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1. 发明授权

US4898966A Process for the preparation of phenylalanine n-propyl ester hydrochloride 失效
标题翻译：苯丙氨酸正丙酯盐酸盐的制备方法
公开(公告)号：US4898966A
公开(公告)日：1990-02-06
申请号：US256052
申请日：1988-10-11
申请人： Heinz Erpenbach , Klaus Gehrmann , Peter Horstermann , Erhard Jagers , Georg Kohl
发明人： Heinz Erpenbach , Klaus Gehrmann , Peter Horstermann , Erhard Jagers , Georg Kohl
IPC分类号： C07C229/36
CPC分类号： C07C227/18
摘要： In order to prepare phenylalanine n-propyl ester hydrochloride, phenylalanine hydrochloride is reacted with n-propanol in the molar ration 1: (5 to 20) at temperatures from 80.degree. to 110.degree. C., preferably 85.degree. to 105.degree. C., at pressures from 0.1 to 1.5 bar in the presence of 0.1 to 0.75 mole of HCl/mole of phenylalanine hydrochloride as catalyst and in the presence of water entrainer, a concentration of water entrainer of 20 to 50% by weight being maintained in the reaction mixture.
摘要翻译：为了制备苯丙氨酸正丙酯盐酸盐，将苯丙氨酸盐酸盐与摩尔比1：（5〜20）的正丙醇在80〜110℃，优选85〜105℃反应，在0.1至0.75摩尔HCl /摩尔苯丙氨酸盐酸盐作为催化剂的存在下，在0.1至1.5巴的压力下，在水夹带剂的存在下，在反应混合物中保持20至50重量％的水夹带剂浓度。

2. 发明授权

US5380929A Process for the preparation of acetic acid and acetic anhydride 失效
标题翻译：乙酸和乙酸酐的制备方法
公开(公告)号：US5380929A
公开(公告)日：1995-01-10
申请号：US236669
申请日：1994-05-02
申请人： Heinz Erpenbach , Klaus Gehrmann , Erhard Jagers , Georg Kohl
发明人： Heinz Erpenbach , Klaus Gehrmann , Erhard Jagers , Georg Kohl
IPC分类号： B01J31/20 , C07B61/00 , C07C51/12 , C07C51/56 , C07C53/08 , C07C53/12
CPC分类号： C07C51/12 , C07C51/56
摘要： To prepare acetic acid and acetic anhydride, methanol and methyl acetate are reacted under anhydrous conditions with carbon monoxide in the presence of a catalyst system containing carbonyl complexes of group VIII noble metals, methyl iodide, an alkali metal acetate or iodide, or quaternary organophosphonium or organoammonium acetate or iodide, The hot carbonylation mixture is decompressed, the evaporated components are fed to a first distillation zone, and the catalyst solution which remains is fed back to the reaction zone. In the first distillation zone, the volatile carbonylation products are subjected to fractional distillation; the low-boiling methyl iodide and methyl acetate pass back into the reaction zone, and the bottom product produced is a mixture of acetic acid and acetic anhydride, which is split into the pure components in a second distillation zone and a third distillation zone.
摘要翻译：为了制备乙酸和乙酸酐，在无水条件下，甲醇和乙酸甲酯在含有VIII族贵金属，甲基碘，碱金属乙酸酯或碘化物的羰基络合物或季有机鏻的催化剂体系存在下与一氧化碳反应，或乙酸有机铵或碘化物。将热羰基化混合物减压，将蒸发的组分进料至第一蒸馏区，将剩余的催化剂溶液反馈回反应区。在第一蒸馏区中，将挥发性羰基化产物进行分馏; 低沸点甲基碘和乙酸甲酯回到反应区，产生的底部产物是乙酸和乙酸酐的混合物，其在第二蒸馏区和第三蒸馏区被分成纯组分。

