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1. 发明授权

US6117645A Human LH-RH receptor expression cells and use thereof 失效
标题翻译：人LH-RH受体表达细胞及其用途
公开(公告)号：US6117645A
公开(公告)日：2000-09-12
申请号：US867260
申请日：1997-06-02
申请人： Haruo Onda , Shoichi Ohkubo , Shuji Hinuma
发明人： Haruo Onda , Shoichi Ohkubo , Shuji Hinuma
IPC分类号： A61K38/00 , A61K39/00 , C07K7/23 , C07K14/72 , C12N15/12 , G01N33/53
CPC分类号： C07K7/23 , C07K14/723 , A61K38/00 , A61K39/00
摘要： Disclosed are CHO cells which are capable of continued production of human LH-RH receptor proteins, or cell membrane fractions thereof; recombinant human LH-RH receptor proteins or partial peptides thereof; methods for screening compounds which have affinity for an LH-RH receptor by contacting the compound with the CHO cells or the cell membrane fractions thereof, or the recombinant human LH-RH receptor proteins or the partial peptides thereof; kits for screening them; the compounds which have affinity for the LH-RH receptor obtained by methods for the screening or kits for the screening; and pharmaceutical compositions containing the compound, thereby being able to early provide prophylactic or therapeutic compositions, for example, for prostate cancer, uterine cancer, breast cancer, a pituitary tumor, endometriosis, hysteromyoma or precocious puberty. They are also useful as a pregnancy controlling composition such as contraceptive or a menstrual cycle controlling composition.
摘要翻译：公开了能够连续产生人LH-RH受体蛋白质或其细胞膜级分的CHO细胞; 重组人LH-RH受体蛋白或其部分肽; 通过使化合物与CHO细胞或其细胞膜级分或重组人LH-RH受体蛋白质或其部分肽接触来筛选对LH-RH受体具有亲和性的化合物的方法; 用于筛选它们的试剂盒通过筛选方法获得的对LH-RH受体具有亲和力的化合物或用于筛选的试剂盒; 以及含有该化合物的药物组合物，从而能够早期提供例如前列腺癌，子宫癌，乳腺癌，垂体瘤，子宫内膜异位症，子宫肌瘤或早熟青春期的预防或治疗组合物。它们也可用作妊娠控制组合物，例如避孕或月经周期控制组合物。

2. 发明授权

US5677184A CHO cells that express human LH-RH receptor 失效
标题翻译：表达人LH-RH受体的CHO细胞
公开(公告)号：US5677184A
公开(公告)日：1997-10-14
申请号：US423691
申请日：1995-04-18
申请人： Haruo Onda , Shoichi Ohkubo , Shuji Hinuma , Hidekazu Sawada
发明人： Haruo Onda , Shoichi Ohkubo , Shuji Hinuma , Hidekazu Sawada
IPC分类号： A61K38/00 , A61K39/00 , C07K7/23 , C07K14/72 , C12N15/12 , G01N33/53 , C12N15/85
CPC分类号： C07K7/23 , C07K14/723 , A61K38/00 , A61K39/00
摘要： Disclosed are CHO cells which are capable of continued production of human LH-RH receptor proteins, or cell membrane fractions thereof; recombinant human LH-RH receptor proteins or partial peptides thereof; methods for screening compounds which have affinity for an LH-RH receptor by contacting the compound with the CHO cells or the cell membrane fractions thereof, or the recombinant human LH-RH receptor proteins or the partial peptides thereof; kits for screening them; the compounds which have affinity for the LH-RH receptor obtained by methods for the screening or kits for the screening; and pharmaceutical compositions containing the compound, thereby being able to early provide prophylactic or therapeutic compositions, for example, for prostate cancer, uterine cancer, breast cancer, a pituitary tumor, endometriosis, hysteromyoma or precocious puberty. They are also useful as a pregnancy controlling composition such as contraceptive or a menstrual cycle controlling composition.
摘要翻译：公开了能够连续产生人LH-RH受体蛋白质或其细胞膜级分的CHO细胞; 重组人LH-RH受体蛋白或其部分肽; 通过使化合物与CHO细胞或其细胞膜级分或重组人LH-RH受体蛋白或其部分肽接触来筛选对LH-RH受体具有亲和力的化合物的方法; 用于筛选它们的试剂盒通过筛选方法获得的对LH-RH受体具有亲和力的化合物或用于筛选的试剂盒; 以及含有该化合物的药物组合物，从而能够早期提供例如前列腺癌，子宫癌，乳腺癌，垂体瘤，子宫内膜异位症，子宫肌瘤或早熟青春期的预防或治疗组合物。它们也可用作妊娠控制组合物，例如避孕或月经周期控制组合物。

