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1. 发明授权

US4776869A Method for preparing substrates for optical sensors 失效
标题翻译：光学传感器基板的制备方法
公开(公告)号：US4776869A
公开(公告)日：1988-10-11
申请号：US53617
申请日：1987-05-26
申请人： Helmut Offenbacher , Herbert Kroneis
发明人： Helmut Offenbacher , Herbert Kroneis
IPC分类号： C03B8/00 , C03C3/091 , C03C11/00 , C03C15/00 , C03C23/00 , G01N31/22
CPC分类号： C03C11/005 , C03C23/008
摘要： Bodies of borosilicate glass with a B.sub.2 O.sub.3 content of less than 13 percent by weight are provided with a microporous layer of a thickness of 5 to 20 .mu.m, and are thus turned into carriers for optical sensors. This process is characterized by the following steps. Thermal decomposition for 5 to 10 days at 500.degree. to 560.degree. C.; removal of the topmost layer of glass to a depth of at least 10 .mu.m in the part of the surface to be rendered porous; leaching of the separated borate phase with diluted mineral acids for a minimum of 2 days at 70.degree. to 98.degree. C.; and after-treatment of the microporous layer, including (a) chemical treatment with concentrated sulphuric acid and concentrated nitric acid for 2 hours at 20.degree. C., and (b) heat-treatment for 10 minutes to 2 hours at 450.degree. to 700.degree. C.
摘要翻译：具有小于13重量％的B 2 O 3含量的硼硅酸盐玻璃体具有厚度为5至20μm的微孔层，因此被转成光学传感器的载体。该过程的特征在于以下步骤。在500〜560℃下热分解5〜10天。在待表面多孔的部分表面去除最上层的玻璃至少10μm的深度; 将分离的硼酸盐相与稀释的无机酸一起在70℃至98℃下浸出最少2天; （a）在20℃下用浓硫酸和浓硝酸进行2小时的化学处理，和（b）在450〜700℃下热处理10分钟〜2小时 DEG C.

2. 发明授权

US4965087A Method of making a sensor element for fluorescence-optical measurements 失效
标题翻译：制造用于荧光光学测量的传感器元件的方法
公开(公告)号：US4965087A
公开(公告)日：1990-10-23
申请号：US172959
申请日：1988-03-23
申请人： Otto Wolfbeis , Herbert Kroneis , Helmut Offenbacher
发明人： Otto Wolfbeis , Herbert Kroneis , Helmut Offenbacher
IPC分类号： G01N21/64 , G01N21/80
CPC分类号： G01N21/643 , G01N21/6428 , G01N21/80
摘要： A sensor element useful in making fluorescence-optical measurements includes a substrate having a carrier surface, particles having a large specific surface are which are glued, melted or sintered onto the carrier surface so as to provide small elevations of a regular distribution on the carrier surface, and an indicator substance immobilized on the particles. Additional substances can be applied to the particles to reduce undesirable influences of properties of the sample on the indicator substance.
摘要翻译：可用于制造荧光光学测量的传感器元件包括具有载体表面的基底，具有大比表面的颗粒被胶合，熔化或烧结到载体表面上，以便在载体表面上提供规则分布的小高度，和固定在颗粒上的指示剂物质。可以向颗粒施加另外的物质以减少样品对指示剂物质的不良影响。

3. 发明授权

US4703182A Arrangement for fluorescence-optical measurement of concentrations of substances contained in a sample 失效
标题翻译：用于荧光光学测量样品中所含物质浓度的布置
公开(公告)号：US4703182A
公开(公告)日：1987-10-27
申请号：US776586
申请日：1985-09-16
申请人： Herbert Kroneis , Helmut Offenbacher
发明人： Herbert Kroneis , Helmut Offenbacher
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N21/648 , G01N21/7703 , G01N2021/6463
摘要： An arrangement for the fluorescence-optical measurement of concentrations of substances contained in a sample includes a detector, a light source and a sensor element that includes a carrier element, the carrier element having an indicator layer on a portion thereof and an indicator-free surface, the carrier element being transparent to the radiation used, and having a refractive index which is greater than that of the ambient medium at the indicator-free surface, the light space being positioned such that the transmission of light from the light source to the indicator layer, and from there to the detector, is achieved, at least partially, by total reflection in the carrier element.
摘要翻译：包含在样品中的物质的浓度的荧光光学测量装置包括检测器，光源和包括载体元件的传感器元件，载体元件在其一部分上具有指示剂层和无指示表面载体元件对所使用的辐射是透明的，并且在无指示器表面处具有大于环境介质的折射率的折射率，所述光空间定位成使得从光源到指示器的光的传输层，并且从那里到检测器，至少部分地通过载体元件中的全反射来实现。

