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1. 发明授权

US06352507B1 Method and apparatus for providing real-time calculation and display of tissue deformation in ultrasound imaging 有权
标题翻译：用于提供实时计算和显示超声成像组织变形的方法和装置
公开(公告)号：US06352507B1
公开(公告)日：2002-03-05
申请号：US09432061
申请日：1999-11-02
申请人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
发明人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
IPC分类号： A61B800
CPC分类号： A61B8/485 , A61B5/0456 , A61B5/7239 , A61B8/488 , A61B8/543 , G01S7/52036 , G01S7/52038 , G01S7/52042 , G01S7/52057 , G01S7/52085 , G01S7/52095 , G01S15/584 , G01S15/8979
摘要： An ultrasound system and method for calculation and display of tissue deformation parameters are disclosed. An ultrasound acquisition technique that allows a high frame rate in tissue velocity imaging or stain rate imaging is employed. The tissue deformation parameter strain is determined by an accumulation of stain rate estimates for consecutive frames over an interval. The interval may be a triggered interval generated by, for example, an R-wave in an ECG trace. The strain calculation may be improved by moving the sample volume from which the stain rate is accumulated from frame-to-frame according to the relative displacement of the tissue within the original sample volume. The relative displacement of the tissue is defined by the instantaneous tissue velocity of the sample volume. An estimation of strain rate based upon a spatial derivative of tissue velocity is improved by adaptively varying the spatial offset, dr. The spatial offset, dr, can be maximized to cover the entire tissue segment (e.g., heart wall width) while still keeping both of the sample volumes at each end of the offset within the tissue segment. This nay be accomplished by determining whether various parameters (e.g., grayscale value, absolute power estimate, magnitude of the autocorrelation function with unity temporal lag and/or magnitude of strain correlation) of the sample volumes within in the spatial offset are above a given threshold.
摘要翻译：公开了用于计算和显示组织变形参数的超声系统和方法。采用允许组织速度成像或染色率成像中的高帧速率的超声波采集技术。组织变形参数应变是通过间隔上连续帧的染色率估计的积累来确定的。该间隔可以是由例如ECG迹线中的R波产生的触发间隔。通过根据原始样品体积内的组织的相对位移，通过从逐帧移动污染率从其累积的样品体积来改善应变计算。组织的相对位移由样品体积的瞬时组织速度定义。通过自适应地改变空间偏移，提高了基于组织速度的空间导数的应变速率的估计。空间偏移量dr可以最大化以覆盖整个组织段（例如，心脏壁宽度），同时仍保持组织区段内的偏移的每个端部处的两个样本体积。这可以通过确定在空间偏移内的样本体积的各种参数（例如，灰度值，绝对功率估计，具有单位时间滞后的自相关函数的幅度和/或应变相关的幅度）是否高于给定阈值来实现。

2. 发明授权

US07077807B2 Method and apparatus for providing real-time calculation and display of tissue deformation in ultrasound imaging 有权
标题翻译：用于提供实时计算和显示超声成像组织变形的方法和装置
公开(公告)号：US07077807B2
公开(公告)日：2006-07-18
申请号：US10705190
申请日：2003-11-10
申请人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
发明人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B5/0456 , A61B5/7239 , A61B8/488 , A61B8/543 , G01S7/52036 , G01S7/52038 , G01S7/52042 , G01S7/52057 , G01S7/52085 , G01S7/52095 , G01S15/584 , G01S15/8979
摘要： An ultrasound system and method for calculation and display of tissue deformation parameters are disclosed. A method to estimate a strain rate in any direction, not necessarily along the ultrasound beam, based on tissue velocity data from a small region of interest around a sample volume is disclosed. Quantitative tissue deformation parameters, such as tissue velocity, tissue velocity integrals, strain rate and/or strain, may be presented as functions of time and/or spatial position for applications such as stress echo. For example, strain rate or strain values for three different stress levels may be plotted together with respect to time over a cardiac cycle.
摘要翻译：公开了用于计算和显示组织变形参数的超声系统和方法。公开了一种基于来自围绕样本体积的小的感兴趣区域的组织速度数据来估计任何方向（不一定沿着超声波束）的应变速率的方法。可以将诸如组织速度，组织速度积分，应变速率和/或应变的定量组织变形参数呈现为诸如应力回波的应用的时间和/或空间位置的函数。例如，三个不同应力水平的应变速率或应变值可以相对于心脏周期上的时间被绘制在一起。

