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1. 发明授权

US07396467B2 Method of preparing a chromatography matrix 有权
标题翻译：制备色谱基质的方法
公开(公告)号：US07396467B2
公开(公告)日：2008-07-08
申请号：US10964269
申请日：2004-10-13
申请人： Hans Berg , David Buckley , Maria Brännholm , Anders Hagvall , Henrik Ihre , Eva Holmgren , Anders Larsson , Dag Lindstrom
发明人： Hans Berg , David Buckley , Maria Brännholm , Anders Hagvall , Henrik Ihre , Eva Holmgren , Anders Larsson , Dag Lindstrom
IPC分类号： B01D15/08
CPC分类号： B01J20/262 , B01J20/24 , B01J20/26 , B01J20/267 , B01J20/285 , B01J2220/4825
摘要： The present invention relates to a method of preparing a porous cross-linked polysaccharide chromatography matrix, which comprises to provide an aqueous solution of a gellable polysaccharide, wherein part of the hydroxyl groups are substituted with groups which are not susceptible to nucleophilic attack; to provide essentially spherical droplets of the substituted polysaccharide solution; to form a gel of the substituted polysaccharide solution; and to cross-link the gel by adding a cross-linking agent. The invention also encompasses a chromatography column packed with a matrix so produced as well as use thereof in e.g. protein purification.
摘要翻译：本发明涉及一种制备多孔交联多糖色谱基质的方法，其包括提供可凝胶多糖的水溶液，其中部分羟基被不易受亲核攻击的基团取代; 以提供取代的多糖溶液的基本上球形的液滴; 以形成取代的多糖溶液的凝胶; 并通过加入交联剂来交联凝胶。本发明还包括填充有如此制备的基质的色谱柱，以及其在例如，蛋白质纯化。

2. 发明申请

US20080154031A1 Method of Preparing a Separation Matrix 有权
标题翻译：准备分离矩阵的方法
公开(公告)号：US20080154031A1
公开(公告)日：2008-06-26
申请号：US11913236
申请日：2006-06-28
申请人： Hans Berg , Maria Brannholm , David Buckley , Philippe Busson , Anders Hagvall , Eva Holmgren , Henrik Ihre , Anders Larsson , Dag Lindstrom
发明人： Hans Berg , Maria Brannholm , David Buckley , Philippe Busson , Anders Hagvall , Eva Holmgren , Henrik Ihre , Anders Larsson , Dag Lindstrom
IPC分类号： C07H3/00
CPC分类号： B01J20/291 , B01J20/24 , B01J20/262 , B01J20/267 , B01J20/28033 , B01J20/28042 , B01J20/285 , B01J20/3206 , B01J20/3244 , B01J20/3274 , B01J20/3282 , B01J2220/54 , C08B37/0039 , C08J3/24 , C08J2301/00
摘要： The present invention relates to a method of preparing an insoluble separation matrix, which method comprises salt-treatment of a polysaccharide gel followed by cross-linking of the polysaccharide polymers. In one embodiment, the method comprises providing an aqueous solution of a gelatable native polysaccharide; lowering the temperature of the polysaccharide solution to a value below its gelling point; salt-treatment by adding at least one salt to the resulting polysaccharide; and cross-linking the salt-treated polysaccharide. The polysaccharide may be prepared e.g. into particles, membranes or monoliths.
摘要翻译：本发明涉及一种制备不溶性分离基质的方法，该方法包括多糖凝胶的盐处理，然后交联多糖聚合物。在一个实施方案中，该方法包括提供可胶凝天然多糖的水溶液; 将多糖溶液的温度降低到低于其凝胶点的值; 通过向所得多糖中加入至少一种盐进行盐处理; 并交联盐处理的多糖。多糖可以例如制备。成颗粒，膜或整料。

