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1. 发明申请

US20170218451A1 METHOD OF TREATING, OR AT LEAST INHIBITING THE ONSET OF, URATE TRANSPORT FAILURE 审中-公开
公开(公告)号：US20170218451A1
公开(公告)日：2017-08-03
申请号：US15486788
申请日：2017-04-13
申请人： HIROTAKA MATSUO , NARIYOSHI SHINOMIYA , TAKAHIRO NAKAMURA , THE UNIVERSITY OF TOKYO , TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES
发明人： HIROTAKA MATSUO , Nariyoshi Shinomiya , Takahiro Nakamura , Tappei Takada , Hiroshi Suzuki , Yuki Ikebuchi , Kousei Ito , Kimiyoshi Ichida
IPC分类号： C12Q1/68 , A61K38/17
CPC分类号： C12Q1/6883 , A61K38/177 , C07K14/705 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , G01N33/566 , G01N33/6893 , G01N2800/24 , G01N2800/32 , G01N2800/34
摘要： Methods of treating, or at least inhibiting the onset of, urate transport failure are provided. The methods can include a step for detecting variations in genes that encode ABCG2 protein. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F208S, G268R, E334X, S441N, L447V, S486N, F506SfsX4, R575X, and/or C608X, it can be concluded that the subject has a factor that is capable of inducing urate transport failure, or a state or disease attributable to that failure. When a subject has an SNP of V12M, it can be concluded that, unlike the other SNPs, there is a possibility that the subject does not possess such a factor because, although this variation itself does not lead to a change in urate transport capability, said variation is related to linkage disequilibrium with other SNPs.

2. 发明申请

US20150080257A1 METHOD FOR EVALUATING URATE TRANSPORT-RELATED DISEASE FACTOR AND INFLAMMATION-RELATED DISEASE FACTOR 审中-公开
标题翻译：评估尿酸运输相关疾病因子和与炎症相关疾病因子的方法
公开(公告)号：US20150080257A1
公开(公告)日：2015-03-19
申请号：US14542633
申请日：2014-11-16
申请人： HIROTAKA MATSUO , NARIYOSHI SHINOMIYA , TAKAHIRO NAKAMURA , THE UNIVERSITY OF TOKYO , TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES
发明人： HIROTAKA MATSUO , Nariyoshi Shinomiya , Takahiro Nakamura , Tappei Takada , Hiroshi Suzuki , Yuki Ikebuchi , Kousei Ito , Kimiyoshi Ichida
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K38/177 , C07K14/705 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , G01N33/566 , G01N33/6893 , G01N2800/24 , G01N2800/32 , G01N2800/34
摘要： A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and inflammation-related disease. The method can include a step for detecting variations in genes that encode ABCG2 protein. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F2085, G268R, E334X, S441N, L447V, S486N, F506SfsX4, R575X, and/or C608X, it can be concluded that the subject has a factor that is capable of inducing urate transport failure, or a state or disease attributable to that failure. When a subject has an SNP of V12M, it can be concluded that, unlike the other SNPs, there is a possibility that the subject does not possess such a factor because, although this variation itself does not lead to a change in urate transport capability, said variation is related to linkage disequilibrium with other SNPs.
摘要翻译：提供了一种方法和评价试剂盒，其中确定了高容量尿酸转运蛋白，以协助早期治疗和预防与尿酸运输有关的疾病和炎症相关疾病。该方法可以包括用于检测编码ABCG2蛋白的基因变异的步骤。当受试者具有V12M，R113X，Q126X，Q141K，F2085，G268R，E334X，S441N，L447V，S486N，F506SfsX4，R575X和/或C608X的SNP时，可以得出结论，受试者具有能够诱导尿酸盐运输失败，或归因于该失败的状态或疾病。当受试者具有V12M的SNP时，可以得出结论，与其他SNP不同，存在受试者不具有这样的因素的可能性，因为尽管该变化本身不会导致尿酸盐转运能力的变化，所述变异与其他SNP的连锁不平衡有关。

