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1. 发明申请

US20110117575A1 ISOLATION AND/OR IDENTIFICATION OF STEM CELLS HAVING ADIPOCYTIC, CHONDROCYTIC AND PANCREATIC DIFFERENTIATION POTENTIAL 有权
标题翻译：具有ADIPOCYTIC，CHONDROCYTIC和PANCREATIVE差异潜力的干细胞的分离和/或鉴定
公开(公告)号：US20110117575A1
公开(公告)日：2011-05-19
申请号：US12980092
申请日：2010-12-28
申请人： Hans-Joerg Buehring , Sabrina Treml , Reiner Lammers
发明人： Hans-Joerg Buehring , Sabrina Treml , Reiner Lammers
IPC分类号： G01N33/566 , C12N5/077 , C12N5/074
CPC分类号： G01N33/56966 , C07K16/2803 , C07K16/40 , C12N5/0663 , G01N33/531
摘要： The present invention relates to a method for isolating and/or identifying stem cells having adipocytic, chondrocytic and pancreatic differentiation potential, wherein an antibody is used that binds to the antigen TNAP, alone or in combination with an antibody that binds to the cell surface antigen CD56. The invention also relates to stem cells isolated by the method according to the invention for treating defects or damages or diseases in bone or cartilage of a patient in need thereof.
摘要翻译：本发明涉及用于分离和/或鉴定具有脂肪细胞，软骨细胞和胰腺分化潜能的干细胞的方法，其中使用与抗原TNAP单独或与结合细胞表面抗原的抗体结合的抗体 CD56。本发明还涉及通过根据本发明的方法分离的用于治疗有需要的患者的骨或软骨中的缺陷或损伤或疾病的干细胞。

2. 发明授权

US09052316B2 Isolation and/or identification of stem cells having adipocytic, chondrocytic and pancreatic differentiation potential 有权
标题翻译：具有脂肪细胞，软骨细胞和胰腺分化潜能的干细胞的分离和/或鉴定
公开(公告)号：US09052316B2
公开(公告)日：2015-06-09
申请号：US12980092
申请日：2010-12-28
申请人： Hans-Joerg Buehring , Sabrina Treml , Reiner Lammers
发明人： Hans-Joerg Buehring , Sabrina Treml , Reiner Lammers
IPC分类号： G01N33/531 , G01N33/569 , C07K16/28 , C07K16/40 , C12N5/0775
CPC分类号： G01N33/56966 , C07K16/2803 , C07K16/40 , C12N5/0663 , G01N33/531
摘要： The present invention relates to a method for isolating and/or identifying stem cells having adipocytic, chondrocytic and pancreatic differentiation potential, wherein an antibody is used that binds to the antigen TNAP, alone or in combination with an antibody that binds to the cell surface antigen CD56. The invention also relates to stem cells isolated by the method according to the invention for treating defects or damages or diseases in bone or cartilage of a patient in need thereof.
摘要翻译：本发明涉及用于分离和/或鉴定具有脂肪细胞，软骨细胞和胰腺分化潜能的干细胞的方法，其中使用与抗原TNAP单独或与结合细胞表面抗原的抗体结合的抗体 CD56。本发明还涉及通过根据本发明的方法分离的用于治疗有需要的患者的骨或软骨中的缺陷或损伤或疾病的干细胞。

3. 发明授权

US07741114B2 Antibodies for identifying and/or isolating at least one cell population 有权
标题翻译：用于鉴定和/或分离至少一个细胞群体的抗体
公开(公告)号：US07741114B2
公开(公告)日：2010-06-22
申请号：US12401539
申请日：2009-03-10
申请人： Hans-Joerg Buehring , Reiner Lammers , Selim Kuci , Tim Conze
发明人： Hans-Joerg Buehring , Reiner Lammers , Selim Kuci , Tim Conze
IPC分类号： C12N5/12 , C12N5/074 , C12N5/077 , C12N5/0797
CPC分类号： C07K16/18 , C07K16/28
摘要： Monoclonal antibodies, or fragments thereof, are used for isolating and/or identifying at least one cell population. The cell population can include any of the following types of cells: haematopoietic stem cells, neuronal stem cells, neuronal progenitor cells, mesenchymal stem cells and mesenchymal progenitor cells. The antibodies, or fragments thereof, bind to an antigen which is the same as that bound by an antibody which is produced by the hybridoma cell lines CUB1, CUB2, CUB3 and CUB4, which were deposited in the DSMZ under the numbers DSM ACC2569, DSM ACC2566 and DSM ACC2565, on 14 Aug. 2002, and DSM ACC2551, on 12 Jul. 2002.
摘要翻译：单克隆抗体或其片段用于分离和/或鉴定至少一个细胞群体。细胞群可以包括以下类型的细胞：造血干细胞，神经元干细胞，神经元祖细胞，间充质干细胞和间充质祖细胞。抗体或其片段与由通过杂交瘤细胞系CUB1，CUB2，CUB3和CUB4产生的抗体结合的抗原结合，所述抗体以DSM ACC2569，DSM 2002年8月14日的ACC2566和DSM ACC2565以及2002年7月12日的DSM ACC2551。

