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1. 发明授权

US5562909A Phosphazene polyelectrolytes as immunoadjuvants 失效
标题翻译：磷腈聚电解质作为免疫佐剂
公开(公告)号：US5562909A
公开(公告)日：1996-10-08
申请号：US090841
申请日：1993-07-12
申请人： Harry R. Allcock , Alexander K. Andrianov , Robert S. Langer , Karyn B. Visscher
发明人： Harry R. Allcock , Alexander K. Andrianov , Robert S. Langer , Karyn B. Visscher
IPC分类号： A61K39/385 , A61K9/16 , A61K39/39 , C08G79/02
CPC分类号： C08G79/025 , A61K39/39 , A61K9/1641 , A61K2039/541 , A61K2039/55555
摘要： A immunoadjuvant soluble phosphazene polyelectrolyte is disclosed. In one embodiment, the polymeric adjuvant is an poly(organophosphazene) with (i) ionized or ionizable pendant groups that contain, for example, carboxylic acid, sulfonic acid, or hydroxyl moieties, and (ii) pendant groups that are susceptible to hydrolysis under the conditions of use, to impart biodegradability to the polymer.
摘要翻译：公开了一种免疫佐剂可溶性磷腈聚电解质。在一个实施方案中，聚合物助剂是具有（i）含有例如羧酸，磺酸或羟基部分的离子化或可离子化侧基的聚（有机膦腈），和（ii）易于水解的侧基使用条件，赋予聚合物生物降解性。

2. 发明授权

US5308701A Ionically cross-linked polymeric microcapsules 失效
标题翻译：离子交联聚合物微胶囊
公开(公告)号：US5308701A
公开(公告)日：1994-05-03
申请号：US880248
申请日：1992-05-08
申请人： Smadar Cohen , Carmen Bano , Karyn B. Visscher , Marie B. Chow , Harry R. Allcock , Robert S. Langer
发明人： Smadar Cohen , Carmen Bano , Karyn B. Visscher , Marie B. Chow , Harry R. Allcock , Robert S. Langer
IPC分类号： A61K9/127 , A61K9/16 , A61K9/50 , A61K31/70 , A61K31/708 , A61K31/715 , A61K35/12 , A61K38/00 , A61K47/02 , A61K47/30 , A61K47/32 , A61K47/34 , A61K49/22 , A61K51/12 , B01J13/02 , B01J13/10 , B01J13/14 , C08G79/02 , C12N11/04
CPC分类号： A61K49/223 , A61K49/225 , A61K49/226 , A61K51/1258 , A61K9/1271 , A61K9/1641 , A61K9/5031 , B01J13/14 , C08G79/025 , C12N11/04 , A61K2123/00 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked with multivalent ions of the opposite charge to form a gel encapsulating biological material, that is optionally further stabilized by interactions with multivalent polyions of the same charge as those used to form the gel. In the preferred embodiment, hydrolytically stable polyphosphazenes are formed of monomers having carboxylic acid side groups that are crosslinked by divalent or trivalent cations such as Ca.sup.2+ or Al.sup.3+, then stabilized with a polycation such as poly-L-lysine. A variety of different compositions can be formed from the crosslinked polymer. In a preferred embodiment, microcapsules are made by spraying an aqueous solution of polyphosphazene and material to be encapsulated into a calcium chloride solution. A semi-permeable membrane is formed on the microspheres by complexation of the surface carboxylate groups with poly(L-lysine).
摘要翻译：公开了一种将生物不稳定材料如蛋白质，脂质体，细菌和真核细胞包封在合成聚合物胶囊内的方法及其产品。该方法基于使用具有带电侧链的水溶性聚合物，其与相反电荷的多价离子交联以形成包封生物材料的凝胶，其任选通过与相同电荷的多价离子的相互作用进一步稳定用于形成凝胶的那些。在优选的实施方案中，水解稳定的聚磷腈由具有羧酸侧基的单体形成，其通过二价或三价阳离子如Ca 2+或Al 3+交联，然后用聚阳离子如聚-L-赖氨酸稳定。可以从交联聚合物形成各种不同的组合物。在优选的实施方案中，通过将聚磷腈的水溶液和待包封的材料喷雾到氯化钙溶液中来制备微胶囊。通过表面羧酸酯基与聚（L-赖氨酸）的络合，在微球上形成半透膜。

