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1. 发明授权

US07501073B2 Methods for producing metallic implants having roughened surfaces 失效
标题翻译：生产具有粗糙表面的金属植入物的方法
公开(公告)号：US07501073B2
公开(公告)日：2009-03-10
申请号：US10770157
申请日：2004-02-02
申请人： Hai Bo Wen , Panjian Li , Todd Smith
发明人： Hai Bo Wen , Panjian Li , Todd Smith
IPC分类号： B44C1/22 , C03C15/00 , C03C25/68 , C23F1/00 , C25F3/00
CPC分类号： C23F1/26 , A61F2/30767 , A61F2/3094 , A61F2002/30769 , A61F2002/30925 , A61F2002/30968 , A61F2002/3097 , A61F2002/3098 , A61F2002/30986 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00407 , A61F2310/00598 , A61F2310/00796 , A61F2310/00928 , A61F2310/00976 , A61L27/04 , A61L27/50 , A61L2400/18 , B22F3/1134 , B22F2999/00 , B22F7/004 , B22F9/16
摘要： The invention provides a method of providing a metallic orthopaedic implant with a micron or nanometer-scale surface roughness to facilitate acceptance of tissue and bone growth or apposition after implantation while maintaining the structural integrity of the orthopaedic implant. The invention also provides a metallic orthopaedic implant comprising a metallic body and metallic elements adhered to a portion of the surface of the metallic body to define a three-dimensional porous surface geometry, wherein at least some of the metallic elements have a micron or nanometer-scale surface roughness.
摘要翻译：本发明提供了一种提供具有微米或纳米级表面粗糙度的金属整形外科植入物的方法，以便于在植入之后接受组织和骨生长或并置，同时保持矫形植入物的结构完整性。本发明还提供一种金属矫形植入物，其包括金属体和附着到金属体表面的一部分上的金属元素，以限定三维多孔表面几何形状，其中至少一些金属元素具有微米或纳米级，表面粗糙度。

2. 发明授权

US07087086B2 Biological agent-containing ceramic coating and method 有权
标题翻译：含生物剂的陶瓷涂层及方法
公开(公告)号：US07087086B2
公开(公告)日：2006-08-08
申请号：US10355827
申请日：2003-01-31
申请人： Panjian Li , Hai Bo Wen , Elizabeth A. Hippensteel
发明人： Panjian Li , Hai Bo Wen , Elizabeth A. Hippensteel
IPC分类号： A61F2/28
CPC分类号： A61L27/32 , A61L27/54 , A61L2300/252 , A61L2300/406 , A61L2300/414 , A61L2300/606
摘要： The invention provides an implantable article, a method of preparing the same, and methods of modifying a ceramic-coated implantable article. The implantable article comprises a biocompatible substrate and a bioactive ceramic surface coating into which a biological agent is incorporated. The preparation and modification of an implantable article involve incubating a biocompatible substrate surface or pre-existing ceramic coating thereon with a composition comprising (i) a biological agent, (ii) calcium ions, (iii) phosphate ions, and (iv) a liquid carrier.
摘要翻译：本发明提供了可植入制品，其制备方法以及改性陶瓷涂覆的可植入制品的方法。可植入制品包括生物相容性底物和生物活性陶瓷表面涂层，生物制剂掺入其中。可植入制品的制备和修饰包括将生物相容性底物表面或预先存在的陶瓷涂层与其组合物一起孵育，所述组合物包含（i）生物剂，（ii）钙离子，（iii）磷酸根离子和（iv）液体载体