3. 发明授权

US4564593A Messenger RNA, production and use thereof 失效
标题翻译：信使RNA，其生产和使用
公开(公告)号：US4564593A
公开(公告)日：1986-01-14
申请号：US452282
申请日：1982-12-22
申请人： Kyozo Tsukamoto , Shuji Hinuma , Haruo Onda
发明人： Kyozo Tsukamoto , Shuji Hinuma , Haruo Onda
IPC分类号： C12N15/09 , C07H21/02 , C07K14/55 , C12P19/34 , C12P21/00 , C12R1/91 , C07H17/00 , C12N5/00 , C12N15/00
CPC分类号： C07K14/55
摘要： The present invention provides human Interleukin 2-encording messenger RNA which is free of human cells, a method of producing the same from the cells which are capable of producing human Interleukin 2 and a method of producing human Interleukin 2 using the same in an in vitro protein synthesis system.
摘要翻译：本发明提供了不含人细胞的人白细胞介素2记录信使RNA，其能够产生人白细胞介素2的细胞的制备方法以及在体外制备人白细胞介素2的方法蛋白质合成系统。

4. 发明授权

US5879896A Method of screening for inhibitors of human thyrotropin releasing hormone (TRH) receptor 失效
标题翻译：筛选人类促甲状腺激素释放激素（TRH）受体抑制剂的方法
公开(公告)号：US5879896A
公开(公告)日：1999-03-09
申请号：US288663
申请日：1994-08-09
申请人： Shuji Hinuma , Masaki Hosoya , Haruo Onda
发明人： Shuji Hinuma , Masaki Hosoya , Haruo Onda
IPC分类号： A61K38/00 , C07K14/72 , C07K16/28 , C12N15/12 , G01N33/76 , G01N33/53 , G01N33/566
CPC分类号： G01N33/76 , C07K14/72 , C07K16/2869 , A61K38/00
摘要： A human receptor protein capable of binding TRH, a DNA coding for said protein, use of the proetein and DNA, a method for preparing said protein, and antibodies to the protein are described.The human TRH receptor protein and the DNA coding for the protein of the present invention are useful as (1) a diagnostic composition for neuropathy (particularly, dementia), (2) a pharmaceutical composition for neuropathy and (3) a material used for screening a TRH receptor agonist or antagonist.
摘要翻译：描述了能够结合TRH的人受体蛋白质，编码所述蛋白质的DNA，使用原蛋白和DNA，制备所述蛋白质的方法和对蛋白质的抗体。人TRH受体蛋白质和编码本发明蛋白质的DNA可用作（1）神经病（特别是痴呆）的诊断用组合物，（2）神经病的药物组合物和（3）用于筛选的材料 TRH受体激动剂或拮抗剂。

5. 发明授权

US06399325B1 DNA encoding a galanin receptor 失效
标题翻译：编码甘丙肽受体的DNA
公开(公告)号：US06399325B1
公开(公告)日：2002-06-04
申请号：US08540650
申请日：1995-10-11
申请人： Shuji Hinuma , Ryo Fujii , Shoji Fukusumi , Tetsuya Ohtaki , Masaki Hosoya , Kazuhiro Ohgi , Haruo Onda
发明人： Shuji Hinuma , Ryo Fujii , Shoji Fukusumi , Tetsuya Ohtaki , Masaki Hosoya , Kazuhiro Ohgi , Haruo Onda
IPC分类号： C12N1512
CPC分类号： C07K14/723
摘要： Galanin receptor proteins, production and use thereof including screening of galanin receptor agonists and antagonists are provided. Galanin receptor proteins, etc. or salts thereof, partial peptides thereof, DNAs coding for the above galanin receptor protein, processes for producing the above receptor protein, methods of screening for a galanin receptor agonist and/or antagonist or screening kits therefor, agonist and/or antagonist compounds or salts thereof obtained by the above screening method or the screening kit, pharmaceutical compositions containing the above compound or its salt, and antibodies against the above receptor protein are provided. It is allowable to efficiently screen a galanin receptor agonist or antagonist by using the galanin receptor protein, the partial peptide thereof, the galanin receptor protein-encoding DNA, the receptor protein-containing cell or its membrane fraction. The pharmaceuticals thus screened or characterized permits various applications including prophylactic and/or therapeutic treatments against a variety of diseases, e.g., stomach ulcer, diabetes, Alzheimer's disease, dementia, etc. and a sedative.
摘要翻译：提供了Galanin受体蛋白质，其生产和使用，包括甘露糖素受体激动剂和拮抗剂的筛选。加兰林素受体蛋白等或其盐，其部分肽，编码上述甘丙肽受体蛋白质的DNA，产生上述受体蛋白质的方法，筛选甘丙肽受体激动剂和/或拮抗剂的方法或其筛选试剂盒，激动剂和 /或通过上述筛选方法获得的拮抗剂化合物或其盐或筛选试剂盒，含有上述化合物或其盐的药物组合物和抗上述受体蛋白的抗体。可以通过使用甘丙肽受体蛋白，其部分肽，编码甘露糖素受体蛋白的DNA，含受体蛋白的细胞或其膜部分来有效筛选甘丙肽受体激动剂或拮抗剂。如此筛选或表征的药物允许各种应用，包括针对各种疾病（例如胃溃疡，糖尿病，阿尔茨海默病，痴呆等）和镇静剂的预防和/或治疗性治疗。