3. 发明授权

US5494682A Ionically cross-linked polymeric microcapsules 失效
标题翻译：离子交联聚合物微胶囊
公开(公告)号：US5494682A
公开(公告)日：1996-02-27
申请号：US210018
申请日：1994-03-18
申请人： Smadar Cohen , Carmen Bano , Karyn B. Visscher , Marie Chow , Harry R. Allcock , Robert S. Langer
发明人： Smadar Cohen , Carmen Bano , Karyn B. Visscher , Marie Chow , Harry R. Allcock , Robert S. Langer
IPC分类号： A61K9/127 , A61K9/16 , A61K9/50 , A61K31/70 , A61K31/708 , A61K31/715 , A61K35/12 , A61K38/00 , A61K47/02 , A61K47/30 , A61K47/32 , A61K47/34 , A61K49/22 , A61K51/12 , B01J13/02 , B01J13/10 , B01J13/14 , C08G79/02 , C12N11/04
CPC分类号： A61K49/223 , A61K49/225 , A61K49/226 , A61K51/1258 , A61K9/1271 , A61K9/1641 , A61K9/5031 , B01J13/14 , C08G79/025 , C12N11/04 , A61K2123/00 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked with multivalent ions of the opposite charge to form a gel encapsulating biological material, that is optionally further stabilized by interactions with multivalent polyions of the same charge as those used to form the gel. In the preferred embodiment, hydrolytically stable polyphosphazenes are formed of monomers having carboxylic acid side groups that are crosslinked by divalent or trivalent cations such as Ca.sup.2+ or Al.sup.3+, then stabilized with a polycation such as poly-L-lysine. A variety of different compositions can be formed from the crosslinked polymer. In a preferred embodiment, microcapsules are made by spraying an aqueous solution of polyphosphazene and material to be encapsulated into a calcium chloride solution.
摘要翻译：公开了一种将生物不稳定材料如蛋白质，脂质体，细菌和真核细胞包封在合成聚合物胶囊内的方法及其产品。该方法基于使用具有带电侧链的水溶性聚合物，其与相反电荷的多价离子交联以形成包封生物材料的凝胶，其可任选地通过与相同电荷的多价离子的相互作用进一步稳定用于形成凝胶的那些。在优选的实施方案中，水解稳定的聚磷腈由具有羧酸侧基的单体形成，其通过二价或三价阳离子如Ca 2+或Al 3+交联，然后用聚阳离子如聚-L-赖氨酸稳定。可以从交联聚合物形成各种不同的组合物。在优选的实施方案中，通过将聚磷腈的水溶液和待包封的材料喷雾到氯化钙溶液中来制备微胶囊。

