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1. 发明授权

US4916249A Glycero-3(2)-phospho-L-serine derivatives and salts thereof 失效
标题翻译：甘油-3（2） - 磷酸-L-丝氨酸衍生物及其盐
公开(公告)号：US4916249A
公开(公告)日：1990-04-10
申请号：US376161
申请日：1989-07-07
申请人： Hans Brachwitz , Peter Langen , Christine Lehmann , Eckart Matthes , Jurgen Schildt , Iduna Fichtner , Albin Hermetter , Friedrich Paltauf
发明人： Hans Brachwitz , Peter Langen , Christine Lehmann , Eckart Matthes , Jurgen Schildt , Iduna Fichtner , Albin Hermetter , Friedrich Paltauf
IPC分类号： C07F9/10
CPC分类号： C07F9/10
摘要： The invention relates to novel glycero-3(2)phospho-L-serine derivatives of the general formula ##STR1## in which A represents unsubstituted or substituted (C5-C30) alkoxy, or unsubstituted or substituted (C5-C30) alkenoxy, whereby a double bond of the alkenoxy residue does not originate at the C atom bound to oxygen, or halogen, or a group of the general formula--O--(CH.sub.2).sub.n --CF.sub.3 II,wherein n is 0 or an integer 1, 2 or 3, one of the two residues B and C, which is identical to or different from A, has one of the definitions given for A or represents hydrogen, and the respective other residue represents the phosphatidyl-Lserine group of the formula ##STR2## with the proviso that at least one residue A, B or C represents (C5-C30) alkoxy or (C5-C30) alkenoxy; and the pharmaceutically acceptable salts of compounds of general formula I with bases, a process for the preparation thereof, pharmaceutical preparations containing the said compounds, and their use in drugs with cytostatic activity.
摘要翻译：本发明涉及通式“IMAGE”I的新的甘油基-3（2）磷酸-L-丝氨酸衍生物，其中A代表未取代或取代的（C 5 -C 30）烷氧基或未取代或取代的（C 5 -C 30）烯氧基，其中链烯氧基残基的双键不是起源于与氧或卤素键合的C原子或通式-O-（CH 2）n -CF 3 II的基团，其中n为0或整数1,2或 3中，与A相同或不同的两个残基B和C之一之一具有对A给出的定义之一或代表氢，并且各自的其它残基表示式III的磷脂酰-L-丝氨酸基条件是至少一个残基A，B或C表示（C 5 -C 30）烷氧基或（C 5 -C 30）链烯氧基; 和通式I的化合物的药学上可接受的盐与碱，其制备方法，含有所述化合物的药物制剂，以及它们在具有细胞抑制活性的药物中的用途。

2. 发明申请

US20050019386A1 Orally administered pharmaceutical preparation comprising liposomically encapsulated paclitaxel 审中-公开
标题翻译：口服给药的药物制剂，其包含脂质体包封的紫杉醇
公开(公告)号：US20050019386A1
公开(公告)日：2005-01-27
申请号：US10495039
申请日：2002-11-06
申请人： Regina Reszka , Iduna Fichtner
发明人： Regina Reszka , Iduna Fichtner
IPC分类号： C07D305/14 , A61K9/08 , A61K9/127 , A61K9/14 , A61K9/19 , A61K9/20 , A61K9/48 , A61K31/337 , A61K38/13 , A61K38/19 , A61K45/00 , A61K47/12 , A61K47/24 , A61K47/28 , A61K47/30 , A61K47/34 , A61P35/00
CPC分类号： A61K38/19 , A61K9/127 , A61K9/1271 , A61K31/337 , A61K38/13 , A61K2300/00
摘要： The invention relates to pharmaceutical preparations suitable for oral application of liposomally encapsulated Taxol, its derivatives and Taxan. Preferably, they additionally contain at least one immuno-modulator, preferably Cyclosporine, and/or at least one cytokine, preferably PEG cytokines.
摘要翻译：本发明涉及适用于脂质体包裹的紫杉醇，其衍生物和紫杉烷的口服应用的药物制剂。优选地，它们另外含有至少一种免疫调节剂，优选环孢霉素，和/或至少一种细胞因子，优选PEG细胞因子。