4. 发明授权

US4568518A Sensor element for fluorescence-optical measurement 失效
标题翻译：用于荧光光学测量的传感器元件
公开(公告)号：US4568518A
公开(公告)日：1986-02-04
申请号：US557209
申请日：1983-12-02
申请人： Otto Wolfbeis , Herbert Kroneis , Helmut Offenbacher
发明人： Otto Wolfbeis , Herbert Kroneis , Helmut Offenbacher
IPC分类号： G01N21/64 , G01N21/80 , G01N31/22
CPC分类号： G01N21/6428 , G01N21/80
摘要： Fluorescence-optical indicator material is chemically bonded in a network structure permeating a carrier membrane of the sensor element. As this network structure is independent of the membrane and not chemically bonded thereto, the properties of the membrane and the indicator are not affected by the immobilization.
摘要翻译：荧光光学指示剂材料在渗透传感器元件的载体膜的网络结构中化学键合。由于该网络结构独立于膜而不与其化学键合，因此膜和指示剂的性质不受固定影响。

5. 发明授权

US5185263A Method for calibration of a measurement apparatus 失效
标题翻译：校准测量装置的方法
公开(公告)号：US5185263A
公开(公告)日：1993-02-09
申请号：US785878
申请日：1991-11-04
申请人： Herbert Kroneis , Hermann Marsoner , Taghi Noormofidi
发明人： Herbert Kroneis , Hermann Marsoner , Taghi Noormofidi
IPC分类号： G01N27/416
CPC分类号： G01N27/4165 , Y10T436/10 , Y10T436/107497 , Y10T436/115831
摘要： In order to calibrate a measurement apparatus used for determining at least the pH and pCO.sub.2 values in aqueous media, two aqueous base solutions A and B with good storage stability are mixed at a defined ratio immediately prior to calibration, the desired pH and pCO.sub.2 values being provided for calibration of the measuring electrodes of the measurement apparatus only after chemical reaction of the base solutions A and B has taken place.
摘要翻译：为了校准用于确定水性介质中的至少pH和pCO 2值的测量装置，具有良好储存稳定性的两种碱性水溶液A和B在校准之前以确定的比例混合，所需的pH和pCO 2值为仅在基础溶液A和B发生化学反应之后才提供测量装置的测量电极的校准。

6. 发明申请

US20080173064A1 Creatinine Sensor Calibration 有权
标题翻译：肌酸酐传感器校准
公开(公告)号：US20080173064A1
公开(公告)日：2008-07-24
申请号：US12057636
申请日：2008-03-28
申请人： Bernhard Schaffar , Herbert Kroneis , Taghi Noormofidi , Gernot Florian , Wolf-Dietrich Steinbock
发明人： Bernhard Schaffar , Herbert Kroneis , Taghi Noormofidi , Gernot Florian , Wolf-Dietrich Steinbock
IPC分类号： G01N33/48
CPC分类号： G01N33/96 , C12Q1/001 , C12Q1/26 , C12Q1/34
摘要： In a method for calibrating a biosensor for the amperometric determination of creatinine in biological liquids, consisting of one electrode system each for measuring the concentrations of creatinine and creatine, with at least two calibration solutions being used, the electrode system for measuring the creatinine concentration is calibrated with a creatinine solution which, prior to the calibration measurement, was mixed in the form of an acidic solution with an alkaline buffer solution, and the electrode system for measuring the creatine concentration is calibrated with a solution in which creatinine and creatine are at a thermodynamic equilibrium.
摘要翻译：在用于校准生物液体中肌酸酐电流测定的生物传感器的方法中，由用于测量肌酸酐和肌酸浓度的一个电极系统组成，使用至少两种校准溶液，用于测量肌酸酐浓度的电极系统是用肌酸酐溶液校准，其在校准测量之前以酸性溶液与碱性缓冲溶液的形式混合，并用肌酸酐和肌酸酐溶液中的溶液校准用于测量肌酸浓度的电极系统热力学平衡。

7. 发明授权

US4657736A Sensor element for determining the oxygen content and a method of preparing the same 失效
标题翻译：用于确定氧含量的传感器元件及其制备方法
公开(公告)号：US4657736A
公开(公告)日：1987-04-14
申请号：US883430
申请日：1986-07-14
申请人： Hermann Marsoner , Herbert Kroneis , Otto Wolfbeis
发明人： Hermann Marsoner , Herbert Kroneis , Otto Wolfbeis
IPC分类号： G01N21/76 , C08L83/04 , C09K11/02 , C09K11/06 , G01N21/64 , G01N21/78 , G01N31/00 , G01N31/22 , G01J3/30 , G01N21/26 , G01N21/48 , G01N33/16
CPC分类号： G01N21/643 , C09K11/02 , C09K11/025 , C09K11/06 , G01N21/648 , G01N2021/773 , G01N2021/7786 , G01N21/6428 , Y10T436/207497
摘要： In an O.sub.2 sensor element which contains a fluorescent indicator substance, a polymerized silicone polymer is used as a carrier material in which the indicator substance is incorporated in solubilized form and in an at least approximately homogeneous distribution. Solubilization of the indicator substance may essentially be performed in analogy to Friedel-Crafts alkylation of aromatics, which will increase solubility of the indicator substance in the polymer carrier without affecting quenching behavior.
摘要翻译：在含有荧光指示物质的O 2传感器元件中，使用聚合的硅氧烷聚合物作为载体材料，其中指示剂物质以溶解形式并入至少近似均匀的分布。指示剂物质的溶解可以基本上类似于芳烃的Friedel-Crafts烷基化进行，这将增加指示剂物质在聚合物载体中的溶解度，而不影响猝灭行为。

