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    • 1. 发明授权
    • Powdered human milk fortifier
    • 粉状人乳强化剂
    • US06294206B1
    • 2001-09-25
    • US09532838
    • 2000-03-21
    • Bridget Barrett-ReisPatricia A. ReynoldsMichael B. MontaltoDeborah L. O'Connor
    • Bridget Barrett-ReisPatricia A. ReynoldsMichael B. MontaltoDeborah L. O'Connor
    • A23L1302
    • A23C9/206A23C11/04Y10S426/801
    • The invention relates to a powdered human milk fortifier comprising a protein component typically present in an amount of from about 24 wt/wt % to about 55 wt/wt % of the fortifier powder, and a fat component typically present in an amount of from about 1 wt/wt % to about 30 wt/wt % of the fortifier powder and a carbohydrate component present in a quantity of from about 15 wt/wt % to about 75 wt/wt % of the fortifier powder. Preferably, the powdered human milk fortifier is provided in a unit dose container which holds from about 0.5 gm to about 10 gm of powder. The instant invention also relates to a method of providing nutrition to preterm infants by adding a fortifier powder to human milk and administering the fortified human milk to a premature infant. The invention further provides a method of promoting growth of a premature infant by administering fortified human milk to a premature infant.
    • 本发明涉及一种粉末状的人乳强化剂,其包含通常以强化剂粉末的约24重量/重量%至约55重量/重量%的量存在的蛋白质组分,和通常以约 强化剂粉末的1重量%至约30重量/重量%和以强化剂粉末的约15重量%至约75重量%的量存在的碳水化合物组分。 优选地,将粉末状的人乳强化剂设置在保持约0.5gm至约10gm粉末的单位剂量容器中。 本发明还涉及通过向人乳添加强化剂粉末并将强化人乳给予早产儿来提供早产儿营养的方法。 本发明还提供了一种通过向早产儿施用强化人乳来促进早产儿生长的方法。
    • 2. 发明授权
    • Hyper-absorption of vitamin E combined with milk protein
    • 维生素E与牛奶蛋白的超吸收
    • US06503545B1
    • 2003-01-07
    • US09678180
    • 2000-09-28
    • Daniel PerlmanKenneth C. Hayes
    • Daniel PerlmanKenneth C. Hayes
    • A23L1302
    • A23C9/158A23C11/04A23C19/0921A23L33/15A23V2002/00A23V2250/5424A23V2250/712
    • A milk product providing an individual at least 31 IU (International Units) of vitamin E per serving, or an ingestible blend of at least one mammalian milk protein or fragment thereof, and vitamin E or other fat-soluble micronutrient or pharmacological agent is described. The vitamin E is uniformly microdispersed throughout the milk product, and ingestion of at least 100 IU of vitamin E per day in the product is sufficient to cause the fasting plasma vitamin E/cholesterol ratio in human subjects to be elevated at least 50% above the basal fasting level of vitamin E measured in the same subjects consuming no vitamin E dietary supplements. A method for elevating the plasma vitamin E level at least 50% in human subjects is also described. The method includes ingesting a milk product as described. A method for increasing the bioavailability of an orally administered fat-soluble micronutrient or pharmaceutical agent is also described. The method includes providing a microdispersed mixture of at least one fat-soluble micronutrient or pharmaceutical agent, and at least one mammalian milk protein or fragment thereof, in which the weight ratio of the milk protein to the micronutrient or pharmaceutical agent is between 1:1 and 1000:1.
