专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5189216A Isolation of a carboxylic acid from an aqueous solution thereof 失效
标题翻译：从其水溶液中分离羧酸
公开(公告)号：US5189216A
公开(公告)日：1993-02-23
申请号：US730768
申请日：1991-07-16
申请人： Hans Kiefer , Werner Reutemann
发明人： Hans Kiefer , Werner Reutemann
IPC分类号： C07C51/50 , C07C51/48 , C07C53/02 , C07C53/08 , C07C53/122 , C07C57/07 , C07C231/02 , C07C233/04 , C07C233/05 , C07C233/06 , C07C233/07
CPC分类号： C07C51/48
摘要： A process for the isolation of a carboxylic acid of the general formula (I)R.sup.1 --COOH (I),in which R.sup.1 denotes hydrogen, methyl, ethyl, or vinyl, from a dilute aqueous solution thereof by extraction with a secondary amide of the general formula (II) ##STR1## in which R.sup.1 has the meanings stated, and R.sup.2 and R.sup.3 are independently of each other C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.4 -C.sub.20 -cycloalkylalkyl, aryl, C.sub.7 -C.sub.20 -aralkyl, or R.sup.2 and R.sup.3 together form a 1,4- or 1,5-alkylene group which may be mono- to penta-substituted by C.sub.1 -C.sub.4 -alkyl, wherein the losses of secondary amide (II) are compensated by the addition of the corresponding amine of the general formula (III) ##STR2## in which R.sup.2 and R.sup.3 have the meanings stated above.
摘要翻译：通过用二级酰胺萃取从其稀水溶液中分离通式（I）的羧酸R1-COOH（I）的方法，其中R 1表示氢，甲基，乙基或乙烯基通式（II）其中R 1具有所述的含义，并且R 2和R 3彼此独立地为C 1 -C 8 - 烷基，C 3 -C 8 - 环烷基，C 4 -C 20环烷基烷基，芳基， C 20 - 芳烷基或R 2和R 3一起形成可被C 1 -C 4烷基单 - 五取代的1,4-亚烷基或1,5-亚烷基，其中仲酰胺（II）的损失由加入其中R2和R3具有上述含义的通式（III）的相应胺。

2. 发明授权

US06939951B1 Refolding of membrane proteins 失效
标题翻译：膜蛋白重折叠
公开(公告)号：US06939951B1
公开(公告)日：2005-09-06
申请号：US10069433
申请日：2000-08-10
申请人： Hans Kiefer , Klaus Maier
发明人： Hans Kiefer , Klaus Maier
IPC分类号： C12P21/02 , C07K1/08 , C07K1/113 , C07K1/16 , C07K1/34 , C07K14/705 , C07K1/02
CPC分类号： C07K1/1136
摘要： In a method for production of membrane proteins or receptors folded into their native structure, first, proteins solubilized in a first detergent are provided. To induce folding of proteins into their native form, the first detergent is exchanged for a second detergent. Both for the first and for the second detergent, examples are shown.
摘要翻译：在生产折叠成其天然结构的膜蛋白或受体的方法中，首先提供溶解在第一种洗涤剂中的蛋白质。为了诱导蛋白质折叠成天然形式，将第一种洗涤剂换成第二种洗涤剂。对于第一和第二种洗涤剂都是示出的。

3. 发明授权

US4735969A Menadione choline bisulfite adduct, its preparation and antihemorrhagic compositions 失效
标题翻译：甲萘醌胆碱亚硫酸氢盐加合物，其制备和抗出血组合物
公开(公告)号：US4735969A
公开(公告)日：1988-04-05
申请号：US799026
申请日：1985-11-18
申请人： Joachim U. Schneider , Hans Kiefer
发明人： Joachim U. Schneider , Hans Kiefer
IPC分类号： A23K20/174 , A61K31/14 , A61K31/185 , A61K31/205 , A61P7/04 , C07C67/00 , C07C213/00 , C07C215/40 , C07C301/00 , C07C301/02 , C07C303/20 , C07C303/32 , C07C309/25 , C07C309/41 , C07C323/22 , C07C50/14 , A23K1/16 , A61K31/12 , C07C143/30
CPC分类号： A61K31/185 , A23K20/174 , C07C309/00 , Y10S514/834 , Y10S514/973
摘要： A novel bisulfite adduct of menadione, the menadione choline bisulfite adduct, a process for its preparation, and its use as an antihemorrhagic agent.
摘要翻译：甲萘醌的新型亚硫酸氢盐加合物，甲萘醌胆碱亚硫酸氢盐加合物，其制备方法及其作为抗出血药物的用途。

