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    • 7. 发明授权
    • Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds
    • 吲哚-3-基-A-四氢吡啶基或哌啶基化合物
    • US5256673A
    • 1993-10-26
    • US377343
    • 1989-07-10
    • Henning BottcherHans-Heinrich HausbergChristoph SeyfriedKlaus-Otto Minck
    • Henning BottcherHans-Heinrich HausbergChristoph SeyfriedKlaus-Otto Minck
    • C07D401/06C07D401/12A61K31/44
    • C07D401/06C07D401/12
    • Indole derivatives of the general formula I ##STR1## wherein Ind is an indol-3-yl radical which is substituted by a hydroxymethyl or COW group and can additionally be monosubstituted or disubstituted by alkyl, O-alkyl, OH, F, Cl or Br,W is H, OH, Oalkyl, NH.sub.2, NHalkyl or N(alkyl).sub.2,A is --(CH.sub.2).sub.n --, CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2,n is 2, 3, 4 or 5,the two radicals Y are each H or together are a C--C bond, one radical Z is Ar,the other radical Z is H andAr is a phenyl group which is unsubstituted or monosubstituted or disubstituted by O-alkyl and/or OH or is substituted by a methylenedioxy group, or Ar is a 2-thienyl or 3-thienyl group,the alkyl groups each having 1-4 C atoms,wherein, however, when n is 2 or 3, the hydroxymethyl or COW group must be in the 4-, 5-, 6- or 7-position of the indol-3-yl radical,and physiologically acceptable acid addition salts thereof exhibit an action on the central nervous system.
    • 其中Ind是被羟甲基或COW基团取代的吲哚-3-基,并且可以另外被烷基,O-烷基,OH,F,Cl或Br单取代或二取代的通式I的吲哚衍生物 ,W是H,OH,O烷基,NH2,NH烷基或N(烷基)2,A是 - (CH2)n-,CH2-S-CH2CH2-,-CH2-SO-CH2CH2或-CH2-SO2-CH2CH2,n 2个,3个,4个或5个,两个基团Y各自为H或一起为CC键,一个基团Z为Ar,另一个基团Z为H,Ar为未被取代或被O取代或二取代的苯基 - 烷基和/或OH或被亚甲二氧基取代,或Ar是2-噻吩基或3-噻吩基,所述烷基各自具有1-4个C原子,但是,当n为2或3时, 羟甲基或COW基必须在吲哚-3-基自由基的4-,5-,6-或7-位,其生理上可接受的酸加成盐对中枢神经系统表现出作用。