3. 发明授权

US08309709B2 Method of preparing a separation matrix 有权
标题翻译：制备分离基质的方法
公开(公告)号：US08309709B2
公开(公告)日：2012-11-13
申请号：US11913236
申请日：2006-06-28
申请人： Hans Berg , Maria Brannholm , David Buckley , Philippe Busson , Anders Hagvall , Eva Holmgren , Henrik Ihre , Anders Larsson , Dag Lindstrom
发明人： Hans Berg , Maria Brannholm , David Buckley , Philippe Busson , Anders Hagvall , Eva Holmgren , Henrik Ihre , Anders Larsson , Dag Lindstrom
IPC分类号： C07H1/00 , A61K31/715 , A01N43/04
CPC分类号： B01J20/291 , B01J20/24 , B01J20/262 , B01J20/267 , B01J20/28033 , B01J20/28042 , B01J20/285 , B01J20/3206 , B01J20/3244 , B01J20/3274 , B01J20/3282 , B01J2220/54 , C08B37/0039 , C08J3/24 , C08J2301/00
摘要： The present invention relates to a method of preparing an insoluble separation matrix, which method comprises salt-treatment of a polysaccharide gel followed by cross-linking of the polysaccharide polymers. In one embodiment, the method comprises providing an aqueous solution of a gelatable native polysaccharide; lowering the temperature of the polysaccharide solution to a value below its gelling point; salt-treatment by adding at least one salt to the resulting polysaccharide; and cross-linking the salt-treated polysaccharide. The polysaccharide may be prepared e.g. into particles, membranes or monoliths.
摘要翻译：本发明涉及一种制备不溶性分离基质的方法，该方法包括多糖凝胶的盐处理，然后交联多糖聚合物。在一个实施方案中，该方法包括提供可胶凝天然多糖的水溶液; 将多糖溶液的温度降低到低于其凝胶点的值; 通过向所得多糖中加入至少一种盐进行盐处理; 并交联盐处理的多糖。多糖可以例如制备。成颗粒，膜或整料。

4. 发明申请

US20060060534A1 Method of preparing a chromatography matrix 有权
标题翻译：制备色谱基质的方法
公开(公告)号：US20060060534A1
公开(公告)日：2006-03-23
申请号：US10964269
申请日：2004-10-13
申请人： Hans Berg , David Buckley , Maria Brannholm , Anders Hagvall , Henrik Ihre , Eva Holmgren , Anders Larsson , Dag Lindstrom
发明人： Hans Berg , David Buckley , Maria Brannholm , Anders Hagvall , Henrik Ihre , Eva Holmgren , Anders Larsson , Dag Lindstrom
IPC分类号： C12P19/04 , B01J20/22 , C08B37/00
CPC分类号： B01J20/262 , B01J20/24 , B01J20/26 , B01J20/267 , B01J20/285 , B01J2220/4825
摘要： The present invention relates to a method of preparing a porous cross-linked polysaccharide chromatography matrix, which comprises to provide an aqueous solution of a gellable polysaccharide, wherein part of the hydroxyl groups are substituted with groups which are not susceptible to nucleophilic attack; to provide essentially spherical droplets of the substituted polysaccharide solution; to form a gel of the substituted polysaccharide solution; and to cross-link the gel by adding a cross-linking agent. The invention also encompasses a chromatography column packed with a matrix so produced as well as use thereof in e.g. protein purification.
摘要翻译：本发明涉及一种制备多孔交联多糖色谱基质的方法，其包括提供可凝胶多糖的水溶液，其中部分羟基被不易受亲核攻击的基团取代; 以提供取代的多糖溶液的基本上球形的液滴; 以形成取代的多糖溶液的凝胶; 并通过加入交联剂来交联凝胶。本发明还包括填充有如此制备的基质的色谱柱，以及其在例如，蛋白质纯化。

5. 发明申请

US20110203929A1 RECOVERY OF LITHIUM FROM AQUEOUS SOLUTIONS 审中-公开
标题翻译：从水溶液中回收锂
公开(公告)号：US20110203929A1
公开(公告)日：2011-08-25
申请号：US12935663
申请日：2009-11-12
申请人： David Buckley , J. David Genders , Dan Atherton , Rainer Aul
发明人： David Buckley , J. David Genders , Dan Atherton , Rainer Aul
IPC分类号： B01D61/44 , B01D61/46
CPC分类号： B01D61/445 , C22B3/22 , C22B7/006 , C22B26/12 , Y02P10/234
摘要： A method for recovering lithium as lithium hydroxide by feeding an aqueous stream containing lithium ions to a bipolar electrodialysis cell, wherein the cell forms a lithium hydroxide solution. An apparatus or system for practicing the method is also provided.
摘要翻译：一种通过将含有锂离子的含水流送入双极电渗析池的方式回收锂作为氢氧化锂的方法，其中所述电池形成氢氧化锂溶液。还提供了一种用于实施该方法的装置或系统。

