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1. 发明授权

US10717087B2 Automated analysis device 有权
公开(公告)号：US10717087B2
公开(公告)日：2020-07-21
申请号：US16487029
申请日：2018-03-08
申请人： Hitachi High-Tech Corporation
发明人： Akihiro Yasui , Akihisa Makino , Masashi Akutsu , Hiroyuki Mishima , Yoshihiro Suzuki
IPC分类号： B01L9/00 , G01N35/00 , G01N35/02 , G01N35/10
摘要： Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement. Further, the automated analysis device 100 includes a controller 21 which controls the drive of the reaction disk 1 such that in one cycle the reaction vessels 2 move by an amount A in the circumferential direction in such a way that N and A are mutually prime, B and C are mutually prime, and the relationship A×B=N×C±1 holds, where N is the total number of reaction vessels 2 accommodated in the reaction disk 1, the reaction disk 1 moves through C (where C>1) rotations+an amount equivalent to one reaction vessel after B (where B>2) cycles, and the number of reaction vessels 2 moved in one cycle is A (where N>A>N/B+1).

2. 发明授权

US12000849B2 Automatic analyzer 有权
公开(公告)号：US12000849B2
公开(公告)日：2024-06-04
申请号：US17530623
申请日：2021-11-19
申请人： HITACHI HIGH-TECH CORPORATION
发明人： Akihisa Makino , Hajime Yamazaki , Keiko Yoshikawa , Manabu Ando , Masahiko Iijima
IPC分类号： G01N35/02 , G01N21/11 , G01N21/82 , G01N33/86 , G01N35/00 , G01N35/10 , G01N35/04
CPC分类号： G01N35/025 , G01N21/11 , G01N21/82 , G01N33/86 , G01N35/00584 , G01N35/00693 , G01N35/0092 , G01N35/1004 , G01N2021/115 , G01N2035/00425 , G01N2035/00673 , G01N2035/0094 , G01N2035/0097 , G01N2035/0437 , G01N2035/0453
摘要： A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.

3. 发明授权

US11826759B2 Automated analysis device 有权
公开(公告)号：US11826759B2
公开(公告)日：2023-11-28
申请号：US17555764
申请日：2021-12-20
申请人： Hitachi High-Tech Corporation
发明人： Akihiro Yasui , Akihisa Makino , Masashi Akutsu , Hiroyuki Mishima , Yoshihiro Suzuki
IPC分类号： B01L9/00 , G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： B01L9/00 , B01L13/02 , G01N35/00584 , G01N35/026 , G01N35/1002 , G01N35/1004 , B01L2200/143 , B01L2200/16 , B01L2200/18 , B01L2300/0663 , B01L2300/0803
摘要： Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement. Further, the automated analysis device 100 includes a controller 21 which controls the drive of the reaction disk 1 such that in one cycle the reaction vessels 2 move by an amount Ain the circumferential direction in such a way that N and A are mutually prime, B and C are mutually prime, and the relationship A×B=N×C±1 holds, where N is the total number of reaction vessels 2 accommodated in the reaction disk 1, the reaction disk 1 moves through C (where C>1) rotations+an amount equivalent to one reaction vessel after B (where B>2) cycles, and the number of reaction vessels 2 moved in one cycle is A (where N>A>N/B+1).

4. 发明授权

US11946941B2 Automatic analysis device and automatic analysis method 有权
公开(公告)号：US11946941B2
公开(公告)日：2024-04-02
申请号：US16912897
申请日：2020-06-26
申请人： Hitachi High-Tech Corporation
发明人： Chie Yabutani , Naoto Suzuki , Akihisa Makino
IPC分类号： G01N35/04 , G01N21/27 , G01N21/82 , G01N33/49 , G01N33/86 , G01N33/96 , G01N35/00 , G01N35/02 , G01N35/10 , G01N1/38
CPC分类号： G01N33/86 , G01N21/272 , G01N21/82 , G01N33/4905 , G01N33/96 , G01N35/00 , G01N35/00722 , G01N35/00732 , G01N35/0092 , G01N35/0095 , G01N35/02 , G01N35/025 , G01N35/04 , G01N35/1002 , G01N1/38 , G01N2035/00356 , G01N2035/00534 , G01N2035/00544 , G01N2035/00554 , G01N2035/00831 , G01N2035/00891 , G01N2035/0094 , G01N2035/0441 , G01N2035/0444
摘要： The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light.

