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1. 发明授权

US06320935B1 Dosimeter for a miniature energy transducer for emitting X-ray radiation 有权
标题翻译：用于发射X射线辐射的微型能量换能器的剂量计
公开(公告)号：US06320935B1
公开(公告)日：2001-11-20
申请号：US09513959
申请日：2000-02-28
申请人： Guy Shinar , Shmuel Bukshpan
发明人： Guy Shinar , Shmuel Bukshpan
IPC分类号： A61N510
CPC分类号： A61N5/1001 , A61N5/1002 , A61N5/1048 , G01T1/161 , G01T1/201
摘要： A dosimeter for an x-ray brachytherapy system permits in situ monitoring and control of radiation treatment via a miniaturized energy transducer within a human body. The dosimeter comprises a scintillating optical fiber having a distal end which is placed at the treatment site and a proximal end which is coupled to a dosimeter measurement unit. Utilizing energy supplied by an energy source, the miniaturized transducer generates x-ray photons. The scintillating optical fiber absorbs x-ray photons, converts the x-ray photons into light photons, and conveys the light photons to a dosimeter measurement unit. The light photons are converted into an electrical current which is representative of the intensity of the x-ray photons. The dosimeter measurement unit utilizes the electrical current to calculate and display the instantaneous and accumulated radiation dose, and radiation dose parameters are utilized to adjust energy levels, which are sent to the miniature energy transducer. Use of the miniaturized energy transducer in combination with the dosimeter eliminates most of the problems related to the methods based on the use of radioactive sources and offers a method for efficient, accurate, and controllable radiation treatment.
摘要翻译：用于X射线近距离放射治疗系统的剂量计允许通过人体内的小型化能量换能器原位监测和控制辐射治疗。剂量计包括闪烁光纤，其具有放置在治疗部位的远端，以及耦合到剂量计测量单元的近端。利用由能源提供的能量，小型化的换能器产生x射线光子。闪烁光纤吸收x射线光子，将x射线光子转换为光子，并将光子传输到剂量计测量单元。光子被转换为代表x射线光子强度的电流。剂量计测量单元使用电流来计算和显示瞬时和累积的辐射剂量，并且使用辐射剂量参数来调节发送到微型能量换能器的能量水平。将微型能量换能器与剂量计结合使用消除了与基于放射源使用的方法相关的大部分问题，并提供了一种有效，准确和可控的辐射治疗的方法。

2. 发明授权

US06964639B2 System and method of mapping irregularities of hard tissue 失效
标题翻译：绘制硬组织不规则的系统和方法
公开(公告)号：US06964639B2
公开(公告)日：2005-11-15
申请号：US10500987
申请日：2003-01-05
申请人： Natan Sela , Shmuel Bukshpan , Michael Kardash , Lior Cohen
发明人： Natan Sela , Shmuel Bukshpan , Michael Kardash , Lior Cohen
IPC分类号： A61B8/00 , A61B8/08
CPC分类号： A61B8/0875 , A61B8/461 , A61B8/467 , A61B8/483
摘要： A system and method of mapping irregularities of hard tissue. The method includes repeatedly transmitting ultra-sonic energy towards the hard tissue at a first angle of incidence, registering the origin of transmission if an echo-reflection the hard tissue is received, defining the origin of transmission in six degrees of freedom, calculating position co-ordinates for a point causing the echo-reflection and changing the origin of transmission. The method further includes compiling position co-ordinates to generate a map of the irregularities in the surface of the hard tissue. The system includes at least one ultrasonic transducer, a central processing unit and a position locator and adjustment mechanism operably connectable and configured to accomplish the disclosed method.
摘要翻译：绘制硬组织不规则的系统和方法。该方法包括以第一入射角向硬组织重复传输超声波能量，如果接收到硬组织的回波反射，记录传输原点，定义六自由度的传播原点，计算位置co 对于导致回波反射和改变传播原点的点。该方法还包括编译位置坐标以产生硬组织表面中的不规则图。该系统包括至少一个超声波换能器，中央处理单元和位置定位器以及可操作地连接并被配置成完成所公开的方法的调节机构。

3. 发明授权

US10325379B2 Sweat pores imaging method and device 有权
公开(公告)号：US10325379B2
公开(公告)日：2019-06-18
申请号：US15264653
申请日：2016-09-14
申请人： Shmuel Bukshpan , Uriel Halavee , Arie Heiman
发明人： Shmuel Bukshpan , Uriel Halavee , Arie Heiman
IPC分类号： G06K9/00 , G06T7/70 , A61B5/1171 , A61B5/00
摘要： A biometric device that may include a sensor that reacts to a chemical element associated with a sweat gland; wherein when the sensor is contacted by an area of a skin of a person, an image that comprises information about locations of sweat glands within the area of the skin of the person is generated by the sensor; an image processor that is configured to generate an authentication result by comparing between (a) the information of the image generated by the sensor and (b) reference information of locations of sweat glands of a given person; wherein the authentication result indicates whether the person is the given person; and a communication module for communicating an authentication result indication.