3. 发明申请

US20050203390A1 Method and apparatus for providing real-time calculation and display of tissue deformation in ultrasound imaging 有权
公开(公告)号：US20050203390A1
公开(公告)日：2005-09-15
申请号：US10705087
申请日：2003-11-10
申请人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
发明人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
IPC分类号： A61B8/13 , A61B5/0456 , A61B8/08 , G01S7/52 , G01S15/58 , G01S15/89 , A61B8/00
CPC分类号： A61B8/485 , A61B5/0456 , A61B5/7239 , A61B8/488 , A61B8/543 , G01S7/52036 , G01S7/52038 , G01S7/52042 , G01S7/52057 , G01S7/52085 , G01S7/52095 , G01S15/584 , G01S15/8979
摘要： An ultrasound system and method for calculation and display of tissue deformation parameters are disclosed. An ultrasound acquisition technique that allows a high frame rate in tissue velocity imaging or strain rate imaging is employed. With this acquisition technique the same ultrasound pulses are used for the tissue image and the Doppler based image. A sliding window technique is used for processing. The tissue deformation parameter strain is also determined by an accumulation of strain rate estimates for consecutive frames over an interval. The interval may be a triggered interval generated by, for example, an R-wave in an ECG trace. The strain calculation may be improved by moving the sample volume from which the strain rate is accumulated from frame-to-frame according to the relative displacement of the tissue within the original sample volume. The relative displacement of the tissue is determined by the instantaneous tissue velocity of the sample volume. An estimation of strain rate based upon a spatial derivative of tissue velocity is improved by adaptively varying the spatial offset, dr. The spatial offset, dr, can be maximized to cover the entire tissue segment (e.g., heart wall width) while still keeping both of the sample volumes at each end of the offset within the tissue segment. This may be accomplished by determining whether various parameters (e.g., grayscale value, absolute power estimate, magnitude of the autocorrelation function with unity temporal lag and/or magnitude of strain correlation) of the sample volumes within in the spatial offset are above a given threshold. Strain rate may be estimated using a generalized strain rate estimator that is based on a weighted sum of two-sample strain rate estimators with different spatial offsets. The weights are proportional to the magnitude of the strain rate correlation estimate for each spatial offset, and thus reduce the effect of noisy, i.e. poorly correlated, samples. An improved signal correlation estimator that uses a spatial lag in addition to the usual temporal lag is disclosed. The spatial lag is found from the tissue velocity. The improved signal correlation estimator can be utilized both in the estimation of strain rate and tissue velocity. Tissue velocity may be estimated in a manner that reduces aliasing while maintaining spatial resolution. Three copies of a received ultrasound signal are bandpass filtered at three center frequencies. The middle of the three center frequencies is centered at the second harmonic of the ultrasound signal. A reference tissue velocity is estimated from the two signals filtered at the outside center frequencies. The reference tissue velocity is used to choose a tissue velocity from a number of tissue velocities estimated from the signal centered at the second harmonic. A method to estimate the strain rate in any direction, not necessarily along the ultrasound beam, based on tissue velocity data from a small region of interest around a sample volume is disclosed. Quantitative tissue deformation parameters, such as tissue velocity, tissue velocity integrals, strain rate and/or strain, may be presented as functions of time and/or spatial position for applications such as stress echo. For example, strain rate or strain values for three different stress levels may be plotted together with respect to time over a cardiac cycle. Parameters which are derived from strain rate or strain velocity, such as peak systolic wall thickening percentage, may be plotted with respect to various stress levels,