3. 发明授权

US4717454A Process for removing acetone from reaction mixtures of carbonylation reactions 失效
标题翻译：从羰基化反应的反应混合物中除去丙酮的方法
公开(公告)号：US4717454A
公开(公告)日：1988-01-05
申请号：US774384
申请日：1985-09-10
申请人： Heinz Erpenbach , Klaus Gehrmann , Peter Horstermann , Georg Kohl
发明人： Heinz Erpenbach , Klaus Gehrmann , Peter Horstermann , Georg Kohl
IPC分类号： C07C69/34 , B01J31/00 , C07C45/00 , C07C45/82 , C07C45/85 , C07C49/08 , C07C51/00 , C07C51/573 , C07C53/12 , C07C67/00 , B01D5/00
CPC分类号： C07C51/573 , C07C45/82 , C07C45/85 , C07C67/36 , C07C67/37 , C07C67/60 , Y10S203/06
摘要： A process for removing by product acetone from reaction mixtures obtained by reacting methyl acetate and/or dimethylether with carbon monoxide at elevated temperatures to obtain acetic anhydride in the presence of a catalyst system consisting essentially of carbonyl complexes of noble metals belonging to group VIII of the Periodic System of the elements, acetic acid, an organophosphorus or organonitrogen compound, and methyl iodide whereby the acetone obtained as a by-product during the reaction is subjected to condensation at temperatures of 50.degree. to 250.degree. C., under pressures of 0.01 to 150 bars and at a molar ratio as above defined for the catalyst system constituent of 1:(25-500):(10-100):(15-150) so as to obtain predominantly higher-boiling secondary products to be distillatively separated in a successive distillation zone together with volatile constituents of the catalyst system.
摘要翻译：通过产物丙酮从反应混合物中除去反应混合物的方法，该反应混合物通过在高温下使乙酸甲酯和/或二甲醚与一氧化碳反应而获得，以在催化剂体系存在下获得乙酸酐，所述催化剂体系主要由以下组分的贵金属的羰基络合物组成：元素的定期系统，乙酸，有机磷或有机氮化合物和甲基碘，由此在反应过程中作为副产物获得的丙酮在温度为50至250℃，压力为0.01至 150巴，摩尔比如上述对于催化剂体系成分1：（25-500）：（10-100）：（15-150）所定义的摩尔比，从而获得主要是较高沸点的次要产物，以蒸馏分离连续的蒸馏区和催化剂体系的挥发性成分。

4. 发明授权

US4549937A Process for separating the catalyst system from the reaction mixtures of carbonylation reactions 失效
标题翻译：将催化剂体系与羰基化反应的反应混合物分离的方法
公开(公告)号：US4549937A
公开(公告)日：1985-10-29
申请号：US442107
申请日：1982-11-16
申请人： Heinz Erpenbach , Klaus Gehrmann , Peter Horstermann , Hans-Klaus Kubbeler , Georg Kohl
发明人： Heinz Erpenbach , Klaus Gehrmann , Peter Horstermann , Hans-Klaus Kubbeler , Georg Kohl
IPC分类号： C07C69/34 , B01J31/00 , C07C51/00 , C07C51/573 , C07C53/12 , C07C67/00 , C07C67/54 , C07C69/16 , B01D3/06 , C07C51/56
CPC分类号： C07C51/573 , C07C67/54
摘要： The disclosure relates to a process for separating the catalyst system from reaction mixtures which are obtained by reacting methyl acetate and/or dimethylether with carbon monoxide and optionally hydrogen at elevated temperatures to acetic anhydride and optionally ethylidene diacetate in the presence of a catalyst system consisting of carbonyl complexes of noble metals belonging to group VIII of the Periodic System, acetic acid, an organophosphorus or organonitrogen compound, methyl iodide and optionally compounds of carbonyl-yielding common metals, and which issue from the reaction zone under a pressure of 25 to 150 bars at a temperature of 100.degree. to 250.degree. C. More particularly, the reaction mixture coming from the reaction zone is introduced into a separator heated to 60.degree. to 140.degree. C. and released to a pressure of 0.5 to 3.5 bars with spontaneous evaporation of the bulk of volatile constituents; the stream of liquid matter coming from the separator is delivered to a distilling zone and the bulk of still volatile constituents is distilled off therein under a pressure of 0.05 to 1 bar at a base temperature of 70.degree. to 170.degree. C.; and catalyst solution retained as base product is recycled to the reaction zone.
摘要翻译：本公开涉及一种从反应混合物中分离催化剂体系的方法，其通过使乙酸甲酯和/或二甲醚与一氧化碳和任选的氢气在高温下反应而获得，所述方法是在催化剂体系存在下在高温下在乙酸酐和任选的亚乙基二乙酸酯属于周期系第VIII族的贵金属的羰基络合物，乙酸，有机磷或有机氮化合物，甲基碘和任选的产生羰基的常见金属的化合物，并且在25至150巴的压力下从反应区发出更优选地，将来自反应区的反应混合物引入加热至60℃至140℃的隔膜中，并释放至0.5至3.5巴的压力，并自发蒸发大部分挥发性成分; 来自分离器的液体物流被输送到蒸馏区，并且在基本温度为70至170℃的压力下，在0.05至1巴的压力下蒸馏出大部分挥发性挥发性成分。将作为基础产物保留的催化剂溶液再循环至反应区。

