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1. 发明授权

US07316817B2 Method and device for topical delivery of therapeutic agents to the skin 有权
标题翻译：将治疗剂局部递送至皮肤的方法和装置
公开(公告)号：US07316817B2
公开(公告)日：2008-01-08
申请号：US10751189
申请日：2004-01-02
申请人： Haitham Matloub , Wilfred Lynch
发明人： Haitham Matloub , Wilfred Lynch
IPC分类号： A61F13/00 , A61K9/70 , A61L15/16
CPC分类号： A61K8/0208 , A61K9/7023 , A61Q19/00
摘要： A composite sheet for delivering therapeutic agents to the skin and method of use is disclosed. The composite sheet comprises a flexible porous polymer for holding and releasing the therapeutic agent in a polymer enrobing material. Micro-channels pass through the polymer enrobing material and flexible porous polymer to promote the release of the therapeutic agent. The composite sheet is capable of releasing the therapeutic agent for periods of up to about 14 to about 30 days.
摘要翻译：公开了一种用于将治疗剂递送至皮肤的复合片材和使用方法。复合片材包括用于在聚合物包被材料中保持和释放治疗剂的柔性多孔聚合物。微通道穿过聚合物引入材料和柔性多孔聚合物以促进治疗剂的释放。复合片材能够释放长达约14至约30天的治疗剂。

2. 发明申请

US20050147654A1 Method and device for topical delivery of therapeutic agents to the skin 有权
标题翻译：将治疗剂局部递送至皮肤的方法和装置
公开(公告)号：US20050147654A1
公开(公告)日：2005-07-07
申请号：US10751189
申请日：2004-01-02
申请人： Haitham Matloub , Wilfred Lynch
发明人： Haitham Matloub , Wilfred Lynch
IPC分类号： A61K8/02 , A61K9/70 , A61Q19/00
CPC分类号： A61K8/0208 , A61K9/7023 , A61Q19/00
摘要： A composite sheet for delivering therapeutic agents to the skin and method of use is disclosed. The composite sheet comprises a flexible porous polymer for holding and releasing the therapeutic agent in a polymer enrobing material. Micro-channels pass through the polymer enrobing material and flexible porous polymer to promote the release of the therapeutic agent. The composite sheet is capable of releasing the therapeutic agent for periods of up to about 14 to about 30 days.
摘要翻译：公开了一种用于将治疗剂递送至皮肤的复合片材和使用方法。复合片材包括用于在聚合物包被材料中保持和释放治疗剂的柔性多孔聚合物。微通道穿过聚合物引入材料和柔性多孔聚合物以促进治疗剂的释放。复合片材能够释放长达约14至约30天的治疗剂。

3. 发明授权

US08591940B2 Method of treating scar tissue 有权
标题翻译：治疗瘢痕组织的方法
公开(公告)号：US08591940B2
公开(公告)日：2013-11-26
申请号：US11961476
申请日：2007-12-20
申请人： Haitham Matloub , Wilfred Lynch
发明人： Haitham Matloub , Wilfred Lynch
IPC分类号： A61F13/00 , A61K9/70 , A61F13/02 , A61L15/16 , A61L15/00
CPC分类号： A61K8/0208 , A61K8/11 , A61K8/14 , A61K8/494 , A61K8/63 , A61K8/64 , A61K8/671 , A61K8/673 , A61K8/676 , A61K8/678 , A61K8/922 , A61K8/97 , A61K9/703 , A61K2800/522 , A61Q19/00 , A61Q19/08
摘要： A method of treating scar tissue by applying a composite sheet for delivering therapeutic agents to the skin is disclosed. The composite sheet comprises a flexible porous polymer for holding and releasing the therapeutic agent in a polymer enrobing material. Microchannels pass through the polymer enrobing material and flexible porous polymer to promote the release of the therapeutic agent. The composite sheet is capable of releasing the therapeutic agent for periods of about 0 to about 30 days.
摘要翻译：公开了通过施加用于将治疗剂递送至皮肤的复合片来治疗瘢痕组织的方法。复合片材包括用于在聚合物包被材料中保持和释放治疗剂的柔性多孔聚合物。微通道穿过聚合物引入材料和柔性多孔聚合物以促进治疗剂的释放。复合片材能够释放约0至约30天的治疗剂。

