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1. 发明授权

US06761914B2 Immunogenic formulations comprising oil bodies 失效
标题翻译：包含油体的免疫原性制剂
公开(公告)号：US06761914B2
公开(公告)日：2004-07-13
申请号：US09880901
申请日：2001-06-15
申请人： Harm M. Deckers , Gijs van Rooijen , Joseph Boothe , Janis Goll , Maurice M. Moloney , Anthony B. Schryvers , Joenel Alcantara , Wendy A. Hutchins
发明人： Harm M. Deckers , Gijs van Rooijen , Joseph Boothe , Janis Goll , Maurice M. Moloney , Anthony B. Schryvers , Joenel Alcantara , Wendy A. Hutchins
IPC分类号： A61K4500
CPC分类号： C11B1/10 , A23D7/001 , A23D7/003 , A23G3/343 , A23G3/346 , A23G3/40 , A23G3/48 , A23G4/066 , A23G4/068 , A23G9/327 , A23G9/42 , A23G2200/08 , A23G2200/14 , A23K20/168 , A23K50/80 , A23L9/10 , A23L23/00 , A23L27/18 , A23L27/60 , A23P20/10 , A61K8/06 , A61K8/922 , A61K9/0014 , A61K9/0019 , A61K36/00 , A61K39/39 , A61K47/44 , A61K2039/54 , A61K2039/55566 , A61K2039/55588 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q5/00 , A61Q11/00 , A61Q13/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , C07K14/415 , C07K2319/00 , C09D5/022 , Y02A40/818 , Y10S424/812 , Y10S514/885
摘要： The present invention provides novel adjuvants which comprise oil bodies. The invention also provides vaccine formulations comprising oil bodies and an antigen and methods for preparing the vaccines and the use of the vaccines to elicit an immune response.
摘要翻译：本发明提供了包含油体的新型佐剂。本发明还提供包含油体和抗原的疫苗制剂以及用于制备疫苗的方法和疫苗引起免疫应答的用途。

2. 发明授权

US6048539A Lactoferrin receptor protein 失效
公开(公告)号：US6048539A
公开(公告)日：2000-04-11
申请号：US552232
申请日：1995-11-02
申请人： Anthony B. Schryvers , Robert A. Bonnah
发明人： Anthony B. Schryvers , Robert A. Bonnah
IPC分类号： A61K39/00 , A61P31/04 , C07K14/21 , C07K14/22 , A61K39/095
CPC分类号： C07K14/22 , C07K14/212 , A61K39/00
摘要： An isolated and purified lactoferrin receptor protein is isolated and purified from bacterial pathogens, including Moraxella and Neisseria, and has a molecular weight of between about 70,000 and about 90,000, as determined by SDS-PAGE. Such lactoferrin receptor protein may be provided in combination with a lactoferrin receptor protein from the bacterial pathogen of a molecular weight of about 100,000 to about 105,000 daltons. The lactoferrin receptor protein may be produced by providing a solubilized membrane preparation from the bacterial pathogen containing lactoferrin receptor proteins, non-lactoferrin receptor proteins and other contaminants, complexing the lactoferrin receptor proteins with lactoferrin and purifying the resulting complexes substantially free from the non-lactoferrin receptor proteins and the other contaminants, and separating the novel lactoferrin receptor protein from the complexes. The lactoferrin receptor protein is useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the lactoferrin receptor protein or produces a protein capable of inducing antibodies in a host specifically reactive with the lactoferrin receptor protein.

3. 发明授权

US06391316B1 Vaccine compositions comprising Haemophilus somnus transferrin-binding proteins and methods of use 有权
标题翻译：包含嗜血杆菌转铁蛋白结合蛋白的疫苗组合物和使用方法
公开(公告)号：US06391316B1
公开(公告)日：2002-05-21
申请号：US09405728
申请日：1999-09-24
申请人： Andrew A. Potter , Clement Rioux , Anthony B. Schryvers
发明人： Andrew A. Potter , Clement Rioux , Anthony B. Schryvers
IPC分类号： A61K39102
CPC分类号： C07K14/285 , A61K39/00
摘要： Cloning and expression of genes encoding H. somnus transferrin-binding proteins are described. The transferrin-binding proteins can be used in vaccine compositions for the prevention and treatment of H. somnus infections, as well as in diagnostic methods for determining the presence of H. somnus infections.
摘要翻译：描述了编码嗜睡细胞转铁蛋白结合蛋白的基因的克隆和表达。转铁蛋白结合蛋白可用于疫苗组合物中，用于预防和治疗嗜睡睡眠感染，以及用于确定睡眠嗜血杆菌感染存在的诊断方法。

