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1. 发明申请

US20060036218A1 Method and apparatus for selective material delivery via an intra-renal catheter 有权
标题翻译：通过肾内导管选择性物质输送的方法和装置
公开(公告)号：US20060036218A1
公开(公告)日：2006-02-16
申请号：US11084738
申请日：2005-03-16
申请人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M25/00
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自插管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

2. 发明申请

US20070249997A1 METHOD AND APPARATUS FOR SELECTIVE MATERIAL DELIVERY VIA AN INTRA-RENAL CATHETER 有权
标题翻译：通过内镜导管选择性材料输送的方法和装置
公开(公告)号：US20070249997A1
公开(公告)日：2007-10-25
申请号：US11768390
申请日：2007-06-26
申请人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M31/00 , A61F2/06
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自套管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

3. 发明申请

US20060030814A1 Method and apparatus for selective drug infusion via an intra-aortic flow diverter delivery catheter 审中-公开
标题翻译：通过主动脉内分流器输送导管选择性药物输注的方法和装置
公开(公告)号：US20060030814A1
公开(公告)日：2006-02-09
申请号：US11083802
申请日：2005-03-18
申请人： Aurelio Valencia , Ricardo Aboytes , Jeffrey Elkins , Harry Goodson , Samir Patel , Craig Ball , Trevor Greenan , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Aurelio Valencia , Ricardo Aboytes , Jeffrey Elkins , Harry Goodson , Samir Patel , Craig Ball , Trevor Greenan , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M31/00
CPC分类号： A61M25/1002 , A61M25/00 , A61M25/0074 , A61M25/0082 , A61M25/04 , A61M29/02 , A61M39/06 , A61M2025/0073 , A61M2025/1052
摘要： A local renal delivery system includes a flow isolation assembly and a local injection assembly. The flow isolation assembly in one mode is adapted to isolate only a partial flow region along the outer circumference along the aorta wall such that fluids inject there are maintained to flow substantially into the renal arteries. Various types of flow isolation assemblies and local injection assemblies are described.
摘要翻译：局部肾递送系统包括流动隔离组件和局部注射组件。在一种模式中的流动隔离组件适于仅沿着沿着主动脉壁的外周隔离部分流动区域，使得在其中注入的流体被维持以基本上流入肾动脉。描述了各种类型的流动隔离组件和局部注射组件。

4. 发明申请

US20080103442A1 INTRA-AORTIC RENAL DRUG DELIVERY CATHETER 审中-公开
标题翻译： INTRA-AORTIC肾脏药物输送管
公开(公告)号：US20080103442A1
公开(公告)日：2008-05-01
申请号：US11968237
申请日：2008-01-02
申请人： Randy Kesten , Michael Rosenthal , Sam Payne , Andrew Kramer , Sophia Pesotchinsky
发明人： Randy Kesten , Michael Rosenthal , Sam Payne , Andrew Kramer , Sophia Pesotchinsky
IPC分类号： A61M31/00 , A61M29/02
CPC分类号： A61M25/1002 , A61M2025/0034 , A61M2025/0035 , A61M2025/0036 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61M2025/1004 , A61M2025/105 , A61M2025/1059 , A61M2025/1084
摘要： A catheter for delivering a therapeutic or diagnostic agent to a branch blond vessel of a major blood vessel comprises an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.
摘要翻译：用于将治疗剂或诊断剂递送到主要血管的分支金黄色血管的导管包括细长轴，其具有至少一个内腔，其与所述轴的远侧部分中的药剂输送端口流体连通，所述可扩张管状构件所述轴的远端部分和所述管状部件上的径向可扩张部件。管状构件构造成在分支容器的上游和下游的血管内延伸，并且具有在血管内可径向扩张的内部通道，以将通过血管的血液分离成外部血流管状构件的外部和管状构件的内部通道内的内部血流。

5. 发明申请

US20060189960A1 Intra-aortic renal drug delivery catheter 有权
标题翻译：主动脉内肾脏药物输送导管
公开(公告)号：US20060189960A1
公开(公告)日：2006-08-24
申请号：US11221679
申请日：2005-09-07
申请人： Randy Kesten , Michael Rosenthal , Sam Payne , Andrew Kramer , Sophia Pesotchinsky
发明人： Randy Kesten , Michael Rosenthal , Sam Payne , Andrew Kramer , Sophia Pesotchinsky
IPC分类号： A61M31/00
CPC分类号： A61M25/1002 , A61M2025/0034 , A61M2025/0035 , A61M2025/0036 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61M2025/1004 , A61M2025/105 , A61M2025/1059 , A61M2025/1084
摘要： A catheter for delivering a therapeutic or diagnostic agent to a branch blond vessel of a major blood vessel comprises an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.
摘要翻译：用于将治疗剂或诊断剂递送到主要血管的分支金黄色血管的导管包括细长轴，其具有至少一个内腔，其与所述轴的远侧部分中的药剂输送端口流体连通，所述可扩张管状构件所述轴的远端部分和所述管状部件上的径向可扩张部件。管状构件构造成在分支容器的上游和下游的血管内延伸，并且具有在血管内可径向扩张的内部通道，以将通过血管的血液分离成外部血流管状构件的外部和管状构件的内部通道内的内部血流。