4. 发明授权

US4565894A Preparation of ionones 失效
标题翻译：紫罗兰酮的制备
公开(公告)号：US4565894A
公开(公告)日：1986-01-21
申请号：US637890
申请日：1984-08-06
申请人： Otto Hertel , Hans Kiefer , Lothar Arnold
发明人： Otto Hertel , Hans Kiefer , Lothar Arnold
IPC分类号： C07C403/16 , C07C45/61 , C07C49/21 , C07C67/00 , C07C401/00 , C07C403/00
CPC分类号： C07C403/16 , C07C2101/16
摘要： Ionones are prepared by cyclization of pseudoionone with concentrated sulfuric acid in the presence of an organic solvent or diluent, while cooling, and by dilution of the reaction mixture with water, by a continuous process in which the pseudoionone is combined with an aliphatic or cycloaliphatic hydrocarbon which boils at 25.degree.-65.degree. C. under the reaction conditions, or an aliphatic chlorohydrocarbon, and the sulfuric acid, with thorough mixing and evaporative cooling by partial or complete vaporization of the solvent present in the reaction mixture, combination being effected so that the temperature of the reaction mixture is from 25.degree. to 65.degree. C. and the residence time of this mixture before it is diluted with water is from 0.5 to 20, preferably from 0.1 to 5, seconds.The novel process can be used to prepare .alpha.- and .beta.-ionone in a technically simple and advantageous manner and in very good yields.
摘要翻译：紫罗兰酮是通过在有机溶剂或稀释剂的存在下，用浓硫酸环化来制备的，同时冷却，通过用水稀释反应混合物，其中将假性离子与脂族或脂环族烃结合在反应条件下在25°-65℃下沸腾，或在脂肪族氯代烃和硫酸中，通过部分或完全蒸发存在于反应混合物中的溶剂进行充分混合和蒸发冷却，进行组合，使得反应混合物的温度为25-65℃，该混合物在用水稀释之前的停留时间为0.5-20秒，优选为0.1-5秒。该新方法可用于以技术上简单和有利的方式以非常好的产率制备α-和β-丁酮。

5. 发明授权

US4217460A Isolation of formic acid from its aqueous solutions 失效
标题翻译：从其水溶液中分离甲酸
公开(公告)号：US4217460A
公开(公告)日：1980-08-12
申请号：US893953
申请日：1978-04-06
申请人： Heinz Hohenschutz , Johannes E. Schmidt , Hans Kiefer
发明人： Heinz Hohenschutz , Johannes E. Schmidt , Hans Kiefer
IPC分类号： C07C51/48 , C07C51/44 , C07C53/02
CPC分类号： C07C51/48 , Y10S203/22
摘要： Carboxylic acids of the general formula IR.sup.1 -COOH Iwhere R.sup.1 is hydrogen, methyl, ethyl or vinyl, are isolated from their dilute aqueous solutions by extraction followed by distillation of the mixtures obtained, the extractant used being a secondary amide of the general formula II ##STR1## where R.sup.2 and R.sup.3 are alkyl, cycloalkyl, aryl or aralkyl or conjointly are 1,4- or 1,5-alkylene, in each case of not more than 8 carbon atoms, with the proviso that the sum of the carbon atoms of R.sup.2 and R.sup.3 is from 7 to 14 and that only one of these radicals is aryl, and where R.sup.4 is one of the radicals R.sup.1.
摘要翻译：通过萃取从其稀释的水溶液中分离通式为I，R 1 -COOH的通式ⅠR1 -COOH I的羧酸，然后蒸馏得到的混合物，所用的萃取剂是通式 II，其中R 2和R 3是烷基，环烷基，芳基或芳烷基或联合地为1,4-或1,5-亚烷基，在每种情况下不超过8个碳原子，条件是 R 2和R 3的碳原子为7至14，并且这些基团中只有一个为芳基，并且其中R 4为基团R 1之一。

6. 发明申请

US20060058509A1 Refolding of membrane proteins 审中-公开
标题翻译：膜蛋白重折叠
公开(公告)号：US20060058509A1
公开(公告)日：2006-03-16
申请号：US11217124
申请日：2005-08-31
申请人： Hans Kiefer , Klaus Maier
发明人： Hans Kiefer , Klaus Maier
IPC分类号： C07K14/47
CPC分类号： C07K1/1136
摘要： In a method for production of membrane receptors folded into their native structure, first, receptors solubilized in a first detergent are provided. To induce folding of receptors into their native form, the first detergent is exchanged for a second detergent. Both for the first and for the second detergent, examples are shown.
摘要翻译：在制备折叠成其天然结构的膜受体的方法中，首先提供溶解在第一种洗涤剂中的受体。为了诱导受体折叠成天然形式，将第一种洗涤剂换成第二种洗涤剂。对于第一和第二种洗涤剂都是示出的。

7. 发明申请

US20050255556A1 Refolding of ion channel proteins 审中-公开
标题翻译：离子通道蛋白重折叠
公开(公告)号：US20050255556A1
公开(公告)日：2005-11-17
申请号：US11102487
申请日：2005-04-08
申请人： Dietrich Loebel , Tilmann Roos , Klaus Maier , Hans Kiefer
发明人： Dietrich Loebel , Tilmann Roos , Klaus Maier , Hans Kiefer
IPC分类号： C07K1/113 , C07K14/705 , C07H21/04 , C12N15/09 , C12P21/06 , C12Q1/68
CPC分类号： C07K1/1136 , C07K14/705
摘要： A method of ion channels folded into their active structure, or functional subunits thereof, is described. For this purpose, initially expressed subunits, which are solubilized and denatured in a first detergent, of an ion channel are provided, and subsequently the first detergent is replaced by a second detergent which induces folding of the subunits of an ion channel into their native structure. The subunits of the ion channel are then assembled into its active structure.
摘要翻译：描述了折叠成其活性结构的离子通道的方法或其功能性亚单位。为此目的，提供了初始表达的在第一洗涤剂中溶解和变性的亚基，其具有离子通道，随后第一种洗涤剂被第二种洗涤剂代替，第二种洗涤剂诱导将离子通道的亚基折叠成其天然结构。然后将离子通道的亚基组装成其活性结构。

