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    • 2. 发明授权
    • Bis(4-hydroxy-3,5-dialkylbenzyl)cyano-carboxylic acid esters
    • 双(4-羟基-3,5-二烷基苄基)氰基 - 羧酸酯
    • US3950382A
    • 1976-04-13
    • US511078
    • 1974-10-01
    • Heinz EggenspergerVolker FranzenKarl-Heinz DiehlWilfred Kloss
    • Heinz EggenspergerVolker FranzenKarl-Heinz DiehlWilfred Kloss
    • C07C255/53C08K5/315C07C121/76
    • C07C255/00C07C323/00C08K5/315
    • The reaction of one mole of a Mannich base corresponding to the formula ##SPC1##And one mole of a Mannich base corresponding to the formula ##SPC2##Wherein R.sub.1, R.sub.2, R.sub.4 and R.sub.5 are independently selected from alkyl groups having 1 to 6 carbon atoms and R is alkyl, preferably lower alkyl, with 1 mole of a carboxylic acid ester corresponding to the formula R.sub.3 CH.sub.2 COOR.sub.4 wherein R.sub.3 is --H, --CN or --COOR.sub.4 and R.sub.4 is an alkyl, thioether, oxyether or aralkyl group having up to 20 carbons in the presence of a catalytically effective amount of an alkaline catalyst is useful for preparing compounds corresponding to the formula ##SPC3##The compounds represented by the above formula are useful as stabilizers for synthetic resins, particularly polyolefins. Compounds of the above formula, when R.sub.3 is --CN are novel and may also be prepared by reacting 1 mole of ##SPC4##And 1 mole of ##SPC5##Wherein X is halogen with 1 mole of NCCH.sub.2 COOR.sub.4 in the presence of an alkali metal and an anhydrous inert organic solvent.
    • 对应于对应于式WHEREIN R1,R2,R4和R5的曼尼希碱的式1的曼尼希碱的1摩尔曼尼希碱的反应独立地选自具有1至6个碳原子的烷基,R是烷基,优选 低级烷基,与1摩尔对应于式R3CH2COOR4的羧酸酯,其中R3是-H,-CN或-COOR4,R4是在催化剂存在下具有至多20个碳的烷基,硫醚,氧醚或芳烷基 有效量的碱性催化剂可用于制备相应于式的化合物。由上式表示的化合物可用作合成树脂,特别是聚烯烃的稳定剂。 当R3是-CN时,上式的化合物是新的,也可以通过使1摩尔的X 1为1的X为卤素的1 MOLE与1摩尔的NCCH 2 COOR 4在碱金属和无水惰性有机溶剂的存在下反应来制备。
    • 5. 发明授权
    • Preservatives and their use
    • 防腐剂及其用途
    • US5670160A
    • 1997-09-23
    • US649254
    • 1996-01-30
    • Heinz EggenspergerKarl-Heinz DiehlPeter Oltmanns
    • Heinz EggenspergerKarl-Heinz DiehlPeter Oltmanns
    • A01N31/04A01N39/00A01N47/44A61K8/34A61K8/368A61K8/43A61K8/49A61Q17/00A01N25/00A01N25/02
    • A61Q17/005A01N31/04A01N39/00A01N47/44A61K8/34A61K8/368A61K8/43A61K8/498A61K2800/524
    • A preservative, for compositions having an aqueous phase, comprising a) 5 to 60% by weight of an organic acid selected from the group consisting of benzoic acid, 4-hydroxybenzoic acid, salicylic acid, formic acid, acetic acid, propionic acid, sorbic acid, undecylenic acid and dehydracetic acid or their mixtures including their sodium, potassium, calcium, magnesium, ammonium and ethanolamine salts b) 10 to 95% by weight of alcohols of the general formulae I, II or III ##STR1## in which R.sub.1 denotes hydrogen, an n-alkyl, iso-alkyl or alkoxy radical having 1 to 3 C atoms, and R.sub.2 and R.sub.3 denote hydrogen or a CH.sub.3 -- or C.sub.2 H.sub.5 -- radical and n has the value of 3 or 4, and c) 0.1 to 20% by weight of one or more poly(hexa-methylenebiguanide) salts of the general formula ##STR2## in which Z represents hydrochloride, acetate, lactate, benzoate, propionate, 4-hydroxybenzoate, sorbate or salicylate; and n has the value of 4 to 6, in combination in a customary carrier or solvent.
    • 一种防腐剂,用于具有水相的组合物,其包含a)5-60重量%的有机酸,其选自苯甲酸,4-羟基苯甲酸,水杨酸,甲酸,乙酸,丙酸,山梨酸 酸,十一碳烯酸和脱氢乙酸或它们的混合物,包括其钠,钾,钙,镁,铵和乙醇胺盐b)10至95重量%的通式I,II或III的醇。 IMAGE>其中R1表示氢,具有1-3个C原子的正烷基,异烷基或烷氧基,R2和R3表示氢或CH3-或C2H5-基,n的值为3或4, 和c)0.1至20重量%的一种或多种通式“IMAGE”的聚(六亚甲基双胍)盐,其中Z表示盐酸盐,乙酸盐,乳酸盐,苯甲酸盐,丙酸盐,4-羟基苯甲酸盐,山梨酸盐或水杨酸盐; 在通常的载体或溶剂中,n的值为4〜6。