5. 发明授权

US4892971A Process for the preparation of n-acetylphenylalanine 失效
标题翻译：制备正乙酰苯丙氨酸的方法
公开(公告)号：US4892971A
公开(公告)日：1990-01-09
申请号：US257715
申请日：1988-10-14
申请人： Heinz Erpenbach , Klaus Gehrmann , Peter Horstermann
发明人： Heinz Erpenbach , Klaus Gehrmann , Peter Horstermann
IPC分类号： C07C231/00 , B01J23/44 , C07B61/00 , C07C67/00 , C07C231/12 , C07C231/14 , C07C233/47 , C07C237/00
CPC分类号： C07C237/00
摘要： In the process for the preparation of N-acetylphenylalanine by opening the ring of 2-methyl-4-benzylidene-1,3-oxazolin-5-one with water to give 2-acetaminocinnamic acid and subsequently catalytically hydrogenating the latter, both reaction stages are carried out in a mixture of an aliphatic C.sub.3 -ketone to C.sub.10 -ketone or a water-miscible ether and water as the solvent, and the hydrogenation of the 2-acetaminocinnamic acid is carried out at temperatures of 10.degree. to 50.degree. C. and pressures of 1 to 15 bar in the presence of a supported palladium catalyst.
摘要翻译：在通过用水打开2-甲基-4-亚苄基-1,3-恶唑啉-5-酮的环以制备N-乙酰基苯丙氨酸的方法中，得到2-乙酰氨基肉桂酸，随后催化氢化后者，两个反应阶段在脂肪族C 3-酮与C 10 - 酮或水混溶性醚和水作为溶剂的混合物中进行，2-乙酰氨基肉豆蔻酸的氢化在10〜50℃的温度下进行。和在负载的钯催化剂存在下，压力为1至15巴。

6. 发明授权

US3954854A Recovery of monomeric acrylic acid from residues originating from processed crude acrylic acid 失效
标题翻译：从加工粗丙烯酸的残留物中回收单体丙烯酸
公开(公告)号：US3954854A
公开(公告)日：1976-05-04
申请号：US549176
申请日：1975-02-12
申请人： Klaus Gehrmann , Heinz Erpenbach , Georg Kohl , Hans Klaus Kuebbeler
发明人： Klaus Gehrmann , Heinz Erpenbach , Georg Kohl , Hans Klaus Kuebbeler
IPC分类号： B01J23/00 , B01J27/00 , B01J31/00 , C07B61/00 , C07C51/00 , C07C51/487 , C07C57/065 , C07C57/07 , C07C57/075 , C07C67/00
CPC分类号： C07C51/487
摘要： Monomeric acrylic acid is recovered from residues originating from processed crude acrylic acid and containing .beta.-acryloyloxypropionic acid, .beta.-acetoxypropionic acid, hydracrylic acid, dihydracrylic acid and polymeric hydracrylic acid. To this end, the residues are heated to temperatures within the range 130.degree. and 250.degree.C under pressures within the range 0.01 and 1 atmosphere absolute in contact with catalysts selected from alkali metal or alkaline earth metal carboxylates, phosphates or borates, or from alkali metal or alkaline earth metal compounds producing carboxylates together with the carboxylic acids being contained in the residues.
摘要翻译：来自加工粗丙烯酸和含有β-丙烯酰氧基丙酸，β-乙酰氧基丙酸，氢丙烯酸，二丙烯酸和聚合丙烯酸的残余物中回收单体丙烯酸。为此，将残余物加热到130℃和250℃范围内的温度，在0.01和1个绝对大气压范围内的压力下，与选自碱金属或碱土金属羧酸盐，磷酸盐或硼酸盐或碱的催化剂接触与残留物中含有的羧酸一起产生羧酸盐的金属或碱土金属化合物。

