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1. 发明授权

US09044523B2 Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light 有权
标题翻译：使用光敏剂和光的峰值波长减少血液和血液制品中的污染物
公开(公告)号：US09044523B2
公开(公告)日：2015-06-02
申请号：US11840759
申请日：2007-08-17
申请人： Dennis J. Hlavinka , Raymond P. Goodrich , Heather Reddy
发明人： Dennis J. Hlavinka , Raymond P. Goodrich , Heather Reddy
IPC分类号： A01N1/02 , A61L2/24 , A61K41/00 , A61L2/00 , A61L2/08 , A61L2/10 , C07F11/00 , C07F13/00 , C07F15/02 , C07F17/00
CPC分类号： A61L2/24 , A61K41/0019 , A61L2/0011 , A61L2/0088 , A61L2/08 , A61L2/10 , C07F11/005 , C07F13/005 , C07F15/02 , C07F17/00
摘要： Methods and apparatuses are provided for reduction of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.
摘要翻译：提供了用于减少含有血液制品的流体中的病原体的方法和装置。优选的方法包括将有效的无毒量的光敏剂如核黄素添加到血液制品中并将流体暴露于具有峰值波长的光的步骤。

2. 发明授权

US07049110B2 Inactivation of West Nile virus and malaria using photosensitizers 有权
标题翻译：使用光敏剂灭活西尼罗病毒和疟疾
公开(公告)号：US07049110B2
公开(公告)日：2006-05-23
申请号：US10358073
申请日：2003-02-03
申请人： Heather Reddy , Raymond P. Goodrich
发明人： Heather Reddy , Raymond P. Goodrich
IPC分类号： C12N13/00 , C12N7/04 , A61L2/08 , A61L2/10
CPC分类号： A61L2/10 , A61K41/0019 , A61K41/0057 , A61L2/0011 , A61L2/0082 , A61L2/0088 , A61L2/08 , A61M1/0213 , A61M1/3681 , A61M1/3683 , A61M1/3693 , A61M2205/123
摘要： Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer to a fluid and exposing the fluid to photoradiation sufficient to activate the photosensitizer whereby microorganisms are inactivated.
摘要翻译：提供了用于灭活流体或表面上的微生物的方法和装置。优选地，流体含有血液或血液制品并且包含生物活性蛋白质。优选的方法包括以下步骤：将有效的无毒量的光敏剂加入到流体中，并使流体暴露于足以激活光敏剂的光热释放剂中，从而使微生物灭活。

3. 发明授权

US07901673B2 Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light 有权
公开(公告)号：US07901673B2
公开(公告)日：2011-03-08
申请号：US10648536
申请日：2003-08-25
申请人： Robert Owen Lockerbie , Vijay Kumar , Shawn D. Keil , Raymond P. Goodrich
发明人： Robert Owen Lockerbie , Vijay Kumar , Shawn D. Keil , Raymond P. Goodrich
IPC分类号： A01N63/00 , A01N1/02 , C12N5/00 , C12N5/07 , C12N5/10 , C12N5/071
CPC分类号： A61L2/084 , A61K41/0019 , A61L2/0011 , A61L2/0082 , A61L2/0088 , A61L2/08 , A61L2/10 , A61L2202/22 , A61M1/0213 , A61M1/3681 , A61M1/3683 , A61M1/3693 , A61M2205/123
摘要： A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.

4. 发明授权

US07186543B1 Preparation of vaccines using a photosensitizer and light 有权
标题翻译：使用光敏剂和光制备疫苗
公开(公告)号：US07186543B1
公开(公告)日：2007-03-06
申请号：US10325402
申请日：2002-12-20
申请人： Raymond P. Goodrich
发明人： Raymond P. Goodrich
IPC分类号： C12N7/04 , C12N7/06
CPC分类号： C12N7/00 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/5152 , A61K2039/521 , A61K2039/5252 , C12N2700/00 , C12N2740/16034 , C12N2740/16063
摘要： Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but not enough to damage the antigenic characteristics of the infectious particles.
摘要翻译：提供了用于治疗含有感染性颗粒的疫苗的方法，所述感染性颗粒本质上可以是病毒，细菌和/或细胞。优选的方法包括以下步骤：将有效的无毒量的内源性光敏剂添加到流体中，并使流体暴露于足以灭活感染性颗粒但不足以损害感染性颗粒的抗原特征的光照射。