4. 发明授权

US07541030B2 Antibodies for identifying and/or isolating at least one cell population which is selected from the group comprising haematopoietic stem cells, neuronal stem cells, neuronal precursor cells, mesenchymal stem cells and mesenchymal precursor cells 有权
标题翻译：用于鉴定和/或分离至少一个细胞群的抗体，其选自包括造血干细胞，神经元干细胞，神经元前体细胞，间充质干细胞和间充质前体细胞
公开(公告)号：US07541030B2
公开(公告)日：2009-06-02
申请号：US10627884
申请日：2003-07-25
申请人： Hans-Joerg Buehring , Reiner Lammers , Selim Kuci , Tim Conze
发明人： Hans-Joerg Buehring , Reiner Lammers , Selim Kuci , Tim Conze
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/18 , C07K16/28
摘要： The invention relates to monoclonal antibodies, or fragments thereof, for isolating and/or identifying at least one cell population which is selected from the group comprising haematopoietic stem cells, neuronal stem cells, neuronal progenitor cells, mesenchymal stem cells and mesenchymal progenitor cells. The antibodies, or fragments thereof, bind to an antigen which is the same as that bound by an antibody which is produced by the hybridoma cell lines CUB1, CUB2, CUB3 and CUB4, which were deposited in the DSMZ under the numbers DSM ACC2569, DSM ACC2566 and DSM ACC2565, on Aug, 14, 2002, and DSM ACC2551, on Dec. 7, 2002.
摘要翻译：本发明涉及用于分离和/或鉴定至少一种选自包括造血干细胞，神经元干细胞，神经元祖细胞，间充质干细胞和间充质祖细胞的细胞群的单克隆抗体或其片段。抗体或其片段与由通过杂交瘤细胞系CUB1，CUB2，CUB3和CUB4产生的抗体结合的抗原结合，所述抗体以DSM ACC2569，DSM 2002年8月14日的ACC2566和DSM ACC2565以及2002年12月7日的DSM ACC2551。

5. 发明申请

US20050214873A1 Antibody for isolating and/or identifying mesenchymal stem cells, and method for isolating and/or identifying mesenchymal stem cells 有权
标题翻译：用于分离和/或鉴定间充质干细胞的抗体，以及用于分离和/或鉴定间充质干细胞的方法
公开(公告)号：US20050214873A1
公开(公告)日：2005-09-29
申请号：US11077486
申请日：2005-03-09
申请人： Hans-Joerg Buehring , Reiner Lammers , Wichard Vogel
发明人： Hans-Joerg Buehring , Reiner Lammers , Wichard Vogel
IPC分类号： C07K16/28 , C12N5/06 , C12N5/08 , G01N33/53 , G01N33/567 , G01N33/569 , G01N33/68
CPC分类号： G01N33/6887 , C07K16/28 , G01N33/56966
摘要： The invention relates to a monoclonal antibody, or fragments thereof, for isolating and/or identifying mesenchymal stem cells. In this connection, the antibody, or fragments thereof, bind to an antigen which is the same as that bound to by an antibody which is produced by the hybridoma cell line W8B2, which was deposited on 14.08.2002 in the DSMZ [German collection of microorganisms and cell cultures] under the number DSM ACC2567.
摘要翻译：本发明涉及用于分离和/或鉴定间充质干细胞的单克隆抗体或其片段。在这方面，抗体或其片段与抗原结合，该抗原与通过由DSMZ [德国专利公开说明书]中保藏的杂交瘤细胞系W8B2产生的抗体相结合微生物和细胞培养物]，号码为DSM ACC2567。