3. 发明申请

US20120255044A1 URATE TRANSPORTER, AS WELL AS METHOD AND KIT FOR EVALUATING URATE TRANSPORT-RELATED DISEASE FACTOR AND INFLAMMATION-RELATED DISEASE FACTOR, AND TEST SAMPLE AND DRUG 有权
标题翻译： URATE TRANSPORTER，作为评估与运输相关的疾病因素和与炎症有关的疾病因素和测试样品和药物的方法和工具包
公开(公告)号：US20120255044A1
公开(公告)日：2012-10-04
申请号：US13379346
申请日：2010-06-22
申请人： Hirotaka Matsuo , Nariyoshi Shinomiya , Takahiro Nakamura , Tappei Takada , Hiroshi Suzuki , Yuki Ikebuchi , Kousei Ito , Kimiyoshi Ichida
发明人： Hirotaka Matsuo , Nariyoshi Shinomiya , Takahiro Nakamura , Tappei Takada , Hiroshi Suzuki , Yuki Ikebuchi , Kousei Ito , Kimiyoshi Ichida
IPC分类号： C12Q1/68 , G01N21/64 , C40B40/06 , A01K67/027 , C12N5/10 , C12N1/00 , C07H21/04 , C40B30/04
CPC分类号： C12Q1/6883 , A61K38/177 , C07K14/705 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , G01N33/566 , G01N33/6893 , G01N2800/24 , G01N2800/32 , G01N2800/34
摘要： A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and inflammation-related disease. The method can include a step for detecting variations in genes that encode ABCG2 protein. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F208S, G268R, E334X, S441N, L447V, S486N, F506SfsX4, R575X, and/or C608X, it can be concluded that the subject has a factor that is capable of inducing urate transport failure, or a state or disease attributable to that failure. When a subject has an SNP of V12M, it can be concluded that, unlike the other SNPs, there is a possibility that the subject does not possess such a factor because, although this variation itself does not lead to a change in urate transport capability, said variation is related to linkage disequilibrium with other SNPs.
摘要翻译：提供了一种方法和评价试剂盒，其中确定了高容量尿酸转运蛋白，以协助早期治疗和预防与尿酸运输有关的疾病和炎症相关疾病。该方法可以包括用于检测编码ABCG2蛋白的基因变异的步骤。当受试者具有V12M，R113X，Q126X，Q141K，F208S，G268R，E334X，S441N，L447V，S486N，F506SfsX4，R575X和/或C608X的SNP时，可以得出结论，受试者具有能够诱导尿酸盐运输失败，或归因于该失败的状态或疾病。当受试者具有V12M的SNP时，可以得出结论，与其他SNP不同，存在受试者不具有这样的因素的可能性，因为尽管该变化本身不会导致尿酸盐转运能力的变化，所述变异与其他SNP的连锁不平衡有关。