4. 发明授权

US07261694B2 Method and apparatus for providing real-time calculation and display of tissue deformation in ultrasound imaging 有权
标题翻译：用于提供实时计算和显示超声成像组织变形的方法和装置
公开(公告)号：US07261694B2
公开(公告)日：2007-08-28
申请号：US10705419
申请日：2003-11-10
申请人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
发明人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B5/0456 , A61B5/7239 , A61B8/488 , A61B8/543 , G01S7/52036 , G01S7/52038 , G01S7/52042 , G01S7/52057 , G01S7/52085 , G01S7/52095 , G01S15/584 , G01S15/8979
摘要： An ultrasound system and method for calculation and display of tissue deformation parameters are disclosed. The tissue deformation parameter strain is determined by an accumulation of strain rate estimates for consecutive frames over an interval. The interval may be a triggered interval generated by, for example, an R-wave in an ECG trace. Three quantitative tissue deformation parameters, such as tissue velocity, tissue velocity integrals, strain rate and/or strain, may be presented as functions of time and/or spatial position for applications such as stress echo. For example, strain rate or strain values for three different stress levels may be plotted together with respect to time over a cardiac cycle. Parameters which are derived from strain rate or strain velocity, such as peak systolic wall thickening percentage, may be plotted with respect to various stress levels.
摘要翻译：公开了用于计算和显示组织变形参数的超声系统和方法。组织变形参数应变由连续帧在一个间隔上的应变速率估计的积累来确定。该间隔可以是由例如ECG迹线中的R波产生的触发间隔。可以将诸如组织速度，组织速度积分，应变速率和/或应变的三个定量组织变形参数呈现为诸如应力回波的应用的时间和/或空间位置的函数。例如，三个不同应力水平的应变速率或应变值可以相对于心脏周期上的时间被绘制在一起。可以根据各种应力水平绘制从应变速率或应变速度得到的参数，如收缩期峰值增厚百分比。

5. 发明授权

US06676599B2 Method and apparatus for providing real-time calculation and display of tissue deformation in ultrasound imaging 有权
标题翻译：用于提供实时计算和显示超声成像组织变形的方法和装置
公开(公告)号：US06676599B2
公开(公告)日：2004-01-13
申请号：US10054033
申请日：2002-01-22
申请人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
发明人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
IPC分类号： A61B800
CPC分类号： A61B8/485 , A61B5/0456 , A61B5/7239 , A61B8/488 , A61B8/543 , G01S7/52036 , G01S7/52038 , G01S7/52042 , G01S7/52057 , G01S7/52085 , G01S7/52095 , G01S15/584 , G01S15/8979
摘要： An ultrasound system and method for calculation and display of tissue deformation parameters are disclosed. Tissue velocity may be estimated by filtering a received ultrasound signal at three center frequencies related to the second harmonic of the ultrasound signal, estimating a reference tissue velocity from the two signals filtered at the outside center frequencies and using the reference tissue velocity to choose a tissue velocity from tissue velocities estimated using the middle center frequency. Estimation of strain rate in any direction, not necessarily along the ultrasound beam, is disclosed. Quantitative tissue deformation parameters may be presented as functions of time and/or spatial position for applications such as stress echo. For example, strain rate or strain values for three different stress levels may be plotted together with respect to time over a cardiac cycle. Parameters derived from strain rate or strain velocity may be plotted with respect to various stress levels.
摘要翻译：公开了用于计算和显示组织变形参数的超声系统和方法。可以通过在与超声信号的二次谐波相关的三个中心频率处过滤接收到的超声信号来估计组织速度，从在外部中心频率处过滤的两个信号估计参考组织速度，并使用参考组织速度来选择组织使用中心频率估计的组织速度的速度。公开了不一定沿着超声波束的任何方向的应变率的估计。定量组织变形参数可以表示为诸如应力回波的应用的时间和/或空间位置的函数。例如，三个不同应力水平的应变速率或应变值可以相对于心脏周期上的时间被绘制在一起。从应变速率或应变速度导出的参数可以相对于各种应力水平绘制。

6. 发明授权

US07798965B2 Method and apparatus for providing real-time calculation and display of tissue deformation in ultrasound imaging 有权
标题翻译：用于提供实时计算和显示超声成像组织变形的方法和装置
公开(公告)号：US07798965B2
公开(公告)日：2010-09-21
申请号：US10705087
申请日：2003-11-10
申请人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
发明人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B5/0456 , A61B5/7239 , A61B8/488 , A61B8/543 , G01S7/52036 , G01S7/52038 , G01S7/52042 , G01S7/52057 , G01S7/52085 , G01S7/52095 , G01S15/584 , G01S15/8979
摘要： An ultrasound system and method for calculation and display of tissue deformation parameters are disclosed. The tissue deformation parameter strain is also determined by an accumulation of strain rate estimates for consecutive frames over an interval. The interval may be a triggered interval generated by, for example, an R-wave in an ECG trace. The strain calculation may be improved by moving the sample volume from which the strain rate is accumulated from frame-to-frame according to the relative displacement of the tissue within the original sample volume. The relative displacement of the tissue is determined by the instantaneous tissue velocity of the sample volume.
摘要翻译：公开了用于计算和显示组织变形参数的超声系统和方法。组织变形参数应变也通过对间隔的连续帧的应变速率估计的积累来确定。该间隔可以是由例如ECG迹线中的R波产生的触发间隔。应变计算可以通过根据原始样品体积内的组织的相对位移来移动从框架到框架的应变速率累积的样品体积来改进。组织的相对位移由样品体积的瞬时组织速度决定。

