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1. 发明授权

US5288898A N-methylphenylserine alkyl ester derivatives and uses thereof 失效
标题翻译： N-甲基苯基丝氨酸烷基酯衍生物及其用途
公开(公告)号：US5288898A
公开(公告)日：1994-02-22
申请号：US56619
申请日：1993-05-04
申请人： Hamao Umezawa , Toshiharu Nagatsu , Tomio Takeuchi , Hajime Morishima , Yoshio Sawasaki , Hiroshi Takezawa , Fujinori Sasaki
发明人： Hamao Umezawa , Toshiharu Nagatsu , Tomio Takeuchi , Hajime Morishima , Yoshio Sawasaki , Hiroshi Takezawa , Fujinori Sasaki
IPC分类号： A61K31/195 , C07C229/36 , A61K31/24
CPC分类号： A61K31/195
摘要： As new compounds are now provided N-methyl-3-(3,4-dihydroxyphenyl)serine alkyl esters which are effective as an .alpha.-adrenergic and .beta.-adrenergic agent to stimulate the .alpha.-adrenergic and .beta.-adrenergic functions of the central nervous system of mammalian animals and are expectable to be useful for therapeutic treatment of disorders as invoked by reduced biological activities or functions of the .alpha.- and/or .beta.-adrenergic neurons. N-methyl-L-threo-3-(3,4-dihydroxyphenyl)serine (C.sub.1 -C.sub.6) alkyl esters are preferred amongst the new compounds of this invention.
摘要翻译：由于新化合物现在提供作为（α） - 肾上腺素能和（β） - 肾上腺素能药物有效的N-甲基-3-（3,4-二羟基苯基）丝氨酸烷基酯，以刺激（α） - 肾上腺素能和（β ） - 哺乳动物中枢神经系统的肾上腺素能功能，并且预期可用于通过减少（α） - 和/或（β） - 肾上腺素能神经元的生物活性或功能引起的病症的治疗性治疗。 N-甲基-L-苏式-3-（3,4-二羟基苯基）丝氨酸（C1-C6）烷基酯在本发明的新化合物中是优选的。

2. 发明授权

US5173997A Tongue plate stopper 失效
标题翻译： TONGUE PLATE STOPPER
公开(公告)号：US5173997A
公开(公告)日：1992-12-29
申请号：US810131
申请日：1991-12-19
申请人： Hiroshi Takezawa , Ichiro Nakagawa , Masahiro Tanabe , Masanaga Tsuchikawa
发明人： Hiroshi Takezawa , Ichiro Nakagawa , Masahiro Tanabe , Masanaga Tsuchikawa
IPC分类号： A44B17/00 , B60R22/02 , B60R22/12
CPC分类号： B60R22/023 , B60R2022/021 , Y10T24/3651 , Y10T24/3685 , Y10T24/38
摘要： A tongue plate stopper has a first disc having its webbing side face formed with at least one needle to be inserted through a webbing; and a second disc having a fitting portion for fitting the needle therein. At least one of the first and second discs has its webbing side face formed with a plurality of pins for biting into the webbing. The needle of the first disc projects from the central portion thereof. The fitting portion of the second disc has a hole. The pins include a first set of pins projecting from the circumferential edge of the back face thereof and at a circumferential spacing from one another, and a second set of pins projecting from the middle portion between the needle and the circumferential edge and at a circumferential spacing from one another. The second disc has its webbing side face formed with a first circumferential groove, which extends in the circumferential direction at a radius substantially equal to that of the first set of pins, and a second circumferential groove which extend in the circumferential direction at a radius substantially equal to that of the second set of pins, so that the first set of pins can have their tips engaging with the first circumferential groove whereas the second set of pins can have their tips engaging with the second circumferential groove.
摘要翻译：舌板止动器具有第一盘，其第一盘的带状侧面形成有至少一个针穿过织带插入; 以及具有用于将针安装在其中的装配部分的第二盘。第一和第二盘中的至少一个具有其带状侧面形成有用于咬入织带的多个销。第一盘的针从其中心部突出。第二盘的装配部分具有孔。销包括从其背面的周缘突出并且彼此以圆周间隔突出的第一组销，以及第二组销，其从针和周缘之间的中间部分突出并且周向间隔从彼此。第二盘的带状侧面形成有第一周向槽，该第一周向槽沿圆周方向以与第一组销的大致相等的半径延伸;第二周向槽，其沿圆周方向以大体上的半径等于第二组销的第一组，使得第一组销可以使其尖端与第一周向槽接合，而第二组销可以使其尖端与第二周向槽啮合。