4. 发明授权

US6028049A Compositions comprising the Tbp2 subunit of the transferrin receptor of Neisseria meningitidis 失效
标题翻译：包含脑膜炎奈瑟球菌转铁蛋白受体的Tbp2亚基的组合物
公开(公告)号：US6028049A
公开(公告)日：2000-02-22
申请号：US448194
申请日：1995-05-23
申请人： Eric Jacobs , Michele Legrain , Veronique Mazarin , Bernadette Bouchon-Theisen , Anthony B. Schryvers , Marie-Aline Bloch
发明人： Eric Jacobs , Michele Legrain , Veronique Mazarin , Bernadette Bouchon-Theisen , Anthony B. Schryvers , Marie-Aline Bloch
IPC分类号： A61K39/095 , A61P31/04 , C07K14/22 , C07K14/705 , C07K16/12 , C12N1/21 , C12N15/09 , C12N15/31 , C12P21/02 , C12P21/08 , C12R1/19 , A61K38/00
CPC分类号： C07K14/22 , C07K14/70582 , C07K16/1217
摘要： The subject of the present invention is a DNA fragment which encodes a protein capable of being recognised by an antiserum against the transferrin receptor of the strain IM2394 or IM2169 of N. meningitidis as well as a process for producing the said protein by a recombinant route. By way of example, such a DNA fragment encodes the tbp1 subunit of the strain IM2394 or IM2169 or the tbp2 subunit of the strain IM2394 or IM2169.
摘要翻译：本发明的主题是编码能够被来自脑膜炎奈瑟氏球菌的IM2394或IM2169的转铁蛋白受体的抗血清识别的蛋白质的DNA片段，以及通过重组途径制备所述蛋白质的方法。举例来说，这样的DNA片段编码菌株IM2394或IM2169或菌株IM2394或IM2169的tbp2亚基的tbp1亚基。

5. 发明授权

US5292869A Method for isolating and purifying transferrin and lactoferrin receptor proteins from bacteria and the preparation of vaccines containing the same 失效
标题翻译：从细菌中分离和纯化转铁蛋白和乳铁蛋白受体蛋白的方法以及含有该蛋白的疫苗的制备
公开(公告)号：US5292869A
公开(公告)日：1994-03-08
申请号：US507481
申请日：1990-04-11
申请人： Anthony B. Schryvers
发明人： Anthony B. Schryvers
IPC分类号： A61K20060101 , A61K39/095 , A61K39/02 , A61K39/04 , C07C103/52
CPC分类号： A61K39/095
摘要： The present invention relates to a method for isolating and purifying transferrin and lactoferrin receptor proteins from bacterial pathogens by affinity chromatography and to the preparation of vaccine antigens containing the purified receptor proteins.
摘要翻译：本发明涉及通过亲和层析分离和纯化来自细菌病原体的转铁蛋白和乳铁蛋白受体蛋白的方法以及制备含有纯化的受体蛋白的疫苗抗原。

6. 发明授权

US07241449B1 Transferrin receptor genes of moraxella 失效
标题翻译：转铁蛋白受体基因的moraxella
公开(公告)号：US07241449B1
公开(公告)日：2007-07-10
申请号：US09673133
申请日：1999-04-12
申请人： Lisa E. Myers , Anthony B. Schryvers , Robin E. Harkness , Sheena M. Loosmore , Run-Pan Du , Yan-Ping Yang , Michel H. Klein
发明人： Lisa E. Myers , Anthony B. Schryvers , Robin E. Harkness , Sheena M. Loosmore , Run-Pan Du , Yan-Ping Yang , Michel H. Klein
IPC分类号： A61K39/02 , A61K38/00 , C07K17/00 , C07K14/195
CPC分类号： C07K14/212 , A61K39/00
摘要： Purified and isolated nucleic acid molecules are provided which encode Tbp2 proteins of M. catarrhalis strains M35, 3 and LES1. The nucleic acid sequence may be used to produce recombinant Tbp2 proteins of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecules may be used in the diagnosis of infection.
摘要翻译：提供纯化和分离的核酸分子，其编码卡他莫拉菌M35,3和LES1的Tbp2蛋白。为了诊断和治疗的目的，核酸序列可用于产生不含莫拉氏菌属菌株的其它蛋白质的莫拉氏菌属菌株的重组Tbp2蛋白。此外，核酸分子可以用于感染的诊断。

7. 发明授权

US07118749B2 Transferrin receptor genes 失效
公开(公告)号：US07118749B2
公开(公告)日：2006-10-10
申请号：US10043344
申请日：2002-01-14
申请人： Sheena M. Loosmore , Robin E. Harkness , Anthony B. Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew D. Murdin , Michel H. Klein
发明人： Sheena M. Loosmore , Robin E. Harkness , Anthony B. Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew D. Murdin , Michel H. Klein
IPC分类号： A61K51/00 , A61K39/395 , A61K39/00 , A61K39/02 , A61K39/38
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C12N2799/021
摘要： Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.