7. 发明授权

US06517485B2 Method and apparatus for providing real-time calculation and display of tissue deformation in ultrasound imaging 有权
标题翻译：用于提供实时计算和显示超声成像组织变形的方法和装置
公开(公告)号：US06517485B2
公开(公告)日：2003-02-11
申请号：US10054526
申请日：2002-01-22
申请人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
发明人： Hans Torp , Bjorn Olstad , Andreas Heimdal , Steinar Bjaerum
IPC分类号： A61B800
CPC分类号： A61B8/485 , A61B5/0456 , A61B5/7239 , A61B8/488 , A61B8/543 , G01S7/52036 , G01S7/52038 , G01S7/52042 , G01S7/52057 , G01S7/52085 , G01S7/52095 , G01S15/584 , G01S15/8979
摘要： An ultrasound system and method for calculation and display of tissue deformation parameters, such as tissue Doppler and strain rate imaging, are disclosed. An ultrasound acquisition technique that allows a high frame rate in tissue velocity imaging or strain rate imaging is employed. With this acquisition technique the same ultrasound pulses are used for the tissue image and the Doppler based image. The number of beams used in Doppler subframes are increased to allow tissue visualization based only on Doppler subframes. A sliding window technique is used for processing.
摘要翻译：公开了一种用于计算和显示组织变形参数的超声系统和方法，例如组织多普勒和应变速率成像。采用允许组织速度成像或应变速率成像中的高帧速率的超声波采集技术。使用这种采集技术，相同的超声脉冲用于组织图像和基于多普勒的图像。在多普勒子帧中使用的波束的数量增加以允许仅基于多普勒子帧的组织可视化。使用滑动窗口技术进行处理。

8. 发明授权

US6099471A Method and apparatus for real-time calculation and display of strain in ultrasound imaging 有权
标题翻译：超声成像实时计算和应变显示的方法和装置
公开(公告)号：US6099471A
公开(公告)日：2000-08-08
申请号：US167896
申请日：1998-10-07
申请人： Hans Torp , Andreas Heimdal , Bjorn Olstad , Kjell Kristofferson
发明人： Hans Torp , Andreas Heimdal , Bjorn Olstad , Kjell Kristofferson
IPC分类号： A61B8/08 , B23P19/04 , B23Q17/20 , F01N3/021 , F01N3/28 , F01N13/18 , G01S15/89 , A61B8/00
CPC分类号： G01S15/8979 , A61B8/08 , B23P19/04 , B23Q17/20 , G01S7/52042
摘要： An ultrasound system and method for calculation and display of strain velocity in real time is disclosed. Strain velocity may be determined from tissue velocity. Tissue velocity determined by measuring the pulse-to-pulse Doppler shift at range positions along an ultrasound beam and calculating tissue velocity based on the Doppler shift. The strain velocity is then calculated as a gradient of tissue velocity. Alternatively, linear regression methods may be used to calculate strain velocity from tissue velocity. Alternatively, strain velocity may be determined directly from the difference in Doppler shift between range positions. The result of the strain velocity determination may be displayed in a number of manners such as M-mode, color-coded video images or time-variation curves, and may be displayed in combination, or as a mixture, with a B-mode image. A reliability index may be calculated and used to modify the display of strain velocity information.
摘要翻译：公开了一种用于实时计算和显示应变速度的超声系统和方法。应变速度可以从组织速度确定。通过测量沿着超声波束的范围位置处的脉冲 - 脉冲多普勒频移并基于多普勒频移计算组织速度来确定组织速度。然后应变速度被计算为组织速度的梯度。或者，可以使用线性回归方法来从组织速度计算应变速度。或者，可以直接从范围位置之间的多普勒频移的差异确定应变速度。应变速度确定的结果可以以多种方式显示，例如M模式，彩色编码视频图像或时间变化曲线，并且可以与B模式图像组合或混合显示。可以计算可靠性指标并用于修改应变速度信息的显示。