3. 发明授权

US06177255B1 Method for detecting a hormone or antihormone resistance in cancers 失效
标题翻译：检测癌症中激素或抗激素抗性的方法
公开(公告)号：US06177255B1
公开(公告)日：2001-01-23
申请号：US09214805
申请日：1999-02-22
申请人： Helga Naundorf , Claudia Neumann , Iduna Fichtner , Michael Becker
发明人： Helga Naundorf , Claudia Neumann , Iduna Fichtner , Michael Becker
IPC分类号： G01N3353
CPC分类号： G01N33/57415 , G01N33/57449 , G01N2333/723 , G01N2800/52
摘要： The invention concerns a method for detecting a hormone or antihormone resistance in cancers. The invention is intended for use in medicine, biology and the pharmaceutical industry. The aim of the invention is to consistently improve the use of antihormones in the treatment of cancer so that unnecessary treatment can be avoided as much as possible. The aim is to develop a method which can be used to identify the type of cancer before corresponding antihormone treatment is given. This aim is achieved by measuring the immune reactivity of the hormone receptors of cancers. The method as per the invention is characterized in that an antihormone receptor antibody, which is attached to a solid, is incubated with a prepared cytosol from the cancer tissue being investigated and, following removal of the liquid, is once again incubated with the addition of the respective hormone or antihormone, then a second enzyme-labelled antibody is added, the color reaction measured and the determined value for the immune reaction is compared with the control value which is obtained in the same way but without the respective hormone or antihormone being incubated.
摘要翻译：本发明涉及用于检测癌症中激素或抗激素抗性的方法。本发明旨在用于医药，生物学和制药工业。本发明的目的是一直改进抗激素在治疗癌症中的用途，从而尽可能地避免不必要的治疗。目的是开发一种方法，可以用于在给予相应的抗激素治疗之前鉴定癌症的类型。这一目标通过测量癌症激素受体的免疫反应性来实现。根据本发明的方法的特征在于将附着于固体的抗激素受体抗体与来自所研究的癌组织的制备的细胞溶质一起温育，并且在除去液体后，再次加入相应的激素或抗激素，然后加入第二个酶标记的抗体，将测定的显色反应和免疫反应的测定值与以相同方式获得但不相应激素或抗激素孵育的对照值进行比较。

4. 发明授权

US5620703A Stimulating hematopoietic activity with carboplatin or lobaplatin 失效
标题翻译：用卡铂或洛帕铂刺激造血活性
公开(公告)号：US5620703A
公开(公告)日：1997-04-15
申请号：US221017
申请日：1994-03-31
申请人： Regina Reszka , Iduna Fichtner
发明人： Regina Reszka , Iduna Fichtner
IPC分类号： A61K31/282 , A61K31/555 , A61K9/127 , A61K31/28 , A61K31/56
CPC分类号： B82Y5/00 , A61K31/555 , A61K9/127 , Y10S424/81 , Y10S424/812 , Y10S514/885 , Y10S514/889 , Y10S514/908 , Y10S514/937 , Y10S514/938
摘要： A process for stimulating hematopoietic activity in animals which comprises administering to a patient in need therefor a therapeutically effective amount of an agent containing as its active ingredient a water-soluble or lipid-soluble transition metal compound in a lyotropic mesophase, the agent optionally containing one or more additional carriers for stimulating hematopoietic activity.
摘要翻译：一种用于刺激动物造血活性的方法，其包括向需要的患者施用治疗有效量的含有作为其活性成分的溶溶性或脂溶性过渡金属化合物在溶致中间相中的药剂，所述药剂任选地含有一种或更多额外的载体刺激造血活性。

5. 发明授权

US6090955A Liposome-encapsulated taxol, its preparation and its use 失效
标题翻译：脂质体包裹的紫杉醇，其制备及其用途
公开(公告)号：US6090955A
公开(公告)日：2000-07-18
申请号：US793238
申请日：1997-06-19
申请人： Regine Reszka , Martin Brandl , Iduna Fichtner , Gernot Warnke
发明人： Regine Reszka , Martin Brandl , Iduna Fichtner , Gernot Warnke
IPC分类号： A61K9/00 , A61K9/127 , A61K31/335 , A61K31/337 , A61K31/555 , C07D493/00
CPC分类号： A61K9/0078 , A61K31/337 , A61K31/555 , A61K9/1277
摘要： The aim of the invention is to produce liposome-encapsulated taxol with a high taxol concentration and high stability and hence a high therapeutic effect. The invention involves the development of specific forms of taxol encapsulation and the use of these, optionally in combination with other substances, in the treatment of various types of tumor. The liposome-encapsulated taxol is characterized in that it is prepared by high-pressure homogenization or by aerosol formulation.
摘要翻译： PCT No.PCT / DE95 / 01163 Sec。 371日期：1997年6月19日 102（e）日期1997年6月19日PCT 1995年8月18日PCT PCT。公开号WO96 / 05821 日期1996年2月29日本发明的目的是制备具有高紫杉醇浓度和高稳定性的脂质体包裹的紫杉醇，因此具有高治疗效果。本发明涉及特定形式的紫杉醇包封的开发，以及它们的使用，任选地与其他物质组合用于治疗各种类型的肿瘤。脂质体包裹的紫杉醇的特征在于其通过高压均化或通过气溶胶制剂制备。

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