8. 发明授权

US5527706A Method for mixing two initial solutions 失效
标题翻译：混合两种初始溶液的方法
公开(公告)号：US5527706A
公开(公告)日：1996-06-18
申请号：US321791
申请日：1994-10-12
申请人： Herbert Kroneis , Taghi Noormofidi , Wolf-Dietrich Steinbock , Herfried Huemer
发明人： Herbert Kroneis , Taghi Noormofidi , Wolf-Dietrich Steinbock , Herfried Huemer
IPC分类号： G01N1/00 , B01F3/08 , B01F15/00 , B01F15/04 , G01N1/10 , G01N27/416 , G05D11/00 , G05D11/13 , G01N31/00
CPC分类号： G05D11/135 , B01F15/00253 , Y10S435/967 , Y10T436/10 , Y10T436/107497 , Y10T436/115831 , Y10T436/12
摘要： In a process for mixing two initial solutions to produce a working solution with an accurately defined mixing ratio, the two initial solutions are coarsely mixed in a first step, having a mixing ratio lying within a given range, and the value of an internal parameter of the working solution is determined in a second step. The values of this internal parameter are known and differ significantly for the two initial solutions. Then the accurate mixing ratio of the working solution is determined from the measured value of the internal parameter in a third step.
摘要翻译：在将两种初始溶液混合以产生具有精确限定的混合比的工作溶液的方法中，将两种初始溶液在混合比在给定范围内的第一步骤中粗混合，并且内部参数的值在第二步确定工作解决方案。该内部参数的值是已知的，并且对于两个初始解决方案显着不同。然后在第三步骤中根据内部参数的测量值确定工作溶液的精确混合比。

9. 发明授权

US06174728B1 Control or calibration standard for use with instruments for optical measurement of hemoglobin concentration in blood samples 失效
标题翻译：用于血液样品中血红蛋白浓度光学测量仪器的控制或校准标准
公开(公告)号：US06174728B1
公开(公告)日：2001-01-16
申请号：US09054461
申请日：1998-04-03
申请人： Daniel Ben-David , Charles L. Laughinghouse , James K. Tusa , Werner Ziegler , Herbert Kroneis , Ewald Jöbstl
发明人： Daniel Ben-David , Charles L. Laughinghouse , James K. Tusa , Werner Ziegler , Herbert Kroneis , Ewald Jöbstl
IPC分类号： G01N3100
CPC分类号： G01N21/4785 , Y10T436/10 , Y10T436/101666 , Y10T436/102499 , Y10T436/105831 , Y10T436/106664 , Y10T436/108331
摘要： A control or calibration standard for use with instruments for the optical measurement of the hemoglobin content in blood samples, features scattering particles or beads dispersed in aqueous electrolyte solution. To prevent sedimentation of the beads during storage, they have a mean diameter of
摘要翻译：用于血液样品中血红蛋白含量的光学测量仪器的控制或校准标准，散布在水性电解质溶液中的散射颗粒或珠粒。为了防止在储存期间珠的沉降，它们的平均直径<0.6μm，优选约0.3μm，体积浓度<1％，优选<0.3％。为了防止长期的聚集，配方中可以包含具有添加的抗氧化剂的非离子表面活性剂。

10. 发明授权

US5157262A Sensor element for determination of concentration of substances 失效
标题翻译：用于确定物质浓度的传感器元件
公开(公告)号：US5157262A
公开(公告)日：1992-10-20
申请号：US706004
申请日：1991-05-28
申请人： Hermann Marsoner , Herbert Kroneis , Hellfried Karpf , Otto S. Wolfbeis , Helmut List , Alfred Leitner
发明人： Hermann Marsoner , Herbert Kroneis , Hellfried Karpf , Otto S. Wolfbeis , Helmut List , Alfred Leitner
IPC分类号： G01N21/64 , G01N21/25 , G01N21/27 , G01N21/77 , G01N21/81
CPC分类号： G01N21/77 , G01N21/255 , G01N2021/174 , G01N2021/7786 , G01N21/6428 , G01N21/81 , G01N2201/0621 , G01N2201/0622
摘要： Due to the size of the devices used for the excitation and measuring of light, conventional sensor elements for optically determining the concentrations of substances contained in gaseous and liquid samples, featuring an indicator layer with one or more indicator substances, are not well suited for use with microanalysis equipment, nor are they easy to mass-produce. These disadvantages are eliminated by integrating on the carrier layer (1) at least one photosensitive element (3) and its electric contact leads in planar arrangement, and by establishing optical contact between the indicator substance (7, 7') of the indicator layer (6) stimulated by the excitation radiation (11), and the photosensitive elements (3).

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