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1. 发明申请

US20130071475A1 Method For Producing An Oral Pharmaceutical Form With Immediate Disintegration And Active Ingredient Release 审中-公开
标题翻译：生产具有立即崩解和活性成分释放的口服药物形式的方法
公开(公告)号：US20130071475A1
公开(公告)日：2013-03-21
申请号：US13677740
申请日：2012-11-15
申请人： Hans-Ulrich PETEREIT , Christian MEIER , Andreas GRYCZKE
发明人： Hans-Ulrich PETEREIT , Christian MEIER , Andreas GRYCZKE
IPC分类号： A61J3/10 , A61K31/192 , A61K9/14
CPC分类号： A61J3/10 , A61K9/0056 , A61K9/146 , A61K9/1647 , A61K9/2054 , A61K31/192
摘要： The invention relates to a method for producing an oral form of administration which decomposes immediately and releases active ingredients in the mouth. According to said method, (a) an anionic pharmaceutical active ingredient is intensively mixed with (b) a copolymer consisting of radically polymerized C1-C4 esters of the acrylic acid or methacrylic acid and other (meth)acrylate monomers containing functional tertiary amino groups, and (c) between 5 and 50 wt. %, in relation to (b), of a C12-C22 carboxylic acid in the melted mass; the mixture is solidified and ground to form a powder containing active ingredients having an average particle size of 200 μm or less; and the powder is encapsulated in a water-soluble matrix consisting of pharmaceutically standard adjuvants, on the condition that no more than 3 wt. %, in relation to the copolymer, of emulsifiers with an HLB value of at least 14 must be contained therein. The invention also relates to the powder containing active ingredients and the uses of the same.
摘要翻译：本发明涉及一种生产口服给药方法，该方法立即分解并释放口腔内的活性成分。根据所述方法，（a）阴离子药物活性成分与（b）由丙烯酸或甲基丙烯酸的自由基聚合的C1-C4酯和含有官能叔氨基的其它（甲基）丙烯酸酯单体组成的共聚物强烈混合，和（c）5-50wt。％的（b）相对于熔融物质中的C 12 -C 22羧酸; 将混合物固化并研磨形成含有平均粒径为200μm以下的活性成分的粉末; 并将粉末包封在由药学上标准的佐剂组成的水溶性基质中，条件是不超过3wt。相对于共聚物，HLB值至少为14的乳化剂的％必须包含在其中。本发明还涉及含有活性成分的粉末及其用途。

2. 发明申请

US20080260814A1 INJECTION MOULDING PROCESS FOR NEUTRAL AND ACID-GROUP-CONTAINING (METH)ACRYLATE COPOLYMERS 审中-公开
标题翻译：用于中性和含酸基（甲基）丙烯酸酯共聚物的注射成型工艺
公开(公告)号：US20080260814A1
公开(公告)日：2008-10-23
申请号：US12106669
申请日：2008-04-21
申请人： Hans-Ulrich PETEREIT , Thomas Beckert , Manfred Assmus , Werner Hoess , Wolfgang Fuchs , Hartmut Schikowsky
发明人： Hans-Ulrich PETEREIT , Thomas Beckert , Manfred Assmus , Werner Hoess , Wolfgang Fuchs , Hartmut Schikowsky
IPC分类号： A61K47/32 , C08L33/08 , C08L33/10 , A61K9/48 , B29C45/46
CPC分类号： A61K9/2095 , A61J3/077 , A61K9/2027 , A61K9/4816 , B29C45/0001
摘要： Processes for producing moldings by injection moulding, include melting a mixture made from a (meth)acrylate copolymer and a release agent, devolatilizing the mixture, injecting the molten and devolatilized mixture into a mold cavity of an injection mold, cooling the molten mixture, and removing the resultant molding from the mold.
摘要翻译：通过注射成型制造模制品的方法包括熔融由（甲基）丙烯酸酯共聚物和脱模剂制成的混合物，使混合物脱挥发分，将熔融和脱挥发分的混合物注入注模的模腔中，冷却熔融混合物，以及从模具中取出所得模制品。

