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1. 发明授权

US08297959B2 Systems for producing multilayered particles, fibers and sprays and methods for administering the same 失效
标题翻译：用于生产多层颗粒，纤维和喷雾剂的系统及其施用方法
公开(公告)号：US08297959B2
公开(公告)日：2012-10-30
申请号：US11743560
申请日：2007-05-02
申请人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
发明人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
IPC分类号： B29B9/10 , A61J3/07
CPC分类号： A61K9/5146 , A61K9/5094 , A61K9/5115 , A61K9/5192 , A61K47/551 , A61K47/642 , A61K47/6425 , A61K47/6849 , A61K47/6925 , A61K49/0043 , A61K49/0047 , A61K49/0056 , A61K49/0065 , A61K49/0093 , A61K49/1878 , A61K51/1244 , B01J13/04 , B05B5/0255 , B05B7/061 , B82Y5/00
摘要： Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.
摘要翻译：具有至少一种包封和/或包埋的试剂（例如治疗剂，成像剂和其它成分）的胶囊和颗粒可以通过电动力学方法制备。更具体地，封装在载体，胶囊，颗粒，载体或载体中的试剂可以最大限度地减少治疗和/或成像的不利影响，从而最大化恶性癌症的治疗和/或成像。

2. 发明授权

US08168229B2 Methods for making a multicomponent hemostatic dressing 有权
标题翻译：制备多组分止血敷料的方法
公开(公告)号：US08168229B2
公开(公告)日：2012-05-01
申请号：US12299842
申请日：2006-09-27
申请人： Gustavo Larsen , Ruben Spretz
发明人： Gustavo Larsen , Ruben Spretz
IPC分类号： A61K35/16 , A61F13/00
CPC分类号： A61F13/00991 , A61F2013/00463 , A61L15/32 , A61L15/64 , A61L2400/04
摘要： A method of making a pliable, bioabsorbable hemostatic dressing wherein the dressing is composed of fibers with at least one molecular-scale coating, which upon first contact with blood and due to a large area of contact with blood per unit weight of active ingredients, initiates and accelerates the biochemical blood clotting cascade processes. The steps of the method include dissolving in an organic solvent one or more soluble bioabsorbable polymers and organic or aqueous-organic media of non-protein constituents to create a homogeneous mixture; forming fibers from the homogeneous mixture; adding to the fibers a molecular-scale first coating of one or more proteins of blood clotting species that minimally react with each other; and optionally adding a second coating of one or more proteins of blood clotting species to the fibers that minimally react with each other and that, together with the one or more proteins of blood clotting species in the molecular-scale first coating, induce blood coagulation in the presence of blood. The fibers may optionally have occluded in them or at their surface other chemicals of abiological or biological origin that aid in the blood clotting process.
摘要翻译：一种制造柔韧的生物吸收性止血敷料的方法，其中所述敷料由具有至少一种分子级涂层的纤维组成，其在首次接触血液并且由于与每单位重量活性成分的血液接触面积大时，起始并加速生化血液凝固级联过程。该方法的步骤包括在有机溶剂中溶解一种或多种可溶性生物可吸收聚合物和非蛋白质组分的有机或水性有机介质以产生均匀混合物; 从均匀混合物形成纤维; 向所述纤维添加一种或多种最小程度地彼此反应的凝血物质的蛋白质的分子级第一次涂层; 并且任选地将一种或多种血液凝固物质的第二涂层添加到彼此最少反应的纤维中，并且与分子级第一涂层中的一种或多种血液凝固物质的蛋白质一起诱导血液凝固血液的存在纤维可以任选地在其中或在其表面上封闭有助于血液凝固过程的生物或生物来源的其它化学物质。

3. 发明申请

US20070296099A1 SYSTEMS FOR PRODUCING MULTILAYERED PARTICLES, FIBERS AND SPRAYS AND METHODS FOR ADMINISTERING THE SAME 失效
标题翻译：用于生产多层颗粒，纤维和喷雾的系统及其管理方法
公开(公告)号：US20070296099A1
公开(公告)日：2007-12-27
申请号：US11743560
申请日：2007-05-02
申请人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
发明人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
IPC分类号： A61K9/00
CPC分类号： A61K9/5146 , A61K9/5094 , A61K9/5115 , A61K9/5192 , A61K47/551 , A61K47/642 , A61K47/6425 , A61K47/6849 , A61K47/6925 , A61K49/0043 , A61K49/0047 , A61K49/0056 , A61K49/0065 , A61K49/0093 , A61K49/1878 , A61K51/1244 , B01J13/04 , B05B5/0255 , B05B7/061 , B82Y5/00
摘要： Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.
摘要翻译：具有至少一种包封和/或包埋的试剂（例如治疗剂，成像剂和其它成分）的胶囊和颗粒可以通过电动力学方法制备。更具体地，封装在载体，胶囊，颗粒，载体或载体中的试剂可以最大限度地减少治疗和/或成像的不利影响，从而最大化恶性癌症的治疗和/或成像。