4. 发明申请

US20170116492A1 Sweat Pores Imaging Method and Device 审中-公开
公开(公告)号：US20170116492A1
公开(公告)日：2017-04-27
申请号：US15264653
申请日：2016-09-14
申请人： Shmuel Bukshpan , Uriel Halavee , Arie Heiman
发明人： Shmuel Bukshpan , Uriel Halavee , Arie Heiman
IPC分类号： G06K9/00 , A61B5/00 , G06T7/70 , G06K9/62 , G06K9/52 , A61B5/1171 , G06K9/78
CPC分类号： G06T7/70 , A61B5/0077 , A61B5/1171 , A61B5/4266 , A61B5/4887 , A61B2562/029 , G06K9/00885
摘要： A biometric device that may include a sensor that reacts to a chemical element associated with a sweat gland; wherein when the sensor is contacted by an area of a skin of a person, an image that comprises information about locations of sweat glands within the area of the skin of the person is generated by the sensor; an image processor that is configured to generate an authentication result by comparing between (a) the information of the image generated by the sensor and (b) reference information of locations of sweat glands of a given person; wherein the authentication result indicates whether the person is the given person; and a communication module for communicating an authentication result indication

5. 发明申请

US20100178268A1 BIOCIDIC PACKAGING FOR COSMETICS AND FOODSTUFFS 审中-公开
标题翻译：生物化学包装用于化妆品和食品
公开(公告)号：US20100178268A1
公开(公告)日：2010-07-15
申请号：US12598433
申请日：2008-04-03
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A61K31/74
CPC分类号： A61L2/16 , A01N25/34 , A01N37/08 , A01N37/20 , A01N41/04 , A01N61/00 , A23L3/3463
摘要： The present invention presents a biocidic packaging for cosmetics and/or foodstuffs, comprises at least one insoluble proton sink or source (PSS). The packaging is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of said LTCs' environment. The present invention also discloses a method for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC being in a packaging, especially cosmetic or foodstuffs' packaging.
摘要翻译：本发明提出了一种用于化妆品和/或食品的生物杀伤剂包装，包括至少一种不溶性质子沉或源（PSS）。提供的包装用于杀死活的靶细胞（LTC）或以其他方式破坏接触时所述LTC的细胞内过程和/或细胞间相互作用。 PSS尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS有效地破坏LTC的限制体积内的pH稳态和/或电气平衡和/或破坏LTC的重要的细胞间相互作用，同时有效地保持所述LTC的环境的pH。本发明还公开了一种用于杀死活的靶细胞（LTC）或以其它方式破坏所述LTC在包装，特别是化妆品或食品包装中的细胞内过程和/或细胞间相互作用的方法。

6. 发明申请

US20080314751A1 Electrophoretic Separation of Analytes by Molecular Mass 审中-公开
标题翻译：分子质量分析物的电泳分离
公开(公告)号：US20080314751A1
公开(公告)日：2008-12-25
申请号：US11994791
申请日：2006-07-05
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： B01D59/42 , G01N27/447
CPC分类号： G01N27/44747
摘要： The present invention relates to a method and apparatus for the separation of analytes based on their molecular weight, by application of an electric field across a low-friction matrix that includes with a charged separation agent. The matrix comprises charged regions ordered in a monotonous sequence distributed throughout the matrix so as to generate a charge density gradient. When an external electric field is applied, the complex will move through the different charged regions and focusing of different analytes in different charge regions will occur. These systems are suitable for planar, capillary in-tube electrophoresis, as well as multi-channel arrays of capillaries filled with charge gradient gels, serial arrays of discrete compartments with charge density gradient, arrays in a chip format, pre-designed mass focusing arrays for specific protein masses in application for protein and DNA marker diagnostics, and multi compartment trapping devices for specific mass ranges.
摘要翻译：本发明涉及通过在包含带电分离剂的低摩擦基质上施加电场来分离基于其分子量的分析物的方法和装置。矩阵包括以分布在整个矩阵中的单调序列排列的带电区域，以产生电荷密度梯度。当施加外部电场时，复合体将移动穿过不同的充电区域，并且将发生不同分析物在不同电荷区域中的聚焦。这些系统适用于平面，毛细管内电泳，以及填充有电荷梯度凝胶的多通道阵列的毛细管阵列，具有电荷密度梯度的离散隔室的串行阵列，芯片格式的阵列，预先设计的质量聚焦阵列用于蛋白质和DNA标记诊断的特定蛋白质质量，以及用于特定质量范围的多隔室捕获装置。

7. 发明申请

US20070098235A1 Age Verification 审中-公开
标题翻译：年龄验证
公开(公告)号：US20070098235A1
公开(公告)日：2007-05-03
申请号：US11535661
申请日：2006-09-27
申请人： Uriel Halavee , Shmuel Bukshpan
发明人： Uriel Halavee , Shmuel Bukshpan
IPC分类号： G06K9/00
CPC分类号： G06K9/0008 , G06K2009/00322
摘要： A method of estimating a range of age of a subject, the method comprising: a) making at least one measurement of epidermal ridges of the subject; and b) estimating at least a range of age of the subject, using the measurements of the epidermal ridges, without using the measurements to identify the subject.
摘要翻译：一种估计受试者年龄范围的方法，所述方法包括：a）对受试者的表皮脊进行至少一次测量; 以及b）使用所述表皮脊的测量来估计所述受试者的年龄的至少一个范围，而不使用所述测量来识别所述受试者。