3. 发明授权

US5136817A Automatic lapping apparatus for piezoelectric materials 失效
标题翻译：压电材料自动研磨装置
公开(公告)号：US5136817A
公开(公告)日：1992-08-11
申请号：US662444
申请日：1991-02-28
申请人： Makoto Tabata , Hiroshi Takezawa
发明人： Makoto Tabata , Hiroshi Takezawa
IPC分类号： B24B37/013 , B24B49/04
CPC分类号： B24B37/013 , B24B49/04
摘要： An automatic lapping apparatus for lapping a piezoelectric material has upper and lower lapping plates, and a carrier disposed between the plates, for holding a piezoelectric material so that it is sandwiched between the plates. The carrier is rotatable to lap the piezoelectric material parallel to the lapping surfaces of the plates while supplying a lapping slurry therebetween. The apparatus also includes a sweep oscillator for applying a sweep signal corresponding to the count of a counter, through an AGC amplifier and a resistor to an electrode supported by one of the plates, a comparing circuit for determining whether the quartz crystal wafer is present underneath the electrode based on the level of the sweep signal applied to the electrode, a memory for storing output data from the comparing circuit at an address corresponding to the count, a dip detector for detecting a dip in the signal applied to the electrode and stopping operation of the counter, a frequency detector for reading the frequency from the sweep oscillator when the dip is detected and the presence of the piezoelectric material underneath the electrode is detected, a frequency determining circuit for determining whether the read frequency is a true resonant frequency of the quartz crystal wafer, a frequency comparator for determining that lapping is completed when the true resonant frequency falls within a predetermined target frequency, and an drive unit control circuit for stopping the carrier when the lapping is completed.
摘要翻译：用于研磨压电材料的自动研磨装置具有上下研磨板和设置在板之间的载体，用于保持压电材料以使其夹在板之间。载体可旋转，以在平行于板的研磨表面的同时搭接压电材料，同时在其间提供研磨浆料。该装置还包括扫频振荡器，用于通过AGC放大器和电阻器将对应于计数器的计数的扫描信号施加到由一个板支撑的电极，用于确定石英晶片是否存在于下面的比较电路基于施加到电极的扫描信号的电平的电极，用于在对应于计数的地址存储来自比较电路的输出数据的存储器，用于检测施加到电极的信号的下降的停止检测器和停止操作所述频率检测器，当检测到所述浸渍时，从所述扫描振荡器读取频率，并且检测到所述电极下方的所述压电材料的存在;频率确定电路，用于确定所述读取频率是否为真实谐振频率石英晶体晶片，用于确定正确谐振频率时完成研磨的频率比较器 cy落在预定目标频率内，以及驱动单元控制电路，用于在研磨完成时停止载体。

4. 外观设计

USD463347S1 Wheel cap 失效
公开(公告)号：USD463347S1
公开(公告)日：2002-09-24
申请号：US29137963
申请日：2001-03-05
申请人： Hiroshi Takezawa
设计人： Hiroshi Takezawa