5. 发明授权

US08017110B1 Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light 有权
标题翻译：使用核黄素和轻度诱导和维持病原体中的核酸损伤
公开(公告)号：US08017110B1
公开(公告)日：2011-09-13
申请号：US13155983
申请日：2011-06-08
申请人： Raymond P. Goodrich , Shawn D. Keil , Robert Owen Lockerbie , Vijay Kumar
发明人： Raymond P. Goodrich , Shawn D. Keil , Robert Owen Lockerbie , Vijay Kumar
IPC分类号： A01N63/00 , A01N1/02 , C12N13/00 , C12N5/07 , C12N5/10 , C12N5/071 , C12N5/00 , C12N5/02
CPC分类号： A01N43/90 , A01N25/00 , A01N2300/00
摘要： A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.
摘要翻译：一种损害和维护可能包含在血液或血液成分中的病原体核酸如白细胞，细菌和病毒的损害的过程。该方法包括向含有病原体的血液或血液成分中加入有效量的核黄素，并将该液体暴露于适当波长的光以损害病原体的核酸，并且基本维持致病性核酸的损伤，以允许随后输血到接受者。

6. 发明申请

US20070178437A1 METHODS AND COMPOSITIONS FOR THE PRODUCTION OF HIGH CONCENTRATION ALLOXAZINE SOLUTIONS 有权
标题翻译：用于生产高浓度氧化铝溶液的方法和组合物
公开(公告)号：US20070178437A1
公开(公告)日：2007-08-02
申请号：US11626692
申请日：2007-01-24
申请人： Eric T. Hansen , Raymond P. Goodrich
发明人： Eric T. Hansen , Raymond P. Goodrich
IPC分类号： A01N1/02 , A61K31/525
CPC分类号： C07D475/14 , A01N1/02 , A01N1/0226 , A01N43/90 , A61K31/525 , A01N25/02 , A01N59/04 , A01N2300/00
摘要： Methods are provided for preparation of compositions having an enhanced level of soluble alloxazine, as compared to compositions prepared using conventional techniques. Compositions and a riboflavin form having higher solubility in solution is also provided.
摘要翻译：与使用常规技术制备的组合物相比，提供了用于制备具有增强水平的可溶性环氮嗪的组合物的方法。还提供了在溶液中具有较高溶解度的组合物和核黄素形式。

7. 发明授权

US07985588B2 Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light 有权
公开(公告)号：US07985588B2
公开(公告)日：2011-07-26
申请号：US11932629
申请日：2007-10-31
申请人： Raymond P. Goodrich , Shawn D. Keil
发明人： Raymond P. Goodrich , Shawn D. Keil
IPC分类号： C12N5/00
CPC分类号： A01N43/90 , A61K41/0019 , A61L2/0011 , A61L2/0082 , A61L2/0088 , A61L2/08 , A61L2/084 , A61L2/10 , A61L2202/22 , A61M1/0213 , A61M1/3681 , A61M1/3683 , A61M1/3693 , A61M2205/123 , A01N25/00 , A01N2300/00
摘要： A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.

