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1. 发明申请

US20080172185A1 AUTOMATIC CLASSIFYING METHOD, DEVICE AND SYSTEM FOR FLOW CYTOMETRY 审中-公开
标题翻译：自动分类方法，流式细胞仪的装置和系统
公开(公告)号：US20080172185A1
公开(公告)日：2008-07-17
申请号：US11966703
申请日：2007-12-28
申请人： Hanping Yi , Jianjun Chu , Wen Gu
发明人： Hanping Yi , Jianjun Chu , Wen Gu
IPC分类号： G01N33/48
CPC分类号： G01N33/5005
摘要： An automatic classification method for flow cytometry includes characterizing cells or particles as a vector based on at least two-path optical signals generated when the cells or particles pass through an irradiated area one by one, calculating a distance between the effective cells or particles, in which a shorter distance indicates a higher similarity between the two cells or particles, clustering the cells or particles with high similarity into the same class, continuing to cluster similar cells or particles into the same class until the effective cells or particles are clustered into a number L of classes which should be contained in a sample and is determined based on a measuring principle. This method automatically classifies particles accurately and efficiently.
摘要翻译：用于流式细胞术的自动分类方法包括基于当细胞或颗粒逐个通过照射区域时产生的至少两路光学信号来表征细胞或颗粒作为载体，计算有效细胞或颗粒之间的距离，较短的距离表示两个细胞或颗粒之间的相似性较高，将具有高相似性的细胞或颗粒聚集成相同的类别，继续将相似的细胞或颗粒聚集到相同的类别中，直到有效细胞或颗粒聚集成数 L应该包含在样本中并且基于测量原理确定的类。该方法可以自动对粒子进行准确高效的分类。

2. 发明授权

US07385682B2 Cytometer 有权
标题翻译：细胞计数器
公开(公告)号：US07385682B2
公开(公告)日：2008-06-10
申请号：US11516657
申请日：2006-09-07
申请人： Jianjun Chu , Yingchun Li
发明人： Jianjun Chu , Yingchun Li
IPC分类号： G01N21/00
CPC分类号： G01N15/1459 , G01N15/1434 , G01N2015/1486
摘要： A cytometer includes an illuminating unit having a laser and a light beam shaping module for shaping and converging the laser beam emitted from the laser. A sample generation unit includes a gas-liquid transmission controlling module and a flow chamber which are connected to each other, so the sample liquid containing the cells to be detected may flow through the flow chamber while being encircled by the sheath fluid. A signal processing unit receives, converts and processes the scattering light emitted from the flow chamber. The signal processing unit includes at least a photoelectric detection module, wherein the light beam shaping module has at least one aspheric collimating lens and a pair of mutually crossing cylindrical lenses, and the numerical aperture of the aspheric collimating lens is at least 0.3.
摘要翻译：细胞计数器包括具有激光的照明单元和用于使从激光发射的激光束成形和会聚的光束整形模块。样品生成单元包括彼此连接的气液传输控制模块和流动室，因此容纳要检测的单元的样品液体可以在被护套流体包围的同时流过流动室。信号处理单元接收，转换和处理从流动室发射的散射光。信号处理单元至少包括光电检测模块，其中光束整形模块具有至少一个非球面准直透镜和一对相互交叉的柱面透镜，非球面准直透镜的数值孔径至少为0.3。

3. 发明申请

US20080186490A1 IRRADIATION UNIT FOR A FLOW-CYTOMETRY-BASED ANALYTICAL INSTRUMENT AND ANALYTICAL INSTRUMENT INCLUDING THE SAME 有权
标题翻译：基于流式细胞分析仪的分析仪器和包括其的分析仪器的辐射单元
公开(公告)号：US20080186490A1
公开(公告)日：2008-08-07
申请号：US11932847
申请日：2007-10-31
申请人： Jianjun Chu
发明人： Jianjun Chu
IPC分类号： G01N21/00 , F21S2/00
CPC分类号： G01N15/1434 , G01N15/1459 , G01N2015/1477
摘要： The invention provides an irradiation unit for a flow-cytometry-based analytical instrument and analytical instrument including the same. The irradiation unit comprises a light source; a light beam focusing module for focusing the illuminating light beam on an irradiated area; and a light beam shaper disposed between the light source and the light beam focusing module, for flattening the distribution of light intensity on the irradiated area in a direction that is perpendicular to both directions in which cells to be detected flow and the light beam spreads. The irradiation unit and the analytical instrument including the same enable the illuminating light beam to form the irradiated area with the uniform distribution of intensity in a predetermined direction to avoid misjudging particles of the same kind entering into different positions of the irradiated area as different, thereby improving accuracy.
摘要翻译：本发明提供了一种用于基于流式细胞仪的分析仪器和包括其的分析仪器的照射单元。照射单元包括光源; 用于将照明光束聚焦在照射区域上的光束聚焦模块; 以及光束整形器，其设置在光源和光束聚焦模块之间，用于使被照射区域上的光强度的分布在垂直于待检测的细胞流动的两个方向和光束扩展的方向上变平。照射单元和包括该照明单元的分析用具能够使照明光束以预定方向以强度均匀分布形成照射区域，以避免误认为进入照射区域的不同位置的同一粒子不同，由此提高准确性。

