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1. 发明授权

US5776481A Controlled-release device and preparation process 失效
标题翻译：控制释放装置及制备工艺
公开(公告)号：US5776481A
公开(公告)日：1998-07-07
申请号：US588921
申请日：1996-01-19
申请人： Christian Karst , Thierry Gozlan , Guy Derrieu , Luc Castelli
发明人： Christian Karst , Thierry Gozlan , Guy Derrieu , Luc Castelli
IPC分类号： A01K13/00 , A01K27/00 , A01M29/00 , A01N25/34 , A61D7/00 , A61K9/00
CPC分类号： A01K27/007
摘要： Device capable of being used in combination with a restraining or ornamental collar or with any other support for animals, intended to make possible the controlled and optically continuous and complete release of chemical substances, including medicaments, for more or less lengthy, continuous or noncontinuous, periods and process for producing the said device. The device comprises a polymeric matrix enclosing at least one active substance capable of being released towards an appropriate area of an animal. The device is composed of at least one tubular component of any cross-section, containing at least one layer of flexible polymeric matrix containing at least one active substance, the length of the said tubular component can be regulated to adjust the daily dose of the active substance to the weight of the animal and the ratio of the external surface area of said tubular component to the thickness of its' wall is as great as possible to obtain linear removal of the active substance.
摘要翻译：能够与限制性或装饰性领结合使用的装置，或与动物的任何其它支持物一起使用的装置，其旨在使得化学物质（包括药物）的受控和光学连续和完全释放可能或多或少地长时间连续或不连续，期间和用于生产所述装置的过程。该装置包括聚合物基体，其包围能够朝向动物的适当区域释放的至少一种活性物质。该装置由任何横截面的至少一个管状部件组成，其包含至少一层包含至少一种活性物质的柔性聚合物基质，可调节所述管状组分的长度以调节活性物质的日剂量物质相对于动物的重量，并且所述管状部件的外表面积与其壁的厚度的比率尽可能大以获得活性物质的线性去除。

2. 发明授权

US6010720A Composition and system for oral administration to animals 失效
标题翻译：用于口服给予动物的组合物和系统
公开(公告)号：US6010720A
公开(公告)日：2000-01-04
申请号：US615285
申请日：1996-05-22
申请人： Guy Derrieu , Bernard Raynier , Jean-Luc Pougnas , Luc Castelli
发明人： Guy Derrieu , Bernard Raynier , Jean-Luc Pougnas , Luc Castelli
IPC分类号： A23K1/16 , A01N25/00 , A23K1/00 , A23K1/18 , A61K9/00 , A61K9/20 , A61K9/10 , A61K9/16 , A61K47/32
CPC分类号： A01N25/004 , A23K40/20 , A23K40/30 , A23K50/40 , A23K50/80 , A61K9/0056
摘要： Composition and system for oral administration of chemicals or medicaments, and applications thereof (for example as medicament, dietetic product, food product, bait). Said composition comprises essentially (a) from 3% to 20% by weight of at least one water-insoluble polymer selected from the polyamides and ethylene copolymers such as ethylene/vinyl acetate; (b) from 35% to 60% by weight of lipidic substances, at least one of these lipidic substances being solid at room temperature, the melting point of the solid lipidic substance(s) being lower than that of the polymer(s); (c) from 5% to 45% of at least one paletable substance; (d) from 0% to 50% of another suitable complementary ingredient. Said composition can be obtained by (i) melting of the solid lipidic substances at a temperature lower than the melting point of the polymer(s), and (ii) mixing of the polymer(s) and the other constituents at the same temperature as for (i). A method of preparing said systems and composition is also disclosed.
摘要翻译： PCT No.PCT / FR94 / 01120 Sec。 371日期：1996年5月22日 102（e）日期1996年5月22日PCT 1994年9月27日PCT公布。公开号WO95 / 08931 日期1995年04月6日化学品或药物的口服化合物和制剂及其应用（例如药物，饮食品，食品，诱饵）。所述组合物基本上包含（a）3重量％至20重量％的至少一种选自聚酰胺和乙烯共聚物如乙烯/乙酸乙烯酯的水不溶性聚合物; （b）35％至60％重量的脂质物质，这些脂质物质中的至少一种在室温下为固体，固体脂质物质的熔点低于聚合物的熔点; （c）至少一种可定制物质的5％至45％; （d）0％至50％的另一种合适的互补成分。所述组合物可以通过（i）在低于聚合物熔点的温度下熔化固体脂质物质获得，和（ii）将聚合物和其它组分在与为我）。还公开了制备所述体系和组合物的方法。

