专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08124118B2 Composition comprising biodegradable hydrating ceramics for controlled drug delivery 有权
标题翻译：包含用于受控药物递送的可生物降解的水合陶瓷的组合物
公开(公告)号：US08124118B2
公开(公告)日：2012-02-28
申请号：US10576857
申请日：2004-10-21
申请人： Hans Lennernäs , Bo Lennernäs , Jonas Hugosson , Niklas Axén
发明人： Hans Lennernäs , Bo Lennernäs , Jonas Hugosson , Niklas Axén
IPC分类号： A61K31/56 , A61K31/7088 , A61P35/00
CPC分类号： A61K45/06 , A61K9/1611 , A61K9/1617 , A61K9/1652 , A61K31/00 , A61K31/167 , A61K2300/00
摘要： The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.
摘要翻译：本发明涉及药物载体组合物，其包含i）一种或多种可生物降解的水合陶瓷ii）一种或多种可发性剂，和iii）固体形式的具有破裂结构的吸水性水性介质。可膨胀剂的功能是在凝固组合物中产生断裂结构，泡沫状结构或分解结构，其中其被分成大量的部分，颗粒，单位，颗粒或块，以获得在施用时暴露于降解或侵蚀的扩大的表观表面积。获得这种表面扩大效果的合适物质是气体形成剂或溶胀剂，胶凝剂或崩解剂，这里称为可膨胀剂。可膨胀剂可以是生物可再吸收的或非生物可再吸收的。

2. 发明授权

US09034359B2 Composition comprising biodegradable hydrating ceramics for controlled drug delivery 有权
标题翻译：包含用于受控药物递送的可生物降解的水合陶瓷的组合物
公开(公告)号：US09034359B2
公开(公告)日：2015-05-19
申请号：US13405887
申请日：2012-02-27
申请人： Hans Lennernäs , Bo Lennernäs , Jonas Hugosson , Niklas Axén
发明人： Hans Lennernäs , Bo Lennernäs , Jonas Hugosson , Niklas Axén
IPC分类号： A61K31/167 , A61K38/09 , A61P35/00 , A61K9/00 , A61P13/08 , A61K45/06 , A61K9/16 , A61K31/00
CPC分类号： A61K45/06 , A61K9/1611 , A61K9/1617 , A61K9/1652 , A61K31/00 , A61K31/167 , A61K2300/00
摘要： The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.
摘要翻译：本发明涉及药物载体组合物，其包含i）一种或多种可生物降解的水合陶瓷ii）一种或多种可发性剂，和iii）固体形式的具有破裂结构的吸水性水性介质。可膨胀剂的功能是在凝固组合物中产生断裂结构，泡沫状结构或分解结构，其中其被分成大量的部分，颗粒，单位，颗粒或块，以获得在施用时暴露于降解或侵蚀的扩大的表观表面积。获得这种表面扩大效果的合适物质是气体形成剂或溶胀剂，胶凝剂或崩解剂，这里称为可膨胀剂。可膨胀剂可以是生物可再吸收的或非生物可再吸收的。

3. 发明授权

US08999389B2 Bioresorbable controlled-release composition 有权
标题翻译：生物可吸收的控释组合物
公开(公告)号：US08999389B2
公开(公告)日：2015-04-07
申请号：US12224942
申请日：2007-03-14
申请人： Hans Lennernäs , Niklas Axén
发明人： Hans Lennernäs , Niklas Axén
IPC分类号： A61K9/00 , A61K9/16
CPC分类号： A61K9/0024 , A61K9/0034 , A61K9/1611 , A61K9/1694
摘要： A novel method for the preparation of a highly densified and at least partly, preferably fully or almost fully hydrated ceramic for use in the preparation of a pharmaceutical composition notably for controlled-release of one or more therapeutically, prophylactically and/or diagnostically active substance. The method involves a concomitant step of hydrating and densifying a bioresorbable and hydratable ceramic such as calcium sulphate. The invention also relates to compositions comprising such a highly densified ceramic. The pharmaceutical composition is useful for targeted and controlled local prolonged release of active substances, e.g. anti-cancer agents, whereby the spectrum and severity of side effects are minimized due to an optimized local concentration-time profile.
摘要翻译：一种用于制备高致密化和至少部分，优选完全或几乎完全水合的陶瓷的新方法，用于制备药物组合物，特别是用于控制释放一种或多种治疗，预防和/或诊断活性物质。该方法包括水合和致密化生物可再吸收和可水合的陶瓷如硫酸钙的伴随步骤。本发明还涉及包含这种高密度陶瓷的组合物。药物组合物可用于靶向和受控局部延长的活性物质的释放，例如，由于优化的局部浓度 - 时间曲线，抗癌剂的副作用的频谱和严重程度被最小化。