9. 发明授权

US06579240B2 Ultrasound display of selected movement parameter values 有权
公开(公告)号：US06579240B2
公开(公告)日：2003-06-17
申请号：US10064083
申请日：2002-06-10
申请人： Steinar Bjaerum , Bjorn Olstad , Kjell Kristoffersen
发明人： Steinar Bjaerum , Bjorn Olstad , Kjell Kristoffersen
IPC分类号： A61B812
CPC分类号： A61B8/485 , A61B5/0456 , A61B8/08 , A61B8/0883 , A61B8/463 , A61B8/488 , G01S7/52042 , G01S7/52066 , G01S7/52071 , G01S7/52087 , G01S7/52088 , G01S15/8979 , G01S15/8981
摘要： An ultrasound machine is disclosed that generates a color representation of moving structure, such as a cardiac wall tissue within a region of interest, and is displayed on a monitor. The color representation is generated by displaying at least one color characteristic related to a movement parameter of the structure, such as mean velocity or mean strain rate. The related feature of the movement parameter is mapped to the color characteristic by an apparatus comprising a front-end that generates received signals in response to backscattered ultrasound waves. A Doppler processor generates a set of parameter signals representing a spatial set of values of the movement parameter within the structure. A host processor embodies a tracking function and a peak-detection function to generate a set of tracked movement parameter profiles and a set of peak values of the movement parameter over a time period corresponding to anatomical locations within the region of interest. The set of peak values of the movement parameter are then mapped to a set of color characteristic signals. A display processor applies the mapped values of the color characteristic signals to the set of peak values of the movement parameter, representing the moving structure, to display a color representation, on a monitor.

10. 发明授权

US06863655B2 Ultrasound display of tissue, tracking and tagging 有权
标题翻译：超声显示组织，跟踪和标记
公开(公告)号：US06863655B2
公开(公告)日：2005-03-08
申请号：US10064085
申请日：2002-06-10
申请人： Steinar Bjaerum , Bjorn Olstad , Kjell Kristoffersen
发明人： Steinar Bjaerum , Bjorn Olstad , Kjell Kristoffersen
IPC分类号： A61B5/0456 , A61B8/08 , G01S7/52 , G01S15/89 , G06T7/20 , A61B8/06
CPC分类号： G06T7/20 , A61B5/0456 , A61B8/0883 , A61B8/463 , A61B8/485 , A61B8/488 , G01S7/52042 , G01S7/52066 , G01S7/52071 , G01S7/52087 , G01S7/52088 , G01S15/8979 , G06T2207/30048
摘要： An ultrasound machine that generates a pattern of indicia corresponding to tracked moving structure, such as a cardiac wall tissue that is displayed on a monitor. The pattern of indicia is generated by displaying a set of tagging symbols related to the tracked movement of the structure over a time period by an apparatus comprising a front-end that generates received signals in response to backscattered ultrasound waves. A Doppler processor generates a spatial set of signals values representing movement within the structure. A non-Doppler processor generates a set of parameter signals representing a spatial set of B-mode values within the structure. A host processor embodies a tracking function to generate a set of tracked movement parameter profiles and motion parameter profiles over a time period corresponding to anatomical locations associated with the set of tagging symbols. A display processor overlays the set of tagging symbols onto an image of the moving structure on a monitor, such as B-mode, showing a pattern of indicia that allows visualization of the expansion and contraction of the moving structure in real-time over the time period.
摘要翻译：一种产生对应于跟踪的运动结构的标记图案的超声机器，例如显示在监视器上的心脏壁组织。通过包括响应于反向散射超声波产生接收信号的前端的装置，通过显示与一段时间内的结构的跟踪运动相关的一组标签符号来生成标记的图案。多普勒处理器产生表示结构内移动的空间信号值集合。非多普勒处理器生成表示该结构内的B模式值的空间集合的一组参数信号。主机处理器体现跟踪功能，以在对应于与该组标签符号相关联的解剖位置的时间周期内生成一组跟踪运动参数轮廓和运动参数轮廓。显示处理器将标记符号集合覆盖在诸如B模式的监视器上的移动结构的图像上，示出了标记的图案，其允许在时间上实时地可视化移动结构的扩展和收缩期。

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