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1. 发明申请

US20100292781A1 STENT ADVANCEMENT ASSISTANT AND LESION DILATOR WIRE 审中-公开
标题翻译： STENT ADVANCEMENT ASSISTANT和LESION DILATOR WIRE
公开(公告)号：US20100292781A1
公开(公告)日：2010-11-18
申请号：US12812530
申请日：2009-01-05
申请人： Gurpreet S. Sandhu , Charanjit S. Rihal , Rajiv Gulati , John F. Bresnahan
发明人： Gurpreet S. Sandhu , Charanjit S. Rihal , Rajiv Gulati , John F. Bresnahan
IPC分类号： A61F2/82
CPC分类号： A61M25/09 , A61F2/95 , A61F2250/0062 , A61M25/09041 , A61M2025/09133
摘要： Materials and methods for placement of catheters, stents, and other therapeutic or diagnostic devices in blood vessels.
摘要翻译：在血管中放置导管，支架和其他治疗或诊断装置的材料和方法。

2. 发明申请

US20100331809A1 CONFORMABLE STENTS AND METHODS FOR MAKING 有权
标题翻译：一致的制造方法和制造方法
公开(公告)号：US20100331809A1
公开(公告)日：2010-12-30
申请号：US12919122
申请日：2009-02-25
申请人： Gurpreet S. Sandhu , Dan Dragomir Daescu , Charanjit S. Rihal , Samuel J. Asirvatham
发明人： Gurpreet S. Sandhu , Dan Dragomir Daescu , Charanjit S. Rihal , Samuel J. Asirvatham
IPC分类号： A61M25/10
CPC分类号： A61F2/945 , A61F2/88 , A61F2/90 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2210/0085 , A61F2230/0067 , A61F2250/0039 , A61M25/1002 , A61M2025/1086
摘要： Materials and methods for making conformable stents. The stents can be generated by, for example, injecting a fluid into a scaffold on the outer surface of an angioplasty balloon inflated at the site of a stenosis, and allowing the fluid to harden or set, thus generating a stent that can remain in the vessel at the site of stenosis.
摘要翻译：制作适形支架的材料和方法。支架可以通过例如将流体注射到在狭窄部位膨胀的血管成形术球囊的外表面上的支架中，并且允许流体硬化或固定，从而产生可保留在支架中的支架血管狭窄部位。

3. 发明授权

US08388674B2 Conformable stents and methods for making 有权
标题翻译：合适的支架和制作方法
公开(公告)号：US08388674B2
公开(公告)日：2013-03-05
申请号：US12919122
申请日：2009-02-25
申请人： Gurpreet S. Sandhu , Dan Dragomir Daescu , Charanjit S. Rihal , Samuel J. Asirvatham
发明人： Gurpreet S. Sandhu , Dan Dragomir Daescu , Charanjit S. Rihal , Samuel J. Asirvatham
IPC分类号： A61F2/82 , A61F11/00
CPC分类号： A61F2/945 , A61F2/88 , A61F2/90 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2210/0085 , A61F2230/0067 , A61F2250/0039 , A61M25/1002 , A61M2025/1086
摘要： Materials and methods for making conformable stents. The stents can be generated by, for example, injecting a fluid into a scaffold on the outer surface of an angioplasty balloon inflated at the site of a stenosis, and allowing the fluid to harden or set, thus generating a stent that can remain in the vessel at the site of stenosis.
摘要翻译：制作适形支架的材料和方法。支架可以通过例如将流体注射到在狭窄部位膨胀的血管成形术球囊的外表面上的支架中，并且允许流体硬化或固定，从而产生可保留在支架中的支架血管狭窄部位。

