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1. 发明授权

US06680032B1 Process and apparatus for preparing granulates 失效
标题翻译：颗粒制备方法及装置
公开(公告)号：US06680032B1
公开(公告)日：2004-01-20
申请号：US08002528
申请日：1993-01-11
申请人： Hans Uhlemann , Burkhard Braun , Heinz Hausmann , Gerhard Stopp , Horts Karkossa
发明人： Hans Uhlemann , Burkhard Braun , Heinz Hausmann , Gerhard Stopp , Horts Karkossa
IPC分类号： B01J808
CPC分类号： B01J8/006 , B01J2/16 , B01J8/003 , B01J2208/00539 , B01J2208/00761
摘要： A new process for continuously preparing granules having narrow grain size distribution, comprising a) spraying the product to be granulated in liquid form into a fluidized bed, b) separating the proportions of fine material escaping from the fluidized bed from the off-gas and returning said fine material to the fluidized bed as nuclei for granule formation, c) setting the fluidizing gas flow such that granules are formed which are of a predetermined size, and d) removing the completed granules solely by way of at least one countercurrent gravity classifier inserted into the outflow bottom of the fluidized-bed vessel. A new apparatus for carrying out the process according to the invention and new granules.
摘要翻译：一种用于连续制备颗粒尺寸分布窄的颗粒的新方法，包括：a）将待造粒的产品喷射到流化床中，b）将从流化床中排出的细料与废气分离出来，并返回所述作为颗粒形成的核的流化床的细材料，c）使流化气体流动使得形成具有预定尺寸的颗粒，并且d）仅通过插入到所述流化床中的至少一个逆流重力分级器去除完成的颗粒流化床容器的流出底部。用于实施根据本发明的方法和新的颗粒的新装置。

2. 发明授权

US4946654A Process for preparing granulates 失效
标题翻译：颗粒制备方法
公开(公告)号：US4946654A
公开(公告)日：1990-08-07
申请号：US224524
申请日：1988-07-26
申请人： Hans Uhlemann , Burkhard Braun , Heinz Heusmann , Gerhard Stopp , Horst Karkossa
发明人： Hans Uhlemann , Burkhard Braun , Heinz Heusmann , Gerhard Stopp , Horst Karkossa
IPC分类号： B01J2/02 , B01J2/16 , B01J8/00 , B01J8/18
CPC分类号： B01J8/006 , B01J2/16 , B01J8/003 , B01J2208/00539 , B01J2208/00761 , Y10S118/05
摘要： A new process for continuously preparing granules having narrow grain size distribution, comprisinga. spraying the product to be granulated in liquid form into a fluidized bed,b. separating the proportions of fine material escaping from the fluidized bed from the off-gas and returning said fine material to the fluidized bed as nuclei for granule formation,c. setting the fluidizing gas flow such that granules are formed which are of a predetermined size, andd. removing the completed granules solely by way of at least one countercurrent gravity classifier inserted into the outflow bottom of the fluidized-bed vessel.A new apparatus for carrying out the process according to the invention and new granules.
摘要翻译：一种用于连续制备粒度分布窄的颗粒的新方法，包括a。将待制粒的液体形式的产品喷洒到流化床中，b。将从流化床排出的细料与废气分离的比例分离，并将所述细料返回到作为颗粒形成的核的流化床，c。设置流化气体流，使得形成具有预定尺寸的颗粒，以及d。仅通过插入到流化床容器的流出底部的至少一个逆流重力分级器去除完成的颗粒。用于实施本发明方法的新设备和新的颗粒剂。

3. 发明授权

US06433137B1 TUP1 sequences from Candida albicans and methods for screening agents for inhibiting virulence in Candida albicans using TUP1 失效
标题翻译：来自白色念珠菌的TUP1序列和用于使用TUP1抑制白色念珠菌中毒性的筛选剂的方法
公开(公告)号：US06433137B1
公开(公告)日：2002-08-13
申请号：US09108857
申请日：1998-07-01
申请人： Alexander D. Johnson , Burkhard Braun
发明人： Alexander D. Johnson , Burkhard Braun
IPC分类号： C07K100
CPC分类号： C07K14/40 , A61K38/00 , C12Q1/6895 , C12Q2600/158
摘要： The present invention provides TUP1 polynucleotides, including TUP1 polynucleotides encoding Tup1, and Tup1 polypeptides, from Candida albicans. Disruption of TUP1 function in C. albicans is associated with filamentous formation as well as low infectivity. These TUP1 polynucleotide and Tup1 polypeptide sequences (and anti-Tup1 antibodies derived from Tup1 polypeptides) may be used in methods of detecting C. albicans sequences in a biological sample. Further, the invention provides methods for screening agents which may control C. albicans virulence and compositions comprising these agents. The invention also provides methods of obtaining gene(s) and/or gene product(s) which are involved in a TUP1 pathway, as well as methods of controlling C. albicans virulence by comprising TUP1 function.
摘要翻译：本发明提供了TUP1多核苷酸，包括编码Tup1的TUP1多核苷酸和来自白色念珠菌的Tup1多肽。白色念珠菌中TUP1功能的破坏与丝状形成以及低感染性有关。这些TUP1多核苷酸和Tup1多肽序列（和衍生自Tup1多肽的抗Tup1抗体）可用于检测生物样品中的白色念珠菌序列的方法中。此外，本发明提供了可以控制白念珠菌毒力的筛选剂的方法和包含这些试剂的组合物。本发明还提供了获得参与TUP1途径的基因和/或基因产物的方法，以及通过包含TUP1功能来控制白念珠菌毒力的方法。

