem cells using gangliosides and other surface markers 有权
标题翻译：使用神经节苷脂和其他表面标志物分离神经干细胞
公开(公告)号：US08241897B2
公开(公告)日：2012-08-14
申请号：US11934597
申请日：2007-11-02
申请人： Henry Klassen , Michael Schwartz , Michael J. Young
发明人： Henry Klassen , Michael Schwartz , Michael J. Young
IPC分类号： C12N5/0797 , C12N5/079 , C12N5/074
CPC分类号： C12N5/0623 , A61K35/12 , C07K16/28 , C12N2503/00 , G01N33/57407 , G01N33/57484
摘要： During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included gene products as well as non-protein molecules and sugar epitopes not directly coded in the genome. Together with surface markers which were determined to be absent from the surface of hNSCs, the molecules described herein provide a means to enrich for neural stem cells, or neural progenitor subpopulations, particularly using combinatorial cell sorting strategies. These same molecules also represent targets for pharmacological manipulation of NSC populations and subpopulations, both in vivo and ex vivo. Furthermore, these molecules provide potential targets for therapeutic manipulation of other neural precursor-related cell types including malignant conditions as well as other diseases originating from, or preferentially affecting, various uncommitted or replication-competent cell types.
摘要翻译：在NSCs的生长和研究期间，鉴定出存在于多能神经干细胞和祖细胞（NSCs）表面上的一系列分子。使用许多人和鼠神经干细胞系（包括视网膜干细胞（RSCs））鉴定这些标记物。鉴定的NSC特异性标记物包括基因产物以及非直接编码在基因组中的非蛋白质分子和糖表位。与被确定为不存在于hNSC表面的表面标志物一起，本文所述的分子提供了富集神经干细胞或神经祖细胞亚群的方法，特别是使用组合细胞分选策略。这些相同的分子也代表体内和体外NSC群体和亚群体药理学操作的目标。此外，这些分子提供治疗性治疗其他神经前体相关细胞类型的潜在靶标，包括恶性疾病以及源于或优先影响各种未提及或复制的细胞类型的其他疾病。

3. 发明授权

US07419825B2 Isolation of neural stem cells using gangliosides and other surface markers 有权
标题翻译：使用神经节苷脂和其他表面标志物分离神经干细胞
公开(公告)号：US07419825B2
公开(公告)日：2008-09-02
申请号：US10128009
申请日：2002-04-22
申请人： Henry Klassen , Michael Schwartz , Michael J. Young
发明人： Henry Klassen , Michael Schwartz , Michael J. Young
IPC分类号： C12N5/00 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0623 , A61K35/12 , C07K16/28 , C12N2503/00 , G01N33/57407 , G01N33/57484
摘要： During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included gene products as well as non-protein molecules and sugar epitopes not directly coded in the genome. Together with surface markers which were determined to be absent from the surface of hNSCs, the molecules described herein provide a means to enrich for neural stem cells, or neural progenitor subpopulations, particularly using combinatorial cell sorting strategies. These same molecules also represent targets for pharmacological manipulation of NSC populations and subpopulations, both in vivo and ex vivo. Furthermore, these molecules provide potential targets for therapeutic manipulation of other neural precursor-related cell types including malignant cell types as well as diseases originating from, or preferentially affecting, various uncommitted or replication-competent cell types.
摘要翻译：在NSCs的生长和研究期间，鉴定出存在于多能神经干细胞和祖细胞（NSCs）表面上的一系列分子。使用许多人和鼠神经干细胞系（包括视网膜干细胞（RSCs））鉴定这些标记物。鉴定的NSC特异性标记物包括基因产物以及非直接编码在基因组中的非蛋白质分子和糖表位。与被确定为不存在于hNSC表面的表面标志物一起，本文所述的分子提供了富集神经干细胞或神经祖细胞亚群的方法，特别是使用组合细胞分选策略。这些相同的分子也代表体内和体外NSC群体和亚群体药理学操作的目标。此外，这些分子提供潜在的目标，用于治疗其他神经前体相关细胞类型的治疗操作，包括恶性细胞类型以及源于或优先影响各种未提交或复制能力的细胞类型的疾病。

4. 发明申请

US20090104694A1 ISOLATION AND TRANSPLANTATION OF RETINAL STEM CELLS 审中-公开
标题翻译：离体干细胞的分离和移植
公开(公告)号：US20090104694A1
公开(公告)日：2009-04-23
申请号：US12266116
申请日：2008-11-06
申请人： Michael J. Young , Henry J. Klassen , Marie A. Shatos , Keiko Mizumoto
发明人： Michael J. Young , Henry J. Klassen , Marie A. Shatos , Keiko Mizumoto
IPC分类号： C12N5/06 , C12N5/08
CPC分类号： C12N5/0621 , A01K67/0271 , A61K35/12 , C12N5/0623 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/02
摘要： The present invention relates to the isolation, in vitro propagation, and transplantation and integration of non-pigmented retinal stem cells derived from the neuroretina of the eye, ex vivo and in vivo.
摘要翻译：本发明涉及从体外和体内衍生自眼神经视网膜的非着色视网膜干细胞的分离，体外扩增和移植和整合。