4. 发明申请

US20120171355A1 Method of Manufacturing Fibrous Hemostatic Bandages 失效
标题翻译：制造纤维性止血绷带的方法
公开(公告)号：US20120171355A1
公开(公告)日：2012-07-05
申请号：US13414949
申请日：2012-03-08
申请人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz
发明人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz
IPC分类号： A61F13/02
CPC分类号： A61K38/363 , A61K38/4833 , A61K38/484 , A61L15/32 , A61L2400/04 , D01D5/0061 , D01D5/0092 , D01D5/18 , D01D10/00 , D01F1/10
摘要： A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.
摘要翻译：通过制造最大限度地暴露每单位重量活性成分的表面积的纤维作为帮助凝块形成过程的手段并且作为使活性成分的浪费最小化的手段来制造坚固和柔韧的纤维止血敷料的方法。该方法使用旋转物体来分离其中心附加的液体生物相容性纤维前体。形成的纤维然后沉积在与旋转物体一定距离处的收集器上，在收集器上产生纤维层。在旋转盘和收集器之间保持电位差。然后，将液体促凝物质引入旋转盘的中心，使其旋转旋转盘并涂覆纤维。

5. 发明申请

US20090136651A1 Method of Manufacturing Fibrous Hemostatic Bandages 审中-公开
标题翻译：制造纤维性止血绷带的方法
公开(公告)号：US20090136651A1
公开(公告)日：2009-05-28
申请号：US12281588
申请日：2007-01-13
申请人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz
发明人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz
IPC分类号： B05D3/12
CPC分类号： A61K38/363 , A61K38/4833 , A61K38/484 , A61L15/32 , A61L2400/04 , D01D5/0061 , D01D5/0092 , D01D5/18 , D01D10/00 , D01F1/10
摘要： A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.
摘要翻译：通过制造最大限度地暴露每单位重量活性成分的表面积的纤维作为帮助凝块形成过程的手段并且作为使活性成分的浪费最小化的手段来制造坚固和柔韧的纤维止血敷料的方法。该方法使用旋转物体来分离其中心附加的液体生物相容性纤维前体。形成的纤维然后沉积在与旋转物体一定距离处的收集器上，在收集器上产生纤维层。在旋转盘和收集器之间保持电位差。然后，将液体促凝物质引入旋转盘的中心，使其旋转旋转盘并涂覆纤维。

6. 发明授权

US08257778B2 Method of manufacturing fibrous hemostatic bandages 失效
标题翻译：纤维止血绷带的制造方法
公开(公告)号：US08257778B2
公开(公告)日：2012-09-04
申请号：US13414949
申请日：2012-03-08
申请人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz
发明人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz
IPC分类号： A61F13/02
CPC分类号： A61K38/363 , A61K38/4833 , A61K38/484 , A61L15/32 , A61L2400/04 , D01D5/0061 , D01D5/0092 , D01D5/18 , D01D10/00 , D01F1/10
摘要： A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.
摘要翻译：通过制造最大限度地暴露每单位重量活性成分的表面积的纤维作为帮助凝块形成过程的手段并且作为使活性成分的浪费最小化的手段来制造坚固和柔韧的纤维止血敷料的方法。该方法使用旋转物体来分离其中心附加的液体生物相容性纤维前体。形成的纤维然后沉积在与旋转物体一定距离处的收集器上，在收集器上产生纤维层。在旋转盘和收集器之间保持电位差。然后，将液体促凝物质引入旋转盘的中心，使其旋转旋转盘并涂覆纤维。

7. 发明申请

US20090181072A1 Methods for Making a Multicomponent Hemostatic Dressing 有权
标题翻译：制造多组分止血敷料的方法
公开(公告)号：US20090181072A1
公开(公告)日：2009-07-16
申请号：US12299842
申请日：2006-09-27
申请人： Gustavo Larsen , Ruben Spretz
发明人： Gustavo Larsen , Ruben Spretz
IPC分类号： A61L15/00
CPC分类号： A61F13/00991 , A61F2013/00463 , A61L15/32 , A61L15/64 , A61L2400/04
摘要： A method of making a pliable, bioabsorbable hemostatic dressing wherein the dressing is composed of fibers with at least one molecular-scale coating, which upon first contact with blood and due to a large area of contact with blood per unit weight of active ingredients, initiates and accelerates the biochemical blood clotting cascade processes. The steps of the method include dissolving in an organic solvent one or more soluble bioabsorbable polymers and organic or aqueous-organic media of non-protein constituents to create a homogeneous mixture; forming fibers from the homogeneous mixture; adding to the fibers a molecular-scale first coating of one or more proteins of blood clotting species that minimally react with each other; and optionally adding a second coating of one or more proteins of blood clotting species to the fibers that minimally react with each other and that, together with the one or more proteins of blood clotting species in the molecular-scale first coating, induce blood coagulation in the presence of blood. The fibers may optionally have occluded in them or at their surface other chemicals of abiological or biological origin that aid in the blood clotting process.
摘要翻译：一种制造柔韧的生物吸收性止血敷料的方法，其中所述敷料由具有至少一种分子级涂层的纤维组成，其在首次接触血液并且由于与每单位重量活性成分的血液接触面积大时，起始并加速生化血液凝固级联过程。该方法的步骤包括在有机溶剂中溶解一种或多种可溶性生物可吸收聚合物和非蛋白质组分的有机或水性有机介质以产生均匀混合物; 从均匀混合物形成纤维; 向所述纤维添加一种或多种最小程度地彼此反应的凝血物质的蛋白质的分子级第一次涂层; 并且任选地将一种或多种血液凝固物质的第二涂层添加到彼此最少反应的纤维中，并且与分子级第一涂层中的一种或多种血液凝固物质的蛋白质一起诱导血液凝固血液的存在纤维可以任选地在其中或在其表面上封闭有助于血液凝固过程的生物或生物来源的其它化学物质。

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