5. 发明授权

US10684298B2 Automated analyzer 有权
公开(公告)号：US10684298B2
公开(公告)日：2020-06-16
申请号：US15758993
申请日：2016-07-25
申请人： HITACHI HIGH-TECH CORPORATION
发明人： Akihisa Makino , Toshiyuki Inabe , Chie Yabutani
IPC分类号： G01N1/00 , G01N35/00 , B01L3/00 , G01N33/86 , G01N35/04
摘要： In blood coagulation time measurement, the reaction time relies on the blood coagulation ability of a specimen and is not fixed. In particular, in module-type devices, errors may occur in the specimen processing, measurement number, and measurement time between a plurality of blood coagulation analysis units, leading to the risk of lowering the processing capability of the device as a whole. The present invention is a module-type automated analyzer provided with a plurality of blood coagulation analysis units capable of analyzing blood coagulation time items in which the reaction time between a specimen and a reagent differs depending on the specimen, wherein a control unit that controls the specimen rack conveying operation finds the total of forecasted measurement times of measurement items requested for specimens being analyzed and queued specimens in each of the plurality of blood coagulation analysis units, and determines the conveyance destination of the specimen rack on the basis of the total of the forecasted measurement times that was found.

6. 发明授权

US11235334B2 Automated analysis device 有权
公开(公告)号：US11235334B2
公开(公告)日：2022-02-01
申请号：US16918858
申请日：2020-07-01
申请人： Hitachi High-Tech Corporation
发明人： Akihiro Yasui , Akihisa Makino , Masashi Akutsu , Hiroyuki Mishima , Yoshihiro Suzuki
IPC分类号： B01L9/00 , G01N35/00 , G01N35/02 , G01N35/10
摘要： Provided is an automated analysis device with which sufficient reaction process data can be acquired irrespective of the scale of the device, and with which it is possible to ensure freedom of the device configuration. An automated analysis device 100 is provided with: a reaction disk 1 which circumferentially accommodates a plurality of reaction vessels 2; a specimen dispensing mechanism 11 which dispenses a specimen into the reaction vessels 2; a reagent dispensing mechanism 7 which dispenses a reagent into the reaction vessels 2; a measuring unit 4 which measures a reaction process of a mixture of the specimen and the reagent in the reaction vessels 2; and a cleaning mechanism 3 which cleans the reaction vessels 2 after measurement. Further, the automated analysis device 100 includes a controller 21 which controls the drive of the reaction disk 1 such that in one cycle the reaction vessels 2 move by an amount A in the circumferential direction in such a way that N and A are mutually prime, B and C are mutually prime, and the relationship A×B=N×C±1 holds, where N is the total number of reaction vessels 2 accommodated in the reaction disk 1, the reaction disk 1 moves through C (where C>1) rotations+an amount equivalent to one reaction vessel after B (where B>2) cycles, and the number of reaction vessels 2 moved in one cycle is A (where N>A>N/B+1).

7. 发明授权

US11808671B2 Automatic analysis device 有权
公开(公告)号：US11808671B2
公开(公告)日：2023-11-07
申请号：US16982146
申请日：2019-03-11
申请人： HITACHI HIGH-TECH CORPORATION
发明人： Sakuichiro Adachi , Kyoko Yamamoto , Chie Yabutani , Rei Konishi , Akihisa Makino
IPC分类号： G01N35/10 , B01F31/65 , G01N1/38
CPC分类号： G01N35/1016 , G01N35/1002 , B01F31/651 , G01N1/38
摘要： It is necessary to efficiently agitate a small amount of sample (such as blood) and reagent (such as diluted solution) in a short time with a dispensing probe having a constant tube inner diameter. An automatic analysis device, by a dispensing probe, executes an aspiration step of aspirating a reagent from a reagent vessel; a first dispensing and aspiration step of dispensing a first liquid amount of the aspirated reagent to a reaction vessel and aspirating, from the reaction vessel, a second liquid amount of a mixed liquid obtained by mixing the reagent and the sample in the reaction vessel; and a final dispensing step of dispensing the aspirated mixed liquid and the reagent in a predetermined dispensing amount. A first liquid amount Va is less than a predetermined dispensing amount Vdil.