4. 发明授权

US5149543A Ionically cross-linked polymeric microcapsules 失效
标题翻译：离子交联聚合物微球
公开(公告)号：US5149543A
公开(公告)日：1992-09-22
申请号：US593684
申请日：1990-10-05
申请人： Smadar Cohen , Carmen Bano , Karyn B. Visscher , Marie Chow , Harry R. Allcock , Robert S. Langer
发明人： Smadar Cohen , Carmen Bano , Karyn B. Visscher , Marie Chow , Harry R. Allcock , Robert S. Langer
IPC分类号： A61K9/127 , A61K9/16 , A61K9/50 , A61K31/70 , A61K31/708 , A61K31/715 , A61K35/12 , A61K38/00 , A61K47/02 , A61K47/30 , A61K47/32 , A61K47/34 , A61K49/22 , A61K51/12 , B01J13/02 , B01J13/10 , B01J13/14 , C08G79/02 , C12N11/04
CPC分类号： A61K49/223 , A61K49/225 , A61K49/226 , A61K51/1258 , A61K9/1271 , A61K9/1641 , A61K9/5031 , B01J13/14 , C08G79/025 , C12N11/04 , A61K2123/00 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked with multivalent ions of the opposite charge to form a gel encapsulating biological material, that is optionally further stabilized by interactions with multivalent polyions of the same charge as those used to form the gel. In the preferred embodiment, hydrolytically stable polyphosphazenes are formed of monomers having carboxylic acid side groups that are crosslinked by divalent or trivalent cations such as Ca.sup.2+ or Al.sup.3+, then stabilized with a polycation such as poly-L-lysine. A variety of different compositions can be formed from the crosslinked polymer. In a preferred embodiment, microcapsules are made by spraying an aqueous solution of polyphosphazene and material to be encapsulated into a calcium chloride solution. A semipermeable membrane is formed on the microspheres by complexation of the surface carboxylate groups with poly(L-lysine).
摘要翻译：公开了一种将生物不稳定材料如蛋白质，脂质体，细菌和真核细胞包封在合成聚合物胶囊内的方法及其产品。该方法基于使用具有带电侧链的水溶性聚合物，其与相反电荷的多价离子交联以形成包封生物材料的凝胶，其任选通过与相同电荷的多价离子的相互作用进一步稳定用于形成凝胶的那些。在优选的实施方案中，水解稳定的聚磷腈由具有羧酸侧基的单体形成，其通过二价或三价阳离子如Ca 2+或Al 3+交联，然后用聚阳离子如聚-L-赖氨酸稳定。可以从交联聚合物形成各种不同的组合物。在优选的实施方案中，通过将聚磷腈的水溶液和待包封的材料喷雾到氯化钙溶液中来制备微胶囊。通过表面羧酸酯基与聚（L-赖氨酸）的络合，在微球上形成半透膜。

5. 发明授权

US5487390A Gas-filled polymeric microbubbles for ultrasound imaging 失效
标题翻译：用于超声成像的气体填充聚合物微泡
公开(公告)号：US5487390A
公开(公告)日：1996-01-30
申请号：US182216
申请日：1994-01-14
申请人： Smadar Cohen , Alexander K. Andrianov , Margaret Wheatley , Harry R. Allcock , Robert S. Langer
发明人： Smadar Cohen , Alexander K. Andrianov , Margaret Wheatley , Harry R. Allcock , Robert S. Langer
IPC分类号： A61K9/127 , A61K9/16 , A61K9/50 , A61K49/22 , A61K51/12 , B01J13/14 , C08G79/02 , C12N11/04 , A61B8/14
CPC分类号： A61K9/1271 , A61K49/223 , A61K49/225 , A61K49/226 , A61K51/1258 , A61K9/1641 , A61K9/5031 , B01J13/14 , C08G79/025 , C12N11/04 , A61K2123/00 , Y10S977/753 , Y10S977/929 , Y10T428/2987
摘要： Compositions, methods for preparing and methods of using air-filled polymeric microcapsules for ultrasound imaging are disclosed. Air-encapsulating microcapsules are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(methacrylic acid) and methacrylic acid copolymers (Eudragit's) by contact with multivalent ions such as calcium ions. In the preferred embodiment, the average size of the microcapsules is less than seven .mu.m so that they are suitable for injection intravenously. The polymeric microcapsules are stable to imaging and display high echogenicity, both in vitro and in vivo. Due to their in vivo stability their potential application is extended beyond vascular imaging to liver and renal diseases, fallopian tube diseases, detecting and characterizing tumor masses and tissues, and measuring peripheral blood velocity. The microcapsules can optionally be linked with ligands that minimize tissue adhesion or that target the microcapsules to specific regions.
摘要翻译：公开了组合物，制备方法和使用空气填充的聚合物微胶囊用于超声成像的方法。通过与多价离子如钙离子接触，通过离子交换胶凝聚合电解质如聚（羧基苯氧基）磷腈，聚（丙烯酸），聚（甲基丙烯酸）和甲基丙烯酸共聚物（Eudragit's））形成空气封装的微胶囊。在优选的实施方案中，微胶囊的平均尺寸小于7μm，使得它们适合静脉内注射。聚合物微胶囊在体外和体内都能稳定成像并显示高回波性。由于其体内稳定性，其潜在应用范围超出血管成像，肝肾疾病，输卵管疾病，检测和表征肿瘤块和组织，并测量外周血速度。微胶囊可以任选地与使组织粘附最小化或将微胶囊靶向特定区域的配体连接。