8. 发明授权

US08697102B2 Compositions and methods for cell killing 失效
标题翻译：细胞杀伤的组合物和方法
公开(公告)号：US08697102B2
公开(公告)日：2014-04-15
申请号：US12823354
申请日：2010-06-25
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A01N25/34 , A61K31/74
CPC分类号： A61L31/16 , A01N25/10 , A01N27/00 , A01N41/08 , A61K31/745 , A61K31/795 , A61L2/232 , A61L15/24 , A61L15/44 , A61L17/005 , A61L17/145 , A61L31/10 , A61L2202/26 , A61L2300/404 , A61L2300/606 , A61L2420/00 , Y02A50/471 , A01N33/12 , A01N37/18 , A01N41/04
摘要： A solid buffer including one or more ion exchange materials, wherein said solid buffer has a volumetric buffering capacity greater than about 20 mM H+/(L.pH unit) and further wherein, when said material is in an environment capable of transporting H+ ions, said solid buffer is adapted to cause the death of at least one target cell within or in contact with said environment. A selectively permeable barrier layer may be provided covering the solid buffer.
摘要翻译：一种包含一种或多种离子交换材料的固体缓冲液，其中所述固体缓冲液具有大于约20mM H + /（L.pH单位）的体积缓冲能力，此外，当所述材料处于能够输送H +离子的环境中时，所述固体缓冲液适于引起至少一个目标细胞在所述环境中或与所述环境接触中的死亡。可以提供覆盖固体缓冲液的选择性可渗透阻挡层。

9. 发明授权

US07914656B2 Matrixes, arrays, systems and methods 有权
标题翻译：矩阵，数组，系统和方法
公开(公告)号：US07914656B2
公开(公告)日：2011-03-29
申请号：US11619796
申请日：2007-01-04
申请人： Shmuel Bukshpan , Gleb Zilbertstein
发明人： Shmuel Bukshpan , Gleb Zilbertstein
IPC分类号： G01N27/447
CPC分类号： G01N27/44795 , G01N27/44747
摘要： The present invention relates to matrixes, arrays, systems and methods for analyzing biomolecules by their isoelectric point, optionally, in combination with a second dimension analysis. The assortment of matrixes, arrays and systems provided herein are useful for causing a biomolecule under the influence of an electrical field to accumulate into an buffer that comprises a pH value that is the same as the isoelectric point of the biomolecule. The methods of this invention are useful for, e.g., research and diagnostic purposes.
摘要翻译：本发明涉及用于通过其等电点分析生物分子的基质，阵列，系统和方法，任选地与第二维度分析结合。本文提供的基质，阵列和系统的分类可用于使电场的影响下的生物分子积累到包含与生物分子的等电点相同的pH值的缓冲液中。本发明的方法可用于例如研究和诊断目的。

10. 发明申请

US20100136077A1 BIOCIDIC HOUSEHOLD CLEANSING MATERIALS 审中-公开
标题翻译：生物化学家用清洁材料
公开(公告)号：US20100136077A1
公开(公告)日：2010-06-03
申请号：US12598428
申请日：2008-04-03
申请人： Shmuel Bukshpan , Gleb Zilberstein
发明人： Shmuel Bukshpan , Gleb Zilberstein
IPC分类号： A01N61/00 , A01N25/00 , C08F112/08
CPC分类号： A01N61/00 , A61L2/22 , C11D3/48 , C11D17/049 , Y10T442/10 , Y10T442/60
摘要： The present invention discloses household cleaning materials comprising at least one insoluble proton sink or source (PSS) and to method for utilizing the PSS as a biocidic agent. The household cleaning materials are provided useful for killing living target cells (LTCs) or otherwise inhibiting LTCs growth, disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The household cleaning materials consisting of at least one PSS, comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of said LTC and/or disrupting vital intercellular interactions of said LTCs while efficiently preserving the pH of said LTCs' environment.
摘要翻译：本发明公开了包含至少一种不溶性质子沉或源（PSS）的家用清洁材料以及将PSS用作生物杀伤剂的方法。家用清洁材料可用于杀死活细胞（LTC）或以其他方式抑制LTC的生长，破坏LTC在接触时的重要细胞内过程和/或细胞间相互作用。由至少一个PSS组成的家用清洁材料尤其包括（i）提供缓冲能力的质子源或接收器; 和（ii）提供质子传导性和/或电势的手段。 PSS有效地破坏所述LTC的限定体积内的pH稳态和/或电平衡和/或破坏所述LTC的重要细胞间相互作用，同时有效地保持所述LTC的环境的pH。

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