5. 发明授权

US6110242A Apparatus for separating solids from a gas 有权
标题翻译：用于从气体中分离固体的装置
公开(公告)号：US6110242A
公开(公告)日：2000-08-29
申请号：US170548
申请日：1998-10-13
申请人： Michael J. Young
发明人： Michael J. Young
IPC分类号： B01D45/12 , B01D50/00 , B07B7/086
CPC分类号： B07B7/086 , B01D45/12 , B01D50/002
摘要： An apparatus for separating solids, such as scrap material, from a gas such as an air stream. The apparatus includes a horizontally mounted outer cylinder or drum and an inner perforated cylindrical member is mounted concentrically within the drum to provide an annular space therebetween. High velocity air containing scrap material is delivered through one or more tangential inlets to the annular space and the heavy scrap material is thrown outwardly by centrifugal force along the inner surface of the drum and discharged through a tangential outlet, while the air passes inwardly through the perforated member and is discharged through an axial outlet in the drum. The scrap material being discharged from the separator is fed to the lower end of a closed, inclined auger and conveyed upwardly and discharged into a surge tube of a baler where the scrap is converted into bales.
摘要翻译：一种用于从例如气流的气体中分离诸如废料的固体的装置。该装置包括水平安装的外筒或滚筒，并且内穿孔的圆柱形构件同心地安装在滚筒内以在它们之间提供环形空间。包含高速空气的废料通过一个或多个切向入口输送到环形空间，并且重的废料通过沿鼓的内表面的离心力向外抛出，并通过切向出口排出，同时空气向内通过穿孔构件，并通过滚筒中的轴向出口排出。将从分离器排出的废料被送入封闭的倾斜螺旋钻的下端并向上输送并排放到打捆机的冲击管中，其中废料被转化成捆。

6. 发明授权

US5797147A Spill-resistent urinal 失效
标题翻译：防漏小便池
公开(公告)号：US5797147A
公开(公告)日：1998-08-25
申请号：US738665
申请日：1996-10-25
申请人： Michael J. Young , James A. Young , Jack Bankier
发明人： Michael J. Young , James A. Young , Jack Bankier
IPC分类号： A47K11/12 , A61G9/00
CPC分类号： A61G9/006 , A47K11/12 , Y10T137/7854 , Y10T137/7882
摘要： A urinal for men who cannot use a toilet or are otherwise incapacitated has a canister with a removable spout. A manual seal in the spout can be manipulated between open and closed positions by a trigger on the exterior of the spout, and locked into the open position by a releasable locking arm. A vertically-arranged opening in a dome seal attached to the spout helps prevent spillage in the event the urinal is knocked onto its side when the manual seal is locked open. The spout is attached to the canister by a releasable collar, and thus can be easily separated for cleaning.
摘要翻译：不能使用厕所或其他无法使用的男子的小便池有一个带有可拆卸喷口的罐子。喷嘴中的手动密封可以通过喷嘴外部的触发器在打开和关闭位置之间操纵，并通过可释放的锁定臂锁定在打开位置。安装在喷嘴上的圆顶密封件中的垂直布置的开口有助于防止当手动密封件锁定打开时小便器被撞到其侧面的情况下溢出。喷嘴通过可释放的套环附接到罐，因此可以容易地分离以进行清洁。

7. 发明申请

US20090306772A1 Ocular Scaffolds and Methods for Subretinal Repair of Bruch's Membrane 审中-公开
标题翻译：眼支架和Bruch膜的视网膜下修复方法
公开(公告)号：US20090306772A1
公开(公告)日：2009-12-10
申请号：US12426066
申请日：2009-04-17
申请人： Sarah L. Tao , Henry J. Klassen , Michael J. Young
发明人： Sarah L. Tao , Henry J. Klassen , Michael J. Young
IPC分类号： A61F2/14 , C08G63/08
CPC分类号： A61F9/00 , A61F2/14 , A61K35/12 , C08G63/08 , C12N5/0621 , C12N2501/11 , C12N2533/30 , C12N2533/52
摘要： The present invention provides ocular scaffolds composed of poly (e-caprolactone) configured to be inserted into the sub-retinal space of a subject, as well as methods for treating eye disease (e.g., age-related macular degeneration) with such scaffolds. The present invention also provides methods of making such scaffolds.
摘要翻译：本发明提供由配置成插入受试者的子视网膜空间的聚（ε-己内酯）构成的眼支架，以及用这种支架治疗眼病（例如年龄相关性黄斑变性）的方法。本发明还提供了制备这种支架的方法。

