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1. 发明授权

US4638023A Process for the production of reagent films and reagent films produced thereby 失效
标题翻译：用于制备由此制备的试剂膜和试剂膜的方法
公开(公告)号：US4638023A
公开(公告)日：1987-01-20
申请号：US701089
申请日：1985-02-13
申请人： Heinz-Freidrich Trasch , Anselm Rothe , Bernward Sojka , Wolfgang Werner , Hans Wielinger
发明人： Heinz-Freidrich Trasch , Anselm Rothe , Bernward Sojka , Wolfgang Werner , Hans Wielinger
IPC分类号： G01N31/22 , G01N33/52
CPC分类号： G01N31/22 , Y10T442/2484 , Y10T442/2893
摘要： The present invention provides a process for the production of reagent films in which an aqueous synthetic resin dispersion which contains the usual adjuvants and reagents is coated on to a solid substrate or on to a thin fabric in a thin layer and dried, wherein to the crude film mass used for the coating there are added 0.5 to 5% by weight of a scleroprotein hydrolysate with a molecular weight of from 5000 to 50,000 and 0.5 to 10% by weight of a higher alcohol containing 5 to 10 carbon atoms.
摘要翻译：本发明提供一种制备试剂膜的方法，其中将含有通常的助剂和试剂的水性合成树脂分散体涂覆在固体基质上或薄层上的薄织物上并干燥，添加0.5〜5重量％的分子量为5000〜50,000的硬脂蛋白水解物和0.5〜10重量％的含有5〜10个碳原子的高级醇的膜。

2. 发明授权

US4587099A Test strips for the detection of a liquid sample component 失效
标题翻译：用于检测液体样品组分的测试条
公开(公告)号：US4587099A
公开(公告)日：1986-05-06
申请号：US677899
申请日：1984-12-05
申请人： Anselm Rothe , Adolf K. Selle , Bernward Sojka
发明人： Anselm Rothe , Adolf K. Selle , Bernward Sojka
IPC分类号： G01N33/66 , C12Q1/00 , C12Q1/54 , G01N31/22 , G01N33/48 , G01N33/52 , G01N21/78
CPC分类号： G01N33/525
摘要： A test strip for analyzing a liquid sample has a carrier or handle, a slowly-absorbent layer fixed thereupon which slowly sucks up the liquid sample, a liquid impermeable layer fixer thereover, an absorbent reagent layer fixed thereover, and a mesh covering these, which mesh layer is fixed next to the slowly-absorbent layer on to the carrier. The mesh and layer portions of the test strip can thus be briefly immersed in the liquid sample with the carrier and withdrawn for observing the analyzing reaction of the reagent and liquid sample absorbed into the absorbent reagent layer through the mesh, the mesh serving to conduct excess liquid sample from the adjacent surface of the absorbent reagent layer to the still absorbent slowly-absorbent layer so that the excess liquid sample does not interfere with the observation of the reaction.
摘要翻译：用于分析液体样品的测试条具有载体或手柄，固定在其上的缓慢吸收层，缓慢吸收液体样品，其上不透液层定影剂，固定在其上的吸收剂层和覆盖它们的网网状层固定在载体上的缓慢吸收层的旁边。因此，测试条的网格和层部分可以与载体短暂地浸入液体样品中，并取出，以观察通过网孔吸收到吸收剂层中的试剂和液体样品的分析反应，筛网用于过量液体样品从吸收剂试剂层的相邻表面到吸收缓慢吸收层，使得过量的液体样品不会干扰反应的观察。

3. 发明授权

US4492754A Composition and method for the determination of hydrogen peroxide 失效
标题翻译：用于测定过氧化氢的组合物和方法
公开(公告)号：US4492754A
公开(公告)日：1985-01-08
申请号：US387392
申请日：1982-06-11
申请人： Ulrich Trager , Bernward Sojka , Hans Lange
发明人： Ulrich Trager , Bernward Sojka , Hans Lange
IPC分类号： G01N33/50 , C07C67/00 , C07C227/00 , C07C229/38 , C07C301/00 , C07C309/45 , C07C309/46 , C12Q1/28 , G01N33/52 , G01N33/66 , G01N33/70 , G01N33/92
CPC分类号： C12Q1/28 , C12Q2326/00 , Y10S435/805 , Y10S436/904 , Y10T436/206664
摘要： Composition for the detection of(a) hydrogen peroxide or hydrogen peroxide forming substrates or(b) peroxidases or peroxidatively reacting substances which composition comprises a substrate capable of coupling and an oxidizable substance known to undergo the Trinder reaction, and(a) a peroxidase or(b) hydrogen peroxidewherein the substrate capable of coupling is a compound of the formula ##STR1## in which n and m are individually selected from whole numbers of 1 to 4,X and Y, which can be the same or different represent a valence bond or a phenylene radical,R.sub.1 and R.sub.2 are individually selected from carboxyl or sulfonic acid groups and one of R.sub.1 and R.sub.2 can also be hydrogen or lower alkyl, andR.sub.3 and R.sub.4 are individually selected from hydrogen and alkyl radicals of up to 6 carbon atoms;and/or a salt of such compound.The present invention also provides a method wherein the composition is brought together with a sample and the coloration obtained is evaluated visually or with a photometer.
摘要翻译：用于检测（a）过氧化氢或过氧化氢形成底物的组合物或（b）过氧化物酶或过氧化物反应物质，其组合物包含能够偶联的底物和已知可进行Trinder反应的可氧化物质，和（a）过氧化物酶或（b）过氧化氢，其中能够偶联的基质是下式的化合物，其中n和m分别选自1至4的整数，X和Y可以相同或不同代表价键或亚苯基，R 1和R 2分别选自羧基或磺酸基，R 1和R 2中的一个也可以是氢或低级烷基，并且R 3和R 4分别选自氢和烷基直到 6个碳原子; 和/或这种化合物的盐。本发明还提供了一种方法，其中将组合物与样品一起放置，并且目测或使用光度计评估所获得的着色。

