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1. 发明授权

US5685875A Fluid sampling device for closed collection systems 失效
标题翻译：用于封闭收集系统的流体取样装置
公开(公告)号：US5685875A
公开(公告)日：1997-11-11
申请号：US484835
申请日：1995-06-07
申请人： Dennis J. Hlavinka , Robert Lee White , Todd Curtis Green
发明人： Dennis J. Hlavinka , Robert Lee White , Todd Curtis Green
IPC分类号： A61M5/14 , B29C57/10 , B29C65/00 , B29C65/04 , B29C65/74 , B29L23/00 , B65B51/10 , A61B19/00
CPC分类号： B29C65/04 , B29C65/743 , B29C66/1122 , B29C66/4312 , B29C66/73921 , B29C66/8122 , B29C66/81263 , B29C66/81422 , B29C66/8187 , B29C66/8322 , B29C66/857 , B29C66/8614 , B29C57/10 , B29C66/71 , B29C66/81871 , B29L2023/007 , B29L2031/753 , Y10S128/24 , Y10S604/905
摘要： A method and device for sampling biological fluids during collection without opening the functionally closed collection system, thereby compromising the sterility of the collected fluid. A sample bag connected to a fluid line or collection reservoir is filled coincident with fluid collection, then hermetically sealed and physically separated from the collection system using a radio frequency tubing sealer. A vacuum tube collection device is attached to the sample bag to minimize exposure to the fluid during sample handling and processing.
摘要翻译：一种用于在收集期间对生物流体进行采样的方法和装置，而不打开功能密闭的收集系统，从而损害所收集的流体的无菌性。连接到流体管线或收集容器的样品袋与流体收集一致地填充，然后使用射频管封口机与收集系统气密密封并物理分离。真空管收集装置连接到样品袋，以在样品处理和处理期间最小化对流体的暴露。

2. 发明授权

US6153113A Method for using ligands in particle separation 失效
标题翻译：在粒子分离中使用配体的方法
公开(公告)号：US6153113A
公开(公告)日：2000-11-28
申请号：US253696
申请日：1999-02-22
申请人： Raymond P. Goodrich , Todd Curtis Green
发明人： Raymond P. Goodrich , Todd Curtis Green
IPC分类号： B01D21/01 , B03D3/02 , G01N15/04 , G01N33/543 , B01D21/26 , G01N33/537
CPC分类号： G01N33/54313 , B01D21/01 , B01D21/262 , B03D3/02 , B01D2221/10 , B04B2005/0471 , G01N15/042
摘要： A system and method are disclosed for separating particles having different sedimentation velocities. The system includes a container containing a binding substance including first particles and ligands attached to the first particles. When the binding substance is mixed with a liquid carrying at least second and third particles, the ligands bind the first and second particles together to form groups of bound particles. The groups of bound particles are separated from the third particles in a fluid chamber configured to be mounted on a centrifuge rotor. One of the disclosed methods includes forming a saturated fluidized bed of particles to retain the particles groups in the fluid chamber. Another of the disclosed methods includes removing at least some of the first particles after the binding substance is mixed with the liquid carrying second and third particles.
摘要翻译：公开了用于分离具有不同沉降速度的颗粒的系统和方法。该系统包括含有结合物质的容器，该结合物质包括附着在第一颗粒上的第一颗粒和配体。当结合物质与携带至少第二和第三颗粒的液体混合时，配体将第一和第二颗粒结合在一起形成结合颗粒的组。在构造成安装在离心机转子上的流体室中将结合颗粒的组与第三颗粒分离。所公开的方法之一包括形成颗粒的饱和流化床以将颗粒群保持在流体室中。所公开的方法中的另一个包括在结合物质与携带第二和第三颗粒的液体混合之后去除至少一些第一颗粒。

3. 发明授权

US06051146A Methods for separation of particles 失效
标题翻译：颗粒分离方法
公开(公告)号：US06051146A
公开(公告)日：2000-04-18
申请号：US9378
申请日：1998-01-20
申请人： Todd Curtis Green , Raymond P. Goodrich
发明人： Todd Curtis Green , Raymond P. Goodrich
IPC分类号： A61K35/14 , A61M1/02 , A61M1/36 , B04B5/00 , B04B5/04 , B01D21/26
CPC分类号： A61M1/3693 , A61M1/0227 , A61M1/3696 , B04B5/0442 , A61M2205/12 , B04B2005/0471
摘要： A system and method are disclosed for separating particles having different sedimentation velocities. The system includes a fluid chamber for separating the particles form one another. Conduits are provided for flowing liquid carrying particles to the fluid chamber and for mixing the liquid with a diluting liquid. Structure is also provided for separating particles from the liquids after the particles are separated in the fluid chamber. The disclosed methods include forming a saturated fluidized bed of first particles to retain second particles in the fluid chamber. A diluting liquid having a density less than that of the particles is mixed with the liquid carrying particles to reduce overall density of substances in the fluid chamber and thereby reduce Coriolis jetting of liquids in the fluid chamber.
摘要翻译：公开了用于分离具有不同沉降速度的颗粒的系统和方法。该系统包括用于将颗粒彼此分离的流体室。提供导管，用于将液体携带颗粒流动到流体室，并将液体与稀释液体混合。还提供了在流体室中分离颗粒之后从液体中分离颗粒的结构。所公开的方法包括形成第一颗粒的饱和流化床以将第二颗粒保留在流体室中。将密度小于颗粒的稀释液与载液颗粒混合以降低流体室中的物质的总体密度，从而减少流体腔中的液体的科里奥利喷射。