3. 发明申请

US20080026051A1 PHARMACEUTICAL FORM HAVING A TWO-LAYER SEPARATING LAYER 有权
标题翻译：具有两层分离层的药物形式
公开(公告)号：US20080026051A1
公开(公告)日：2008-01-31
申请号：US11780915
申请日：2007-07-20
申请人： Rosario LIZIO , Erna ROTH , Hans-Ulrich PETEREIT
发明人： Rosario LIZIO , Erna ROTH , Hans-Ulrich PETEREIT
IPC分类号： A61K9/14 , A61K9/20 , A61K9/28 , A61K9/48 , A61P43/00
CPC分类号： A61K9/5073 , A61K9/5015 , A61K9/5026 , A61K9/5042
摘要： A pharmaceutical form, contains an active compound-containing core, which is covered with a coating layer of a gastric juice-resistant, intestinal juice-soluble (meth)acrylate copolymer, a separating layer situated between said core and said coating layer, the separating layer containing a film-forming water-soluble polymer, wherein the separating layer contains at least two layers: an inner layer containing a water-repellent substance, and thereon a layer comprising the film-forming water-soluble polymer.
摘要翻译：药物形式包含含有耐胃肠道汁溶性（甲基）丙烯酸酯共聚物的涂层的覆盖有活性化合物的核心，位于所述核心和所述涂层之间的分离层，所述分离层含有成膜性水溶性聚合物的层，其中分离层含有至少两层：含有防水物质的内层，其上包含成膜水溶性聚合物的层。

4. 发明申请

US20160081933A1 PROCESS FOR STABILIZING THE DRUG RELEASE PROFILES OF POLYMER FILM COATED PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：稳定聚合物薄膜包衣药物组合物的药物释放特性的方法
公开(公告)号：US20160081933A1
公开(公告)日：2016-03-24
申请号：US14889741
申请日：2013-08-19
申请人： Odette HENSEL , Shraddha Sanjeev Joshi , Smitha SHETTY , Takayuki MORITA , Tatsuya ISHII , Hans-Ulrich PETEREIT
发明人： Odette HENSEL , Shraddha Sanjeev JOSHI , Smitha SHETTY , Takayuki MORITA , Tatsuya ISHI , Hans-Ulrich PETEREIT
IPC分类号： A61K9/16 , A61K31/138 , A61K31/522 , C09D133/12 , A61K9/28
CPC分类号： A61K9/167 , A61K9/1635 , A61K9/1682 , A61K9/2846 , A61K9/2853 , A61K9/2893 , A61K9/5026 , A61K9/5089 , A61K31/138 , A61K31/522 , C09D133/12
摘要： The invention relates to a process for stabilizing the drug release profile of a polymer film coated pharmaceutical composition, wherein the pharmaceutical composition comprises a core comprising an active pharmaceutical ingredient and a polymer film coating onto the core which was applied by a spray coating process, including a subsequent drying step, by applying microwave-irradiation, infrared-irradiation, UV-irradiation or ultra sonic wave irradiation to the polymer film coated pharmaceutical compositions.
摘要翻译：本发明涉及一种用于稳定聚合物薄膜包衣的药物组合物的药物释放曲线的方法，其中药物组合物包含包含活性药物成分的芯和通过喷涂方法施加的芯上的聚合物膜，包括通过将微波照射，红外线照射，紫外线照射或超声波照射应用于聚合物膜涂覆的药物组合物，进行随后的干燥步骤。