7. 发明授权

US5166452A Process for inhibiting and destroying peroxides in dialkyl ethers 失效
标题翻译：在二氯乙烷中抑制和破坏过氧化物的方法
公开(公告)号：US5166452A
公开(公告)日：1992-11-24
申请号：US756341
申请日：1991-09-06
申请人： Reinhard Gradl , Heinz Erpenbach , Norbert Weferling , Erhard Jagers
发明人： Reinhard Gradl , Heinz Erpenbach , Norbert Weferling , Erhard Jagers
IPC分类号： C07C41/44 , C07C41/46 , C07C43/04
CPC分类号： C07C41/46
摘要： A process for inhibiting and destroying peroxides in dialkyl ethers having the general formula R.sub.1 OR.sub.2 in which R.sub.1 and R.sub.2 are alkyl groups having 1 to 6 carbon atoms, which comprises adding, as inhibitor, a quaternary alkyl iodide of the general formula[CH.sub.3 alk.sub.3 P]Ito the dialkyl ethers.
摘要翻译：一种用于抑制和破坏具有通式R1OR2的二烷基醚中的过氧化物的方法，其中R 1和R 2是具有1至6个碳原子的烷基，其包括将作为抑制剂的通式[CH 3 Cl 3 P] I的季烷基碘加入到二烷基醚。

8. 发明授权

US5075485A Process for the preparation of N-acylphosphinothricin diesters 失效
标题翻译：制备N-氨基磷酰胺胶囊的方法
公开(公告)号：US5075485A
公开(公告)日：1991-12-24
申请号：US373330
申请日：1989-06-29
申请人： Manfred Bohshar , Heinz Erpenbach , Erhard Jagers , Hanss-Jerg Kleiner , Hans-Peter Koll
发明人： Manfred Bohshar , Heinz Erpenbach , Erhard Jagers , Hanss-Jerg Kleiner , Hans-Peter Koll
IPC分类号： C07F9/32
CPC分类号： C07F9/3211
摘要： In order to prepare N-acylphosphinothricin diesters, acetals of methyl-(3-oxopropyl)phosphinic acid esters of the formula ##STR1## are reacted in a dipolar aprotic solvent with a carboxylic acid amide and carbon monoxide in the presence of hydrogen gas using a cobalt compound as a catalyst, where the radical R' is alkyl or aryl or aralkyl.
摘要翻译：为了制备N-酰基次膦酸二酯，将式（IMAGE）的甲基 - （3-氧代丙基）次膦酸酯在氢气存在下，在偶极非质子传递溶剂中与羧酸酰胺和一氧化碳反应，钴化合物作为催化剂，其中基团R'是烷基或芳基或芳烷基。

9. 发明授权

US5124290A Process for removing metallic corrosion products from carbonylation reactions carried out under anhydrous conditions 失效
标题翻译：从非强制性条件下运输的碳化反应中除去金属腐蚀产物的方法
公开(公告)号：US5124290A
公开(公告)日：1992-06-23
申请号：US777066
申请日：1991-10-16
申请人： Heinz Erpenbach , Reinhard Gradl , Erhard Jagers , Andreas Seidel , Peter Prinz
发明人： Heinz Erpenbach , Reinhard Gradl , Erhard Jagers , Andreas Seidel , Peter Prinz
IPC分类号： B01J38/00 , C07B61/00 , C07C51/12 , C07C51/42 , C07C51/47 , C07C51/573 , C07C53/08 , C07C53/12
CPC分类号： C07C51/573 , C07C51/47
摘要： A process for removing metallic corrosion products from carbonylation reactions which are carried out under anhydrous conditions and in which methyl acetate and/or methanol and/or dimethyl ether are reacted over a noble metal catalyst system which comprises a noble metal of group VIII of the periodic table of the elements, a co-catalyst, such as iodide or bromide, in particular methyl iodide, and a promoter, such as an organophosphonium or organoammonium salt, and if appropriate a lithium salt, to give acetic acid and/or acetic anhydride is described, the process comprisinga) bringing the reaction solution which is contaminated with metallic corrosion products and contains the catalyst system into contact with an ion exchanger;b) separating this reaction solution which has been brought into contact in this way from the ion exchanger;c) desorbing the promoter adsorbed on the ion exchanger before regeneration with acetic acid and/or acetic anhydride;d) combining the eluate obtained in step c) with the reaction solution separated off in step b) and recycling the components together into the carbonylation reaction;e) regenerating the ion exchanger obtained from step c) with a strong mineral acid; andf) washing the ion exchanger regenerated in this way with acetic acid and/or acetic anhydride until free from water, before use in step a).
摘要翻译：一种在无水条件下进行羰基化反应的金属腐蚀产物的方法，其中乙酸甲酯和/或甲醇和/或二甲醚在贵金属催化剂体系上反应，贵金属催化剂体系包含周期性的第VIII族贵金属表中的元素，助催化剂如碘化物或溴化物，特别是甲基碘，以及促进剂如有机鏻盐或有机铵盐，以及如果合适的话，锂盐，得到乙酸和/或乙酸酐是描述了该方法，该方法包括：a）将被金属腐蚀产物污染的反应溶液带入与离子交换器接触的催化剂体系; b）将已经以这种方式接触的反应溶液从离子交换器分离; c）在用乙酸和/或乙酸酐再生之前解吸吸附在离子交换剂上的促进剂; d）将步骤c）中获得的洗脱液与步骤b）中分离的反应溶液合并，并将组分一起再循环到羰基化反应中; e）用强无机酸再生步骤c）获得的离子交换剂; 以及f）在步骤a）中使用之前，用乙酸和/或乙酸酐洗涤离子交换剂，直至不含水再洗涤。