8. 发明授权

US06810429B1 Enterprise integration system 失效
标题翻译：企业集成系统
公开(公告)号：US06810429B1
公开(公告)日：2004-10-26
申请号：US09497610
申请日：2000-02-03
申请人： Thomas C. Walsh , Michael J. Young , Joseph J. DiCelie , David W. H. Wong , Alan W. Esenther
发明人： Thomas C. Walsh , Michael J. Young , Joseph J. DiCelie , David W. H. Wong , Alan W. Esenther
IPC分类号： G06F1516
CPC分类号： G06F17/30569
摘要： An enterprise integration system is coupled to a number of legacy data sources. The data sources each use different data formats and different access methods. The integration system includes a back-end interface configured to convert input data source information to input XML documents and to convert output XML document to output data source information. A front-end interface converts the output XML documents to output HTML forms and the input HTML forms to the XML documents. A middle tier includes a rules engine and a rules database. Design tools are used to define the conversion and the XML documents. A network couples the back-end interface, the front-end interface, the middle tier, the design tools, and the data sources. Mobile agents are configured to communicate the XML documents over the network and to process the XML documents according to the rules.
摘要翻译：企业集成系统耦合到许多传统数据源。数据源各自使用不同的数据格式和不同的访问方式。集成系统包括后端接口，配置为将输入数据源信息转换为输入XML文档，并将输出XML文档转换为输出数据源信息。前端接口将输出的XML文档转换为将HTML表单和输入的HTML表单输出到XML文档。中间层包括规则引擎和规则数据库。设计工具用于定义转换和XML文档。网络耦合后端接口，前端接口，中间层，设计工具和数据源。移动代理被配置为通过网络传送XML文档，并根据规则处理XML文档。

9. 发明授权

US5320069A Small animal restraint device 失效
标题翻译：小动物约束装置
公开(公告)号：US5320069A
公开(公告)日：1994-06-14
申请号：US875616
申请日：1992-04-28
申请人： George W. Anderson, Jr. , Wade B. Lawrence , Jae-Ouk Lee , Michael J. Young
发明人： George W. Anderson, Jr. , Wade B. Lawrence , Jae-Ouk Lee , Michael J. Young
IPC分类号： A01K1/06 , A01K15/00 , A61D3/00 , A01K29/00
CPC分类号： A61D3/00 , A01K1/0613
摘要： An improved small animal restraint device is provided which enables an inidual to conduct ocular examinations of a small animal. The device minimizes manipulation of the eyes of the animal and eliminates recovery time associated with anesthetics, while also reducing examination time. The restraint device comprises a cylinder having a longitudinal slot in the wall thereof. A conical member which is attached to one end of the cylinder includes a pair of eye openings in the upper wall thereof and a nose opening at the apex thereof. A plunger placed in the cylinder at the other end thereof assists in holding the animal in place. A set screw, which extends through the slot in the wall of the cylinder, secures the plunger in place.
摘要翻译：提供了一种改进的小动物约束装置，其使得个体能够进行小动物的眼睛检查。该装置最大限度地减少对动物眼睛的操作，并消除与麻醉剂相关的恢复时间，同时也减少检查时间。约束装置包括在其壁中具有纵向狭槽的圆柱体。安装在圆筒的一端的锥形构件包括在其上壁中的一对眼孔和在其顶点的鼻孔。置于其另一端的气缸中的柱塞有助于将动物保持在适当位置。延伸穿过气缸壁中的狭槽的固定螺钉将柱塞固定到位。

10. 发明授权

US4336614A Tube-in-shell heat exchangers 失效
标题翻译：管壳式换热器
公开(公告)号：US4336614A
公开(公告)日：1982-06-22
申请号：US70433
申请日：1979-08-28
申请人： Colin H. Mitchell , Michael J. Young
发明人： Colin H. Mitchell , Michael J. Young
IPC分类号： F28D7/16 , F28F9/00 , F28F9/013 , G21C1/00 , G21C1/03 , G21C1/32 , G21C15/00
CPC分类号： G21C1/326 , F28F9/0133 , G21C1/03 , F28F2265/26 , Y02E30/34 , Y02E30/35
摘要： A tube-in-shell heat exchanger wherein the tube bundle has a central spine which carries a series of bracing grids for the tubes. The grids are resiliently mounted on the spine so that differential thermal expansion of one group of tubes relative to other groups of tubes and structure can be accommodated without inducing severe thermal stress.
摘要翻译：一种管壳式换热器，其中管束具有中心脊，其承载用于管的一系列支撑栅格。栅格弹性地安装在脊柱上，使得一组管相对于其他管组和结构的不同热膨胀可以被容纳而不引起严重的热应力。

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