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1. 发明申请

US20060000712A1 Separation method and device for protein mixtures 失效
标题翻译：蛋白质混合物的分离方法和装置
公开(公告)号：US20060000712A1
公开(公告)日：2006-01-05
申请号：US11120098
申请日：2005-05-02
申请人： Hans-Joachim Hoeltke , Albert Roeder , Alois Rainer , Peter Berndt , Carlo Effenhauser , Hanno Langen , Remo Hochstrasser
发明人： Hans-Joachim Hoeltke , Albert Roeder , Alois Rainer , Peter Berndt , Carlo Effenhauser , Hanno Langen , Remo Hochstrasser
IPC分类号： B01D57/02 , C02F1/40
CPC分类号： G01N27/44773
摘要： A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation element 10 for the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in area 30 of a separation plane. According to the invention it is proposed that the separation element 10 has a channel or transfer structure 14 for the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surface 16 that is preferably suitable for mass spectroscopic analyses.
摘要翻译：用于生物分子样品材料，特别是蛋白质混合物的分离装置和分离方法。为此，在分离平面的区域30中提供用于样品材料的组分的二维和优选的电泳分离的分离元件10。根据本发明，提出了分离元件10具有通道或转移结构14，用于将分离的样品组分在与分离平面成直角的运输方向上局部分解排放到支撑表面16上，其优选地适合用于质谱分析。

2. 发明授权

US07645369B2 Separation method and device for protein mixtures 失效
标题翻译：蛋白质混合物的分离方法和装置
公开(公告)号：US07645369B2
公开(公告)日：2010-01-12
申请号：US11120098
申请日：2005-05-02
申请人： Hans-Joachim Hoeltke , Albert Roeder , Alois Rainer , Peter Berndt , Carlo Effenhauser , Hanno Langen , Remo Anton Hochstrasser
发明人： Hans-Joachim Hoeltke , Albert Roeder , Alois Rainer , Peter Berndt , Carlo Effenhauser , Hanno Langen , Remo Anton Hochstrasser
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44773
摘要： A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation element 10 for the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in area 30 of a separation plane. According to the invention it is proposed that the separation element 10 has a channel or transfer structure 14 for the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surface 16 that is preferably suitable for mass spectroscopic analyses.
摘要翻译：用于生物分子样品材料，特别是蛋白质混合物的分离装置和分离方法。为此，在分离平面的区域30中提供用于样品材料的组分的二维和优选的电泳分离的分离元件10。根据本发明，提出了分离元件10具有通道或转移结构14，用于将分离的样品组分在与分离平面成直角的运输方向上局部分解排放到支撑表面16上，其优选地适合用于质谱分析。

3. 发明申请

US20050008541A1 Method and device for locating and cutting out concentrations in a gel 审中-公开
标题翻译：用于定位和切除凝胶中浓度的方法和装置
公开(公告)号：US20050008541A1
公开(公告)日：2005-01-13
申请号：US10625042
申请日：2003-07-22
申请人： Remo Hochstrasser , Hanno Langen
发明人： Remo Hochstrasser , Hanno Langen
IPC分类号： G01N1/04 , G01N1/28 , G01N27/447 , G01N21/00
CPC分类号： G01N27/44739
摘要： The separate gel pieces from a gel cutting (27), it is necessary firstly to determine the position of the gel piece, e.g., by means of a scanner, and after an interval, which frequently lasts for some hours, to pick the gel pieces from the gel cutting (27). The gel cutting (27) must be stored in a gel holder (21) during this interval in an expansion-stable and positionally stable manner. For this purpose, the gel cutting (27) is held in the gel holder, floating in an equilibrating liquid (31). The equilibrating liquid causes the dimensions of the gel cutting to remain unchanged during the interval. With respect to the gel holder (21) the gel cutting (27) can be definitively positioned in that it is cut out so as to fit exactly in a chamber (24) of the gel holder (21), possibly being slightly larger than the chamber, and/or is held by a clamping device firmly in the edge region which is generally of no significance for the evaluation. Using this holding method the separation of gel pieces from the gel cutting (27) can be conveniently carried out by means of a tubular removal means which is pushed through the gel, since the gel cutting is not connected to the gel holder (21) over its surface but rather floats on a thin layer of equilibrating liquid (31).
摘要翻译：从凝胶切割（27）的单独的凝胶片，首先需要确定凝胶片的位置，例如通过扫描仪，并且经过持续几个小时的间隔之后，选择凝胶片从凝胶切割（27）。凝胶切割（27）必须在此间隔期间以膨胀稳定和位置稳定的方式储存在凝胶保持器（21）中。为此，凝胶切割（27）保持在凝胶保持器中，漂浮在平衡液体（31）中。平衡液体导致凝胶切割的尺寸在间隔期间保持不变。关于凝胶保持器（21），凝胶切割（27）可以被确定地定位，因为它被切出，以便精确地配合在凝胶保持器（21）的腔室（24）中，可能稍微大于并且/或通过夹持装置牢固地保持在边缘区域，该边缘区域对于评估通常没有意义。使用这种保持方法，凝胶切片（27）的分离可以通过被推入凝胶的管状去除装置方便地进行，因为凝胶切割未连接到凝胶保持器（21）上其表面，而是漂浮在薄层平衡液体（31）上。

4. 发明授权

US07566542B2 Use of protein ASC as a marker for breast cancer 失效
标题翻译：使用蛋白质ASC作为乳腺癌的标志物
公开(公告)号：US07566542B2
公开(公告)日：2009-07-28
申请号：US11404218
申请日：2006-04-14
申请人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
发明人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
IPC分类号： G01N33/53 , G01N33/574 , G01N33/48 , G01N33/536 , G01N33/537 , G01N33/577
CPC分类号： G01N33/57415
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring ASC in the sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of breast cancer.
摘要翻译：本发明涉及乳腺癌的诊断。它公开了蛋白质ASC在乳腺癌诊断中的应用。它涉及一种通过测量样品中的ASC从个体获得的来自液体样品的乳腺癌诊断方法。 ASC的测量可以例如用于乳腺癌的早期检测或诊断。

5. 发明申请

US20060141543A1 Cellular retinoic acid binding protein II as a marker for breast cancer 失效
公开(公告)号：US20060141543A1
公开(公告)日：2006-06-29
申请号：US11294176
申请日：2005-12-05
申请人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
发明人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N33/57473 , G01N2333/70567
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein cellular retinoic acid binding protein II in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring cellular retinoic acid binding protein II in said sample. Measurement of cellular retinoic acid binding protein II can, e.g., be used in the early detection or diagnosis of breast cancer.