6. 发明申请

US20080038272A1 Monoclonal antibody against frizzled receptors 失效
标题翻译：针对卷曲受体的单克隆抗体
公开(公告)号：US20080038272A1
公开(公告)日：2008-02-14
申请号：US11787023
申请日：2007-04-12
申请人： Hans-Joerg Buehring , Sigrid Hojak , Ingrid Albert
发明人： Hans-Joerg Buehring , Sigrid Hojak , Ingrid Albert
IPC分类号： A61K39/395 , A61P37/00 , C07K16/28 , C12N5/24 , G01N33/53 , G01N33/577
CPC分类号： C07K16/28
摘要： The present invention relates to a monoclonal antibody or fragment thereof, which binds specifically and/or selectively to human receptors of the Frizzled (FZD) family. It further relates to a hybridoma cell that produces the antibody according to the invention. Another object of the present invention is a method for the detection and/or isolation of receptors of the FZD family or homologs or fragments thereof in a biological sample and a method for the identification and/or isolation of biological material comprising or expressing receptors of the FZD family or homologs or fragments thereof. The invention further relates to the use of the antibody according to the invention or fragments thereof for the specific and/or selective detection and/or isolation of receptors of the FZD family, a composition comprising the monoclonal antibody according to the invention or fragments thereof, and a kit comprising the monoclonal antibody according to the invention or fragments thereof.
摘要翻译：本发明涉及与Frizzled（FZD）家族的人受体特异性和/或选择性结合的单克隆抗体或其片段。它进一步涉及产生本发明抗体的杂交瘤细胞。本发明的另一个目的是检测和/或分离生物样品中FZD家族的受体或其同系物或其片段的方法，以及用于鉴定和/或分离包含或表达受体的生物材料的生物材料的方法 FZD家族或其同系物或其片段。本发明还涉及根据本发明的抗体或其片段用于FZD家族的受体的特异性和/或选择性检测和/或分离的用途，包含本发明的单克隆抗体或其片段的组合物，以及包含本发明的单克隆抗体或其片段的试剂盒。

7. 发明授权

US09023996B2 Anti-FLT3 antibodies 有权
标题翻译：抗FLT3抗体
公开(公告)号：US09023996B2
公开(公告)日：2015-05-05
申请号：US13518779
申请日：2010-12-23
申请人： Ludger Grosse-Hovest , Hans-Joerg Buehring , Martin Hofmann , Steffen Aulwurm , Grundram Jung
发明人： Ludger Grosse-Hovest , Hans-Joerg Buehring , Martin Hofmann , Steffen Aulwurm , Grundram Jung
IPC分类号： C07K16/28 , C07K16/30 , C12N5/10 , C12N15/13 , A61K39/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/72 , C07K2317/732
摘要： The present invention relates to anti-FLT3 antibodies with a modified Fc region comprising the amino acid substitutions 239D and 332E to enhance antibody-dependent cell cytotoxicity (ADCC) of these antibodies. The invention further relates to pharmaceutical compositions containing these antibodies, nucleic acids encoding these antibodies as well as methods of using such antibodies.
摘要翻译：本发明涉及具有包含氨基酸取代239D和332E的修饰的Fc区的抗FLT3抗体以增强这些抗体的抗体依赖性细胞毒性（ADCC）。本发明还涉及含有这些抗体的药物组合物，编码这些抗体的核酸以及使用这些抗体的方法。

