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    • 2. 发明授权
    • Controlled-release device and preparation process
    • 控制释放装置及制备工艺
    • US5776481A
    • 1998-07-07
    • US588921
    • 1996-01-19
    • Christian KarstThierry GozlanGuy DerrieuLuc Castelli
    • Christian KarstThierry GozlanGuy DerrieuLuc Castelli
    • A01K13/00A01K27/00A01M29/00A01N25/34A61D7/00A61K9/00
    • A01K27/007
    • Device capable of being used in combination with a restraining or ornamental collar or with any other support for animals, intended to make possible the controlled and optically continuous and complete release of chemical substances, including medicaments, for more or less lengthy, continuous or noncontinuous, periods and process for producing the said device. The device comprises a polymeric matrix enclosing at least one active substance capable of being released towards an appropriate area of an animal. The device is composed of at least one tubular component of any cross-section, containing at least one layer of flexible polymeric matrix containing at least one active substance, the length of the said tubular component can be regulated to adjust the daily dose of the active substance to the weight of the animal and the ratio of the external surface area of said tubular component to the thickness of its' wall is as great as possible to obtain linear removal of the active substance.
    • 能够与限制性或装饰性领结合使用的装置,或与动物的任何其它支持物一起使用的装置,其旨在使得化学物质(包括药物)的受控和光学连续和完全释放可能或多或少地长时间连续或不连续, 期间和用于生产所述装置的过程。 该装置包括聚合物基体,其包围能够朝向动物的适当区域释放的至少一种活性物质。 该装置由任何横截面的至少一个管状部件组成,其包含至少一层包含至少一种活性物质的柔性聚合物基质,可调节所述管状组分的长度以调节活性物质的日剂量 物质相对于动物的重量,并且所述管状部件的外表面积与其壁的厚度的比率尽可能大以获得活性物质的线性去除。