4. 发明申请

US20080241230A1 Method of Treating Scar Tissue 有权
标题翻译：治疗瘢痕组织的方法
公开(公告)号：US20080241230A1
公开(公告)日：2008-10-02
申请号：US11961476
申请日：2007-12-20
申请人： Haitham Matloub , Wilfred Lynch
发明人： Haitham Matloub , Wilfred Lynch
IPC分类号： A61K9/70 , A61P17/02
CPC分类号： A61K8/0208 , A61K8/11 , A61K8/14 , A61K8/494 , A61K8/63 , A61K8/64 , A61K8/671 , A61K8/673 , A61K8/676 , A61K8/678 , A61K8/922 , A61K8/97 , A61K9/703 , A61K2800/522 , A61Q19/00 , A61Q19/08
摘要： A method of treating scar tissue by applying a composite sheet for delivering therapeutic agents to the skin is disclosed. The composite sheet comprises a flexible porous polymer for holding and releasing the therapeutic agent in a polymer enrobing material. Microchannels pass through the polymer enrobing material and flexible porous polymer to promote the release of the therapeutic agent. The composite sheet is capable of releasing the therapeutic agent for periods of about 0 to about 30 days.
摘要翻译：公开了通过施加用于将治疗剂递送至皮肤的复合片来治疗瘢痕组织的方法。复合片材包括用于在聚合物包被材料中保持和释放治疗剂的柔性多孔聚合物。微通道穿过聚合物引入材料和柔性多孔聚合物以促进治疗剂的释放。复合片材能够释放约0至约30天的治疗剂。

5. 发明申请

US20080219642A1 Collapsible Fluid Containment Device With Semi-Rigid Support Members 有权
标题翻译：具有半刚性支撑构件的可折叠流体封闭装置
公开(公告)号：US20080219642A1
公开(公告)日：2008-09-11
申请号：US11684509
申请日：2007-03-09
申请人： Haitham Matloub , Brenda Matloub , Philip Narini
发明人： Haitham Matloub , Brenda Matloub , Philip Narini
IPC分类号： H04N7/00
CPC分类号： A61F13/00038 , A61F13/00068 , A61F2013/00174 , A61F2013/00297 , A61F2013/00412 , A61F2013/00536 , A61F2013/0054 , A61M1/008 , A61M3/0287
摘要： A collapsible fluid containment bag for irrigating and cleaning wounds on extremities having semi-rigid support members and an elevated lower support member attached to the bottom of the proximal end of the containment bag creating a gradient for allowing irrigation fluids and biological tissue to drain to the distal end of the bag for removal. The containment bag is collapsible, making it a convenient size for storage, transport, and disposal.
摘要翻译：一种用于在具有半刚性支撑构件的四肢上冲洗和清洁伤口的可折叠流体容纳袋，以及附接到容纳袋近端底部的升高的下部支撑构件，形成梯度，以使冲洗流体和生物组织排出到袋的远端用于去除。安全壳可折叠，使其成为存储，运输和处置的便利尺寸。

6. 发明授权

US10016584B1 Multilayered device for controlled topical delivery of therapeutic agents to the skin 有权
公开(公告)号：US10016584B1
公开(公告)日：2018-07-10
申请号：US14970173
申请日：2015-12-15
申请人： Haitham Matloub
发明人： Haitham Matloub
IPC分类号： A61M35/00 , A61L26/00
CPC分类号： A61M35/00 , A61K8/0208 , A61K9/703 , A61L26/0066 , A61L26/0085 , A61L26/0095 , A61L2430/34 , A61Q19/00
摘要： A multilayered composite sheet for delivering one or more therapeutic agents to the skin is disclosed. The composite sheet comprises a flexible porous polymer with open cells of a sufficient size for holding a therapeutic agent, an encapsulating agent for encapsulating the flexible porous polymer and therapeutic agent, and an enrobing agent for enrobing the encapsulated flexible porous polymer and therapeutic agent. Additional layers of the flexible porous polymer, therapeutic agent and other materials are added to the first layer which is in contact with the skin. The first layer has particular particle sizes for the flexible porous polymer, open cell size, and therapeutic agent allowing for relatively quick delivery of the therapeutic agent to the skin. Each successive layer placed on top of the first layer has incrementally larger particle sizes of the flexible porous polymer and therapeutic agent providing successively longer delivery times than the first layer.

7. 发明申请

US20050186260A1 Medicated gel foam and method of use 审中-公开
标题翻译：药用凝胶泡沫及其使用方法
公开(公告)号：US20050186260A1
公开(公告)日：2005-08-25
申请号：US10782553
申请日：2004-02-19
申请人： Philip Narini , Brenda Matloub , Haitham Matloub
发明人： Philip Narini , Brenda Matloub , Haitham Matloub
IPC分类号： A61K38/18 , A61L15/16 , A61L15/42 , A61L15/44
CPC分类号： A61L15/44 , A61L15/425 , A61L2300/254 , A61L2300/30 , A61L2300/404 , A61L2300/414 , A61L2300/428 , A61L2300/606
摘要： A method and improved foam structure for use in vacuum assisted closure therapy comprising an open cell foam structure coated with a therapeutic agent.
摘要翻译：一种用于真空辅助闭合治疗的方法和改进的泡沫结构，其包括用治疗剂涂覆的开孔泡沫结构。