6. 发明授权

US06568151B2 Conveyor for use in contamination sensitive equipment 失效
标题翻译：输送机用于污染敏感设备
公开(公告)号：US06568151B2
公开(公告)日：2003-05-27
申请号：US09778541
申请日：2001-02-07
申请人： David Buckley , Max Yablonovitch
发明人： David Buckley , Max Yablonovitch
IPC分类号： B65B5720
CPC分类号： B65G47/082 , B65G15/42 , B65G15/58 , B65G29/00 , B65G47/80 , B65G2201/02 , Y10S53/90
摘要： The present invention relates to a disposable conveyor for use with an apparatus handling contamination-sensitive discrete items. The conveyor has at least one cavity, each cavity capable to carry at least one discrete item. The conveyor is adapted to be mounted on the contamination-sensitive apparatus that, in operation, is capable to impart movement to the conveyor for displacing the conveyor, and its cavities, along a predetermined path. The present invention also relates to a method for transporting discrete items in a machine performing production runs with different types of contamination-sensitive discrete items. The method involves installing a conveyor as described above on the machine and using it to perform a first production run with a first type of discrete items. The conveyor is then disposed of and a new conveyor installed on the machine, used to perform a second production run with a second type of discrete items, different from the first type.
摘要翻译：本发明涉及一种用于处理污染敏感的离散物品的设备的一次性输送机。输送机具有至少一个空腔，每个空腔能够承载至少一个离散的物品。输送机适于安装在污染敏感设备上，在操作中，能够将传送机构沿着预定路径移动到输送机上以使输送机及其空腔移动。本发明还涉及一种在不同类型的污染敏感的离散物品中进行生产运行的机器中运输离散物品的方法。该方法包括在机器上安装如上所述的输送机，并使用它将第一种类型的离散物品进行第一次生产。输送机然后被丢弃并且安装在机器上的新的输送机，用于执行与第一类型不同的第二类离散物品的第二生产运行。

7. 发明申请

US20060065583A1 Separation medium and method for its preparation 审中-公开
标题翻译：分离介质及其制备方法
公开(公告)号：US20060065583A1
公开(公告)日：2006-03-30
申请号：US10536021
申请日：2003-12-16
申请人： David Buckley , Philippe Busson
发明人： David Buckley , Philippe Busson
IPC分类号： B01D15/08
CPC分类号： B01J20/28019 , B01D15/1807 , B01J20/28026 , B01J20/2803 , B01J20/28054 , B01J20/285 , B01J20/286 , B01J20/291 , B01J20/30 , B01J20/3028 , B01J20/3285
摘要： The present invention relates to a method of preparing a separation medium, which method comprises to provide a slurry of essentially spherical polymer beads in an aqueous solution of a natural polymer and contacting the slurry with an organic solvent in the presence of emulsifier to allow aggregation of the beads. In a preferred embodiment, the natural polymer is agarose. The present invention also encompasses a separation medium comprised of one or more aggregates, wherein each aggregate comprises a plurality of porous and essentially spherical polymer beads assembled by a porous gel.
摘要翻译：本发明涉及一种制备分离介质的方法，该方法包括在天然聚合物的水溶液中提供基本上为球形的聚合物珠的浆料，并在乳化剂存在下使浆料与有机溶剂接触，以使珠子。在优选的实施方案中，天然聚合物是琼脂糖。本发明还包括由一种或多种聚集体组成的分离介质，其中每个聚集体包括由多孔凝胶组装的多个多孔和基本上为球形的聚合物珠。