4. 发明授权

US5104811A Test carrier and method for the analytical determination of components of body fluids 失效
标题翻译：用于分析体内液体组分的测试载体和方法
公开(公告)号：US5104811A
公开(公告)日：1992-04-14
申请号：US134950
申请日：1987-12-18
申请人： Dieter Berger , Wolfgang-Reinhold Knappe , Robert Lorenz , Henry M. Grage, Jr. , Mark T. Skarstedt , Bernward Sojka , Manfred Bleisteiner
发明人： Dieter Berger , Wolfgang-Reinhold Knappe , Robert Lorenz , Henry M. Grage, Jr. , Mark T. Skarstedt , Bernward Sojka , Manfred Bleisteiner
IPC分类号： G01N31/22 , C12M1/34 , G01N21/77 , G01N33/49 , G01N33/52 , G01N33/543 , G01N33/558
CPC分类号： G01N33/525 , G01N33/558 , Y10S435/805 , Y10S435/81 , Y10S436/81
摘要： On a carrier layer there are arranged several test layers which are at least partly in fluid contact with one another, enabling liquid exchange. On the carrier layer are arranged an application zone, a detection zone for the production of a detectable signal characteristic of the analytical determination, which contains at least one said test layer which is a reaction layer, and an absorption zone with a test layer which is an absorptive layer of an absorbent material, wherein the reaction layer and absorption zone are positioned next to each other. Between the application and the absorption zone is a capillary-active transport path on the carrier layer which connects the application zone and the absorption zone. The reaction layer is arranged parallel to the transport path between the application zone and the absorption zone in such a manner that it is in liquid contact with a liquid transported in the transport path. The absorption zone therefore absorbs excess liquid and permits dosing the reaction layer with a reproducible amount of sample.
摘要翻译：在载体层上布置有几个测试层，其至少部分地彼此流体接触，从而实现液体交换。在载体层上布置有应用区域，用于产生分析测定特征的可检测信号的检测区域，其包含至少一个作为反应层的测试层，以及具有测试层的吸收区，其为吸收材料的吸收层，其中反应层和吸收区彼此相邻放置。在应用和吸收区之间是在载体层上的连接施加区和吸收区的毛细管 - 主动传输路径。反应层以与输送路径中输送的液体液体接触的方式平行于施加区域和吸收区域之间的输送路径布置。因此，吸收区吸收多余的液体，并允许用可重复量的样品给反应层。

5. 发明授权

US4439527A Composition and method for the detection of hydrogen peroxide 失效
标题翻译：用于检测过氧化氢的组合物和方法
公开(公告)号：US4439527A
公开(公告)日：1984-03-27
申请号：US385760
申请日：1982-06-07
申请人： Bernd Pakebusch , Carsten A. Carstensen , Bernward Sojka , Hans Lange
发明人： Bernd Pakebusch , Carsten A. Carstensen , Bernward Sojka , Hans Lange
IPC分类号： G01N33/50 , C12Q1/28 , G01N31/00 , G01N21/78
CPC分类号： C12Q1/28 , C12Q2326/96 , Y10S436/904 , Y10T436/206664
摘要： Means and method for the detection of hydrogen peroxide or of hydrogen peroxide-forming substrates, consisting of 4-aminoantipyrine and an aromatic amine or phenol and a neutral to weakly acid buffer as well as other additives and reagents which form H.sub.2 O.sub.2 with the substrate and which are known for use in Trinder's reaction, the 4-aminoantipyrine, in the immiscible state before use, being separate from the acid buffer and from the other reagents if any, and being mixed with a small amount of an alkaline buffer having a pH of 8.5 to 14.0, the two compositions being combined, in a quantity ratio to one another that is suitable for the detection test, in a single package or in a single-use unit.
摘要翻译：用于检测过氧化氢或形成过氧化氢的底物的方法和方法，由4-氨基安替比林和芳族胺或苯酚和中性至弱酸性缓冲剂以及与底物形成H 2 O 2的其它添加剂和试剂组成，其中已知Trinder反应中使用4-氨基安替比林，在使用前不混溶状态，与酸缓冲液和其他试剂分离，如果有的话，并与少量pH为8.5的碱性缓冲液混合至14.0，两种组合物在单个包装或一次性单元中以彼此的量相互组合，适合于检测试验。

6. 发明授权

US3964870A Diagnostic composition for the determination of glucose 失效
标题翻译：用于测定葡萄糖的诊断组成
公开(公告)号：US3964870A
公开(公告)日：1976-06-22
申请号：US555327
申请日：1975-03-04
申请人： Hugo Tiedemann , Bernward Sojka , Hans Lange , Hans-Georg Rey , Peter Rieckmann
发明人： Hugo Tiedemann , Bernward Sojka , Hans Lange , Hans-Georg Rey , Peter Rieckmann
IPC分类号： G01N33/66 , C12Q1/54 , G01N31/14 , G01N31/22 , G01N33/16
CPC分类号： C12Q1/54
摘要： Glucose contained in urine is determined by contacting a sample with a diagnostic composition comprising an absorbent carrier impregnated with glucose oxidase, peroxidase, an indicator compound such as o-tolidine, and as a buffer, 2-(N-morpholino)-ethane-sulfonic acid.
摘要翻译：通过使样品与包含浸渍有葡萄糖氧化酶，过氧化物酶，指示剂化合物如邻甲苯吡啶的缓冲液的诊断组合物接触，测定尿中的葡萄糖，作为缓冲剂，将2-（N-吗啉代） - 乙磺酸酸。

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