10. 发明授权

US4556644A Process for purifying and recovering contaminated catalyst solution obtained in the carbonylation of methyl acetate and/or dimethylether 失效
标题翻译：用于纯化和回收在乙酸甲酯和/或二甲醚的羰基化中获得的污染的催化剂溶液的方法
公开(公告)号：US4556644A
公开(公告)日：1985-12-03
申请号：US405070
申请日：1982-08-04
申请人： Heinz Erpenbach , Klaus Gehrmann , Winfried Lork , Peter Prinz
发明人： Heinz Erpenbach , Klaus Gehrmann , Winfried Lork , Peter Prinz
IPC分类号： C07C67/37 , B01J31/40 , B01J38/00 , C07C27/00 , C07C51/00 , C07C51/12 , C07C51/48 , C07C51/573 , C07C53/08 , C07C53/12 , C07C67/00 , C07C69/16 , C07C51/54 , C07C51/56
CPC分类号： B01J31/0268 , B01J31/0239 , B01J31/20 , B01J31/4038 , B01J31/4046 , C07C51/48 , C07C51/573 , C07C67/36 , C07C67/37 , C07C67/54 , B01J2231/34 , B01J2531/82 , B01J2531/822 , B01J2531/824 , Y02P20/584
摘要： The disclosure relates to a process for purifying and recovering a contaminated catalyst solution which is obtained in the carbonylation of methyl acetate and/or dimethylether, the catalyst solution containing carbonyl complexes of noble metals of group VIII of the Periodic System of the elements, quaternary heterocyclic aromatic nitrogen compounds or quaternary organophosphorus compounds as organic promoters, and optionally compounds of carbonyl-yielding common metals as inorganic promoters, undistillable organic contaminants as well as acetic acid, acetic anhydride and ethylidene diacetate. To this end, the disclosure provides for the catalyst solution to be distillatively freed from its volatile constituents and for the remaining solid distillation residue to be freed from the organic contaminants by extraction with aliphatic ethers; and for the remaining undissolved mixture of noble metal/carbonyl-complex, organic and optionally inorganic promoters to be filtered off and recycled into the carbonylation reaction.
摘要翻译：本公开涉及一种净化和回收在乙酸甲酯和/或二甲醚的羰基化中获得的污染的催化剂溶液的方法，所述催化剂溶液含有元素周期系的VIII族贵金属的羰基络合物，四元杂环芳族氮化合物或季有机磷化合物作为有机促进剂，以及任选的产生羰基的常见金属作为无机助催化剂，不可挥发的有机污染物以及乙酸，乙酸酐和亚乙基二乙酸酯的化合物。为此，本公开内容提供了催化剂溶液从其挥发性成分中蒸馏除去，并且剩余的固体蒸馏残余物通过用脂族醚萃取除去有机污染物; 并且对于剩余的未溶解的贵金属/羰基络合物的混合物，有机和任选的无机助催化剂被滤出并再循环到羰基化反应中。

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