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1. 发明授权

US4831861A Hydraulic cold extrusion press 失效
标题翻译：液压冷挤压机
公开(公告)号：US4831861A
公开(公告)日：1989-05-23
申请号：US155028
申请日：1988-02-11
申请人： Gunter Hofmann , Herbert Ruger
发明人： Gunter Hofmann , Herbert Ruger
IPC分类号： B21J9/06 , B21J9/12 , B21J9/20
CPC分类号： B21J9/06 , B21J9/027 , B21J9/12 , B21J9/20
摘要： A cold-extrusion press wherein a platen (4) carries a die part (31) and is capable of being moved towards and away from a stationary table (2) by piston/cylinder devices (5, 6), working piston/cylinder device (7) acts upon extrusion mandrel (11) to exert a deforming pressure, control means (41) activates an adjustable main valve (12, 28) adjustable for different values of travel and speed of the extrusion mandrel (11), platen (4) entrains the extrusion mandrel (11) by spaced stops (22, 23) to an initial position before the extruding stroke, the working piston/cylinder device (7) is subdivided into two working units (8, 9) arranged in tandem and acting upon the same piston rod (10), and only part of the pressure fluid supplied by the working piston/cylinder device (7) is delivered through the main valve (12) to the one working unit (8), whereas the other part of the pressure fluid is delivered to the other working unit (9) without a controlled main valve. Straightforward selection of different values of extrusion travel and speed is afforded by the main valve and the allied control device in a hydraulic press.
摘要翻译：一种冷挤压机，其中压板（4）承载模具部分（31）并且能够通过活塞/缸装置（5,6），工作活塞/缸装置（5,6）向固定台（2）和/ （7）作用在挤压心轴（11）上以施加变形压力，控制装置（41）启动可调整的主阀（12,28），该可调节主阀（12,28）可针对挤出心轴（11），压板（4）的行进和速度的不同值调节）将挤压心轴（11）通过间隔的止动件（22,23）夹紧到挤出冲程之前的初始位置，工作活塞/缸装置（7）被细分成两个串联布置的作业单元（8,9）在相同的活塞杆（10）上，并且仅由工作活塞/缸装置（7）供应的部分压力流体通过主阀（12）输送到一个工作单元（8），而另一部分压力流体被输送到另一个工作单元（9）而没有受控的主阀。挤压行程和速度的不同值的直接选择由主阀和液压机中的联合控制装置提供。

2. 发明授权

US06678558B1 Method and apparatus for reducing electroporation-mediated muscle reaction and pain response 有权
标题翻译：用于减少电穿孔介导的肌肉反应和疼痛反应的方法和装置
公开(公告)号：US06678558B1
公开(公告)日：2004-01-13
申请号：US09535683
申请日：2000-03-23
申请人： Steve Dimmer , Gunter Hofmann , Daniel Holt , Gurvinder Nanda , Edward M. Nolan
发明人： Steve Dimmer , Gunter Hofmann , Daniel Holt , Gurvinder Nanda , Edward M. Nolan
IPC分类号： A61N118
CPC分类号： A61N1/327 , A61N1/08 , A61N1/306 , A61N1/325
摘要： A method for delivery of an agent to a cell using electroporation is disclosed. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also includes passing an electrical signal between the first electrode and the second electrode, the electrical signal having a frequency greater than about 10 kHz. In one embodiment of the method, the electrical signal has a bipolar waveform. In another embodiment of the method, the electrodes are positioned at a treatment site, e.g., a tumor, for in vivo delivery of an agent.
摘要翻译：公开了使用电穿孔将试剂递送至细胞的方法。该方法包括定位第一电极和第二电极，使得在第一电极和第二电极之间通过的电信号通过电池。该方法还包括在第一电极和第二电极之间传递电信号，电信号具有大于约10kHz的频率。在该方法的一个实施例中，电信号具有双极波形。在该方法的另一个实施方案中，电极位于治疗部位，例如肿瘤，用于药物的体内递送。

