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    • 1. 发明授权
    • Preservatives and their use
    • 防腐剂及其用途
    • US5670160A
    • 1997-09-23
    • US649254
    • 1996-01-30
    • Heinz EggenspergerKarl-Heinz DiehlPeter Oltmanns
    • Heinz EggenspergerKarl-Heinz DiehlPeter Oltmanns
    • A01N31/04A01N39/00A01N47/44A61K8/34A61K8/368A61K8/43A61K8/49A61Q17/00A01N25/00A01N25/02
    • A61Q17/005A01N31/04A01N39/00A01N47/44A61K8/34A61K8/368A61K8/43A61K8/498A61K2800/524
    • A preservative, for compositions having an aqueous phase, comprising a) 5 to 60% by weight of an organic acid selected from the group consisting of benzoic acid, 4-hydroxybenzoic acid, salicylic acid, formic acid, acetic acid, propionic acid, sorbic acid, undecylenic acid and dehydracetic acid or their mixtures including their sodium, potassium, calcium, magnesium, ammonium and ethanolamine salts b) 10 to 95% by weight of alcohols of the general formulae I, II or III ##STR1## in which R.sub.1 denotes hydrogen, an n-alkyl, iso-alkyl or alkoxy radical having 1 to 3 C atoms, and R.sub.2 and R.sub.3 denote hydrogen or a CH.sub.3 -- or C.sub.2 H.sub.5 -- radical and n has the value of 3 or 4, and c) 0.1 to 20% by weight of one or more poly(hexa-methylenebiguanide) salts of the general formula ##STR2## in which Z represents hydrochloride, acetate, lactate, benzoate, propionate, 4-hydroxybenzoate, sorbate or salicylate; and n has the value of 4 to 6, in combination in a customary carrier or solvent.
    • 一种防腐剂,用于具有水相的组合物,其包含a)5-60重量%的有机酸,其选自苯甲酸,4-羟基苯甲酸,水杨酸,甲酸,乙酸,丙酸,山梨酸 酸,十一碳烯酸和脱氢乙酸或它们的混合物,包括其钠,钾,钙,镁,铵和乙醇胺盐b)10至95重量%的通式I,II或III的醇。 IMAGE>其中R1表示氢,具有1-3个C原子的正烷基,异烷基或烷氧基,R2和R3表示氢或CH3-或C2H5-基,n的值为3或4, 和c)0.1至20重量%的一种或多种通式“IMAGE”的聚(六亚甲基双胍)盐,其中Z表示盐酸盐,乙酸盐,乳酸盐,苯甲酸盐,丙酸盐,4-羟基苯甲酸盐,山梨酸盐或水杨酸盐; 在通常的载体或溶剂中,n的值为4〜6。