8. 发明授权

US5017700A Preparation of riboflavin-5'-phosphate (5'-FMN) and its sodium salt, and of riboflavin-4',5'-cyclophosphoric acid ester chloride as an intermediate 失效
标题翻译：制备核黄素-5'-磷酸（5'-FMN）及其钠盐，以及核黄素-4'，5'-环磷酸酯氯化物作为中间体
公开(公告)号：US5017700A
公开(公告)日：1991-05-21
申请号：US413590
申请日：1989-09-28
申请人： Johannes Grimmer , Hans Kiefer
发明人： Johannes Grimmer , Hans Kiefer
IPC分类号： A61K31/675 , A61P3/02 , C07F9/6561 , C07F9/6574
CPC分类号： C07F9/65742
摘要： Riboflavin-4',5'-cyclophosphoric acid chloride of the formula I ##STR1## its preparation by reacting an alkali metal salt of riboflavin, in an aprotic solvent, with phosphorus oxychloride, its use for the preparation of riboflavin-5'-phosphate and of the sodium salt of riboflavin-5'-phosphate, and a process for the preparation of riboflavin-5'-phosphate or its sodium salt via the novel phosphoric acid ester chloride.
摘要翻译：核黄素-4'，5'-环磷酰氯通式Ⅰ（Ⅰ）其核苷酸碱金属盐在非质子传递溶剂中与磷酰氯反应，其用于制备核黄素-5 β-磷酸盐和核黄素-5'-磷酸钠钠盐，以及通过新型磷酸酯氯化物制备核黄素-5'-磷酸或其钠盐的方法。

9. 发明授权

US4038311A Production of N-(1-alkenyl)-carbamyl chlorides 失效
标题翻译： N-（1-烷基） - 氨基甲酰氯的生产
公开(公告)号：US4038311A
公开(公告)日：1977-07-26
申请号：US533143
申请日：1974-12-16
申请人： Hans Kiefer , Herbert Naarmann
发明人： Hans Kiefer , Herbert Naarmann
IPC分类号： C07C271/02 , C07C271/06 , C08F26/02 , C08F226/02 , E04H17/14 , C07C125/03
CPC分类号： C08F226/02 , C07C271/02 , C07C271/06 , C08F26/02 , E04H17/14
摘要： The production of N-(1-alkenyl)-carbamyl chlorides by reaction of a Schiff base with phosgene, and the new N-(1-alkenyl)-carbamyl chlorides themselves. The new compounds which can be prepared by the process of the invention are valuable starting materials for the production of coating intermediates, plastics, paints and plant protection agents.One preferred group of compounds available from said process are the N-vinyl compounds of the formula ##STR1## in which R.sup.1 is cyclohexyl, cyclooctyl, norbornyl, tetrahydrodicyclopentadienyl, n-hexyl, n-octyl, 2-ethylhexyl or phenyl. Another preferred group of compounds are the N-vinyl-N-t-alkylcarbamyl chlorides of 4 to 6 carbon atoms in the tertiary alkyl group, especially N-vinyl-N-t-butylcarbamyl chloride.

10. 发明申请

US20070031926A1 Refolded membrane protein in monodisperse form 审中-公开
标题翻译：单分散形式的重折叠膜蛋白
公开(公告)号：US20070031926A1
公开(公告)日：2007-02-08
申请号：US11453195
申请日：2006-06-14
申请人： Lars Linden , Stefan Prytulla , Thomas Ostermann , Monika Baehner , Tilmann Roos , Andreas Thess , Hans Kiefer , Wolfgang Vogt
发明人： Lars Linden , Stefan Prytulla , Thomas Ostermann , Monika Baehner , Tilmann Roos , Andreas Thess , Hans Kiefer , Wolfgang Vogt
IPC分类号： G06F19/00 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705
摘要： The present invention relates to a method for preparing a solution of a refolded, recombinantly expressed or chemically synthesized eukaryotic membrane protein in monodisperse form, to methods for preparing a crystalline form of a recombinantly expressed or chemically synthesized membrane protein, to a crystalline form of a recombinantly expressed, or chemically synthesized eukaryotic membrane protein, and to a crystalline form of a complex of a recombinantly expressed or chemically synthesized eukaryotic membrane protein and of an accessory agent.
摘要翻译：本发明涉及一种制备重折叠，重组表达或化学合成的单分散形式的真核细胞蛋白质的溶液的方法，用于制备重组表达或化学合成的膜蛋白的结晶形式的方法，重组表达或化学合成的真核膜蛋白，以及重组表达或化学合成的真核细胞蛋白质和辅助剂的复合物的结晶形式。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式