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1. 发明申请

US20070150005A1 Method and apparatus for tissue protection against ischemia using remote conditioning 有权
标题翻译：使用远程调理的组织保护针对缺血的方法和装置
公开(公告)号：US20070150005A1
公开(公告)日：2007-06-28
申请号：US11318263
申请日：2005-12-23
申请人： Haris Sih , Tamara Baynham , Darrell Wagner
发明人： Haris Sih , Tamara Baynham , Darrell Wagner
IPC分类号： A61N1/36
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译：刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。

2. 发明申请

US20070054871A1 Method and apparatus for device controlled gene expression for cardiac protection 有权
标题翻译：心脏保护装置控制基因表达的方法和装置
公开(公告)号：US20070054871A1
公开(公告)日：2007-03-08
申请号：US11220397
申请日：2005-09-06
申请人： Joseph Pastore , Jeffrey Ross , Tamara Baynham , Rodney Salo , Andrew Kramer , Julio Spinelli
发明人： Joseph Pastore , Jeffrey Ross , Tamara Baynham , Rodney Salo , Andrew Kramer , Julio Spinelli
IPC分类号： A61K48/00 , A61N1/00
CPC分类号： A61N1/3627 , A61K48/0083 , A61N1/36514
摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.
摘要翻译：基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。基因调控信号直接或间接调控基因产物的基因表达。

3. 发明申请

US20080027497A1 ATRIAL PACING THERAPY FOR TREATING MITRAL REGURGITATION 有权
标题翻译：用于治疗麻醉药物的药物治疗
公开(公告)号：US20080027497A1
公开(公告)日：2008-01-31
申请号：US11868774
申请日：2007-10-08
申请人： Tamara Baynham
发明人： Tamara Baynham
IPC分类号： A61N1/365
CPC分类号： A61N1/3627
摘要： A method and apparatus are disclosed for treating mitral regurgitation with electrical stimulation. By providing pacing stimulation to the left atrium during ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.
摘要翻译：公开了一种用于通过电刺激治疗二尖瓣反流的方法和装置。通过在心室收缩期间向左心房提供起搏刺激，可以获得可以预防或减少二尖瓣反流程度的有益效果。

4. 发明申请

US20070118177A1 Neural stimulation therapy system for atherosclerotic plaques 失效
标题翻译：动脉粥样硬化斑块神经刺激治疗系统
公开(公告)号：US20070118177A1
公开(公告)日：2007-05-24
申请号：US11284370
申请日：2005-11-21
申请人： Imad Libbus , Julio Spinelli , Tamara Baynham
发明人： Imad Libbus , Julio Spinelli , Tamara Baynham
IPC分类号： A61N1/36
CPC分类号： A61N1/056 , A61N1/0556 , A61N1/36014 , A61N1/36114 , A61N1/36135 , A61N1/362
摘要： A neural stimulation therapy system for atherosclerotic plaques is provided. One aspect of this disclosure relates to a medical device for applying neural stimulation therapy for atherosclerotic plaques. The device includes a neural stimulator adapted to deliver an electrical signal through at least one electrode to an autonomic neural target. The device also includes a controller to control the neural stimulator to provide a therapy for atherosclerotic plaques. The device is external to a human body in an embodiment, and includes an implantable medical device (IMD) in various embodiments. According to an embodiment, the device includes a neural stimulation lead connected to the neural stimulator. The neural stimulator delivers electrical signals with waveform parameters based on sensed arterial blockage levels, according to various embodiments. Other aspects and embodiments are provided herein.
摘要翻译：提供了一种用于动脉粥样硬化斑块的神经刺激治疗系统。本公开的一个方面涉及用于对动脉粥样硬化斑块施加神经刺激疗法的医疗装置。该装置包括适于将电信号通过至少一个电极输送到自主神经靶的神经刺激器。该装置还包括控制器以控制神经刺激器以提供动脉粥样硬化斑块的治疗。在一个实施例中，该装置在人体外部，并且在各种实施例中包括可植入医疗装置（IMD）。根据实施例，该装置包括连接到神经刺激器的神经刺激引线。根据各种实施例，神经刺激器基于感测的动脉阻塞水平递送具有波形参数的电信号。本文提供了其它方面和实施例。

5. 发明申请

US20060241704A1 Method and apparatus for pacing during revascularization 有权
公开(公告)号：US20060241704A1
公开(公告)日：2006-10-26
申请号：US11113828
申请日：2005-04-25
申请人： Allan Shuros , Tamara Baynham , Jihong Qu , Joseph Pastore , Andrew Kramer , Frits Prinzen , Ward Vanagt , Richard Cornelussen
发明人： Allan Shuros , Tamara Baynham , Jihong Qu , Joseph Pastore , Andrew Kramer , Frits Prinzen , Ward Vanagt , Richard Cornelussen
IPC分类号： A61N1/362
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.