3. 发明授权

US06500446B1 Compositions which contain at least one cationic polymer and at least one active molecule contained in at least one micro or nonopartculate vector, and their use for treating living or inert surfaces 失效
标题翻译：含有至少一种阳离子聚合物和至少一种包含在至少一种微型或非公制载体中的活性分子的组合物及其用于处理活性或惰性表面的用途
公开(公告)号：US06500446B1
公开(公告)日：2002-12-31
申请号：US09059200
申请日：1998-04-14
申请人： Guy Derrieu , Jean-Luc Pougnas , Patricia Monginoux , Christian Karst
发明人： Guy Derrieu , Jean-Luc Pougnas , Patricia Monginoux , Christian Karst
IPC分类号： A01N2528
CPC分类号： A61K8/99 , A01N25/10 , A01N25/28 , A61K8/11 , A61K8/14 , A61K9/0014 , A61K9/1272 , A61K47/32 , A61K47/36 , A61K2800/413 , A61K2800/5426 , A61Q5/00 , A61Q17/02 , A61Q19/00 , A61Q19/02 , B82Y5/00
摘要： The present invention relates to compositions which contain at least one cationic polymer and at least one active molecule contained in at least one micro or nanoparticulate vector, and their use for treating living or inert surfaces.
摘要翻译：本发明涉及包含至少一种阳离子聚合物和至少一种包含在至少一种微粒或纳米颗粒载体中的活性分子的组合物及其用于处理活性或惰性表面的用途。

4. 发明授权

US06382137B1 Device for controlled release of active substances and for restraint and method for making same 有权
标题翻译：用于控制释放活性物质和限制的装置及其制造方法
公开(公告)号：US06382137B1
公开(公告)日：2002-05-07
申请号：US09582527
申请日：2000-09-05
申请人： Guy Derrieu , Bruno Roy , Christian Karst , Thierry Grenier
发明人： Guy Derrieu , Bruno Roy , Christian Karst , Thierry Grenier
IPC分类号： A01K2900
CPC分类号： A01K27/007
摘要： Device designed to be carried by an animal and capable of controlled release of one or several active principles and, more particularly, one or several medicinal active principles to protect and/or treat this animal against possible pathologies, and capable of being used as a restraint for controlling and managing the animal. In one embodiment the device is used with a leash or lead fixed to the device. Method for making the device. The device comprises a first material for the controlled release of one or several active substances of polymer matrix type containing this active substance and a second material for providing it with mechanical resistance, the materials being closely bound within a single structure.
摘要翻译：设计为由动物携带并且能够控制释放一种或几种活性成分的装置，更具体地，一种或多种药物活性成分，以保护和/或治疗该动物免受可能的病理学，并且能够用作约束用于控制和管理动物。在一个实施例中，该装置与固定到该装置的皮带或导线一起使用。制造设备的方法该装置包括用于控制释放包含该活性物质的聚合物基质型的一种或多种活性物质的第一材料和用于使其具有机械阻力的第二材料，所述材料紧密地结合在单一结构内。

5. 发明授权

US06599888B1 Chondroitin sulphate and chitosan compositions for treating rheumatic disorders 有权
标题翻译：用于治疗风湿性疾病的硫酸软骨素和壳聚糖组合物
公开(公告)号：US06599888B1
公开(公告)日：2003-07-29
申请号：US09743259
申请日：2002-02-22
申请人： Guy Derrieu , Jean-Luc Pougnas
发明人： Guy Derrieu , Jean-Luc Pougnas
IPC分类号： A61K3172
CPC分类号： A61K31/737 , A61K31/715 , A61K45/06 , A61K31/722 , A61K2300/00
摘要： The subject of the present invention is the use of a preparation comprising: a) from 1 to 50% by weight, relative to the total weight of the preparation, of at least one compound chosen from chondroitin sulfates and their salts, and b) from 1 to 66% by weight, relative to the total weight of the preparation, of at least one compound chosen from chitosan, its salts, its derivatives and the salts of these derivatives, for the preparation of a composition for the prevention or treatment of rheumatic conditions by the general route, and, in particular, for the prevention or treatment of degenerative arthropathies.
摘要翻译：本发明的主题是使用制剂，其包含：a）相对于制剂的总重量为1至50重量％的至少一种选自硫酸软骨素及其盐的化合物，和b）1 至66重量％，相对于制剂的总重量，至少一种选自壳聚糖，其盐，其衍生物和这些衍生物的盐的化合物，用于制备用于预防或治疗风湿病症的组合物通过一般路线，特别是预防或治疗退行性关节病。