8. 发明授权

US07678092B2 Collapsible fluid containment device with semi-rigid support members 有权
标题翻译：具有半刚性支撑构件的可折叠流体容纳装置
公开(公告)号：US07678092B2
公开(公告)日：2010-03-16
申请号：US11684509
申请日：2007-03-09
申请人： Haitham Matloub , Brenda Matloub , Philip Narini
发明人： Haitham Matloub , Brenda Matloub , Philip Narini
IPC分类号： A61F5/44 , A61B19/00 , A61B19/08 , A61M1/00
CPC分类号： A61F13/00038 , A61F13/00068 , A61F2013/00174 , A61F2013/00297 , A61F2013/00412 , A61F2013/00536 , A61F2013/0054 , A61M1/008 , A61M3/0287
摘要： A collapsible fluid containment bag for irrigating and cleaning wounds on extremities having semi-rigid support members and an elevated lower support member attached to the bottom of the proximal end of the containment bag creating a gradient for allowing irrigation fluids and biological tissue to drain to the distal end of the bag for removal. The containment bag is collapsible, making it a convenient size for storage, transport, and disposal.
摘要翻译：一种用于在具有半刚性支撑构件的四肢上冲洗和清洁伤口的可折叠流体容纳袋，以及附接到容纳袋近端底部的升高的下部支撑构件，形成梯度，以使冲洗流体和生物组织排出到袋的远端用于去除。安全壳可折叠，使其成为存储，运输和处置的便利尺寸。

9. 发明申请

US20080131493A1 Method and Multilayered Device for Controlled Topical Delivery of Therapeutic Agents to the Skin 审中-公开
标题翻译：用于皮肤控制局部递送治疗剂的方法和多层装置
公开(公告)号：US20080131493A1
公开(公告)日：2008-06-05
申请号：US11965904
申请日：2007-12-28
申请人： Haitham Matloub
发明人： Haitham Matloub
IPC分类号： A61K9/70 , A61K47/32
CPC分类号： A61M35/00 , A61K8/0208 , A61K9/703 , A61L26/0066 , A61L26/0085 , A61L26/0095 , A61L2430/34 , A61Q19/00
摘要： A multilayered composite sheet for delivering one or more therapeutic agents to the skin is disclosed. The composite sheet comprises a flexible porous polymer with open cells of a sufficient size for holding a therapeutic agent, an encapsulating agent for encapsulating the flexible porous polymer and therapeutic agent, and an enrobing agent for enrobing the encapsulated flexible porous polymer and therapeutic agent. Additional layers of the flexible porous polymer, therapeutic agent and other materials are added to the first layer which is in contact with the skin. The first layer has particular particle sizes for the flexible porous polymer, open cell size, and therapeutic agent allowing for relatively quick delivery of the therapeutic agent to the skin. Each successive layer placed on top of the first layer has incrementally larger particle sizes of the flexible porous polymer and therapeutic agent providing successively longer delivery times than the first layer.
摘要翻译：公开了一种用于将一种或多种治疗剂递送至皮肤的多层复合片材。复合片材包括具有足够尺寸的开放细胞的柔性多孔聚合物，用于保持治疗剂，用于包封柔性多孔聚合物和治疗剂的包封剂，以及用于包封柔性多孔聚合物和治疗剂的包衣剂。将柔性多孔聚合物，治疗剂和其它材料的附加层加入到与皮肤接触的第一层中。第一层具有用于柔性多孔聚合物，开孔尺寸和治疗剂的特定颗粒尺寸，允许将治疗剂相对快速地递送至皮肤。放置在第一层顶部的每个连续层具有递增更大的柔性多孔聚合物和治疗剂的粒度，其提供比第一层相继更长的递送时间。

10. 发明授权

US07235066B1 Fluid containment device 有权
标题翻译：流体容纳装置
公开(公告)号：US07235066B1
公开(公告)日：2007-06-26
申请号：US10750477
申请日：2003-12-31
申请人： Philip P. Narini , Brenda Matloub , Haitham Matloub
发明人： Philip P. Narini , Brenda Matloub , Haitham Matloub
IPC分类号： A61B19/12 , A61M35/00 , A61G10/00
CPC分类号： A61H35/00 , A61B46/20 , A61B46/27 , A61B90/05 , A61B2017/00557 , A61B2046/201 , A61H2201/0103 , A61H2201/0161
摘要： A wound irrigation/fluid containment system having a flexible bag body defining a containment space, the bag body including walls and at least one opening with a seal, means for accessing through the bag body walls to the containment space and means for inflating portions of the walls to provide rigidity and strength to the walls. The containment device isolates a wound on a person and is capable of draining fluids away from the wound.
摘要翻译：一种伤口冲洗/流体容纳系统，其具有限定容纳空间的柔性袋体，所述袋体包括壁和具有密封件的至少一个开口，用于通过所述袋体壁进入所述容纳空间的装置和用于使所述容器的部分膨胀的装置墙壁为墙壁提供刚性和强度。容纳装置将伤口隔离在人身上并能够将流体从伤口排出。

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