4. 发明授权

US08940286B2 Urate transporter, as well as method and kit for evaluating urate transport-related disease factor and inflammation-related disease factor, and test sample and drug 有权
标题翻译：尿酸转运蛋白，以及评估尿酸运输相关疾病因子和炎症相关疾病因子的方法和试剂盒，以及测试样品和药物
公开(公告)号：US08940286B2
公开(公告)日：2015-01-27
申请号：US13379346
申请日：2010-06-22
申请人： Hirotaka Matsuo , Nariyoshi Shinomiya , Takahiro Nakamura , Tappei Takada , Hiroshi Suzuki , Yuki Ikebuchi , Kousei Ito , Kimiyoshi Ichida
发明人： Hirotaka Matsuo , Nariyoshi Shinomiya , Takahiro Nakamura , Tappei Takada , Hiroshi Suzuki , Yuki Ikebuchi , Kousei Ito , Kimiyoshi Ichida
IPC分类号： A61K48/00 , A61K38/00 , C07K14/47 , C07K14/705 , G01N33/566 , G01N33/68
CPC分类号： C12Q1/6883 , A61K38/177 , C07K14/705 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , G01N33/566 , G01N33/6893 , G01N2800/24 , G01N2800/32 , G01N2800/34
摘要： A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and inflammation-related disease. The method can include a step for detecting variations in genes that encode ABCG2 protein. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F208S, G268R, E334X, S441N, L447V, S486N, F506SfsX4, R575X, and/or C608X, it can be concluded that the subject has a factor that is capable of inducing urate transport failure, or a state or disease attributable to that failure. When a subject has an SNP of V12M, it can be concluded that, unlike the other SNPs, there is a possibility that the subject does not possess such a factor because, although this variation itself does not lead to a change in urate transport capability, said variation is related to linkage disequilibrium with other SNPs.
摘要翻译：提供了一种方法和评价试剂盒，其中确定了高容量尿酸转运蛋白，以协助早期治疗和预防与尿酸运输有关的疾病和炎症相关疾病。该方法可以包括用于检测编码ABCG2蛋白的基因变异的步骤。当受试者具有V12M，R113X，Q126X，Q141K，F208S，G268R，E334X，S441N，L447V，S486N，F506SfsX4，R575X和/或C608X的SNP时，可以得出结论，受试者具有能够诱导尿酸盐运输失败，或归因于该失败的状态或疾病。当受试者具有V12M的SNP时，可以得出结论，与其他SNP不同，存在受试者不具有这样的因素的可能性，因为尽管该变化本身不会导致尿酸盐转运能力的变化，所述变异与其他SNP的连锁不平衡有关。

5. 发明授权

US11248232B2 Method of modifying genome of organism and use thereof 有权
公开(公告)号：US11248232B2
公开(公告)日：2022-02-15
申请号：US16060897
申请日：2016-12-12
申请人： KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO , The University of Tokyo , MEIJI UNIVERSITY
发明人： Hidenori Tanaka , Nobuhiko Muramoto , Hiroki Sugimoto , Norihiro Mitsukawa , Chikara Ohto , Satoshi Kondo , Kunihiro Ohta , Takahiro Nakamura , Shuichi Osato
IPC分类号： C12N15/82 , C12N15/10 , C12N15/01
摘要： A method of modifying the genome of an organism, wherein the modification method includes modifying the genome of the organism by using in a cell of the organism a protein having an optimal temperature for double-stranded DNA breakage activity in an ordinary temperature region.

6. 发明申请

US20140220102A1 ECTOCORNEA-LIKE SHEET AND METHOD OF CONSTRUCTING THE SAME 审中-公开
标题翻译： ECTOCORNEA类似的表格及其构造方法
公开(公告)号：US20140220102A1
公开(公告)日：2014-08-07
申请号：US14175369
申请日：2014-02-07
申请人： Takahiro Nakamura , Shigeru Kinoshita
发明人： Takahiro Nakamura , Shigeru Kinoshita
IPC分类号： A61L27/36
CPC分类号： A61L27/3604 , A61L27/3641 , A61L27/3666 , A61L27/3683 , A61L27/3813 , A61L27/3839 , A61L2430/16
摘要： It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells. When a layered structure of the oral mucosal epithelial cells is formed, the outermost layer is brought into contact with air, thereby inducing differentiation. Thus, an ectocornea-like sheet having an oral mucosal epithelial cell layer on the amnion is obtained.
摘要翻译：旨在提供适用于需要外耳道移植的眼表疾病的移植材料（即外胚层样片材）。将口腔粘膜上皮细胞接种到羊膜上，然后在支持细胞共存下培养。当形成口腔粘膜上皮细胞的分层结构时，最外层与空气接触，从而诱导分化。因此，获得了在羊膜上具有口腔粘膜上皮细胞层的异齿角膜状片。