4. 发明申请

US20100030251A1 DEVICES AND METHODS FOR CROSSING CHRONIC TOTAL OCCLUSIONS 审中-公开
标题翻译：用于交叉治疗慢性阻塞性疾病的装置和方法
公开(公告)号：US20100030251A1
公开(公告)日：2010-02-04
申请号：US12302142
申请日：2007-05-22
申请人： Gurpreet S. Sandhu , Charanjit S. Rihal
发明人： Gurpreet S. Sandhu , Charanjit S. Rihal
IPC分类号： A61M29/00 , A61M25/00
CPC分类号： A61B17/3207 , A61B2017/00858 , A61B2017/22094 , A61M25/0043 , A61M25/0662 , A61M29/00 , A61M2025/006
摘要： Devices and methods for crossing total chronic occlusions in body lumens (e.g., blood vessels, etc.). The devices and methods may involve guidewire assisted delivery of a device designed to both traverse a chronic total occlusion (CTO) and create a passageway through the CTO for a treatment device (e.g., an angioplasty balloon, stent, etc.). Some devices of the present invention may include an expandable sleeve constructed of material that expands in response to temperature changes. In other devices, an expandable sleeve may be provided in which two or more interlocking cylindrical sections can be arranged such that the cylindrical sections have a first, smaller diameter at which the expandable sleeve can be inserted through a CTO. The expandable sleeve also has a second, larger diameter that can be achieved by moving the two or more interlocking cylindrical sections relative to each other such that the expandable sleeve moves from the first diameter to the second diameter when the expandable sleeve is located across the CTO. In other aspects, a guide catheter may include a friction-enhanced outer surface to assist in maintaining the guide catheter in a selected location during use. The friction-enhanced property may be provided using, e.g., materials with an increased coefficient of friction, adding features to the surface of an otherwise smooth guide catheter, etc.
摘要翻译：用于穿过体腔（例如血管等）中的全部慢性闭塞的装置和方法。装置和方法可以包括设计成横穿慢性完全闭塞（CTO）并且通过用于治疗装置（例如血管成形术球囊，支架等）的CTO的通道的导丝辅助递送。本发明的一些装置可以包括由可响应于温度变化而膨胀的材料构成的可膨胀套筒。在其他装置中，可以提供可膨胀套筒，其中可以布置两个或更多个互锁圆柱形部分，使得圆柱形部分具有第一较小直径，在该直径下，可扩张套筒可以穿过CTO插入。可膨胀套筒还具有第二较大直径，其可以通过相对于彼此移动两个或更多个互锁的圆柱形部分来实现，使得当可膨胀套筒位于CTO周围时，可膨胀套筒从第一直径移动到第二直径。在其他方面，引导导管可以包括摩擦增强的外表面，以在使用期间辅助将引导导管保持在选定的位置。摩擦增强特性可以使用例如具有增加的摩擦系数的材料来提供，在另外平滑的引导导管的表面上增加特征等。

5. 发明申请

US20090118817A1 Magnetic Medical Apparatus, Kits, and Methods 审中-公开
标题翻译：磁性医疗器械，套件和方法
公开(公告)号：US20090118817A1
公开(公告)日：2009-05-07
申请号：US11922172
申请日：2006-06-16
申请人： Gurpreet S. Sandhu , Robert D. Simari , Nicole P. Sandhu , Rajiv Gulati
发明人： Gurpreet S. Sandhu , Robert D. Simari , Nicole P. Sandhu , Rajiv Gulati
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/04 , A61F2/06 , A61F2/24 , A61F2/30 , A61F2/82 , A61F2002/077 , A61F2002/30079 , A61F2210/009 , A61N2001/0585
摘要： Medical devices with surfaces on which viable biologic cells are magnetically attracted and retained are disclosed along with methods of magnetic coating. The medical devices can be located in a carrier liquid containing high concentrations of magnetic cells before or after implantation. The carrier liquid with magnetic cells may be contact with the medical device in vitro or in vivo. In either case, the carrier liquid may have a concentration of magnetic cells that is high enough to facilitate coating of the medical device within an acceptable period of time, e.g., several hours or less. Magnetization of medical devices before, during, and/or after implantation and apparatus for performing the same are disclosed. Degaussing of magnetic medical devices is also disclosed.
摘要翻译：公开了具有磁力吸引和保留活生物细胞的表面的医疗装置以及磁性涂层的方法。在植入之前或之后，医疗装置可以位于含有高浓度磁性细胞的载液中。具有磁性细胞的载液可以在体外或体内与医疗装置接触。在任一情况下，载液可以具有足够高的磁性细胞浓度，以便于在可接受的时间内（例如数小时或更短）的时间内涂覆医疗装置。公开了在植入之前，期间和/或之后的医疗装置的磁化，以及用于执行它们的装置。还公开了磁性医疗装置的消磁。