6. 发明授权

US09289619B2 Timing cycles for synchronized multisite cardiac pacing 有权
公开(公告)号：US09289619B2
公开(公告)日：2016-03-22
申请号：US11894100
申请日：2007-08-20
申请人： Andrew Kramer , Jeff Stahmann
发明人： Andrew Kramer , Jeff Stahmann
IPC分类号： A61N1/39 , A61N1/362
CPC分类号： A61N1/3956 , A61N1/3622
摘要： The present invention relates to identifying and using groups of cardiac events associated with depolarization wavefronts to coordinate the delivery of pacing therapy to the heart. According to one aspect of the invention, cardiac events associated with a plurality of cardiac sites are detected. The cardiac sites may be located in a single heart chamber or in bilateral heart chambers. A group of detected cardiac events associated with a depolarization wavefront is identified. According to another aspect of the invention, a particular cardiac event of an identified group associated with a depolarization wavefront may be used to synchronize pacing therapy delivered to the heart. According to yet another aspect, premature ventricular contractions may be classified using the identified groups.

7. 发明申请

US20080046057A1 Timing cycles for synchronized multisite cardiac pacing 审中-公开
标题翻译：同步多站点心脏起搏的时序周期
公开(公告)号：US20080046057A1
公开(公告)日：2008-02-21
申请号：US11894100
申请日：2007-08-20
申请人： Andrew Kramer , Jeff Stahmann
发明人： Andrew Kramer , Jeff Stahmann
IPC分类号： A61N1/368
CPC分类号： A61N1/3956 , A61N1/3622
摘要： The present invention relates to identifying and using groups of cardiac events associated with depolarization wavefronts to coordinate the delivery of pacing therapy to the heart. According to one aspect of the invention, cardiac events associated with a plurality of cardiac sites are detected. The cardiac sites may be located in a single heart chamber or in bilateral heart chambers. A group of detected cardiac events associated with a depolarization wavefront is identified. According to another aspect of the invention, a particular cardiac event of an identified group associated with a depolarization wavefront may be used to synchronize pacing therapy delivered to the heart. According to yet another aspect, premature ventricular contractions may be classified using the identified groups.
摘要翻译：本发明涉及识别和使用与去极化波前相关联的心脏事件组，以协调心脏起搏治疗的递送。根据本发明的一个方面，检测与多个心脏部位相关联的心脏事件。心脏部位可以位于单个心室或双侧心室中。识别与去极化波前相关联的一组检测到的心脏事件。根据本发明的另一方面，与去极化波前相关联的识别组的特定心脏事件可用于同步递送至心脏的起搏治疗。根据另一方面，可以使用所识别的组来分类早产性心室收缩。

8. 发明申请

US20060271108A1 Safety control system for implantable neural stimulator 有权
公开(公告)号：US20060271108A1
公开(公告)日：2006-11-30
申请号：US11135883
申请日：2005-05-24
申请人： Imad Libbus , Andrew Kramer , William Linder , Jeffrey Stahmann
发明人： Imad Libbus , Andrew Kramer , William Linder , Jeffrey Stahmann
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/37
摘要： A neural stimulation system includes a safety control system that prevents delivery of neural stimulation pulses from causing potentially harmful effects. The neural stimulation pulses are delivered to one or more nerves to control the physiological functions regulated by the one or more nerves. Examples of such harmful effects include unintended effects in physiological functions associated with autonomic neural stimulation and nerve injuries caused by excessive delivery of the neural stimulation pulses.

9. 发明申请

US20060253161A1 Method and apparatus for controlling autonomic balance using neural stimulation 有权
公开(公告)号：US20060253161A1
公开(公告)日：2006-11-09
申请号：US11124791
申请日：2005-05-09
申请人： Imad Libbus , Andrew Kramer , Julio Spinelli
发明人： Imad Libbus , Andrew Kramer , Julio Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/36057 , A61N1/36114 , A61N1/36139 , A61N1/3621 , A61N1/3627 , A61N1/36585
摘要： A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.

10. 发明申请

US20060241704A1 Method and apparatus for pacing during revascularization 有权
公开(公告)号：US20060241704A1
公开(公告)日：2006-10-26
申请号：US11113828
申请日：2005-04-25
申请人： Allan Shuros , Tamara Baynham , Jihong Qu , Joseph Pastore , Andrew Kramer , Frits Prinzen , Ward Vanagt , Richard Cornelussen
发明人： Allan Shuros , Tamara Baynham , Jihong Qu , Joseph Pastore , Andrew Kramer , Frits Prinzen , Ward Vanagt , Richard Cornelussen
IPC分类号： A61N1/362
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.

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