4. 发明授权

US08936809B2 Method for treating prostate diseases based on local delivery of active substances 有权
标题翻译：基于活性物质的局部递送治疗前列腺疾病的方法
公开(公告)号：US08936809B2
公开(公告)日：2015-01-20
申请号：US11910162
申请日：2006-03-31
申请人： Hans Lennernäs , Bo Lennernäs , Jonas Hugosson , Niklas Axén
发明人： Hans Lennernäs , Bo Lennernäs , Jonas Hugosson , Niklas Axén
IPC分类号： A61K9/22 , A61K49/04 , A61K49/00 , A61K47/00 , A61K31/56 , A61K48/00 , A61K38/00 , A61K9/16
CPC分类号： A61K9/1647
摘要： A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs, and ii) administering locally into the prostate a controlled release pharmaceutical composition comprising one or more active substances in a biodegradable ceramic carrier. The biodegradable hydrating ceramic may be selected from the group consisting of non-hydrated or hydrated calcium sulphate, calcium phosphate, calcium carbonate, calcium fluoride, calcium silicate, magnesium sulphate, magnesium phosphate, magnesium carbonate, magnesium fluoride, magnesium silicate, barium sulphate, barium phosphate, barium carbonate, barium fluoride, barium silicate, or mixtures thereof. In a specific embodiment, the biodegradable hydrating ceramic is non-hydrated or hydrated calcium sulphate.
摘要翻译：一种用于治疗受试者中前列腺相关疾病的方法，所述方法包括i）任选地施用受试者初始增强剂量的一种或多种活性物质和/或前药，以及ii）局部施用于前列腺中的控释药物组合物，其包含一种或更多的活性物质在可生物降解的陶瓷载体中。可生物降解的水合陶瓷可以选自非水合或水合硫酸钙，磷酸钙，碳酸钙，氟化钙，硅酸钙，硫酸镁，磷酸镁，碳酸镁，氟化镁，硅酸镁，硫酸钡，磷酸钡，碳酸钡，氟化钡，硅酸钡或其混合物。在一个具体实施方案中，可生物降解的水合陶瓷是非水合或水合硫酸钙。

5. 发明授权

US08556495B2 Injector device 有权
标题翻译：注射器装置
公开(公告)号：US08556495B2
公开(公告)日：2013-10-15
申请号：US13119258
申请日：2009-09-22
申请人： Niklas Axén , Hans Lennernäs , Johan Yngve , Lars Åke Malmsten , Gunilla Eketorp , Åke G. Pilbrant
发明人： Niklas Axén , Hans Lennernäs , Johan Yngve , Lars Åke Malmsten , Gunilla Eketorp , Åke G. Pilbrant
IPC分类号： B01F15/02
CPC分类号： A61M5/31596 , A61B17/8825 , A61B2017/8838 , A61M5/31511 , A61M5/31515 , A61M2005/31508 , B01F11/0082 , B01F13/002 , B01F13/0023 , B01F15/0279
摘要： An injector device is disclosed, the injector device comprising an elongated mixing container extending along a first axis, and a piston member slidably positioned in the mixing container. The injector device comprises a mixing device comprising a mixing member, an elongated member parallel to the first axis and a handle member. The piston member comprises a piston head and a first locking arm flexibly connected to the piston head, such that the first locking arm in a first position extends substantially parallel to the elongated member and engages with the mixing device in such a way that the piston member moves in a first direction along the first axis with the mixing device. In a second position, the first locking arm may allow the mixing device to move relative to the mixing container independently of the piston member.
摘要翻译：公开了一种注射器装置，所述注射器装置包括沿着第一轴线延伸的细长混合容器和可滑动地定位在所述混合容器中的活塞构件。注射器装置包括混合装置，其包括混合构件，平行于第一轴线的细长构件和手柄构件。活塞构件包括活塞头和柔性地连接到活塞头的第一锁定臂，使得第一位置处的第一锁定臂基本上平行于细长构件延伸并且与混合装置接合，使得活塞构件通过混合装置沿第一轴沿第一方向移动。在第二位置，第一锁定臂可允许混合装置独立于活塞构件相对于混合容器移动。