3. 发明申请

US20120121660A1 BONE VOID FILLERS 有权
标题翻译：骨无孔填料
公开(公告)号：US20120121660A1
公开(公告)日：2012-05-17
申请号：US13297005
申请日：2011-11-15
申请人： Rama Akella , Ian Ross Garrett , Hai Bo Wen , Shuliang Li , Dean M. Acker , Nichole Wilhelm
发明人： Rama Akella , Ian Ross Garrett , Hai Bo Wen , Shuliang Li , Dean M. Acker , Nichole Wilhelm
IPC分类号： A61K35/32 , A61K9/00 , A61P19/00
CPC分类号： A61L27/3608 , A61L24/0063 , A61L24/0084 , A61L27/46 , A61L2300/414 , A61L2430/02 , C08L89/06
摘要： A bone void filler composition is described containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier component that contains a collagenous material. The bone void filler composition may be in the form of a sponge or in the form of a paste or putty used to form a sponge or is obtained from particulated sponge, or that forms after a sponge is rehydrated. A pre-mixed bone void filler composition is described containing the acidic mineral component or the lower alkyl carboxylate source; the osteoinductive component; and a biologically acceptable carrier component that contains a liquid carrier. Methods of making and using the compositions are also described. The ratio of demineralized bone component to acidic mineral component may range from about 0.5:1 to about 80:1.
摘要翻译：描述了一种骨空隙填充剂组合物，其含有含有钙源和磷酸盐源或羧酸低级烷基酯源的酸性矿物组分; 含有脱矿质骨的骨诱导成分; 以及包含胶原材料的三维，骨传导的生物学上可接受的载体组分。骨空隙填充剂组合物可以是海绵的形式或用于形成海绵的糊状或油灰形式，或者由颗粒状海绵获得，或者在海绵再水合后形成。描述了含有酸性矿物组分或羧酸低级烷基酯源的预混合骨空隙填料组合物; 骨诱导成分; 和含有液体载体的生物可接受的载体组分。还描述了制备和使用组合物的方法。软化骨组分与酸性矿物组分的比例可以在约0.5:1至约80:1的范围内。

4. 发明授权

US08613938B2 Bone void fillers 有权
标题翻译：骨缺失填料
公开(公告)号：US08613938B2
公开(公告)日：2013-12-24
申请号：US13297005
申请日：2011-11-15
申请人： Rama Akella , Ian Ross Garrett , Hai Bo Wen , Shuliang Li , Dean M. Acker , Nichole Wilhelm
发明人： Rama Akella , Ian Ross Garrett , Hai Bo Wen , Shuliang Li , Dean M. Acker , Nichole Wilhelm
IPC分类号： A61K9/00 , A61K35/32
CPC分类号： A61L27/3608 , A61L24/0063 , A61L24/0084 , A61L27/46 , A61L2300/414 , A61L2430/02 , C08L89/06
摘要： A bone void filler composition is described containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier component that contains a collagenous material. The bone void filler composition may be in the form of a sponge or in the form of a paste or putty used to form a sponge or is obtained from particulated sponge, or that forms after a sponge is rehydrated. A pre-mixed bone void filler composition is described containing the acidic mineral component or the lower alkyl carboxylate source; the osteoinductive component; and a biologically acceptable carrier component that contains a liquid carrier. Methods of making and using the compositions are also described. The ratio of demineralized bone component to acidic mineral component may range from about 0.5:1 to about 80:1.
摘要翻译：描述了一种骨空隙填充剂组合物，其含有含有钙源和磷酸盐源或羧酸低级烷基酯源的酸性矿物组分; 含有脱矿质骨的骨诱导成分; 以及包含胶原材料的三维，骨传导的生物学上可接受的载体组分。骨空隙填充剂组合物可以是海绵的形式或用于形成海绵的糊状或油灰形式，或者由颗粒状海绵获得，或者在海绵再水合后形成。描述了含有酸性矿物组分或羧酸低级烷基酯源的预混合骨空隙填料组合物; 骨诱导成分; 和含有液体载体的生物可接受的载体组分。还描述了制备和使用组合物的方法。软化骨组分与酸性矿物组分的比例可以在约0.5:1至约80:1的范围内。