6. 发明授权

US08465453B2 Kits, apparatus and methods for magnetically coating medical devices with living cells 有权
标题翻译：用活性细胞磁性涂覆医疗器械的试剂盒，仪器和方法
公开(公告)号：US08465453B2
公开(公告)日：2013-06-18
申请号：US11446861
申请日：2006-06-05
申请人： Gurpreet S. Sandhu , Robert D. Simari , Nicole P. Sandhu , Rajiv Gulati
发明人： Gurpreet S. Sandhu , Robert D. Simari , Nicole P. Sandhu , Rajiv Gulati
IPC分类号： A61M29/00 , A61M25/00 , A61M25/10
CPC分类号： A61F2/06 , A61F2/04 , A61F2/07 , A61F2/24 , A61F2/82 , A61F2/90 , A61F2/958 , A61F2210/0004 , A61F2210/009 , A61L27/28 , A61L27/54 , A61L27/56 , A61L27/58 , A61N1/05 , A61N1/375 , A61N2/06 , A61N2001/0585
摘要： Medical devices with surfaces on which viable biologic cells are magnetically attracted and retained are disclosed along with methods of magnetic coating. The medical devices can be located in a carrier liquid containing high concentrations of magnetic cells before or after implantation. The carrier liquid with magnetic cells may be contact with the medical device in vitro or in vivo. In either case, the carrier liquid may have a concentration of magnetic cells that is high enough to facilitate coating of the medical device within an acceptable period of time, e.g., several hours or less. Magnetization of medical devices before, during, and/or after implantation and apparatus for performing the same are disclosed. Degaussing of magnetic medical devices is also disclosed.
摘要翻译：公开了具有磁力吸引和保留活生物细胞的表面的医疗装置以及磁性涂层的方法。在植入之前或之后，医疗装置可以位于含有高浓度磁性细胞的载液中。具有磁性细胞的载液可以在体外或体内与医疗装置接触。在任一情况下，载液可以具有足够高的磁性细胞浓度，以便于在可接受的时间内（例如数小时或更短）的时间内涂覆医疗装置。公开了在植入之前，期间和/或之后的医疗装置的磁化，以及用于执行它们的装置。还公开了磁性医疗装置的消磁。

7. 发明授权

US09468516B2 Magnetic medical apparatus, kits, and methods 有权
标题翻译：磁性医疗器械，试剂盒和方法
公开(公告)号：US09468516B2
公开(公告)日：2016-10-18
申请号：US13013559
申请日：2011-01-25
申请人： Gurpreet S. Sandhu , Robert D. Simari , Nicole P. Sandhu , Rajiv Gulati
发明人： Gurpreet S. Sandhu , Robert D. Simari , Nicole P. Sandhu , Rajiv Gulati
IPC分类号： A61F2/30 , A61F2/07 , A61F2/04 , A61F2/06 , A61F2/24 , A61F2/82 , A61N1/05
CPC分类号： A61F2/07 , A61F2/04 , A61F2/06 , A61F2/24 , A61F2/30 , A61F2/82 , A61F2002/077 , A61F2002/30079 , A61F2210/009 , A61N2001/0585
摘要： Medical devices with surfaces on which viable biologic cells are magnetically attracted and retained are disclosed along with methods of magnetic coating. The medical devices can be located in a carrier liquid containing high concentrations of magnetic cells before or after implantation. The carrier liquid with magnetic cells may be contact with the medical device in vitro or in vivo. In either case, the carrier liquid may have a concentration of magnetic cells that is high enough to facilitate coating of the medical device within an acceptable period of time, e.g., several hours or less. Magnetization of medical devices before, during, and/or after implantation and apparatus for performing the same are disclosed. Degaussing of magnetic medical devices is also disclosed.
摘要翻译：公开了具有磁力吸引和保留活生物细胞的表面的医疗装置以及磁性涂层的方法。在植入之前或之后，医疗装置可以位于含有高浓度磁性细胞的载液中。具有磁性细胞的载液可以在体外或体内与医疗装置接触。在任一情况下，载液可以具有足够高的磁性细胞浓度，以便于在可接受的时间内（例如数小时或更短）的时间内涂覆医疗装置。公开了在植入之前，期间和/或之后的医疗装置的磁化，以及用于执行它们的装置。还公开了磁性医疗装置的消磁。