6. 发明申请

US20110222366A1 INJECTOR DEVICE 有权
标题翻译：注射器装置
公开(公告)号：US20110222366A1
公开(公告)日：2011-09-15
申请号：US13119258
申请日：2009-09-22
申请人： Niklas Axén , Hans Lennernäs , Johan Yngve , Lars Ake Malmsten , Gunilla Eketorp , Ake G. Pilbrant
发明人： Niklas Axén , Hans Lennernäs , Johan Yngve , Lars Ake Malmsten , Gunilla Eketorp , Ake G. Pilbrant
IPC分类号： B01F5/06
CPC分类号： A61M5/31596 , A61B17/8825 , A61B2017/8838 , A61M5/31511 , A61M5/31515 , A61M2005/31508 , B01F11/0082 , B01F13/002 , B01F13/0023 , B01F15/0279
摘要： An injector device is disclosed, the injector device comprising an elongated mixing container extending along a first axis, and a piston member slidably positioned in the mixing container. The injector device comprises a mixing device comprising a mixing member, an elongated member parallel to the first axis and a handle member. The piston member comprises a piston head and a first locking arm flexibly connected to the piston head, such that the first locking arm in a first position extends substantially parallel to the elongated member and engages with the mixing device in such a way that the piston member moves in a first direction along the first axis with the mixing device. In a second position, the first locking arm may allow the mixing device to move relative to the mixing container independently of the piston member.
摘要翻译：公开了一种注射器装置，所述注射器装置包括沿着第一轴线延伸的细长混合容器和可滑动地定位在所述混合容器中的活塞构件。注射器装置包括混合装置，其包括混合构件，平行于第一轴线的细长构件和手柄构件。活塞构件包括活塞头和柔性地连接到活塞头的第一锁定臂，使得第一位置处的第一锁定臂基本上平行于细长构件延伸并且与混合装置接合，使得活塞构件通过混合装置沿第一轴沿第一方向移动。在第二位置，第一锁定臂可允许混合装置独立于活塞构件相对于混合容器移动。

7. 发明授权

US09198884B2 Use of carboxymethylcellulose to control ejectability and solidification time of compositions comprising one or more bioresorbable ceramics 有权
标题翻译：使用羧甲基纤维素来控制包含一种或多种生物可再吸收陶瓷的组合物的可喷射性和固化时间
公开(公告)号：US09198884B2
公开(公告)日：2015-12-01
申请号：US13127331
申请日：2009-11-27
申请人： Lars Åke Malmsten , Niklas Axén , Hans Lennernäs , Anders Carlsson
发明人： Lars Åke Malmsten , Niklas Axén , Hans Lennernäs , Anders Carlsson
IPC分类号： A61K9/14 , A61K31/167 , A61K31/57 , A61K31/277 , A61K9/00 , A61K47/02 , A61K47/38 , A61L27/44 , A61L27/58
CPC分类号： A61K31/167 , A61K9/0019 , A61K31/57 , A61K47/02 , A61K47/38 , A61L27/446 , A61L27/58 , A61L2400/06 , C08L1/28
摘要： Carboxymethylcellulose, notably sodium carboxymethylcellulose or other alkali metal or alkaline earth metal salts of carboxymethylcellulose, are employed to control solidification time of compositions comprising one or more bioresorbable ceramics, notably a hydratable calcium sulphate, in order to facilitate preparation of a ready-to-use composition for inserting into the body by injection.
摘要翻译：使用羧甲基纤维素，特别是羧甲基纤维素钠或羧甲基纤维素的其它碱金属或碱土金属盐来控制包含一种或多种生物可再吸收陶瓷，特别是可水合硫酸钙的组合物的固化时间，以便于制备即用型用于通过注射插入体内的组合物。