5. 发明授权

US08545625B2 Materials for dental and biomedical application 有权
标题翻译：牙科和生物医学应用材料
公开(公告)号：US08545625B2
公开(公告)日：2013-10-01
申请号：US11518984
申请日：2006-09-12
申请人： Hai Bo Wen , Janet Moradian-Oldak
发明人： Hai Bo Wen , Janet Moradian-Oldak
IPC分类号： C30B7/00 , A61F13/00
CPC分类号： A61L27/12 , A61L27/06 , A61L27/227 , C30B7/005
摘要： The invention provides novel dental enamel inspired materials for biomedical and dental applications. The materials are apatite-like calcium phosphate complexes and may comprise apatite, octacalcium phosphate crystals, or mixtures thereof. In one embodiment, the materials (calcium phosphate coatings) are mixtures of crystals of apatite and its precursor, octacalcium phosphate, nucleated on a titanium surface. They are prepared using a chemical process leading to the formation of biological apatite which is similar to that found in natural bone and teeth. In one embodiment, the materials are prepared by placing a titanium substrate in a supersaturated calcifying solution containing native or purified recombinant amelogenins. The presence of the amelogenins modulates apatite crystal growth to mimic in vivo apatite crystal formation. Applications for the materials include, without limitation, dental tissue (enamel, dentin, cementum) replacement, orthopeadic implants for bone repair, and coatings for improving the biocompatibility and bone regeneration capability of currently available implants or medical devices made of metallic, polymeric, ceramic or composite materials.
摘要翻译：本发明提供用于生物医学和牙科应用的新颖的牙科搪瓷启发材料。这些材料是磷灰石样磷酸钙复合物，并且可以包含磷灰石，磷酸二钙晶体或其混合物。在一个实施方案中，材料（磷酸钙涂层）是磷灰石及其前体的晶体的混合物，磷酸二钙，在钛表面成核。它们使用化学过程制备，导致形成生物磷灰石，其类似于在天然骨骼和牙齿中发现的生物磷灰石。在一个实施方案中，通过将钛底物置于含有天然或纯化的重组朊蛋白原的过饱和钙化溶液中来制备材料。斑log素的存在调节磷灰石晶体生长以模拟体内磷灰石晶体形成。材料的应用包括但不限于牙科组织（牙釉质，牙本质，牙骨质）替代物，用于骨修复的矫形植入物，以及用于改善目前可用的植入物或由金属，聚合物，陶瓷制成的医疗装置的生物相容性和骨再生能力的涂层或复合材料。

6. 发明授权

US07132015B2 Materials for dental and biomedical application 有权
公开(公告)号：US07132015B2
公开(公告)日：2006-11-07
申请号：US10371678
申请日：2003-02-20
申请人： Hai Bo Wen , Janet Moradian-Oldak
发明人： Hai Bo Wen , Janet Moradian-Oldak
IPC分类号： C30B7/00
CPC分类号： A61L27/12 , A61L27/06 , A61L27/227 , C30B7/005
摘要： The invention provides novel dental enamel inspired materials for biomedical and dental applications. The materials are apatite-like calcium phosphate complexes and may comprise apatite, octacalcium phosphate crystals, or mixtures thereof. In one embodiment, the materials (calcium phosphate coatings) are mixtures of crystals of apatite and its precursor, octacalcium phosphate, nucleated on a titanium surface. They are prepared using a chemical process leading to the formation of biological apatite which is similar to that found in natural bone and teeth. In one embodiment, the materials are prepared by placing a titanium substrate in a supersaturated calcifying solution containing native or purified recombinant amelogenins. The presence of the amelogenins modulates apatite crystal growth to mimic in vivo apatite crystal formation. Applications for the materials include, without limitation, dental tissue (enamel, dentin, cementum) replacement, orthopeadic implants for bone repair, and coatings for improving the biocompatibility and bone regeneration capability of currently available implants or medical devices made of metallic, polymeric, ceramic or composite materials.

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