4. 发明授权

US08114003B2 Methods for hemolysis detection in centrifugal blood separator 有权
标题翻译：离心血液分离器溶血检测方法
公开(公告)号：US08114003B2
公开(公告)日：2012-02-14
申请号：US12423883
申请日：2009-04-15
申请人： Todd Curtis Green , Bruce W. Gibbs
发明人： Todd Curtis Green , Bruce W. Gibbs
IPC分类号： B04B15/00
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3696 , A61M1/38 , A61M2205/18
摘要： A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, and an outlet line. Apparatus tests flow conditions using a red light-green light sensor to detect non-recoverable hemolysis during priming by identifying a high R/G ratio, preferably a ratio of greater than or equal to fifty (50), prior to the beginning of the first return of blood components to a donor followed by identifying a R/G ratio at least as great as one and one tenth (1.1) together with a green signal less than a predetermined value, preferably less than or equal to one thousand (1000) reflectance units. If these conditions are detected, an alarm is given and the apheresis procedure is discontinued.
摘要翻译：一种离心血液处理设备，包括离心机转子，分离室，用于传导血液成分和流体的管道组件，并具有入口管线和出口管线。装置使用红色浅绿色光传感器测试流动条件，以通过在第一次开始之前识别高R / G比率，优选大于或等于五十（50）的比率来检测引发期间的不可恢复的溶血将血液成分返回到供体，然后将至少高达十分之一（1.1）的R / G比与绿色信号一起小于预定值，优选小于或等于一千（1000）反射率单位。如果检测到这些情况，则会发出警报，并停止血液分离程序。

5. 发明申请

US20100267538A1 Methods and Apparatus for Hemolysis Detection in Centrifugal Blood Separator 有权
标题翻译：离心血液分离器溶血检测方法与装置
公开(公告)号：US20100267538A1
公开(公告)日：2010-10-21
申请号：US12423883
申请日：2009-04-15
申请人： Todd Curtis GREEN , Bruce W. GIBBS
发明人： Todd Curtis GREEN , Bruce W. GIBBS
IPC分类号： B04B9/10
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3696 , A61M1/38 , A61M2205/18
摘要： A centrifugal blood processing apparatus comprising a centrifuge rotor, a separation chamber, a tubing set for conducting blood components and fluids and having an inlet line, and an outlet line. Apparatus tests flow conditions using a red light-green light sensor to detect non-recoverable hemolysis during priming by identifying a high R/G ratio, preferably a ratio of greater than or equal to fifty (50), prior to the beginning of the first return of blood components to a donor followed by identifying a R/G ratio at least as great as one and one tenth (1.1) together with a green signal less than a predetermined value, preferably less than or equal to one thousand (1000) reflectance units. If these conditions are detected, an alarm is given and the apheresis procedure is discontinued.
摘要翻译：一种离心式血液处理设备，包括离心机转子，分离室，用于传导血液成分和流体的管道组件，并具有入口管线和出口管线。装置使用红色浅绿色光传感器测试流动条件，以通过在第一次开始之前识别高R / G比率，优选大于或等于五十（50）的比率来检测引发期间的不可恢复的溶血将血液成分返回到供体，然后将至少高达十分之一（1.1）的R / G比与绿色信号一起小于预定值，优选小于或等于一千（1000）反射率单位。如果检测到这些情况，则会发出警报，并停止血液分离程序。

6. 发明授权

US06280622B1 System for using ligands in particle separation 失效
标题翻译：在粒子分离中使用配体的系统
公开(公告)号：US06280622B1
公开(公告)日：2001-08-28
申请号：US09571688
申请日：2000-05-16
申请人： Raymond P. Goodrich , Todd Curtis Green
发明人： Raymond P. Goodrich , Todd Curtis Green
IPC分类号： B01D3600
CPC分类号： G01N33/54313 , B01D21/01 , B01D21/26 , B01D21/262 , B01D2221/10 , B03D3/02 , B04B2005/0471 , G01N15/042
摘要： A system and method are disclosed for separating particles having different sedimentation velocities. The system includes a container containing a binding substance including first particles and ligands attached to the first particles. When the binding substance is mixed with a liquid carrying at least second and third particles, the ligands bind the first and second particles together to form groups of bound particles. The groups of bound particles are separated from the third particles in a fluid chamber configured to be mounted on a centrifuge rotor. One of the disclosed methods includes forming a saturated fluidized bed of particles to retain the particles groups in the fluid chamber. Another of the disclosed methods includes removing at least some of the first particles after the binding substance is mixed with the liquid carrying second and third particles.
摘要翻译：公开了用于分离具有不同沉降速度的颗粒的系统和方法。该系统包括含有结合物质的容器，该结合物质包括附着在第一颗粒上的第一颗粒和配体。当结合物质与携带至少第二和第三颗粒的液体混合时，配体将第一和第二颗粒结合在一起形成结合颗粒的组。在构造成安装在离心机转子上的流体室中将结合颗粒的组与第三颗粒分离。所公开的方法之一包括形成颗粒的饱和流化床以将颗粒群保持在流体室中。所公开的方法中的另一个包括在结合物质与携带第二和第三颗粒的液体混合之后去除至少一些第一颗粒。

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