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1. 发明授权

US07385682B2 Cytometer 有权
标题翻译：细胞计数器
公开(公告)号：US07385682B2
公开(公告)日：2008-06-10
申请号：US11516657
申请日：2006-09-07
申请人： Jianjun Chu , Yingchun Li
发明人： Jianjun Chu , Yingchun Li
IPC分类号： G01N21/00
CPC分类号： G01N15/1459 , G01N15/1434 , G01N2015/1486
摘要： A cytometer includes an illuminating unit having a laser and a light beam shaping module for shaping and converging the laser beam emitted from the laser. A sample generation unit includes a gas-liquid transmission controlling module and a flow chamber which are connected to each other, so the sample liquid containing the cells to be detected may flow through the flow chamber while being encircled by the sheath fluid. A signal processing unit receives, converts and processes the scattering light emitted from the flow chamber. The signal processing unit includes at least a photoelectric detection module, wherein the light beam shaping module has at least one aspheric collimating lens and a pair of mutually crossing cylindrical lenses, and the numerical aperture of the aspheric collimating lens is at least 0.3.
摘要翻译：细胞计数器包括具有激光的照明单元和用于使从激光发射的激光束成形和会聚的光束整形模块。样品生成单元包括彼此连接的气液传输控制模块和流动室，因此容纳要检测的单元的样品液体可以在被护套流体包围的同时流过流动室。信号处理单元接收，转换和处理从流动室发射的散射光。信号处理单元至少包括光电检测模块，其中光束整形模块具有至少一个非球面准直透镜和一对相互交叉的柱面透镜，非球面准直透镜的数值孔径至少为0.3。

2. 发明申请

US20070159619A1 Cytometer 有权
标题翻译：细胞计数器
公开(公告)号：US20070159619A1
公开(公告)日：2007-07-12
申请号：US11516657
申请日：2006-09-07
申请人： Jianjun Chu , Yingchun Li
发明人： Jianjun Chu , Yingchun Li
IPC分类号： G01N33/48 , G01N15/02 , G01N21/00
CPC分类号： G01N15/1459 , G01N15/1434 , G01N2015/1486
摘要： The invention relates to a cytometer comprising: an illuminating unit comprising a laser and a light beam shaping module for shaping and converging the laser light beam emitted from the laser so that the light beam irradiates the samples; a sample generation unit comprising a gas-liquid transmission controlling module and a flow chamber which are connected to each other, so the sample liquid containing the cells to be detected may flow through the flow chamber while being encircled by the sheath fluid; and a signal processing unit for receiving, converting and processing the scattering light emitted from the flow chamber, the signal processing unit comprising at least a photoelectric detection module, wherein the light beam shaping module comprises at least one aspheric collimating lens with a large numerical aperture and a pair of mutually crossing cylindrical lenses, and the numerical aperture of the aspheric collimating lens is at least 0.3.
摘要翻译：本发明涉及一种血细胞计数仪，包括：照明单元，包括激光器和光束整形模块，用于使从激光器发射的激光束成形和会聚，使得光束照射样品; 包括彼此连接的气液传输控制模块和流动室的样品产生单元，使得包含被检测单元的样品液体可以在被护套流体包围的同时流过流动室; 信号处理单元，用于接收，转换和处理从流动室发射的散射光，信号处理单元至少包括光电检测模块，其中光束整形模块包括至少一个具有大数值孔径的非球面准直透镜和一对相互交叉的柱面透镜，非球面准直透镜的数值孔径至少为0.3。

3. 发明授权

US08623358B2 Therapeutic DLL4 binding proteins 有权
标题翻译：治疗性DLL4结合蛋白
公开(公告)号：US08623358B2
公开(公告)日：2014-01-07
申请号：US12870276
申请日：2010-08-27
申请人： Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
发明人： Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
摘要翻译：描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病，例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病，例如自身免疫包括多发性硬化的疾病。

4. 发明申请

US20110223176A1 BASIGIN BINDING PROTEINS 审中-公开
标题翻译：基因结合蛋白
公开(公告)号：US20110223176A1
公开(公告)日：2011-09-15
申请号：US13042650
申请日：2011-03-08
申请人： Eve H. Barlow , Chung-Ming Hsieh , Denise D. Karaoglu Hanzatian , Gillian Ann Kingsbury , Susan E. Morgan-Lappe , Edward B. Reilly , Fritz G. Buchanan , Yingchun Li
发明人： Eve H. Barlow , Chung-Ming Hsieh , Denise D. Karaoglu Hanzatian , Gillian Ann Kingsbury , Susan E. Morgan-Lappe , Edward B. Reilly , Fritz G. Buchanan , Yingchun Li
IPC分类号： A61K39/395 , C07K16/28 , C07K16/46 , C07H21/04 , C12N15/63 , C12N5/16 , C12N5/22 , A61P35/00 , G01N33/574
CPC分类号： C07K16/2803 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： Isolated binding proteins, e.g., antibodies, which bind to Basigin (BSG), e.g., human BSG2, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
摘要翻译：公开了分离的结合蛋白，例如结合Basigin（BSG）的抗体，例如人BSG2，以及相关的基于抗体的组合物和分子。还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。