3. 发明申请

US20050192542A1 Method of treatment using electroporation mediated delivery of drugs and genes 审中-公开
标题翻译：使用电穿孔介导的药物和基因递送的治疗方法
公开(公告)号：US20050192542A1
公开(公告)日：2005-09-01
申请号：US10783161
申请日：2004-02-20
申请人： S.B. Dev , Gunter Hofmann , Richard Gilbert , Yasuhiko Hayakawa , Richard Heller , Mark Jaroszeski
发明人： S.B. Dev , Gunter Hofmann , Richard Gilbert , Yasuhiko Hayakawa , Richard Heller , Mark Jaroszeski
IPC分类号： A61N1/30 , A61M37/00 , A61N1/32 , A61M5/24 , A61M5/28
CPC分类号： A61N1/327 , A61N1/0502 , A61N1/325 , C12M35/02
摘要： A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
摘要翻译：提供了使用针阵列装置的体内电疗或电穿孔介导治疗的方法。使用本发明的装置和化学治疗剂组合使用电穿孔治疗肿瘤导致体内肿瘤消退。

4. 发明授权

US5301528A Device for manufacturing toothed pulleys 失效
标题翻译：齿轮滑轮制造装置
公开(公告)号：US5301528A
公开(公告)日：1994-04-12
申请号：US959827
申请日：1992-10-13
申请人： Gunter Hofmann , Willi Schroth , Erwin Klein
发明人： Gunter Hofmann , Willi Schroth , Erwin Klein
IPC分类号： B21D53/28 , B21H5/02 , B21D22/16
CPC分类号： B21H5/02 , B21D53/28 , Y10T29/49471
摘要： A device for non-cutting manufacturing of an annular part having external teeth includes a core tool that supports the blank from which the annular part is manufactured and is axially displaceable between two profiling rollers arranged diametrically opposite each other, and a separate rotating drive for each of the core tool and the two profiled rollers. The device further includes a computer element which controls the three rotating drives for synchronizing rotational speeds of the core tool and the two profiling rollers. The computer element also controls radial adjustment of the two rollers with their respective full-height regions with respect to the core tool by a calibration amount at the conclusion of the shaping operation.
摘要翻译：一种用于非切割制造具有外齿的环形部件的装置包括：一个支承坯料的芯工具，该坯件由该坯件制成，环形部件从该坯件制造，并且可在两个彼此径向相对布置的成型辊之间轴向移动;以及每个的核心工具和两个成型辊。该装置还包括控制三个旋转驱动器的计算机元件，用于使芯工具和两个成型辊的转速同步。计算机元件还可以在整形操作结束时，通过相对于核心工具的相应的全高度区域来控制两个辊的径向调节校准量。

5. 发明申请

US20050171575A1 Electrically induced vessel vasodilation 审中-公开
公开(公告)号：US20050171575A1
公开(公告)日：2005-08-04
申请号：US11064572
申请日：2005-02-23
申请人： Nagendu Dev , Sukhendu Dev , Gunter Hofmann
发明人： Nagendu Dev , Sukhendu Dev , Gunter Hofmann
IPC分类号： A61N1/30 , A61N1/32 , A61N1/00
CPC分类号： A61N1/327 , A61N1/325 , Y10S977/883 , Y10S977/904 , Y10S977/905
摘要： The invention provides methods for inducing or increasing the vasodilation of a vessel. The invention further provides methods for inducing or increasing the flow of fluid through a vessel. An electrical impulse is applied to the vessel in order to induce or increase vessel vasodilation or to induce or increase the flow of fluid through the vessel. In a particular embodiment, a novel double-balloon catheter system incorporating electroporation technology has been designed and is used to apply the electrical impulse endoluminally.