4. 发明授权

US4774271A Processing of polymer dispersions by spray drying 失效
标题翻译：通过喷雾干燥处理聚合物分散体
公开(公告)号：US4774271A
公开(公告)日：1988-09-27
申请号：US13728
申请日：1987-02-09
申请人： Christian Lindner , Pol Bamelis , Jurgen Hinz , Dieter Wittmann , Otto Koch , Burkhard Braun
发明人： Christian Lindner , Pol Bamelis , Jurgen Hinz , Dieter Wittmann , Otto Koch , Burkhard Braun
IPC分类号： C08J3/00 , C08F6/14 , C08F8/00 , C08J3/12 , C08K5/092 , C08K5/5317 , C08K3/20
CPC分类号： C08K5/5317 , C08F6/14 , C08F8/00 , C08J3/122 , C08K5/092 , C08F2800/20
摘要： The invention relates to a process for the recovery of thermoplastic polymers from aqueous dispersions by spray-drying after treatment with carboxylic acid of formula I ##STR1## wherein X is a single bond, --CH.sub.2 -- or --C.sub.2 H.sub.4 --, andR is --H, --OH or ##STR2##
摘要翻译：本发明涉及一种通过喷雾干燥从水分散体中回收热塑性聚合物的方法，该方法是用式I的羧酸（I）（其中X是单键，-CH 2 - 或-C 2 H 4 - ）和R 是-H，-OH或

5. 发明授权

US06344554B1 Polynucleotide sequences from Candida albicans encoding polypeptides associated with filamentous growth 失效
标题翻译：编码与丝状生长有关的多肽的白色念珠菌的多核苷酸序列
公开(公告)号：US06344554B1
公开(公告)日：2002-02-05
申请号：US09165239
申请日：1998-10-01
申请人： Alexander D. Johnson , Burkhard Braun
发明人： Alexander D. Johnson , Burkhard Braun
IPC分类号： C07H2104
CPC分类号： C07K14/40 , A61K39/00
摘要： The present invention provides RBT1 polynucleotides, including RBT1 polynucleotides encoding Rbt1, and Rbt1 polypeptides, from Candida albicans. Expression of the RBT1 gene is upregulated by the inactivation of the TUP1 gene and by environmental conditions that induce filamentous growth. Disruption of TUP1 finction in C. albicans is associated with filament fonnation as well as low infectivity. These RBT1 polynucleotide and Rbtl polypeptide sequences (and anti-Rbt1 antibodies derived from Rbt1 polypeptides) may be used in methods of detecting C. albicans sequences in a biological sample. Further, the invention provides methods for screening agents which may control C. albicans virulence and compositions comprising these agents.
摘要翻译：本发明提供RBT1多核苷酸，其包括来自白色念珠菌的编码Rbt1的RBT1多核苷酸和Rbt1多肽。通过TUP1基因的失活和诱导丝状生长的环境条件，RBT1基因的表达被上调。白色念珠菌中TUP1功能的破坏与丝状细胞形成以及低感染性有关。这些RBT1多核苷酸和Rbt1多肽序列（和衍生自Rbt1多肽的抗Rbt1抗体）可用于检测生物样品中白念珠菌序列的方法。此外，本发明提供了可以控制白念珠菌毒力的筛选剂的方法和包含这些试剂的组合物。

6. 发明授权

US4420892A Thin film contact dryer 失效
标题翻译：薄膜接触式烘干机
公开(公告)号：US4420892A
公开(公告)日：1983-12-20
申请号：US343791
申请日：1982-01-29
申请人： Burkhard Braun , Bernhard Vosteen , Reiner Skerhut , Adolf Sinn
发明人： Burkhard Braun , Bernhard Vosteen , Reiner Skerhut , Adolf Sinn
IPC分类号： B01D1/22 , B01D1/24 , F26B3/22 , F26B11/16 , F26B17/18 , F26B17/20 , F26B17/28
CPC分类号： F26B3/22 , F26B11/16 , F26B17/20
摘要： The thin film contact dryer consists of a rotor having flat rotor elements extending in a radial direction. In the central third of the rotor is arranged at least one combination of distributing elements and an annular weir which revolves with the rotor and leaves a narrow annular gap open to the internal dryer wall, the annular weir being arranged immediately downstream of the distributing elements as viewed in the direction of flow.
摘要翻译：薄膜接触式干燥机由具有沿径向延伸的扁平转子元件的转子组成。在转子的中心三分之一处布置有分配元件和环形堰的至少一个组合，其与转子一起旋转并且留下通向内部干燥器壁的窄的环形间隙，环形堰直接布置在分配元件的下游，从流动方向看。

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