8. 发明申请

US20050086293A1 Rating service for wireless device applications 审中-公开
标题翻译：无线设备应用的评级服务
公开(公告)号：US20050086293A1
公开(公告)日：2005-04-21
申请号：US10687055
申请日：2003-10-15
申请人： David Buckley
发明人： David Buckley
IPC分类号： G06F15/16 , H04L12/56
CPC分类号： H04W4/00
摘要： A method and system for submitting ratings for wireless device applications directly from a wireless device is disclosed. An option to submit a rating for a wireless device application is displayed on the wireless device. When a user selects this option, and the wireless device receives a rating, this rating is sent to a back-end server, along with a unique identifier for the wireless device and the application identifier. This rating is then stored in a database at the server. In this manner, ratings can be submitted directly from the wireless device. In addition, one rating for each wireless device application is stored for each wireless device. A user may submit multiple ratings for the same application on the wireless device, but only the most recent rating is stored.
摘要翻译：公开了一种从无线设备直接提交无线设备应用的评级的方法和系统。在无线设备上显示提供无线设备应用的评级的选项。当用户选择该选项，并且无线设备接收到等级时，该等级将被发送到后端服务器，以及无线设备和应用标识符的唯一标识符。然后将该评级存储在服务器的数据库中。以这种方式，可以直接从无线设备提交评级。另外，为每个无线设备存储每个无线设备应用的一个等级。用户可以在无线设备上为同一应用提交多个评级，但只保存最新的等级。

9. 发明申请

US20050054330A1 Dispatcher for wireless device applications 失效
标题翻译：无线设备应用的调度员
公开(公告)号：US20050054330A1
公开(公告)日：2005-03-10
申请号：US10643636
申请日：2003-08-18
申请人： David Buckley
发明人： David Buckley
IPC分类号： G06F20060101 , H04L12/58 , H04Q7/20
CPC分类号： H04L51/24 , H04L51/38
摘要： A method for handling messages between wireless devices in a network, includes: receiving a message for a device application by a dispatcher application on a receiving wireless device; determining that the device application does not exist on the receiving wireless device by the dispatcher application; and sending a notification to a user of the receiving wireless device of receipt of the message. Because the dispatcher application on the receiving wireless device sends this notification, the developer of the device application has an opportunity to sell the device application to the user, and the user has the opportunity to purchase the device application.
摘要翻译：一种用于在网络中的无线设备之间处理消息的方法，包括：由接收无线设备上的调度器应用接收设备应用的消息; 确定所述调度器应用在所述接收无线设备上不存在所述设备应用; 以及向所述接收无线设备的用户发送接收到所述消息的通知。由于接收无线设备上的调度程序应用程序发送此通知，设备应用程序的开发人员有机会向用户销售设备应用程序，并且用户有机会购买设备应用程序。

10. 发明申请

US20110044882A1 METHOD OF MAKING HIGH PURITY LITHIUM HYDROXIDE AND HYDROCHLORIC ACID 审中-公开
标题翻译：制备高纯度氢氧化锂和氢氯酸的方法
公开(公告)号：US20110044882A1
公开(公告)日：2011-02-24
申请号：US12935658
申请日：2009-04-09
申请人： David Buckley , J. David Genders , Dan Atherton
发明人： David Buckley , J. David Genders , Dan Atherton
IPC分类号： C01B7/01 , C01D15/02 , C25B1/34
CPC分类号： C25B1/16 , C01B7/012 , C01D15/02 , Y02P20/134
摘要： The present invention relates to a process for producing high purity lithium hydroxide monohydrate, comprising following steps: concentrating a lithium containing brine; purifying the brine to remove or to reduce the concentrations of ions other than lithium; adjusting the pH of the brine to about 10.5 to 11 to further remove cations other than lithium, if necessary; neutralizing the brine with acid; purifying the brine to reduce the total concentration of calcium and magnesium to less than 150 ppb via ion exchange; electrolyzing the brine to generate a lithium hydroxide solution containing less than 150 ppb total calcium and magnesium, with chlorine and hydrogen gas as byproducts; producing hydrochloric acid via combustion of the chlorine gas with excess hydrogen and subsequent scrubbing of the resultant gas stream with purified water, if elected to do so; and concentrating and crystallizing the lithium hydroxide solution to produce lithium hydroxide monohydrate crystals.
摘要翻译：本发明涉及一种生产高纯度氢氧化锂一水合物的方法，包括以下步骤：浓缩含锂盐水; 净化盐水以去除或降低锂以外的离子浓度; 如果需要，将盐水的pH调节至约10.5至11以进一步除去锂以外的阳离子; 用酸中和盐水; 净化盐水以通过离子交换将钙和镁的总浓度降至小于150ppb; 电解盐水以产生含有少于150ppb总钙和镁的氢氧化锂溶液，其中氯和氢气作为副产物; 通过氯气与过量氢气的燃烧产生盐酸，随后用净化水洗涤所得气流，如果选择这样做; 并浓缩和结晶氢氧化锂溶液以产生氢氧化锂一水合物晶体。

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