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1. 发明授权

US5446201A Di(3-(2-chloroethylsulfonyl)-1-propyl)amine hydrochloride and a process for its preparation 失效
标题翻译：二（3-（2-氯乙基磺酰基）-1-丙基）胺盐酸盐及其制备方法
公开(公告)号：US5446201A
公开(公告)日：1995-08-29
申请号：US159442
申请日：1993-11-30
申请人： Heinrich Angenendt , Michael Meier , Wolfram Schams
发明人： Heinrich Angenendt , Michael Meier , Wolfram Schams
IPC分类号： C07C315/02 , C07C317/28 , C07C323/25 , C07C323/41 , C09B62/44 , C07C321/14
CPC分类号： C07C323/25 , C07C315/02 , C07C317/28 , C07C323/41 , C09B62/4413
摘要： Process for preparing di(3-(2-chloroethylsulfonyl)-1-propyl)amine hydrochloride, byreacting 1 mol of an N,N-diallylcarboxamide of the formula (1)R-CON(CH.sub.2 --CH.dbd.CH.sub.2).sub.2 (1)in which R is hydrogen, alkyl(C.sub.1 -C.sub.6) or cycloalkyl(C.sub.4 -C.sub.8) with about 4 to about 8 mol of mercaptoethanol at temperatures of about 0.degree. to about -70.degree. C. in the presence of pure oxygen or a mixture of oxygen with an inert gas or an inert gas mixture, if appropriate in an inert organic solvent, to give the carboxamide of the formula (2)R--CON(CH.sub.2 --CH.sub.2 --CH.sub.2 --S--CH.sub.2 --CH.sub.2 --OH).sub.2(2)in which R has the abovementioned meaning,hydrolyzing this compound with the aqueous solution of an alkaline agent at temperatures of about 40.degree. to about 120.degree. C. at a pH of about 10 to about 14, andreacting 1 mol of the di(3-(2-hydroxyethylthio)-1-propyl)amine thus obtained with about 4 to about 6 mol of chlorine gas in about 2 to about 15% hydrochloric acid at temperatures of about 20.degree. to about 110.degree. C. to give di(3-(2-chloroethylsulfonyl)-1-propyl)amine hydrochloride.
摘要翻译：通过使1mol的式（1）R-CON（CH 2 -CH = CH 2）2（1）的N，N-二烯丙基甲酰胺反应制备二（3-（2-氯乙基磺酰基）-1-丙基）胺盐酸盐的方法）其中R为氢，烷基（C1-C6）或环烷基（C4-C8）与约4-约8mol的巯基乙醇在约0℃至约-70℃的温度下，在纯氧或氧气与惰性气体或惰性气体混合物的混合物，如果合适的话，在惰性有机溶剂中，得到式（2）的羧酰胺R-CON（CH 2 -CH 2 -CH 2 -S-CH 2 -CH 2 -OH）2 （2）其中R具有上述含义，在约10至约14℃的pH约40至约120℃的温度下，用碱性试剂的水溶液水解该化合物，并使1mol 二（3-（2-羟基乙硫基）-1-丙基）胺，在大约20至大约110℃的温度下，在约2-约15％的盐酸中用约4至约6mol的氯气，得到二（3-（2-氯乙基磺酰基））-1-丙基）胺盐酸盐。

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