6. 发明申请

US20070218510A1 Use of protein PSA3 as a marker for colorectal cancer 审中-公开
标题翻译：使用蛋白质PSA3作为结肠直肠癌的标志物
公开(公告)号：US20070218510A1
公开(公告)日：2007-09-20
申请号：US11348865
申请日：2006-02-07
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/95
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein proteasome subunit alpha 3 (PSA3) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring PSA3 in said sample. Measurement of PSA3 can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质蛋白酶体亚单位α3（PSA3）在结肠直肠癌诊断中的应用。本发明涉及通过测量所述样品中的PSA3从来自个体的液体样品诊断结肠直肠癌的方法。 PSA3的测定可以例如用于结肠直肠癌的早期检测或诊断。

7. 发明授权

US07205118B2 Nicotinamide N-methyltransferase as a marker for colorectal cancer 有权
标题翻译：烟酰胺N-甲基转移酶作为结肠直肠癌的标志物
公开(公告)号：US07205118B2
公开(公告)日：2007-04-17
申请号：US11152765
申请日：2005-06-14
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Theresa Kott , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Theresa Kott , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/53
CPC分类号： G01N33/57419 , C12Q1/48
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of the protein nicotinamide N-methyltransferase (NNMT) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring NNMT in said sample. Measurement of NNMT can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质烟酰胺N-甲基转移酶（NNMT）在结肠直肠癌诊断中的应用。本发明涉及通过在所述样品中测量NNMT从个体衍生的液体样品中诊断结肠直肠癌的方法。 NNMT的测定可以例如用于结肠直肠癌的早期检测或诊断。

8. 发明申请

US20060257950A1 Use of protein UBC13 as a marker for breast cancer 审中-公开
标题翻译：使用蛋白质UBC13作为乳腺癌的标志物
公开(公告)号：US20060257950A1
公开(公告)日：2006-11-16
申请号：US11404201
申请日：2006-04-14
申请人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
发明人： Gabriele Pestlin , Herbert Andres , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57415
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of ubiquitin-conjugating enzyme E2N (UBC13) in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring UBC13 in the sample. Measurement of UBC13 can, e.g., be used in the early detection or diagnosis of breast cancer.
摘要翻译：本发明涉及乳腺癌的诊断。它公开了泛素结合酶E2N（UBC13）在乳腺癌诊断中的应用。它涉及一种通过测量样品中UBC13从个体得到的来自液体样品的乳腺癌诊断方法。 UBC13的测量可以例如用于乳腺癌的早期检测或诊断。

9. 发明申请

US20060188950A1 Use of protein spee as a marker for colorectal cancer 审中-公开
标题翻译：使用蛋白质spee作为结肠直肠癌的标志物
公开(公告)号：US20060188950A1
公开(公告)日：2006-08-24
申请号：US11348932
申请日：2006-02-07
申请人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
发明人： Michael Tacke , Peter Berndt , Marie-Luise Hagmann , Johann Karl , Hanno Langen , Stefan Palme , Markus Roessler , Wolfgang Rollinger , Werner Zolg
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/91171
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein SPEE (sperrnidine synthase) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring SPEE in said sample. Measurement of SPEE can, e.g., be used in the early detection or diagnosis of colorectal cancer.
摘要翻译：本发明涉及结肠直肠癌的诊断。它公开了蛋白质SPEE（精氨酸合酶）在结肠直肠癌诊断中的应用。本发明涉及一种通过测量所述样品中的SPEE从来自个体的液体样品诊断结肠直肠癌的方法。 SPEE的测量可以例如用于结肠直肠癌的早期检测或诊断。

10. 发明申请

US20070196844A1 Protein PDX1 as a marker for breast cancer 审中-公开
标题翻译：蛋白PDX1作为乳腺癌的标志物
公开(公告)号：US20070196844A1
公开(公告)日：2007-08-23
申请号：US11640523
申请日：2006-12-14
申请人： Gabriele Pestlin , Herbert Andres , Marie-Luise Hagmann , Johann Karl , Michael Thierolf , Werner Zolg , Peter Berndt , Hanno Langen
发明人： Gabriele Pestlin , Herbert Andres , Marie-Luise Hagmann , Johann Karl , Michael Thierolf , Werner Zolg , Peter Berndt , Hanno Langen
IPC分类号： C12Q1/68 , G01N33/574 , C12M3/00
CPC分类号： C12Q1/6886
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein PDX1 (peroxiredoxin 1) in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring PDX1 in said sample. Measurement of PDX1 can, e.g., be used in the early detection or diagnosis of breast cancer.
摘要翻译：本发明涉及乳腺癌的诊断。它公开了蛋白质PDX1（过氧化物氧还蛋白1）在乳腺癌诊断中的应用。本发明涉及通过测定所述样品中的PDX1从个体得到的来自液体样品的乳腺癌诊断方法。 PDX1的测量可以例如用于乳腺癌的早期检测或诊断。

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