8. 发明授权

US11579159B2 Automatic analysis device 有权
公开(公告)号：US11579159B2
公开(公告)日：2023-02-14
申请号：US17159204
申请日：2021-01-27
申请人： HITACHI HIGH-TECH CORPORATION
发明人： Rei Konishi , Akihisa Makino
IPC分类号： G01N35/00 , G01N35/10 , G01N35/02 , G01N35/04 , G01N33/86 , G01N21/47
摘要： A sample dispensing mechanism configured to dispense a sample and a reagent to the reaction vessel at a first dispensing position and the reaction cell positioned at a second dispensing position; a second reagent vessel disposed on a track of the sample dispensing mechanism; and a control unit configured to control the sample dispensing mechanism, in which the control unit is configured to, based on information on presence or absence of incubation of an analysis item, control the sample dispensing mechanism to dispense a sample and a reagent to the reaction vessel positioned at the first dispensing position in a case where the incubation is not required by the analysis item, and control the sample dispensing mechanism to dispense a sample to the reaction cell positioned at the second dispensing position in a case where the incubation is required by the analysis item.

9. 发明授权

US11486887B2 Automated analyzer 有权
公开(公告)号：US11486887B2
公开(公告)日：2022-11-01
申请号：US16468761
申请日：2017-11-13
申请人： Hitachi High-Tech Corporation
发明人： Masashi Akutsu , Akihisa Makino , Hiroyuki Mishima , Akihiro Yasui
IPC分类号： G01N35/04 , G01N35/00 , G01N35/02
摘要： The present invention is provided with a sample rack insertion unit 12 that is capable of holding one or more sample racks 5 having mounted therein one or more sample containers 6 accommodating a sample to be analyzed, one or more analysis devices 2, 3 for analyzing the sample accommodated in the sample containers 6, a sample rack conveyance unit 14 for conveying the sample racks 5 from the sample rack insertion unit 12 to the analysis devices 2, 3, and a control device 4 for acquiring, for each analysis device 2, 3, load information that is information expressing an operating condition of the analysis device 2, 3, and, if there is an analysis device 2, 3 for which the load information is larger than a predetermined conveyance permission value, carrying out control so as to stop the conveyance of the sample racks 5 from the sample rack insertion unit 12 to the analysis device(s) 2, 3. As a result of this configuration, it is possible to mitigate in-device sample conveyance congestion occurring as a result of the insertion of many samples and keep the sample environment and analysis processing power at high levels.

10. 发明授权

US11054433B2 Automated analyzer and control method for same 有权
公开(公告)号：US11054433B2
公开(公告)日：2021-07-06
申请号：US15781530
申请日：2016-12-02
申请人： Hitachi High-Tech Corporation
发明人： Yuya Matsuoka , Akihisa Makino , Hajime Yamazaki
IPC分类号： G01N35/02 , G01N35/10 , G01N35/00 , G01N35/04 , G01N21/01 , G01N33/86 , G01N33/48 , G01N1/00
摘要： An automated analyzer has a reaction disk on which a plurality of reaction vessels capable of holding sample and reagent mixtures can be placed, a first cover for covering at least a portion of the area above the reaction disk, a second cover that can be opened and closed independently from the first cover, at least one sensor for monitoring the opening and closing of the first cover, and a control unit for monitoring a signal from the sensor and carrying out control such that if the first cover has not been opened and closed during the period until a new analysis operation is started, a pre-analysis cleaning operation, blank measurement operation, or both, are skipped.

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