4. 发明授权

US07876436B2 Irradiation unit for a flow-cytometry-based analytical instrument and analytical instrument including the same 有权
标题翻译：用于基于流式细胞术的分析仪器和包括其的分析仪器的照射单元
公开(公告)号：US07876436B2
公开(公告)日：2011-01-25
申请号：US11932847
申请日：2007-10-31
申请人： Jianjun Chu
发明人： Jianjun Chu
IPC分类号： G01N21/00
CPC分类号： G01N15/1434 , G01N15/1459 , G01N2015/1477
摘要： Disclosed is an irradiation unit for a flow-cytometry-based analytical instrument and analytical instrument including the same. The irradiation unit includes a light source, a light beam focusing module for focusing the illuminating light beam on an irradiated area, and a light beam shaper disposed between the light source and the light beam focusing module. The light shaper is used for flattening the distribution of light intensity on the irradiated area in a third direction X that is perpendicular to both a first direction in which the light beam spreads and a second direction in which cells to be detected flow. The irradiation unit and the analytical instrument including the same enable the illuminating light beam to form the irradiated area with the uniform distribution of intensity in a predetermined direction to avoid misjudging particles of the same kind entering into different positions of the irradiated area as different, thereby improving accuracy.
摘要翻译：公开了一种用于基于流式细胞术的分析仪器和包括其的分析仪器的照射单元。照射单元包括光源，用于将照射光束聚焦在照射区域上的光束聚焦模块和设置在光源和光束聚焦模块之间的光束整形器。光整形器用于在与光束扩展的第一方向垂直的第三方向X和要检测的细胞流动的第二方向上的照射区域上的光强度分布变平坦。照射单元和包括该照明单元的分析用具能够使照明光束以预定方向以强度均匀分布形成照射区域，以避免误认为进入照射区域的不同位置的同一粒子不同，由此提高准确性。

5. 发明申请

US20070159619A1 Cytometer 有权
标题翻译：细胞计数器
公开(公告)号：US20070159619A1
公开(公告)日：2007-07-12
申请号：US11516657
申请日：2006-09-07
申请人： Jianjun Chu , Yingchun Li
发明人： Jianjun Chu , Yingchun Li
IPC分类号： G01N33/48 , G01N15/02 , G01N21/00
CPC分类号： G01N15/1459 , G01N15/1434 , G01N2015/1486
摘要： The invention relates to a cytometer comprising: an illuminating unit comprising a laser and a light beam shaping module for shaping and converging the laser light beam emitted from the laser so that the light beam irradiates the samples; a sample generation unit comprising a gas-liquid transmission controlling module and a flow chamber which are connected to each other, so the sample liquid containing the cells to be detected may flow through the flow chamber while being encircled by the sheath fluid; and a signal processing unit for receiving, converting and processing the scattering light emitted from the flow chamber, the signal processing unit comprising at least a photoelectric detection module, wherein the light beam shaping module comprises at least one aspheric collimating lens with a large numerical aperture and a pair of mutually crossing cylindrical lenses, and the numerical aperture of the aspheric collimating lens is at least 0.3.
摘要翻译：本发明涉及一种血细胞计数仪，包括：照明单元，包括激光器和光束整形模块，用于使从激光器发射的激光束成形和会聚，使得光束照射样品; 包括彼此连接的气液传输控制模块和流动室的样品产生单元，使得包含被检测单元的样品液体可以在被护套流体包围的同时流过流动室; 信号处理单元，用于接收，转换和处理从流动室发射的散射光，信号处理单元至少包括光电检测模块，其中光束整形模块包括至少一个具有大数值孔径的非球面准直透镜和一对相互交叉的柱面透镜，非球面准直透镜的数值孔径至少为0.3。

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