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1. 发明授权

US09119961B2 Hadron treatment planning with adequate biological weighting 有权
公开(公告)号：US09119961B2
公开(公告)日：2015-09-01
申请号：US14539045
申请日：2014-11-12
申请人： Hampton University
发明人： Cynthia E. Keppel , Richard A. Britten , Vahagn R. Nazaryan
IPC分类号： A61N5/10 , A61N5/06
CPC分类号： A61N5/103 , A61N5/06 , A61N5/1031 , A61N2005/1087
摘要： Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.

2. 发明授权

US08829476B2 Hadron treatment planning with adequate biological weighting 有权
公开(公告)号：US08829476B2
公开(公告)日：2014-09-09
申请号：US14254301
申请日：2014-04-16
申请人： Hampton University
发明人： Cynthia E. Keppel , Richard A. Britten , Vahagn R. Nazaryan
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/06 , A61N5/1031 , A61N2005/1087
摘要： Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.

3. 发明授权

US08742377B2 Hadron treatment planning with adequate biological weighting 有权
公开(公告)号：US08742377B2
公开(公告)日：2014-06-03
申请号：US14133098
申请日：2013-12-18
申请人： Hampton University
发明人： Cynthia E. Keppel , Richard A. Britten , Vahagn R. Nazaryan
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/06 , A61N5/1031 , A61N2005/1087
摘要： Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.

4. 发明授权

US09028390B2 Apparatus and method for external beam radiation distribution mapping 有权
标题翻译：外部束辐射分布映射的装置和方法
公开(公告)号：US09028390B2
公开(公告)日：2015-05-12
申请号：US13945167
申请日：2013-07-18
申请人： Hampton University
发明人： Cynthia E. Keppel , Paul Gueye , Christopher Sinesi
IPC分类号： A61N5/00 , A61B6/00 , A61M25/10 , G01T1/164 , A61N5/10
CPC分类号： A61B6/425 , A61B6/4216 , A61M25/10 , A61M25/1011 , A61M2025/1013 , A61N5/10 , A61N5/1015 , A61N5/1027 , A61N5/1048 , A61N5/1071 , G01T1/1644 , G01T1/20 , G01T1/201 , G01T1/204 , G01T1/205
摘要： An apparatus and method for in vivo and ex vivo control, detection and measurement of radiation in therapy, diagnostics, and related applications accomplished through scintillating fiber detection. One example includes scintillating fibers placed along a delivery guide such as a catheter for measuring applied radiation levels during radiotherapy treatments, sensing locations of a radiation source, or providing feedback of sensed radiation. Another option is to place the fibers into a positioning device such as a balloon, or otherwise in the field of the radiation delivery. The scintillating fibers provide light output levels correlating to the levels of radiation striking the fibers and comparative measurement between fibers can be used for more extensive dose mapping. Adjustments to a radiation treatment may be made as needed based on actual and measured applied dosages as determined by the fiber detectors. Characteristics of a radiation source may also be measured using scintillating materials.
摘要翻译：用于体内和离体控制，检测和测量通过闪烁纤维检测实现的治疗，诊断和相关应用中的辐射的装置和方法。一个例子包括沿着诸如导管的输送引导件放置的闪烁纤维，用于在放射疗法治疗期间测量施加的辐射水平，感测辐射源的位置或提供感测辐射的反馈。另一种选择是将纤维放置在定位装置中，例如气球，或以其他方式放置在辐射传播领域。闪烁纤维提供与射入纤维的辐射水平相关的光输出水平，并且纤维之间的比较测量可用于更广泛的剂量映射。可以根据由纤维检测器确定的实际和测量的施用剂量根据需要进行放射治疗的调整。也可以使用闪烁材料来测量辐射源的特性。