8. 发明申请

US20120219601A1 Composition Comprising Biodegradable Hydrating Ceramics for Controlled Drug Delivery 有权
标题翻译：包含用于控制药物递送的可生物降解保湿陶瓷的组合物
公开(公告)号：US20120219601A1
公开(公告)日：2012-08-30
申请号：US13405887
申请日：2012-02-27
申请人： Hans Lennernäs , Bo Lennernäs , Jonas Hugosson , Niklas Axén
发明人： Hans Lennernäs , Bo Lennernäs , Jonas Hugosson , Niklas Axén
IPC分类号： A61K31/167 , A61K38/09 , A61P35/00 , A61K9/00 , A61P13/08
CPC分类号： A61K45/06 , A61K9/1611 , A61K9/1617 , A61K9/1652 , A61K31/00 , A61K31/167 , A61K2300/00
摘要： The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.
摘要翻译：本发明涉及药物载体组合物，其包含i）一种或多种可生物降解的水合陶瓷ii）一种或多种可发性剂，和iii）固体形式的具有破裂结构的吸水性水性介质。可膨胀剂的功能是在凝固组合物中产生断裂结构，泡沫状结构或分解结构，其中其被分成大量的部分，颗粒，单位，颗粒或块，以获得在施用时暴露于降解或侵蚀的扩大的表观表面积。获得这种表面扩大效果的合适物质是气体形成剂或溶胀剂，胶凝剂或崩解剂，这里称为可膨胀剂。可膨胀剂可以是生物可再吸收的或非生物可再吸收的。

9. 发明申请

US20110223214A1 USE OF CARBOXYMETHYLCELLULOSE TO CONTROL EJECTABILITY AND SOLIDIFICATION TIME OF COMPOSITIONS COMPRISING ONE OR MORE BIORESORBABLE CERAMICS 有权
标题翻译：使用羧甲基纤维素来控制包含一种或多种可生物陶瓷的组合物的可回收性和固化时间
公开(公告)号：US20110223214A1
公开(公告)日：2011-09-15
申请号：US13127331
申请日：2009-11-27
申请人： Lars Åke Malmsten , Niklas Axén , Hans Lennernäs , Anders Carlsson
发明人： Lars Åke Malmsten , Niklas Axén , Hans Lennernäs , Anders Carlsson
IPC分类号： A61K9/14 , A61K31/167 , A61K31/57 , A61K31/277 , A61P35/00 , A61P29/00 , A61P5/28
CPC分类号： A61K31/167 , A61K9/0019 , A61K31/57 , A61K47/02 , A61K47/38 , A61L27/446 , A61L27/58 , A61L2400/06 , C08L1/28
摘要： Carboxymethylcellulose, notably sodium carboxymethylcellulose or other alkali metal or alkaline earth metal salts of carboxymethylcellulose, are employed to control solidification time of compositions comprising one or more bioresorbable ceramics, notably a hydratable calcium sulphate, in order to facilitate preparation of a ready-to-use composition for inserting into the body by injection.
摘要翻译：使用羧甲基纤维素，特别是羧甲基纤维素钠或羧甲基纤维素的其它碱金属或碱土金属盐来控制包含一种或多种生物可再吸收陶瓷，特别是可水合硫酸钙的组合物的固化时间，以便于制备即用型用于通过注射插入体内的组合物。

10. 发明授权

US09925139B2 Pharmaceutical compositions for acute glucocorticoid therapy 有权
公开(公告)号：US09925139B2
公开(公告)日：2018-03-27
申请号：US11587512
申请日：2005-04-21
申请人： Stanko Skrtic , Jörgen Johnsson , Hans Lennernäs , Thomas Hedner , Gudmundur Johannsson
发明人： Stanko Skrtic , Jörgen Johnsson , Hans Lennernäs , Thomas Hedner , Gudmundur Johannsson
IPC分类号： A61K9/14 , A61K9/08 , A61K9/20 , A61K9/12 , A61K9/16 , A61K9/50 , A61K9/00 , A61K9/70 , A61K31/573 , A61K31/00
CPC分类号： A61K9/0095 , A61K9/006 , A61K9/2018 , A61K9/5078 , A61K9/7007 , A61K31/00 , A61K31/573
摘要： The present invention relates to glucocorticoid-containing pharmaceutical compositions or kits for use in acute emergency situations where acute glucocorticoid therapy is required. Notably, the invention relates to pharmaceutical compositions and kits that are designed to be administered by non-medically trained persons outside a hospital or another medical or clinical setting. The invention also relates to a method for treating a disorder requiring acute glucocorticoid therapy by providing a fast onset of action of a glucocorticoid.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式