7. 发明申请

US20130335486A1 PIEZOELECTRIC ACTUATOR, LIQUID DISCHARGE HEAD, AND RECORDING DEVICE 有权
标题翻译：压电致动器，液体放电头和记录装置
公开(公告)号：US20130335486A1
公开(公告)日：2013-12-19
申请号：US14002365
申请日：2012-03-27
申请人： Naoki Kobayashi , Takahiro Nakamura
发明人： Naoki Kobayashi , Takahiro Nakamura
IPC分类号： B41J2/045 , H01L41/047
CPC分类号： B41J2/045 , B41J2/14209 , B41J2002/14217 , B41J2002/14225 , B41J2002/14306 , B41J2002/14459 , B41J2002/14491 , B41J2202/18 , H01L41/047 , H01L41/0475
摘要： A piezoelectric actuator has a satisfactory electrical connection of a common electrode and a surface electrode without increasing the size of the piezoelectric actuator, as well as a liquid discharge head and a recording device. The piezoelectric actuator includes: a ceramic substrate which is long in one direction and includes a vibrating plate, a common electrode disposed on the vibrating plate and a piezoelectric ceramic layer disposed on the common electrode and having a plurality of first through holes connected to the common electrode; a plurality of individual electrodes disposed in a region of the piezoelectric ceramic layer opposed to the common electrode; and a plurality of first surface electrodes respectively disposed inside a plurality of the first through holes in the piezoelectric ceramic layer and on a circumference of a plurality of the first through holes.
摘要翻译：压电致动器具有公共电极和表面电极的令人满意的电连接，而不增加压电致动器的尺寸，以及液体排出头和记录装置。压电致动器包括：在一个方向上长的并包括振动板的陶瓷基板，设置在振动板上的公共电极和设置在公共电极上的压电陶瓷层，并且具有连接到共用的多个第一通孔电极; 设置在与公共电极相对的压电陶瓷层的区域中的多个单独电极; 以及多个第一表面电极，分别设置在所述压电陶瓷层的多个所述第一通孔的内部，以及多个所述第一通孔的圆周上。

8. 发明授权

US08557915B2 Process for producing conjugated diene polymer, conjugated diene polymer, and rubber composition 有权
标题翻译：用于制备共轭二烯聚合物，共轭二烯聚合物和橡胶组合物的方法
公开(公告)号：US08557915B2
公开(公告)日：2013-10-15
申请号：US13371780
申请日：2012-02-13
申请人： Takahiro Nakamura , Kouichirou Tani , Ryouji Tanaka , Takuo Sone , Toshihiro Tadaki , Junko Kurazumi , Koji Masaki , Yoichi Ozawa
发明人： Takahiro Nakamura , Kouichirou Tani , Ryouji Tanaka , Takuo Sone , Toshihiro Tadaki , Junko Kurazumi , Koji Masaki , Yoichi Ozawa
IPC分类号： C08L9/00 , C08F4/06
CPC分类号： C08L9/00 , C08F36/04 , C08K3/013 , C08F4/545
摘要： A process for simply and inexpensively producing a conjugated diene polymer with a narrow molecular weight distribution and a high cis-bond content at a low cost is provided. The process comprises a polymerization step, wherein a conjugated diene polymer having a cis-1,4-bond content of 98.5 mass % or more and a ratio (Mw/Mn) of the weight average molecular weight (Mw) to the number average molecular weight (Mn) measured by gel permeation chromatography of 2.5 or less is obtained by carrying out a polymerization reaction in conjugated diene compounds using a catalyst composition containing a rare earth element-containing compound or a reaction product of the rare earth element-containing compound with a Lewis base, an aluminoxane and/or organoaluminum compound, and an iodine-containing compound.
摘要翻译：提供了一种以低成本简单且廉价地制备具有窄分子量分布和高顺式键含量的共轭二烯聚合物的方法。该方法包括聚合步骤，其中顺式-1,4-键含量为98.5质量％以上的共轭二烯聚合物和重均分子量（Mw）与数均分子量（Mw）的比率（Mw / Mn）通过凝胶渗透色谱法测定的重量（Mn）为2.5以下，通过使用含有含稀土元素化合物的催化剂组合物或含稀土元素化合物的反应产物与共轭二烯化合物的反应，路易斯碱，铝氧烷和/或有机铝化合物，以及含碘化合物。