6. 发明申请

US20140343004A1 Compositions for Oral Administration to Animals, Processes for Obtaining the Same and the Uses Thereof 审中-公开
标题翻译：口头管理动物的组成，获取动物的过程及其用途
公开(公告)号：US20140343004A1
公开(公告)日：2014-11-20
申请号：US14344246
申请日：2012-08-31
申请人： Guy Derrieu , Giancarlo Mazzola
发明人： Guy Derrieu , Giancarlo Mazzola
IPC分类号： A61K31/7048 , A61K31/4985 , A23K1/17 , A61K31/506
摘要： The present invention concerns a solid, palatable composition and its preparation process which, relative to the total weight of the composition, comprises: 5 to 30%, preferably 8 to 20% by weight of at least one fat chosen from among a liquid oil, a fat, wax or mixture thereof, the liquid oil not to represent more than 8% by weight of the composition; 0.001 to 85% by weight of at least one active substance; and 20 to 95%, preferably 40 to 70% by weight of at least one palatable material, for use thereof as medicinal product, nutraceutical or food supplement, for oral administration to mammals, except man, in particular for domestic animals such as dogs, cats or horses. The said solid composition is obtained by mixing the components, vaporising the fats, calibrating the dry, fluid granular material and compressing the granular material in a stock cube press.
摘要翻译：本发明涉及一种固体，可口的组合物及其制备方法，其相对于组合物的总重量包含：5-30％，优选8-20％重量的至少一种选自液体油，脂肪，蜡或其混合物，液体油不占组合物重量的8％以上; 0.001〜85重量％的至少一种活性物质; 和20至95％，优选40至70重量％的至少一种可口的材料，用于作为医药产品，营养保健品或食品补充剂，用于口服哺乳动物，除了人，特别是家畜如狗，猫或马。所述固体组合物通过混合组分，蒸发脂肪，校准干燥的流体颗粒材料并在原料立方体压榨机中压缩颗粒材料而获得。

7. 发明授权

US08790674B2 Derivative for preparing a topical veterinary pharmaceutical composition for combating external parasites 有权
标题翻译： 1-N-（卤代-3-吡啶基甲基）-N-甲基氨基-1-烷基氨基-2-硝基亚乙基衍生物用于制备用于对抗外部寄生虫的局部兽用药物组合物
公开(公告)号：US08790674B2
公开(公告)日：2014-07-29
申请号：US12682133
申请日：2008-10-10
申请人： Guy Derrieu , Jean Pascal Marc
发明人： Guy Derrieu , Jean Pascal Marc
IPC分类号： A01N25/02 , A61K31/415 , A01N43/40 , A61K31/44
CPC分类号： A01N43/40 , A61K31/415 , A61K31/44 , A61K2300/00
摘要： The present invention relates to the use, as active ingredient, of a 1-N-(halo-3-pyridylmethyl)-N-methylamino-1-alkylamino-2-nitroethylene derivative for preparing a veterinary pharmaceutical composition for topical use in the treatment of external parasites, in particular fleas, in domestic animals, in particular in dogs and cats, intended to be applied at least every 2 weeks.
摘要翻译：本发明涉及作为活性成分使用1-N-（卤代-3-吡啶基甲基）-N-甲基氨基-1-烷基氨基-2-硝基亚乙基衍生物，用于制备用于局部用于治疗的兽用药物组合物外部寄生虫，特别是蚤，家畜，特别是狗和猫，旨在至少每2周施用。

8. 发明授权

US09259448B2 Compositions comprising dehydrated micro-organisms, method for preparing same, and uses thereof 有权
标题翻译：包含脱水微生物的组合物，其制备方法及其用途
公开(公告)号：US09259448B2
公开(公告)日：2016-02-16
申请号：US11815703
申请日：2006-02-06
申请人： Guy Derrieu
发明人： Guy Derrieu
IPC分类号： C12N1/04 , A61K35/742 , A23L1/30 , A61K35/744 , A61K35/745 , A61K35/747 , A61K36/06 , A61K45/06 , A23L1/00 , A23L1/03
CPC分类号： A61K35/747 , A23L29/065 , A23L33/10 , A23L33/135 , A23L33/14 , A23L33/15 , A23L33/16 , A23L33/175 , A23P10/20 , A23P10/28 , A23V2002/00 , A23Y2220/67 , A23Y2240/00 , A61K9/19 , A61K9/20 , A61K35/742 , A61K35/744 , A61K35/745 , A61K36/06 , A61K45/06 , Y10T428/2982 , A61K2300/00 , A23V2200/254 , A23V2250/06 , A23V2250/206 , A23V2250/70 , A23V2250/76
摘要： The invention relates to a composition comprising revivable dehydrated micro-organisms. The invention is characterized in that it further comprises particles at least 50% of which have a mean diameter greater than 250 μm. The invention is applicable, in particular, to human or veterinary pharmaceuticals, to dietetics or to food products.
摘要翻译：本发明涉及包含可再生脱水微生物的组合物。本发明的特征在于，其还包含至少50％的平均直径大于250μm的颗粒。本发明特别适用于人类或兽医药品，饮食学或食品产品。