5. 发明授权

US5234946A Substituted alkylamine derivatives 失效
标题翻译：取代的烷基胺衍生物
公开(公告)号：US5234946A
公开(公告)日：1993-08-10
申请号：US753611
申请日：1991-08-30
申请人： Hiroshi Takezawa , Masahiro Hayashi , Yoshikazu Iwasawa , Masaaki Hosoi , Yoshiaki Iida , Yoshimi Tsuchiya , Masahiro Horie , Toshio Kamei
发明人： Hiroshi Takezawa , Masahiro Hayashi , Yoshikazu Iwasawa , Masaaki Hosoi , Yoshiaki Iida , Yoshimi Tsuchiya , Masahiro Horie , Toshio Kamei
IPC分类号： C07C211/27 , C07C211/30 , C07C211/46 , C07C211/49 , C07C217/48 , C07C217/58 , C07C233/20 , C07C237/40 , C07C255/54 , C07C323/32 , C07D207/08 , C07D207/32 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/38 , C07D213/64 , C07D215/14 , C07D231/12 , C07D239/26 , C07D261/08 , C07D263/32 , C07D271/10 , C07D275/02 , C07D277/24 , C07D277/28 , C07D307/42 , C07D307/68 , C07D307/80 , C07D333/16 , C07D333/18 , C07D333/20 , C07D335/02 , C07D409/10 , C07D413/04 , C07D413/10 , C07D417/04 , C07D521/00
CPC分类号： C07D207/08 , C07C211/27 , C07C211/30 , C07C211/46 , C07C211/49 , C07C217/48 , C07C217/58 , C07C233/20 , C07C237/40 , C07C255/54 , C07C323/32 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/38 , C07D213/64 , C07D215/14 , C07D231/12 , C07D233/56 , C07D239/26 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/10 , C07D275/02 , C07D277/24 , C07D277/28 , C07D307/42 , C07D307/68 , C07D307/80 , C07D333/16 , C07D333/18 , C07D333/20 , C07D335/02 , C07D409/10 , C07D413/04 , C07D413/10 , C07D417/04 , Y10S514/824
摘要： The substituted alkylamine derivatives represented by formula (I) ##STR1## wherein R.sup.1 represents (a) substituted or unsubstituted C.sub.2-6 alkenyl group, (b) substituted or unsubstituted C.sub.3-6 cycloalkenyl group, (c) substituted or unsubstituted C.sub.2-6 alkynyl group, (d) substituted or unsubstituted aryl group, (e) substituted or unsubstituted heterocyclic group, (f) fused heterocyclic group which may be substituted, or (g) group represented by the formula Ru.sup.11 -Ar wherein R.sup.11 is a heterocyclic group and Ar is a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and which may be substituted; ##STR2## represents a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and may be substituted by R.sup.7,X and Y are linking groups,R.sup.2 is H or lower alkyl,R.sup.3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower cycloalkyl,R.sup.4 and R.sup.5 are independently hydrogen or halogen atoms,R.sup.6 represents (a) substituted or unsubstituted acyclic hydrocarbon group which may be unsaturated, (b) substituted or unsubstituted cycloalkyl group, or (c) substituted or unsubstituted phenyl group, or non-toxic salts thereof. (E)-N-(6-6-dimethyl-2-hepten-4-ynyl)-N-ethyl-3-[4-(3-thienyl)-2-thienyl-methyloxy]benzylamine hydrochloride is a representative example. The substituted alkylamine derivatives are useful as pharmaceuticals, particularly for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.
摘要翻译：由式（I）表示的取代烷基胺衍生物其中R 1表示（a）取代或未取代的C 2-6烯基，（b）取代或未取代的C 3-6环烯基，（c）取代或未取代的C 2 -6炔基，（d）取代或未取代的芳基，（e）取代或未取代的杂环基，（f）可被取代的稠合杂环基，或（g）由式Ru11-Ar表示的基团，其中R11为杂环基和Ar是可以含有杂原子N，O或S原子并且可以被取代的5或6元芳环; 表示可含有杂原子N，O或S原子的5或6元芳环，可被R 7取代，X和Y为连接基团，R 2为H或低级烷基，R 3为氢，低级烷基，低级烯基，低级炔基或低级环烷基，R4和R5独立地是氢或卤素原子，R6表示（a）可以是不饱和的取代或未取代的无环烃基，（b）取代或未取代的环烷基，或（c ）取代或未取代的苯基，或其无毒盐。（E）-N-（6-6-二甲基-2-庚烯-4-炔基）-N-乙基-3- [4-（3-噻吩基）-2-噻吩-1-甲氧基]苄胺盐酸盐是一个代表性的例子。取代的烷基胺衍生物可用作药物，特别是用于治疗和预防高胆固醇血症，高脂血症和动脉硬化。