6. 发明授权

US5562099A Polymeric microparticles containing agents for imaging 失效
标题翻译：含有成像剂的聚合物微粒
公开(公告)号：US5562099A
公开(公告)日：1996-10-08
申请号：US292522
申请日：1994-08-18
申请人： Smadar Cohen , Alexander K. Andrianov , Margaret Wheatley , Harry R. Allcock , Robert S. Langer
发明人： Smadar Cohen , Alexander K. Andrianov , Margaret Wheatley , Harry R. Allcock , Robert S. Langer
IPC分类号： A61K9/127 , A61K9/16 , A61K9/50 , A61K49/22 , A61K51/12 , B01J13/14 , C08G79/02 , C12N11/04 , A61K49/00
CPC分类号： B82Y5/00 , A61K49/223 , A61K49/225 , A61K49/226 , A61K51/1258 , A61K9/1271 , A61K9/1641 , A61K9/5031 , B01J13/14 , C08G79/025 , C12N11/04 , A61K2123/00 , Y10S977/753
摘要： Compositions, methods for preparing and methods of using contrast agent-filled polymeric microparticles for imaging are disclosed. In a preferred embodiment, air-encapsulating microparticles are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(methacrylic acid) and methacrylic acid copolymers (Eudragit's) by contact with multivalent ions such as calcium ions. In the preferred embodiment, the average size of the microparticles is less than seven .mu.m so that they are suitable for injection intravenously. The polymeric microparticles are stable to imaging and display high echogenicity, both in vitro and in vivo. Due to their in vivo stability their potential application is extended beyond vascular imaging to liver and renal diseases, fallopian tube diseases, detecting and characterizing tumor masses and tissues, and measuring peripheral blood velocity. The microparticles can optionally be linked with ligands that minimize tissue adhesion or that target the microparticles to specific regions.
摘要翻译：公开了组合物，制备方法和使用造影剂填充的聚合物微粒用于成像的方法。在一个优选的实施方案中，空气封装的微粒通过与多价离子例如钙的接触通过离子交换胶凝合成聚合电解质如聚（羧基苯氧基）磷腈，聚（丙烯酸），聚（甲基丙烯酸）和甲基丙烯酸共聚物（Eudragit's）离子。在优选的实施方案中，微粒的平均尺寸小于7μm，使得它们适于静脉内注射。聚合物微粒对于成像是稳定的，并且在体外和体内均显示出高回波性。由于其体内稳定性，其潜在应用范围超出血管成像，肝肾疾病，输卵管疾病，检测和表征肿瘤块和组织，并测量外周血速度。微粒可任选地与使组织粘附最小化或将微粒靶向特定区域的配体连接。