6. 发明申请

US20070065819A1 Novel fprl1 ligands and use thereof 有权
标题翻译：新型fpr1配体及其用途
公开(公告)号：US20070065819A1
公开(公告)日：2007-03-22
申请号：US10534082
申请日：2003-11-06
申请人： Shuji Hinuma , Makoto Kobayashi , Yugo Habata , Masataka Harada , Shoichi Ohkubo , Hiromi Yoshida , Kazunori Nishi
发明人： Shuji Hinuma , Makoto Kobayashi , Yugo Habata , Masataka Harada , Shoichi Ohkubo , Hiromi Yoshida , Kazunori Nishi
IPC分类号： C12Q1/68 , A61K38/17 , C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K14/723 , A61K38/00
摘要： By using FPRL1 ligand, which comprises the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 17 or SEQ ID NO: 21, and FPRL1, an efficient screening for FPRL1 agonist or FPRL1 antagonist can be performed.
摘要翻译：通过使用包含与SEQ ID NO：1，SEQ ID NO：17或SEQ ID NO：21表示的氨基酸序列相同或基本上相同的氨基酸序列的FPRL1配体和FPRL1，FPRL1激动剂的有效筛选或FPRL1拮抗剂。

7. 发明授权

US07943137B2 FPRL1 ligands and use thereof 有权
标题翻译： FPRL1配体及其用途
公开(公告)号：US07943137B2
公开(公告)日：2011-05-17
申请号：US10534082
申请日：2003-11-06
申请人： Shuji Hinuma , Makoto Kobayashi , Yugo Habata , Masataka Harada , Shoichi Ohkubo , Hiromi Yoshida , Kazunori Nishi
发明人： Shuji Hinuma , Makoto Kobayashi , Yugo Habata , Masataka Harada , Shoichi Ohkubo , Hiromi Yoshida , Kazunori Nishi
IPC分类号： A61K39/00 , A61K39/38 , G01N33/53
CPC分类号： C07K14/723 , A61K38/00
摘要： By using FPRL1 ligand, which comprises the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 17 or SEQ ID NO: 21, and FPRL1, an efficient screening for FPRL1 agonist or FPRL1 antagonist can be performed.
摘要翻译：通过使用包含与SEQ ID NO：1，SEQ ID NO：17或SEQ ID NO：21表示的氨基酸序列相同或基本上相同的氨基酸序列的FPRL1配体和FPRL1，FPRL1激动剂的有效筛选或FPRL1拮抗剂。

8. 发明授权

US07214495B2 Screening method 失效
标题翻译：筛选方法
公开(公告)号：US07214495B2
公开(公告)日：2007-05-08
申请号：US10504726
申请日：2003-02-13
申请人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
发明人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada
IPC分类号： G01N33/566
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译：通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和（2）脂肪酸或类花生酸，化合物或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

9. 发明申请

US20050089866A1 Novel screening method 失效
标题翻译：新型筛选方法
公开(公告)号：US20050089866A1
公开(公告)日：2005-04-28
申请号：US10504726
申请日：2003-02-13
申请人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
发明人： Shuji Hinuma , Masaki Hosoya , Yasuaki Ito , Makoto Kobayashi , Hideyuki Tanaka , Shoichi Ohkubo , Ryo Fujii , Hideki Kizawa , Yuji Kawamata , Kazuhiro Ogi , Masataka Harada , Shoji Fukusumi
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译：通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白质或其盐和（2）脂肪酸或类花生酸，化合物或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

10. 发明授权

US07972800B2 Screening method for binding property or signal transduction alterations 有权
标题翻译：结合性质或信号转导改变的筛选方法
公开(公告)号：US07972800B2
公开(公告)日：2011-07-05
申请号：US12428877
申请日：2009-04-23
申请人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
发明人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
IPC分类号： G01N33/53 , C07K14/435
CPC分类号： G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/68 , G01N2333/726 , G01N2500/00
摘要： By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.
摘要翻译：通过使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和可电离金属元素或其盐可以有效地筛选上述受体蛋白质或其拮抗剂的激动剂或其盐。

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