9. 发明授权

US5935603A Water soluble powder form compositions and their applications thereof 失效
标题翻译：水溶性粉末状组合物及其应用
公开(公告)号：US5935603A
公开(公告)日：1999-08-10
申请号：US945246
申请日：1997-12-22
申请人： Guy Derrieu , Jean-Luc Pougnas , Olivier Broussaud
发明人： Guy Derrieu , Jean-Luc Pougnas , Olivier Broussaud
IPC分类号： A61K47/02 , A61K9/14 , A61K31/43 , A61K31/47 , A61K31/545
CPC分类号： A61K47/02 , Y10S514/951
摘要： Water soluble, powder form compositions suitable for completely and rapidly dissolving active ingredients which usually only dissolve in water in the presence of base salts, such as antibiotics of the betalactamide family, for example penicillins and their derivatives, cephalosporins and their derivatives, or other active ingredients such as sulphamides and quinolones, for oral absorption thereof and their applications. The water soluble powder form compositions contain, in combination and in powder form, at least one water soluble active ingredient, not in salt form, and with an exclusively alkaline pH, an excess of one or more strong base salts, and one or more buffers comprising one or more substances and capable of maintaining the pH of the medium at a level below the normal solubilization pH of said active ingredient. Aqueous solution compositions obtained from said powder form compositions are also described.
摘要翻译： PCT No.PCT / FR96 / 00635 Sec。 371 1997年12月22日第 102（e）日期1997年12月22日PCT提交1996年4月25日PCT公布。公开号WO96 / 33743 日期1996年10月31日适用于完全和快速溶解活性成分的水溶性粉末形式组合物，其通常仅在碱盐存在下溶解在水中，例如betalactamide家族的抗生素，例如青霉素及其衍生物，头孢菌素及其衍生物或其它活性成分，例如磺酰胺和喹诺酮，用于口服吸收及其应用。水溶性粉末形式的组合物组合含有粉末形式的至少一种水溶性活性成分，不是盐形式，并且具有纯碱性pH，过量的一种或多种强碱盐和一种或多种缓冲液包含一种或多种物质并能够将培养基的pH保持在低于所述活性成分的正常溶解pH的水平。还描述了由所述粉末形式组合物获得的水溶液组合物。

10. 发明授权

US5527523A Hydroquinone amino-acid esters, methods of preparation, and pharmaceutical or cosmetic compositions containing them 失效
标题翻译：对苯二酚氨基酸酯，制备方法和含有它们的药物或化妆品组合物
公开(公告)号：US5527523A
公开(公告)日：1996-06-18
申请号：US917077
申请日：1992-10-13
申请人： Claude Laruelle , Bernard Raynier , Guy Derrieu
发明人： Claude Laruelle , Bernard Raynier , Guy Derrieu
IPC分类号： A61K8/30 , A61K8/00 , A61K8/42 , A61K8/44 , A61K8/49 , A61K31/215 , A61K31/22 , A61K31/235 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/404 , A61K31/415 , A61K47/18 , A61P43/00 , A61Q19/00 , A61Q19/02 , C07C229/06 , C07C229/08 , C07C233/47 , C07C233/83 , C07C237/06 , C07C323/57 , C07C323/58 , C07D207/28 , C07D209/20 , C07D233/64 , A61K7/48 , A61K7/00
CPC分类号： C07D207/28 , A61K47/183 , A61K8/44 , A61K8/49 , A61K8/4913 , A61K8/492 , A61K8/494 , A61K9/0014 , A61Q19/02 , C07C233/47 , C07C233/83
摘要： Hydroquinone amino-acid esters having formula (I), pharmaceutical or cosmetic compositions containing them, particularly dermatological compositions having pigment-removing activity, and the pharmaceutical, cosmetic or aesthetic uses thereof. The preparation of these novel hydroquinone esters from natural amino-acid derivatives is also described. ##STR1##
摘要翻译： PCT No.PCT / FR91 / 00114 Sec。 371日期：1992年10月13日 102（e）日期1992年10月13日PCT 1991年2月13日提交PCT公布。公开号WO91 / 11996 日本1991年8月22日。具有式（I）的氢醌氨基酸酯，含有它们的药物或化妆品组合物，特别是具有去除色素的活性的皮肤病学组合物，以及其药物，美容或美容用途。还描述了由天然氨基酸衍生物制备这些新型氢醌酯。（一）

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