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1. 发明授权

US08613938B2 Bone void fillers 有权
标题翻译：骨缺失填料
公开(公告)号：US08613938B2
公开(公告)日：2013-12-24
申请号：US13297005
申请日：2011-11-15
申请人： Rama Akella , Ian Ross Garrett , Hai Bo Wen , Shuliang Li , Dean M. Acker , Nichole Wilhelm
发明人： Rama Akella , Ian Ross Garrett , Hai Bo Wen , Shuliang Li , Dean M. Acker , Nichole Wilhelm
IPC分类号： A61K9/00 , A61K35/32
CPC分类号： A61L27/3608 , A61L24/0063 , A61L24/0084 , A61L27/46 , A61L2300/414 , A61L2430/02 , C08L89/06
摘要： A bone void filler composition is described containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier component that contains a collagenous material. The bone void filler composition may be in the form of a sponge or in the form of a paste or putty used to form a sponge or is obtained from particulated sponge, or that forms after a sponge is rehydrated. A pre-mixed bone void filler composition is described containing the acidic mineral component or the lower alkyl carboxylate source; the osteoinductive component; and a biologically acceptable carrier component that contains a liquid carrier. Methods of making and using the compositions are also described. The ratio of demineralized bone component to acidic mineral component may range from about 0.5:1 to about 80:1.
摘要翻译：描述了一种骨空隙填充剂组合物，其含有含有钙源和磷酸盐源或羧酸低级烷基酯源的酸性矿物组分; 含有脱矿质骨的骨诱导成分; 以及包含胶原材料的三维，骨传导的生物学上可接受的载体组分。骨空隙填充剂组合物可以是海绵的形式或用于形成海绵的糊状或油灰形式，或者由颗粒状海绵获得，或者在海绵再水合后形成。描述了含有酸性矿物组分或羧酸低级烷基酯源的预混合骨空隙填料组合物; 骨诱导成分; 和含有液体载体的生物可接受的载体组分。还描述了制备和使用组合物的方法。软化骨组分与酸性矿物组分的比例可以在约0.5:1至约80:1的范围内。

2. 发明申请

US20120121660A1 BONE VOID FILLERS 有权
标题翻译：骨无孔填料
公开(公告)号：US20120121660A1
公开(公告)日：2012-05-17
申请号：US13297005
申请日：2011-11-15
申请人： Rama Akella , Ian Ross Garrett , Hai Bo Wen , Shuliang Li , Dean M. Acker , Nichole Wilhelm
发明人： Rama Akella , Ian Ross Garrett , Hai Bo Wen , Shuliang Li , Dean M. Acker , Nichole Wilhelm
IPC分类号： A61K35/32 , A61K9/00 , A61P19/00
CPC分类号： A61L27/3608 , A61L24/0063 , A61L24/0084 , A61L27/46 , A61L2300/414 , A61L2430/02 , C08L89/06
摘要： A bone void filler composition is described containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier component that contains a collagenous material. The bone void filler composition may be in the form of a sponge or in the form of a paste or putty used to form a sponge or is obtained from particulated sponge, or that forms after a sponge is rehydrated. A pre-mixed bone void filler composition is described containing the acidic mineral component or the lower alkyl carboxylate source; the osteoinductive component; and a biologically acceptable carrier component that contains a liquid carrier. Methods of making and using the compositions are also described. The ratio of demineralized bone component to acidic mineral component may range from about 0.5:1 to about 80:1.
摘要翻译：描述了一种骨空隙填充剂组合物，其含有含有钙源和磷酸盐源或羧酸低级烷基酯源的酸性矿物组分; 含有脱矿质骨的骨诱导成分; 以及包含胶原材料的三维，骨传导的生物学上可接受的载体组分。骨空隙填充剂组合物可以是海绵的形式或用于形成海绵的糊状或油灰形式，或者由颗粒状海绵获得，或者在海绵再水合后形成。描述了含有酸性矿物组分或羧酸低级烷基酯源的预混合骨空隙填料组合物; 骨诱导成分; 和含有液体载体的生物可接受的载体组分。还描述了制备和使用组合物的方法。软化骨组分与酸性矿物组分的比例可以在约0.5:1至约80:1的范围内。

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