5. 发明申请

US20170333361A1 NANOPARTICLE 审中-公开
公开(公告)号：US20170333361A1
公开(公告)日：2017-11-23
申请号：US15314343
申请日：2015-05-26
申请人： Rosario LIZIO , Silko GRIMM , Hans-Ulrich PETEREIT , Matthias EPPLE , Gregor DOERDELMANN
发明人： Rosario LIZIO , Silko GRIMM , Hans-Ulrich PETEREIT , Matthias EPPLE , Gregor DOERDELMANN
IPC分类号： A61K9/51 , A61K31/7088 , A61K9/00 , C12N15/113 , A61K48/00
CPC分类号： A61K9/5115 , A61K9/0019 , A61K9/0053 , A61K9/5146 , A61K9/5153 , A61K9/5161 , A61K9/5169 , A61K9/5192 , A61K31/7088 , A61K31/713 , A61K48/00 , C12N15/111 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/32
摘要： The invention refers to a nanoparticle with a diameter which is the maximum in the nanoparticle size distribution, in the range of 10-300 nm, comprising a) a calcium phosphate nanoparticle core a), b) an active ingredient coating b) on the calcium phosphate nanoparticle core a), c) a lactic acid polymer coating c) on the active ingredient coating b), d) a cationic polymer coating d) on the lactic acid polymer coating c) selected from the group of polyethylene-imines, chitosan and human lactoferrin-derived peptides with a length of 14 to 30 amino acids.

6. 发明申请

US20110070302A2 COATED PHARMACEUTICAL OR NUTRACEUTICAL PREPARATION WITH ACCELERATED CONTROLLED ACTIVE SUBSTANCE RELEASE 审中-公开
标题翻译：加速控制的活性物质释放的包装药物或营养制剂
公开(公告)号：US20110070302A2
公开(公告)日：2011-03-24
申请号：US12742263
申请日：2008-02-01
申请人： Hema RAVISHANKAR , Hans-Ulrich PETEREIT , Shradda BODINGE
发明人： Hema RAVISHANKAR , Hans-Ulrich PETEREIT , Shradda BODINGE
IPC分类号： A61K9/32 , A61K9/00 , A61K31/522 , A61P43/00
CPC分类号： A61K9/5026 , A61K9/5078
摘要： The present invention relates to pharmaceutical or nutraceutical preparations comprising a) a core containing a pharmaceutically or nutraceutically active substance; and b) a controlling layer surrounding the core comprising i) 55 to 92% by weight based on the total weight of (meth)acrylic copolymers present in the layer of one or a mixture of a plurality of (meth)acrylate copolymers composed of 80 to 98% by weight based on the weight of the (meth)acrylic copolymer of structural units derived from C1 to C4 alkyl esters of (meth)acrylic acid and 2 to 20% by weight based on the weight of the (meth)acrylic copolymer of structural units derived from (meth)acrylate monomers with a quaternary ammonium group in the alkyl radical; and ii) 8 to 45% by weight based on the total weight of (meth)acrylic copolymers present in the layer of one or a mixture of a plurality of (meth)acrylate copolymers composed of more than 5 to 59% by weight based on the weight of the copolymer of structural units derived from acrylic acid or methacrylic acid, and to tablets and capsules containing same.
摘要翻译：本发明涉及药物或营养制剂，其包含a）含有药学或营养物质活性物质的核心; 和b）围绕芯的控制层，其包含i）55至92重量％，基于存在于由80重量份组成的多个（甲基）丙烯酸酯共聚物的一种或多种混合物的层中的（甲基）丙烯酸共聚物的总重量至（甲基）丙烯酸共聚物的重量比为基于（甲基）丙烯酸的C1至C4烷基酯的结构单元的（甲基）丙烯酸共聚物的重量计为98重量％，以及（甲基）丙烯酸共聚物的重量为2至20重量％衍生自烷基中具有季铵基团的（甲基）丙烯酸酯单体的结构单元; 和ii）8至45重量％，基于存在于由多于5至59重量％组成的（甲基）丙烯酸酯共聚物的一种或多种的（甲基）丙烯酸酯共聚物的层中的（甲基）丙烯酸共聚物的总重量）衍生自丙烯酸或甲基丙烯酸的结构单元的共聚物的重量，以及含有它们的片剂和胶囊的重量。

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