8. 发明授权

US06440701B1 Transferrin receptor genes of Moraxella 失效
标题翻译：莫拉氏菌的转铁蛋白受体基因
公开(公告)号：US06440701B1
公开(公告)日：2002-08-27
申请号：US09059584
申请日：1998-04-14
申请人： Lisa E. Myers , Anthony B. Schryvers , Robin E. Harkness , Sheena M. Loosmore , Run-Pan Du , Yan-Ping Yang , Michel H. Klein
发明人： Lisa E. Myers , Anthony B. Schryvers , Robin E. Harkness , Sheena M. Loosmore , Run-Pan Du , Yan-Ping Yang , Michel H. Klein
IPC分类号： C12N1531
CPC分类号： C07K14/212 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51
摘要： Purified and isolated nucleic acid molecules are provided which encode transferrin receptor proteins of Moraxella, such as M. catarrhalis or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce recombinant transferrin receptor proteins Tbp1 and Tbp2 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.
摘要翻译：提供纯化和分离的核酸分子，其编码莫拉氏菌的转铁蛋白受体蛋白，例如卡他莫拉菌或转铁蛋白受体蛋白的片段或类似物。为了诊断和治疗的目的，核酸序列可用于产生不含莫拉氏菌属菌株的其它蛋白质的莫拉氏菌属菌株的重组转铁蛋白受体蛋白质Tbp1和Tbp2。此外，核酸分子可以用于感染的诊断。

9. 发明授权

US06437096B1 Transferrin receptor of moraxella 失效
标题翻译： moraxella的转铁蛋白受体
公开(公告)号：US06437096B1
公开(公告)日：2002-08-20
申请号：US08778570
申请日：1997-01-03
申请人： Lisa E. Myers , Anthony B. Schryvers , Robin E. Harkness , Sheena M. Loosmore , Run-Pan Du , Yan-Ping Yang , Michel H. Klein
发明人： Lisa E. Myers , Anthony B. Schryvers , Robin E. Harkness , Sheena M. Loosmore , Run-Pan Du , Yan-Ping Yang , Michel H. Klein
IPC分类号： C07K14195
CPC分类号： C07K14/212 , A61K39/00
摘要： Purified and isolated nucleic acid molecules are provided which encode transferrin receptor proteins of Moraxella, such as M. catarrhalis or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce recombinant transferrin receptor proteins Tbp1 and Tbp2 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.
摘要翻译：提供纯化和分离的核酸分子，其编码莫拉氏菌的转铁蛋白受体蛋白，例如卡他莫拉菌或转铁蛋白受体蛋白的片段或类似物。为了诊断和治疗的目的，核酸序列可用于产生不含莫拉氏菌属菌株的其它蛋白质的莫拉氏菌属菌株的重组转铁蛋白受体蛋白质Tbp1和Tbp2。此外，核酸分子可以用于感染的诊断。

10. 发明授权

US06326350B1 Transferrin receptor subunit proteins of Neisseria meningitidis 失效
标题翻译：脑膜炎奈瑟球菌的转铁蛋白受体亚基蛋白
公开(公告)号：US06326350B1
公开(公告)日：2001-12-04
申请号：US08867921
申请日：1997-06-03
申请人： Eric Jacobs , Michèle LeGrain , Véronique Mazarin , Bernadette Bouchon-Theisen , Anthony B. Schryvers , Marie-Aline Bloch
发明人： Eric Jacobs , Michèle LeGrain , Véronique Mazarin , Bernadette Bouchon-Theisen , Anthony B. Schryvers , Marie-Aline Bloch
IPC分类号： C07K1422
CPC分类号： C07K14/22 , C07K14/70582 , C07K16/1217
摘要： The subject of the present invention is a DNA fragment which encodes a protein capable of being recognised by an antiserum against the transferrin receptor of the strain IM2394 or IM2169 of N. meningitidis as well as a process for producing the said protein by a recombinant route. By way of example, such a DNA fragment encodes the tbp1 subunit of the strain IM2394 or IM2169 or the tbp2 subunit of the strain IM2394 or IM2169.
摘要翻译：本发明的主题是编码能够被来自脑膜炎奈瑟氏球菌的IM2394或IM2169的转铁蛋白受体的抗血清识别的蛋白质的DNA片段，以及通过重组途径制备所述蛋白质的方法。举例来说，这样的DNA片段编码菌株IM2394或IM2169或菌株IM2394或IM2169的tbp2亚基的tbp1亚基。

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