    • 描述了提供个体至少31IU(国际单位)每份维生素E或至少一种哺乳动物乳蛋白或其片段的可摄入共混物和维生素E或其它脂溶性微量营养素或药理学物质的乳制品。 维生素E在整个乳制品中均匀地微分散,每天至少摄入100 IU维生素E足以使人体受试者的空腹血浆维生素E /胆固醇比例升高至高于 维生素E的基础禁食水平在同一受试者中测量不消耗维生素E膳食补充剂。 还描述了在人受试者中提高血浆维生素E水平至少50%的方法。 该方法包括如上所述摄取牛奶制品。 还描述了用于增加口服给药的脂溶性微量营养素或药剂的生物利用度的方法。 该方法包括提供至少一种脂溶性微量营养素或药剂的微分散混合物和至少一种哺乳动物乳蛋白或其片段,其中乳蛋白与微量营养素或药剂的重量比为1:1 和1000:1。
    • 10. 发明授权
    • Production of oil encapsulated minerals and vitamins in a glassy matrix
    • 在玻璃状基质中生产含油的矿物质和维生素
    • US06436453B1
    • 2002-08-20
    • US09595121
    • 2000-06-16
    • Bernhard H. van LengerichJamileh Lakkis
    • Bernhard H. van LengerichJamileh Lakkis
    • A23L1302
    • A23C9/1322A23C2210/40A23L7/101A23L33/16A23P10/30A23V2002/00A61K9/1623A61K9/1694A23V2200/224A23V2250/606A23V2250/628A23V2250/1592A23V2250/1944A23V2250/50A23V2250/1578
    • A mineral or vitamin fortification ingredient which does not deleteriously affect palatability and appearance of foods is obtained by encapsulation of the mineral or vitamin in a grindable, glassy matrix composition. At least one edible oil is included in the encapsulating composition to prevent substantial adverse interaction between the mineral or vitamin encapsulant and the glass-forming matrix material, and to achieve controlled release of the encapsulant from the glassy matrix. The oil also reduces or eliminates the use of added water as a plasticizer thereby avoiding the need for substantial evaporation or drying to achieve a non-rubbery, grindable encapsulated ingredient. The oil assists in plasticizing the matrix material for extrudability and the prevention of undesirable browning or discoloration of the encapsulating matrix composition. The oil and the glassy matrix material provide a smooth mouthfeel and eliminate the rough, scratchy, gritty, dry, hard, or chalky mouthfeel associated with particulate or crystalline mineral sources. The fortification ingredient may be produced by melting the one or more glass-forming matrix components such as mono- or di-saccharides in the presence of optionally added water. The resulting melt may then be combined with an oil-slurried mineral and/or vitamin encapsulant and cooled to obtain a formable, pliable molten mass. The mass may be extruded and cut into pieces or pellets and cooled to obtain a grindable, glassy matrix which encapsulates the oil encapsulated mineral or vitamin. The encapsulated minerals and/or vitamins may be ground into a particulate composition such as a fine powder for direct incorporation into or for topical application onto foods such as ready-to-eat cereals, yogurt and fruit snacks.
    • 通过将矿物质或维生素包封在可磨碎的玻璃质基质组合物中,可以获得不会有害地影响食物适口性和外观的矿物质或维生素强化成分。 包封组合物中包含至少一种食用油,以防止矿物或维生素包封剂与玻璃形成基质材料之间的实质性不利相互作用,并实现密封剂从玻璃质基质中的受控释放。 油也减少或消除了加入水作为增塑剂的用途,从而避免了实质上蒸发或干燥以实现非橡胶状,可研磨的包封成分的需要。 该油有助于增塑基质材料的挤出性和防止包封基质组合物不希望的褐变或变色。 油和玻璃质基质材料提供光滑的口感,并消除与颗粒状或结晶矿物质相关的粗糙,刮伤,粗糙,干燥,硬化或垩白的口感。 强化成分可以通过在任选添加的水的存在下熔化一种或多种形成玻璃的基质组分如单糖或二糖来制备。 然后将所得熔体与油 - 浆状矿物和/或维生素密封剂混合并冷却,得到可成形的,柔韧的熔融物质。 可以将团块挤出并切割成片或小球,并冷却,得到可封闭的玻璃状基体,其包封油包封的矿物质或维生素。 包封的矿物质和/或维生素可以研磨成颗粒组合物,例如细粉末,用于直接掺入或用于局部施用到诸如即食谷物,酸奶和水果小吃等食品上。