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1. 发明申请

US20070297977A1 Tumor Necrosis Factor-Gamma 有权
标题翻译：肿瘤坏死因子 - 伽玛
公开(公告)号：US20070297977A1
公开(公告)日：2007-12-27
申请号：US11837082
申请日：2007-08-10
申请人： Guo-Liang Yu , Jian Ni , Craig Rosen , Jun Zhang
发明人： Guo-Liang Yu , Jian Ni , Craig Rosen , Jun Zhang
IPC分类号： A61K51/00 , A61K39/395 , A61P29/00
CPC分类号： A61K51/08 , C07K16/241 , Y10S930/144
摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
摘要翻译：公开了人类TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽抑制细胞生长的方法，例如在肿瘤或癌症中，用于促进伤口愈合，提供抗感染，诱导炎症活性和刺激某些细胞类型的生长以治疗疾病，示例再狭窄。还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和/或TNF-γ-β多肽的过表达的诊断方法。还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质，败血性休克，脑疟疾，炎症，关节炎和移植排斥的治疗剂的用途。

2. 发明申请

US20070009525A1 Human Endokine Alpha and Methods of Use 失效
标题翻译：人类内含子阿尔法和使用方法
公开(公告)号：US20070009525A1
公开(公告)日：2007-01-11
申请号：US11427956
申请日：2006-06-30
申请人： Guo-Liang Yu , Jian Ni , Craig Rosen
发明人： Guo-Liang Yu , Jian Ni , Craig Rosen
IPC分类号： A61K39/395 , C12P21/02 , C07H21/04 , C07K14/525 , C07K16/24
CPC分类号： C07K14/7151 , A61K38/00 , C07K14/5255 , C07K16/24 , C07K2317/21 , C07K2317/622 , Y10S514/885
摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
摘要翻译：本发明涉及细胞因子的肿瘤坏死因子（TNF）家族的新成员。特别地，提供了分离的核酸分子，其编码内丝蛋白α蛋白。还提供了内含子α多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了关于TNF家族相关疾病的诊断和治疗方法。

3. 发明申请

US20060147982A1 32 human secreted proteins 审中-公开
标题翻译： 32种人体分泌蛋白
公开(公告)号：US20060147982A1
公开(公告)日：2006-07-06
申请号：US11366001
申请日：2006-03-02
申请人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

4. 发明申请

US20060025574A1 32 human secreted proteins 有权
公开(公告)号：US20060025574A1
公开(公告)日：2006-02-02
申请号：US11226657
申请日：2005-09-15
申请人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： C07H21/04 , C12P21/06 , C12N5/06 , C07K16/44
CPC分类号： C07K14/47 , A61K38/00 , C07K16/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

5. 发明申请

US20050233958A1 Death domain containing receptor 5 审中-公开
标题翻译：含有受体5的死亡域
公开(公告)号：US20050233958A1
公开(公告)日：2005-10-20
申请号：US10979831
申请日：2004-11-03
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig Rosen
IPC分类号： A61K38/00 , A61K38/17 , C07K14/705 , C07K16/28
CPC分类号： C07K16/2878 , A61K38/00 , C07K14/70578 , C07K2317/622 , C07K2319/30
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR5, which may be agonists and/or antagonists of DR5 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。特别地，提供编码人DR5蛋白的分离的核酸分子。还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。本发明还涉及使用DR5特异性抗体（其可以是DR5活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

6. 发明申请

US20060099575A9 67 human secreted proteins 审中-公开
标题翻译： 67人分泌蛋白
公开(公告)号：US20060099575A9
公开(公告)日：2006-05-11
申请号：US09949925
申请日：2001-09-12
申请人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
发明人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/47
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

7. 发明申请

US20050239059A1 67 human secreted proteins 审中-公开
标题翻译： 67人分泌蛋白
公开(公告)号：US20050239059A1
公开(公告)日：2005-10-27
申请号：US09949925
申请日：2001-09-12
申请人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
发明人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
IPC分类号： C07H21/04 , C07K14/47 , C12Q1/68
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

8. 发明申请

US20050214844A1 86 human secreted proteins 审中-公开
标题翻译： 86人分泌蛋白
公开(公告)号：US20050214844A1
公开(公告)日：2005-09-29
申请号：US11111953
申请日：2005-04-22
申请人： Paul Moore , Yanggu Shi , Craig Rosen , Steven Ruben , David Lafleur , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Paul Moore , Yanggu Shi , Craig Rosen , Steven Ruben , David Lafleur , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： G01N33/53 , A61K38/00 , A61K48/00 , A61P43/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/04 , C12N5/06 , C12N5/10 , C12N5/16 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/11 , C12N15/12 , C12P21/02 , C12P21/04 , C12P21/06 , C12Q1/68 , G01N33/566
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

9. 发明申请

US20060198784A1 Methods of treatment using antibodies to Neutrokine-alpha 审中-公开
标题翻译：使用Neutrokine-α抗体治疗方法
公开(公告)号：US20060198784A1
公开(公告)日：2006-09-07
申请号：US11377165
申请日：2006-03-17
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig Rosen
IPC分类号： A61K51/00 , A61K39/395 , G01N33/53
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

10. 发明申请

US20060084082A1 186 human secreted proteins 审中-公开
公开(公告)号：US20060084082A1
公开(公告)日：2006-04-20
申请号：US11144947
申请日：2005-06-06
申请人： Steven Ruben , Craig Rosen , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Carrie Fischer , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Yi Li , ZhiZhen Zeng , Hla Kyaw
发明人： Steven Ruben , Craig Rosen , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Carrie Fischer , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Yi Li , ZhiZhen Zeng , Hla Kyaw
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/00
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

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