6. 发明申请

US20070260284A1 MYOCARDIUM CONDITIONING USING MYOCARDIAL AND PARASYMPATHETIC STIMULATION 失效
公开(公告)号：US20070260284A1
公开(公告)日：2007-11-08
申请号：US11381211
申请日：2006-05-02
申请人： Joseph Pastore , Tamara Baynham , Andrew Kramer , Julio Spinelli , Jeffrey Ross , Rodney Salo
发明人： Joseph Pastore , Tamara Baynham , Andrew Kramer , Julio Spinelli , Jeffrey Ross , Rodney Salo
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，脉冲发生器和控制器。神经刺激器适于产生神经刺激信号。脉冲发生器适用于产生起搏信号以提供心肌起搏。控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。本文提供了其它方面和实施例。

7. 发明申请

US20060287684A1 METHOD AND APPARATUS FOR INITIATING AND DELIVERING CARDIAC PROTECTION PACING 有权
标题翻译：用于启动和输送心脏保护剂的方法和装置
公开(公告)号：US20060287684A1
公开(公告)日：2006-12-21
申请号：US11382849
申请日：2006-05-11
申请人： Tamara Baynham , Julio Spinelli , Frits Prinzen , Richard Cornelussen , Ward Vanagt
发明人： Tamara Baynham , Julio Spinelli , Frits Prinzen , Richard Cornelussen , Ward Vanagt
IPC分类号： A61N1/00
CPC分类号： A61N1/36557 , A61B5/026 , A61N1/3621 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates a cardiac protection pacing sequence in response to the detection of the onset of an ischemic event, such that a pacing concurrent conditioning therapy is applied during the detected ischemic event.
摘要翻译：起搏系统提供心脏保护起搏，以保护心脏免受与缺血事件相关的损伤。起搏系统检测缺血事件，并作为响应启动一个或多个心脏保护起搏序列，每个起搏序列包括替代起搏和非起搏期。在一个实施方案中，响应于检测到缺血事件的发作，起搏系统引发心脏保护起搏序列，使得在检测到的缺血事件期间应用起搏并发调节疗法。

8. 发明申请

US20060259088A1 Method and apparatus for delivering pacing pulses using a coronary stent 审中-公开
公开(公告)号：US20060259088A1
公开(公告)日：2006-11-16
申请号：US11129058
申请日：2005-05-13
申请人： Joseph Pastore , Andrew Kramer , Julio Spinelli , Rodney Salo , Tamara Baynham , Jeffrey Ross , Frits Prinzen , Ward Vanagt , Richard Cornelussen
发明人： Joseph Pastore , Andrew Kramer , Julio Spinelli , Rodney Salo , Tamara Baynham , Jeffrey Ross , Frits Prinzen , Ward Vanagt , Richard Cornelussen
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/3627 , A61N1/36557 , A61N1/37205 , A61N1/3787 , A61N2001/0585
摘要： An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.

9. 发明申请

US20060173503A1 Linear electrode array to treat mitral regurgitation 失效
公开(公告)号：US20060173503A1
公开(公告)日：2006-08-03
申请号：US11046214
申请日：2005-01-28
申请人： Tamara Baynham
发明人： Tamara Baynham
IPC分类号： A61N1/36
CPC分类号： A61N1/3627
摘要： A method and apparatus are disclosed for treating mitral regurgitation with electrical stimulation. By providing pacing stimulation to a region of the left ventricle in proximity to the mitral valve apparatus in a manner which pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

10. 发明申请

US20060173502A1 Atrial pacing therapy for treating mitral regurgitation 有权
标题翻译：心房起搏治疗二尖瓣反流治疗
公开(公告)号：US20060173502A1
公开(公告)日：2006-08-03
申请号：US11046132
申请日：2005-01-28
申请人： Tamara Baynham
发明人： Tamara Baynham
IPC分类号： A61N1/36
CPC分类号： A61N1/3627
摘要： A method and apparatus are disclosed for treating mitral regurgitation with electrical stimulation. By providing pacing stimulation to the left atrium during ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.
摘要翻译：公开了一种用于通过电刺激治疗二尖瓣反流的方法和装置。通过在心室收缩期间向左心房提供起搏刺激，可以获得可以预防或减少二尖瓣反流程度的有益效果。

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