9. 发明授权

US08450893B2 Motor structure with planar coil type rotation detector 失效
标题翻译：电机结构采用平面线圈式旋转检测器
公开(公告)号：US08450893B2
公开(公告)日：2013-05-28
申请号：US12588998
申请日：2009-11-04
申请人： Hiroaki Miyazaki , Takehide Nakamura , Tomoaki Inoue , Takahiro Nakamura
发明人： Hiroaki Miyazaki , Takehide Nakamura , Tomoaki Inoue , Takahiro Nakamura
IPC分类号： H02K11/00 , H02K17/44 , H02K17/42 , G01B7/30
CPC分类号： G01B7/30 , G01D5/208 , H02K29/12
摘要： A casing of a motor with resolver includes a stator, a motor shaft rotatably supported by a bearing, a motor rotor integrally rotatable with the motor shaft, and a resolver for detecting a rotation angle of the motor rotor. The resolver includes a disc-shaped resolver stator held on the motor casing and having a surface on which a thin-film-shaped coil is formed, and a disc-shaped resolver rotor provided on an end face of the motor rotor and having a surface on which a thin-film-shaped coil is formed. Part of the motor casing holding the outer periphery of the resolver stator is formed as a shield portion cylindrically protruding along the outer periphery of the resolver rotor to the rotor. The motor casing and the shield portion are each made of a non-magnetic conductive material.
摘要翻译：具有旋转变压器的电动机的壳体包括定子，由轴承可旋转地支撑的电动机轴，与电动机轴一体旋转的电动机转子，以及用于检测电动机转子的旋转角度的旋转变压器。旋转变压器包括保持在电动机壳体上并具有形成有薄膜状线圈的表面的盘形分解器定子，以及设置在电机转子的端面上的具有表面的圆盘形旋转变压器转子其上形成有薄膜状线圈。保持分解器定子的外周的马达壳体的一部分形成为沿着旋转变压器转子的外周向圆筒状突出的保护部。电动机壳体和屏蔽部分均由非磁性导电材料制成。

10. 发明授权

US08258241B2 Method for producing modified conjugated diene polymer, modified conjugated diene polymer, and rubber composition 有权
标题翻译：改性共轭二烯聚合物，改性共轭二烯聚合物和橡胶组合物的制备方法
公开(公告)号：US08258241B2
公开(公告)日：2012-09-04
申请号：US12521331
申请日：2007-12-27
申请人： Ryouji Tanaka , Takahiro Nakamura , Takuo Sone , Toshihiro Tadaki
发明人： Ryouji Tanaka , Takahiro Nakamura , Takuo Sone , Toshihiro Tadaki
IPC分类号： C08F136/04 , C08F4/14
CPC分类号： C08C19/44 , B60C1/00 , B60C1/0016 , B60C1/0025 , B60C1/0041 , B60C2001/0066 , C08K3/013 , C08K3/04 , C08K3/36 , C08L7/00 , C08L15/00 , C08L21/00 , C08L2666/08
摘要： A method for producing a modified conjugated diene polymer includes a modification step (A) that subjects a conjugated diene polymer having a cis-1,4-bond content of 98.5% or more and possessing an active end to a modification reaction to introduce an alkoxysilane compound having two or more reactive groups including an alkoxysilyl group into the active end of the conjugated diene polymer, and a condensation step (B) that subjects the residue of the alkoxysilane compound introduced into the active end to a condensation reaction in the presence of a condensation catalyst that includes at least one element among the elements of the groups 4A, 2B, 3B, 4B, and 5B in the periodic table. The method can produce a modified conjugated diene polymer that exhibits low heat build-up and excellent wear resistance.
摘要翻译：改性共轭二烯系聚合物的制造方法包括使顺式-1,4-键含量为98.5％以上并具有活性末端的共轭二烯聚合物进行改性反应以引入烷氧基硅烷的改性步骤（A）在共轭二烯聚合物的活性端中具有烷氧基甲硅烷基的具有两个以上的反应性基团的化合物和在引入活性末端的烷氧基硅烷化合物的残基在缩合反应存在下进行缩合步骤（B）缩合催化剂，其包括周期表中的基团4A，2B，3B，4B和5B的元素中的至少一个元素。该方法可以生产出显示低发热性和优异耐磨性的改性共轭二烯聚合物。

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