7. 发明授权

US5457160A Polyphosphazene blends 失效
标题翻译：聚磷腈混合物
公开(公告)号：US5457160A
公开(公告)日：1995-10-10
申请号：US157951
申请日：1993-11-24
申请人： Harry R. Allcock , Karyn B. Visscher
发明人： Harry R. Allcock , Karyn B. Visscher
IPC分类号： C08L25/06 , C08L27/06 , C08L29/04 , C08L33/02 , C08L33/12 , C08L71/00 , C08L85/02
CPC分类号： C08L33/02 , C08L25/06 , C08L27/06 , C08L29/04 , C08L33/12 , C08L85/02 , C08L71/00
摘要： Polymer blends of the following:(i) poly[bis(methylamino)phosphazene] and poly[bis(2-(2-methoxyethoxy)ethoxy)phosphazene;(ii) poly[bis(methylamino)phosphazene] with poly(vinyl chloride), poly(methyl methacrylate), poly(ethylene oxide), or polystyrene;(iii) poly[bis(2-(2-methoxyethoxy)ethoxy)phosphazene with poly(vinyl alcohol) or poly(acrylic acid); and(iv) poly[bis(phenoxy)phosphazene] with polystyrene or poly(methyl methacrylate).
摘要翻译：以下聚合物共混物：（i）聚[双（甲基氨基）磷腈]和聚[双（2-（2-（2-甲氧基乙氧基）乙氧基）磷腈）（ii）与聚（氯乙烯），聚（甲基丙烯酸甲酯），聚（环氧乙烷）或聚苯乙烯的聚[双（甲基氨基）磷腈] （iii）聚[二（2-（2-甲氧基乙氧基）乙氧基）磷腈与聚（乙烯醇）或聚（丙烯酸）; 和（iv）聚[双（苯氧基）磷腈]与聚苯乙烯或聚（甲基丙烯酸甲酯）。

8. 发明授权

US06759157B1 Proton conducting polymer membranes 失效
标题翻译：质子导电聚合物膜
公开(公告)号：US06759157B1
公开(公告)日：2004-07-06
申请号：US09590985
申请日：2000-06-09
申请人： Harry R. Allcock , Michael A. Hofmann , Serguei N. Lvov , Xiang Y. Zhou , Digby McDonald
发明人： Harry R. Allcock , Michael A. Hofmann , Serguei N. Lvov , Xiang Y. Zhou , Digby McDonald
IPC分类号： H01M810
CPC分类号： B01D67/0011 , B01D2325/20 , B01D2325/26 , C08J5/22 , H01M8/04197 , H01M8/1034 , H01M8/1067 , Y02P70/56
摘要： Proton conducting membranes having improved resistance to methanol crossover are provided, along with methods for their manufacture. In a preferred embodiment, the polymeric membranes are formed by (a) dissolving a polymer, preferably a polyphosphazene, in an organic solvent to form a polymer solution; (b) adding an oxyacid to the polymer solution; (c) optionally, adding water to the polymer solution, preferably in a molar ratio equivalent to the oxyacid; (d) optionally, concentrating the polymer solution; (e) casting the polymer solution on a casting surface, such as one formed of or coated with TEFLON™; and (f) removing the organic solvent, so as to form the polymeric membrane. A particularly useful application for these polymeric membranes is in fuel cells, such as those wherein methanol and oxygen are converted into electrical energy.
摘要翻译：提供了具有改进的抗甲醇交联性的质子导电膜及其制造方法。在优选的实施方案中，聚合物膜通过（a）将聚合物，优选聚磷腈溶解在有机溶剂中形成聚合物溶液而形成; （b）向聚合物溶液中加入含氧酸; （c）任选地，向聚合物溶液中加入水，优选以相对于含氧酸的摩尔比加入; （d）任选地，浓缩聚合物溶液; （e）将聚合物溶液浇铸在诸如由TEFLON TM形成或涂覆的铸造表面上; 和（f）除去有机溶剂，以便形成聚合物膜。这些聚合物膜的特别有用的应用是在燃料电池中，例如其中甲醇和氧被转化为电能的那些。