5. 发明授权

US09351691B2 Apparatus and method for external beam radiation distribution mapping 有权
标题翻译：外部束辐射分布映射的装置和方法
公开(公告)号：US09351691B2
公开(公告)日：2016-05-31
申请号：US14686405
申请日：2015-04-14
申请人： Hampton University
发明人： Cynthia E. Keppel , Paul Gueye , Christopher Sinesi
IPC分类号： A61N5/00 , A61B6/00 , A61M25/10 , G01T1/164 , G01T1/20 , G01T1/204 , G01T1/205 , A61N5/10
CPC分类号： A61B6/425 , A61B6/4216 , A61M25/10 , A61M25/1011 , A61M2025/1013 , A61N5/10 , A61N5/1015 , A61N5/1027 , A61N5/1048 , A61N5/1071 , G01T1/1644 , G01T1/20 , G01T1/201 , G01T1/204 , G01T1/205
摘要： An apparatus and method for in vivo and ex vivo control, detection and measurement of radiation in therapy, diagnostcs, and related applications accomplished through scintillating fiber detection. One example includes scintillating fibers placed along a delivery guide such as a catheter for measuring applied radiation levels during radiotherapy treatments, sensing locations of a radiation source, or providing feedback of sensed radiation. Another option is to place the fibers into a positioning device such as a balloon, or otherwise in the field of the radiation delivery. The scintillating fibers provide light output levels correlating to the levels of radiation striking the fibers and comparative measurement between fibers can be used for more extensive dose mapping. Adjustments to a radiation treatment may be made as needed based on actual and measured applied dosages as determined by the fiber detectors. Characteristics of a radiation source may also be measured using scintillating materials.
摘要翻译：用于体内和离体控制，检测和测量治疗，诊断和通过闪烁纤维检测实现的相关应用中的辐射的装置和方法。一个例子包括沿着诸如导管的输送引导件放置的闪烁纤维，用于在放射疗法治疗期间测量施加的辐射水平，感测辐射源的位置或提供感测辐射的反馈。另一种选择是将纤维放置在定位装置中，例如气球，或以其他方式放置在辐射传播领域。闪烁纤维提供与射入纤维的辐射水平相关的光输出水平，并且纤维之间的比较测量可用于更广泛的剂量映射。可以根据由纤维检测器确定的实际和测量的施用剂量根据需要进行放射治疗的调整。也可以使用闪烁材料来测量辐射源的特性。

6. 发明授权

US09211422B2 Accelerated partial breast irradiation with shielded brachytherapy applicator system and method of use 有权
标题翻译：使用屏蔽近距离放射治疗系统加速局部乳房照射及其使用方法
公开(公告)号：US09211422B2
公开(公告)日：2015-12-15
申请号：US14254655
申请日：2014-04-16
申请人： Hampton University
发明人： Cynthia E. Keppel , Vahagn R. Nazaryan
IPC分类号： A61N5/00 , A61N5/10
CPC分类号： A61N5/1015 , A61N5/103 , A61N2005/1094
摘要： The system and methods of the invention partially shields the radiation dose to the skin and/or other anatomical organs by using magnetically responsive material that blocks radiation, which may be fine grains of iron or other ferrous powder for example. The powder is typically injected into an IB applicator, along with inflating saline solution in case of MSB, when a skin spacing problem is encountered, or there is a risk of high doses being delivered to the critical organs surrounding a lumpectomy cavity, for example. A slight magnetic field of predetermined configuration will be applied externally to arrange the shielding material internally under the segment of surface of the IB applicator where the skin spacing is typically less than 7 mm, thereby protecting the skin from radiation damage. Monte Carlo studies to develop parameterizations for treatment planning with the IB applicator utilizing the suggested shielding material is also provided.
摘要翻译：本发明的系统和方法通过使用阻挡辐射的磁响应材料来部分地屏蔽对皮肤和/或其它解剖器官的辐射剂量，其可以是例如铁或其它铁粉的细颗粒。通常，当遇到皮肤间隔问题时，通常将粉末连同IBA施加器一起注入，同时充气的盐水溶液在MSB的情况下，或者存在高剂量被递送至例如肿瘤切除腔周围的关键器官的风险。将外部施加预定构造的轻微磁场，以将屏蔽材料内部布置在IB施加器的表面的部分之下，其中皮肤间隔通常小于7mm，从而保护皮肤免受辐射损伤。还提供了蒙特卡罗研究，以利用建议的屏蔽材料，利用IB施加器开发用于治疗计划的参数化。

7. 发明授权

US08916842B2 Hadron treatment planning with adequate biological weighting 有权
公开(公告)号：US08916842B2
公开(公告)日：2014-12-23
申请号：US14446499
申请日：2014-07-30
申请人： Hampton University
发明人： Cynthia E. Keppel , Richard A. Britten , Vahagn R. Nazaryan
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/06 , A61N5/1031 , A61N2005/1087
摘要： Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.

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