5. 发明授权

US09029508B2 Dual variable domain immunoglobulins and uses thereof 有权
标题翻译：双重可变结构域免疫球蛋白及其用途
公开(公告)号：US09029508B2
公开(公告)日：2015-05-12
申请号：US12431460
申请日：2009-04-28
申请人： Tariq Ghayur , Susan E. Morgan-Lappe , Edward B. Reilly , Gillian A. Kingsbury , Andrew Phillips , Jieyi Wang , Randy L. Bell , Suzanne M. Norvell , Yingchun Li , Junjian Liu , Hua Ying
发明人： Tariq Ghayur , Susan E. Morgan-Lappe , Edward B. Reilly , Gillian A. Kingsbury , Andrew Phillips , Jieyi Wang , Randy L. Bell , Suzanne M. Norvell , Yingchun Li , Junjian Liu , Hua Ying
IPC分类号： C07K16/00 , C12P21/08 , C07H21/04 , G01N33/53 , C12N15/09 , C12P21/04 , C12N5/02 , C12N5/06 , C12N1/20 , C12N15/00 , A61K39/395 , A61K39/40 , C07K16/46 , C07K16/22 , C07K16/28 , C07K16/32 , C07K1/00 , A61K39/00
CPC分类号： C07K16/468 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/565 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/74 , G01N2333/515 , G01N2333/705 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

6. 发明申请

US20140134172A1 ANTI-DLL4/VEGF DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USES THEREOF 有权
标题翻译： ANTI-DLL4 / VEGF双变异型域免疫球蛋白及其用途
公开(公告)号：US20140134172A1
公开(公告)日：2014-05-15
申请号：US14068976
申请日：2013-10-31
申请人： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
发明人： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
IPC分类号： C07K16/28 , A61K45/06 , C07K16/22 , A61K39/395
CPC分类号： C07K16/468 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/525 , A61K31/7068 , A61K39/395 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
摘要翻译：本文公开了多价和多特异性结合蛋白，制备结合蛋白的方法及其在诊断，监测，抑制，预防和/或治疗癌症，肿瘤和/或其它血管发生依赖性疾病中的用途，其特征在于异常DLL4和 /或VEGF表达或活性。

7. 发明申请

US20110217237A1 THERAPEUTIC DLL4 BINDING PROTEINS 有权
标题翻译：治疗DLL4结合蛋白
公开(公告)号：US20110217237A1
公开(公告)日：2011-09-08
申请号：US13037932
申请日：2011-03-01
申请人： Ming-Jiu Chen , Chung-Ming Hsieh , Jijie Gu , Susan E. Morgan-Lappe , Yingchun Li
发明人： Ming-Jiu Chen , Chung-Ming Hsieh , Jijie Gu , Susan E. Morgan-Lappe , Yingchun Li
IPC分类号： A61K49/00 , C07K16/00 , C07K17/00 , C07H21/00 , A61K39/395 , A61P35/00 , A61P43/00 , A61P9/00 , A61P25/28 , A61P17/06 , C12N9/96 , C12N15/63 , C12N1/21 , C12N5/10 , C12N1/15 , C12N1/19 , C12N1/00 , C12P21/00
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.
摘要翻译：本文描述了DLL4结合蛋白，包括抗体，CDR-移植抗体，人源化抗体及其DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4和/或VEGF活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成。

8. 发明申请

US20110117079A1 THERAPEUTIC DLL4 BINDING PROTEINS 有权
标题翻译：治疗DLL4结合蛋白
公开(公告)号：US20110117079A1
公开(公告)日：2011-05-19
申请号：US12870276
申请日：2010-08-27
申请人： Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
发明人： Lorenzo Benatuil , Erwin R. Boghaert , Jijie Gu , Maria Harris , Jonathan A. Hickson , Chung-Ming Hsieh , Yuliya Kutskova , Yingchun Li , Zhihong Liu , Susan Morgan-Lappe
IPC分类号： A61K39/395 , C07K16/18 , C12N9/96 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , C12N1/19 , C12P21/00 , A61P35/00 , A61P13/08 , A61P9/10 , A61P17/02 , A61P35/04
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
摘要翻译：描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病，例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病，例如自身免疫包括多发性硬化的疾病。

9. 发明授权

US09163093B2 Anti-DLL4/VEGF dual variable domain immunoglobulin and uses thereof 有权
公开(公告)号：US09163093B2
公开(公告)日：2015-10-20
申请号：US14068976
申请日：2013-10-31
申请人： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
发明人： Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
IPC分类号： A61K39/395 , A61K39/40 , C07K16/46 , A61K45/06 , C07K16/22 , A61K31/513 , A61K31/7068 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/525 , C07K16/28 , C07K16/00 , A61K39/00
CPC分类号： C07K16/468 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/525 , A61K31/7068 , A61K39/395 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant DLL4 and/or VEGF expression or activity.

10. 发明授权

US09115195B2 Therapeutic DLL4 binding proteins 有权
标题翻译：治疗性DLL4结合蛋白
公开(公告)号：US09115195B2
公开(公告)日：2015-08-25
申请号：US13037932
申请日：2011-03-01
申请人： Ming-Jiu Chen , Chung-Ming Hsieh , Jijie Gu , Susan E. Morgan-Lappe , Yingchun Li
发明人： Ming-Jiu Chen , Chung-Ming Hsieh , Jijie Gu , Susan E. Morgan-Lappe , Yingchun Li
IPC分类号： C07K16/00 , C07K16/28
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.
摘要翻译：本文描述了DLL4结合蛋白，包括抗体，CDR-移植抗体，人源化抗体及其DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4和/或VEGF活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成。

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