8. 发明申请

US20120150015A1 SYSTEM AND METHOD FOR DETECTING HEALING ADJACENT TO IMPLANTED MEDICAL DEVICE 审中-公开
标题翻译：用于检测植入医疗装置的健康相关的系统和方法
公开(公告)号：US20120150015A1
公开(公告)日：2012-06-14
申请号：US13392193
申请日：2010-08-05
申请人： Gurpreet S. Sandhu , Martin G. Rodriguez-Porcel
发明人： Gurpreet S. Sandhu , Martin G. Rodriguez-Porcel
IPC分类号： A61B6/00 , A61B5/05 , G01N23/04 , A61B8/12 , A61B5/055 , B05D3/10 , A61B5/00 , A61B8/00
CPC分类号： A61B8/12 , A61B5/0066 , A61B5/064 , A61B5/6852
摘要： A method of detecting healing adjacent to an implanted medical device can first include pre-treating a surface of the medical device prior to implantation, thereby defining a pre-treated surface of the medical device. Then, subsequent to implantation, a portion of the pre-treated surface that is not covered by endothelial tissue is detected by a detection device.
摘要翻译：检测与植入的医疗装置相邻的愈合的方法可以首先包括在植入之前对医疗装置的表面进行预处理，从而限定医疗装置的预处理表面。然后，在植入后，通过检测装置检测未被内皮组织覆盖的一部分预处理的表面。

9. 发明申请

US20100121188A1 REDUCING CONTRAST AGENT-INDUCED TOXICITY 审中-公开
标题翻译：减少对比剂引起的毒性
公开(公告)号：US20100121188A1
公开(公告)日：2010-05-13
申请号：US12445062
申请日：2007-10-10
申请人： Gurpreet S. Sandhu , David R. Holmes, III , David R. Holmes, JR. , Nicole P. Sandhu , Robert D. Simari
发明人： Gurpreet S. Sandhu , David R. Holmes, III , David R. Holmes, JR. , Nicole P. Sandhu , Robert D. Simari
IPC分类号： A61B6/10 , A61M25/00 , A61M25/10
CPC分类号： A61K49/18 , A61B17/22031 , A61B2017/00876 , A61B2017/22035 , A61F2/01 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0071 , A61F2230/0076
摘要： This document provides methods and materials that can be used to reduce or prevent contrast agent-induced toxicity. For example, devices for capturing contrast agents from blood are provided.
摘要翻译：本文档提供了可用于减少或预防造影剂诱导的毒性的方法和材料。例如，提供用于从血液捕获造影剂的装置。

10. 发明授权

US5763169A Nucleic acid probes for the detection and identification of fungi 失效
标题翻译：用于检测和鉴定真菌的核酸探针
公开(公告)号：US5763169A
公开(公告)日：1998-06-09
申请号：US373127
申请日：1995-01-13
申请人： Gurpreet S. Sandhu , Bruce C. Kline
发明人： Gurpreet S. Sandhu , Bruce C. Kline
IPC分类号： C12N15/09 , C07K14/37 , C12N15/10 , C12Q1/68 , C07H21/04 , C12N1/00 , C12P19/34
CPC分类号： C12N15/1003 , C07K14/37 , C12Q1/6806 , C12Q1/6895 , Y10S435/911 , Y10S435/913 , Y10S435/921 , Y10S435/922 , Y10S435/924 , Y10S435/929 , Y10S435/931 , Y10S435/933 , Y10S435/939 , Y10S435/94 , Y10S435/942 , Y10T436/143333
摘要： Nucleic acid probes and primers are described for detecting fungi that cause disease in humans and animals, as well as spoilage of food and beverages. These probes can detect rRNA, rDNA or polymerase chain reaction products from a majority of fungi in clinical, environmental or food samples. Nucleic acid hybridization assay probes specific for Aspergillus fumigatus, Blastomyces dermatitidis, Candida albicans, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Aspergillus flavus, Aspergillus glaucus, Aspergillus niger, Aspergillus terreus, Candida glabrata, Candida guilliermondii, Candida kefyr, Candida krusei, Candida lusitaniae, Candida parapsilosis, Candida tropicalis, Pseudallescheria boydii, and Sporothrix schenckii are also described.
摘要翻译：描述了核酸探针和引物用于检测在人和动物中引起疾病的真菌，以及食物和饮料的腐败。这些探针可以检测临床，环境或食品样品中大多数真菌的rRNA，rDNA或聚合酶链反应产物。核酸杂交测定探针，特异于烟曲霉，革兰氏阴性菌，白色念珠菌，球孢子菌，新生隐球菌，组织培养物，黄曲霉，曲霉，黑曲霉，土曲霉，光滑假丝酵母，桂皮假丝酵母，假丝酵母，假丝酵母，假丝酵母也描述了Lusitaniae，Parida Pyapsilosis，热带假丝酵母，Pseudallescheria boydii和Sporothrix schenckii。

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