9. 发明授权

US06482910B1 Polynorbornenes with pendant cyclotriphosphazenes 失效
标题翻译：聚降冰片烯与侧链环三磷腈
公开(公告)号：US06482910B1
公开(公告)日：2002-11-19
申请号：US09644592
申请日：2000-08-23
申请人： Harry R. Allcock , Walter R. Laredo
发明人： Harry R. Allcock , Walter R. Laredo
IPC分类号： C08F23620
CPC分类号： C08G61/02 , C08F132/08 , C08G61/06 , C08G61/08
摘要： A polymer composition comprising a polynorbonene backbone and pendant cyclotriphosphazene groups has been developed. The pendant cyclotriphosphazene group can have various substituents such as C1-C10 alkyl, C1-C10 haloalkyl, C3-C6 cycloalkyl, phenyl, substituted phenyl, aryl, —(CH2CH2OCH2CH2)nOCH3 in which n is a positive integer, aminoalkyl, alkoxyalkyl, phenoxyalkyl, aryloxyalkyl and amidoalkyl. The polynorbonene backbone can have substituents such as H, CH3, X which is a halo group, and C2-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkoxy, phenoxy, and aryloxy. In a preferred embodiment, the pendant triphosphazene group can have either —CH2CF3, phenyl, 4-ethylcarboxylatophenyl, —CH2CH3, or —CH2CH2OCH2CH2OCH3 while the polynorbonene backbone can have H and low alkyl groups. The polyphosphazene compositions can be prepared readily via ring-opening-metathesis-polymerization of an olefin having norbornene structure with pendant cyclotriphosphazene groups. The polyphosphazene compositions disclosed are useful as elastomers, optical materials, electrically conductive materials, biomedical materials, compatibilizing agents, surfactants, additives for coatings, and as flame retardants.
摘要翻译：已经开发了包含聚碳链烷骨架和侧链三磷腈基团的聚合物组合物。侧环三膦腈基可以具有各种取代基，例如C1-C10烷基，C1-C10卤代烷基，C3-C6环烷基，苯基，取代的苯基，芳基， - （CH2CH2OCH2CH2）nOCH3，其中n是正整数，氨基烷基，烷氧基烷基，苯氧基烷基，芳氧基烷基和酰氨基烷基。多亚碳烯骨架可以具有取代基，例如H，CH 3，X是卤素基团，和C 2 -C 6烷基，C 3 -C 6环烷基，C 2 -C 6烷氧基，苯氧基和芳氧基。在一个优选的实施方案中，三膦酰基侧基可以具有-CH 2 CF 3，苯基，4-乙基羧基苯基，-CH 2 CH 3或-CH 2 CH 2 OCH 2 CH 2 OCH 3，而多亚氮烷骨架可具有H和低级烷基。聚磷腈组合物可以通过具有降冰片烯结构的烯烃与侧链三环磷腈基团的开环 - 复分解聚合来容易地制备。所公开的聚磷腈组合物可用作弹性体，光学材料，导电材料，生物医学材料，相容剂，表面活性剂，涂料用添加剂和阻燃剂。

10. 发明授权

US5965627A Blends of polyurethane and polyphosphazene and their use as flame-retardant foamed compositions 失效
标题翻译：聚氨酯和聚磷腈的共混物及其作为阻燃发泡组合物的用途
公开(公告)号：US5965627A
公开(公告)日：1999-10-12
申请号：US852769
申请日：1997-05-07
申请人： Harry R. Allcock , Michael M. Coleman , Carey S. Reed , Kevin S. Guigley
发明人： Harry R. Allcock , Michael M. Coleman , Carey S. Reed , Kevin S. Guigley
IPC分类号： C08G18/64 , C08L85/02 , C08L75/00
CPC分类号： C08G18/6461 , C08L85/02 , C08G2101/00
摘要： Flame-retardant polymer blends of a polyurethane polymer or prepolymer and a poly(organophosphazene) are disclosed. Preferred poly(organophosphazenes) contain functional groups capable of reacting with isocyanate groups present during the curing of the polyurethane. The blends are preferably formulated by reacting the poly(organophosphazene) containing functional groups under conditions where some of the functional groups of the poly(organophosphazene) can react with the isocyanate groups present during the polymerization and curing of the polyurethane. These polymer blends are useful for making flame-retardant foamed articles of manufacture.
摘要翻译：公开了聚氨酯聚合物或预聚物和聚（有机膦腈）的阻燃聚合物共混物。优选的聚（有机膦腈）含有能够在聚氨酯固化期间与异氰酸酯基反应的官能团。混合物优选通过在聚（有机膦腈）的一些官能团可以与在聚氨酯的聚合和固化期间存在的异氰酸酯基团反应的条件下使含有聚（有机膦腈）的官能团的反应来配制。这些聚合物共混物可用于制造阻燃发泡制品。

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