8. 发明申请

US20050003461A1 Method for detecting allergies 审中-公开
标题翻译：检测过敏的方法
公开(公告)号：US20050003461A1
公开(公告)日：2005-01-06
申请号：US10861892
申请日：2004-06-04
申请人： Hans-Joerg Buehring
发明人： Hans-Joerg Buehring
IPC分类号： C07K16/40 , G01N33/50 , G01N33/68 , G01N33/567
CPC分类号： G01N33/6869 , C07K16/40 , G01N33/5047 , G01N2333/5403
摘要： The present invention relates to a method for detecting allergies, with a blood sample initially being incubated with a cell-influencing agent, preferably interleukin IL-3, and then being incubated with an allergen, and with this blood sample subsequently being incubated with an antibody which binds to the surface structures on basophils and/or mast cells and/or precursor cells of basophils and/or mast cells to which the antibody 97A6 can bind, which antibody is produced and released by hybridoma cells which were deposited in the Deutsche Sammlung von Mikroorganismen und Zellkulturen [German collection of microorganisms and cell cultures] GmbH, DSMZ, under number DSM ACC 2297, in accordance with the Budapest Treaty, on Dec. 2, 1997, and with the antibodies which have bound to the basophils and/or mast cells and/or precursor cells of the basophils and/or mast cells then being quantified.
摘要翻译：本发明涉及一种用于检测过敏症的方法，其中血液样品最初与细胞影响剂（优选白细胞介素IL-3）孵育，然后与变应原孵育，随后将该血液样品与抗体其结合抗体97A6可以结合的嗜碱性粒细胞和/或肥大细胞的嗜碱性粒细胞和/或肥大细胞和/或前体细胞上的表面结构，该抗体由沉积在德意志山脉血液中的杂交瘤细胞产生和释放 Mikroorganismen und Zellkulturen [德国收集的微生物和细胞培养物]有限公司，DSMZ，根据布达佩斯条约，1997年12月2日，编号为DSM ACC 2297，以及与嗜碱性粒细胞和/或桅杆结合的抗体然后定量嗜碱性粒细胞和/或肥大细胞的细胞和/或前体细胞。

9. 发明申请

US20120328612A1 ANTI-FLT3 ANTIBODIES AND METHODS OF USING THE SAME 有权
标题翻译：抗FLT3抗体及其使用方法
公开(公告)号：US20120328612A1
公开(公告)日：2012-12-27
申请号：US13518779
申请日：2010-12-23
申请人： Ludger Grosse-Hovest , Hans-Joerg Buehring , Martin Hofmann , Steffen Aulwurm , Grundram Jung
发明人： Ludger Grosse-Hovest , Hans-Joerg Buehring , Martin Hofmann , Steffen Aulwurm , Grundram Jung
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , C12N5/10 , A61P35/00 , C12N15/13 , C12N5/07
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/72 , C07K2317/732
摘要： The present invention relates to anti-FLT3 antibodies with a modified Fc region comprising the amino acid substitutions 239D and 332E to enhance antibody-dependent cell cytotoxicity (ADCC) of these antibodies. The invention further relates to pharmaceutical compositions containing these antibodies, nucleic acids encoding these antibodies as well as methods of using such antibodies.
摘要翻译：本发明涉及具有包含氨基酸取代239D和332E的修饰的Fc区的抗FLT3抗体以增强这些抗体的抗体依赖性细胞毒性（ADCC）。本发明还涉及含有这些抗体的药物组合物，编码这些抗体的核酸以及使用这些抗体的方法。

10. 发明授权

US07182946B2 Antibodies isolating and/or identifying neuronal stem cells and method for isolating and/or identifying neuronal progenitor cells 失效
标题翻译：分离和/或鉴定神经元干细胞的抗体以及用于分离和/或鉴定神经元祖细胞的方法
公开(公告)号：US07182946B2
公开(公告)日：2007-02-27
申请号：US11076793
申请日：2005-03-09
申请人： Hans-Joerg Buehring , Wichard Vogel
发明人： Hans-Joerg Buehring , Wichard Vogel
IPC分类号： A61K39/395 , C07K16/28 , G01N33/53
CPC分类号： C07K16/28 , G01N33/56966 , G01N33/6896
摘要： The present invention relates to mono clonal antibodies or fragments thereof for isolating and/or identifying neural progenitor cells. The antibodies or fragments thereof bind to an identical antigen as an antibody which is produced by the hybridoma cell lines W4A5, W8C3 and 57D2 deposited on Aug. 14, 2002, at the Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ) under the numbers DSM ACC2571, DSM ACC2570 and DSM ACC2568.
摘要翻译：本发明涉及用于分离和/或鉴定神经祖细胞的单克隆抗体或其片段。抗体或其片段与作为抗体的抗体结合，该抗体由2002年8月14日在Deutsche Sammlung von Mikroorganismen und Zellkulturen（DSMZ）上以DSM ACC2571号保藏的杂交瘤细胞系W4A5，W8C3和57D2产生，DSM ACC2570和DSM ACC2568。

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