8. 发明授权

US07648699B2 Preventing transfusion related complications in a recipient of a blood transfusion 有权
标题翻译：预防输血的输血相关并发症
公开(公告)号：US07648699B2
公开(公告)日：2010-01-19
申请号：US11469186
申请日：2006-08-31
申请人： Raymond P. Goodrich , Junzhi Li
发明人： Raymond P. Goodrich , Junzhi Li
IPC分类号： C12N5/00 , A01N1/02 , C12N13/00 , C12N5/08
CPC分类号： A61K35/14 , A01N1/0215 , A01N1/0226 , A61K31/525 , A61K35/19 , A61K41/0023 , A61K2300/00
摘要： This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion related complication by the recipient to cells in the donor blood. The invention is also directed towards a process for preventing rejection of a donor organ by a recipient comprising the steps of transfusing the recipient of the donor organ with treated platelets; and transplanting the donor organ into the recipient.
摘要翻译：本发明涉及一种减少异体输血接受者输血相关并发症的方法，该方法是向输注血液中加入含有核黄素的光敏剂，用光照射血液和核黄素，将照射的血液输入接受者，以及将接受者的输血相关并发症减少到供体血液中的细胞。本发明还涉及一种用于防止接受者排出供体器官的方法，包括以下步骤：将经过处理的血小板输入供体器官的受体; 并将供体器官移植到受体中。

9. 发明授权

US06280622B1 System for using ligands in particle separation 失效
标题翻译：在粒子分离中使用配体的系统
公开(公告)号：US06280622B1
公开(公告)日：2001-08-28
申请号：US09571688
申请日：2000-05-16
申请人： Raymond P. Goodrich , Todd Curtis Green
发明人： Raymond P. Goodrich , Todd Curtis Green
IPC分类号： B01D3600
CPC分类号： G01N33/54313 , B01D21/01 , B01D21/26 , B01D21/262 , B01D2221/10 , B03D3/02 , B04B2005/0471 , G01N15/042
摘要： A system and method are disclosed for separating particles having different sedimentation velocities. The system includes a container containing a binding substance including first particles and ligands attached to the first particles. When the binding substance is mixed with a liquid carrying at least second and third particles, the ligands bind the first and second particles together to form groups of bound particles. The groups of bound particles are separated from the third particles in a fluid chamber configured to be mounted on a centrifuge rotor. One of the disclosed methods includes forming a saturated fluidized bed of particles to retain the particles groups in the fluid chamber. Another of the disclosed methods includes removing at least some of the first particles after the binding substance is mixed with the liquid carrying second and third particles.
摘要翻译：公开了用于分离具有不同沉降速度的颗粒的系统和方法。该系统包括含有结合物质的容器，该结合物质包括附着在第一颗粒上的第一颗粒和配体。当结合物质与携带至少第二和第三颗粒的液体混合时，配体将第一和第二颗粒结合在一起形成结合颗粒的组。在构造成安装在离心机转子上的流体室中将结合颗粒的组与第三颗粒分离。所公开的方法之一包括形成颗粒的饱和流化床以将颗粒群保持在流体室中。所公开的方法中的另一个包括在结合物质与携带第二和第三颗粒的液体混合之后去除至少一些第一颗粒。

10. 发明授权

US5178884A Lyophilized and reconstituted red blood cell compositions 失效
标题翻译： LYOPHILIZED和RECOTITUTED红血球细胞组成
公开(公告)号：US5178884A
公开(公告)日：1993-01-12
申请号：US374171
申请日：1989-06-29
申请人： Raymond P. Goodrich , Christine M. Williams , Roger W. Hackett
发明人： Raymond P. Goodrich , Christine M. Williams , Roger W. Hackett
IPC分类号： A01N1/02 , A61K35/14 , A61K35/18
CPC分类号： A01N1/02 , A01N1/0226 , A61K35/14 , A61K35/18
摘要： A process and medium are disclosed for the lyophilization of red blood cells which comprises the use of solutions including monosaccharide hexoses and pentoses, and biocompatible amphipathic polymers to permit the reconstitution of viable red blood cells. Also disclosed are lyophilized and reconstituted erythrocyte and hemosome containing compositions.
摘要翻译：公开了用于冻干红细胞的方法和培养基，其包括使用包括单糖己糖和戊糖的溶液以及生物相容性两亲性聚合物，以允许重建可行的红细胞。还公开了冻干和重构的红细胞和含有血红素的组合物。

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