6. 发明授权

US5500309A Ni/metal hydride accumulator 失效
标题翻译： Ni /金属氢化物蓄电池
公开(公告)号：US5500309A
公开(公告)日：1996-03-19
申请号：US346897
申请日：1994-11-30
申请人： Frank Lichtenberg , Klaus Kleinsorgen , Gunter Hofmann
发明人： Frank Lichtenberg , Klaus Kleinsorgen , Gunter Hofmann
IPC分类号： H01M4/32 , H01M4/62 , H01M10/34 , H01M4/52
CPC分类号： H01M4/625 , H01M10/345 , Y02E60/124
摘要： The positive electrode of a Ni/metal hydride accumulator is formed from a mass mixture of Ni(OH).sub.2 and an oxidation-resistant graphite. The stable graphite is notable for a high degree of crystallinity and a low ash content. In conventional Ni/metal hydride accumulators, cobalt compounds play an essential part in developing a conductive matrix within their positive nickel hydroxide electrodes, leading to reductive destruction of the matrix by severe high temperature short circuit testing. In contrast, the same accumulators, with positive electrodes produced according to the present invention, survive the test with only a temporary and slight decline in capacity.
摘要翻译： Ni /金属氢化物蓄电池的正极由Ni（OH）2和抗氧化石墨的混合物形成。稳定的石墨具有很高的结晶度和较低的灰分含量。在传统的Ni /金属氢化物蓄电池中，钴化合物在其正极性氢氧化镍电极中开发导电基质中起重要作用，导致严重的高温短路试验对基质的还原破坏。相比之下，根据本发明生产的具有正电极的相同蓄电池在试验中仍然能够容忍地暂时和轻微地下降。

7. 发明申请

US20060224192A1 Electroporation devices 审中-公开
标题翻译：电穿孔装置
公开(公告)号：US20060224192A1
公开(公告)日：2006-10-05
申请号：US11443115
申请日：2006-05-30
申请人： Steve Dimmer , Gunter Hofmann , Daniel Holt , Gurvinder Nanda , Edward Nolan
发明人： Steve Dimmer , Gunter Hofmann , Daniel Holt , Gurvinder Nanda , Edward Nolan
IPC分类号： A61N1/30 , A61N1/18
CPC分类号： A61N1/327 , A61N1/08 , A61N1/306 , A61N1/325
摘要： Improved devices and methods for performing electroporation-mediated delivery agents to cells is described. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also includes passing an electrical signal between the first electrode and the second electrode, the electrical signal having a frequency greater than about 10 kHz. In one embodiment of the method, the electrical signal has a bipolar waveform. In another embodiment of the method, the electrodes are positioned at a treatment site, e.g., a tumor, for in vivo delivery of an agent.
摘要翻译：描述了用于对细胞进行电穿孔介导的递送试剂的改进的装置和方法。该方法包括定位第一电极和第二电极，使得在第一电极和第二电极之间通过的电信号通过电池。该方法还包括在第一电极和第二电极之间传递电信号，电信号具有大于约10kHz的频率。在该方法的一个实施例中，电信号具有双极波形。在该方法的另一个实施方案中，电极位于治疗部位，例如肿瘤，用于药物的体内递送。

8. 发明授权

US07054685B2 Method and apparatus for reducing electroporation-mediated muscle reaction and pain response 有权
公开(公告)号：US07054685B2
公开(公告)日：2006-05-30
申请号：US10215963
申请日：2002-08-08
申请人： Steve Dimmer , Gunter Hofmann , Daniel Holt , Gurvinder Nanda , Edward M. Nolan
发明人： Steve Dimmer , Gunter Hofmann , Daniel Holt , Gurvinder Nanda , Edward M. Nolan
IPC分类号： A61N1/362
CPC分类号： A61N1/327 , A61N1/08 , A61N1/306 , A61N1/325
摘要： A method for delivery of an agent to a cell using electroporation is disclosed. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also includes passing an electrical signal between the first electrode and the second electrode, the electrical signal having a frequency greater than about 10 kHz. In one embodiment of the method, the electrical signal has a bipolar waveform. In another embodiment of the method, the electrodes are positioned at a treatment site, e.g., a tumor, for in vivo delivery of an agent.

9. 发明申请

US20070231238A1 METHOD AND PLANT FOR DEPLETING SODIUM THIOCYANATE IN WASHING LIQUORS AND FOR OBTAINING PURE SODIUM THIOCYANATE 审中-公开
标题翻译：用于在洗涤液中除去硫酸钠的方法和设备以及获得纯硫酸钠
公开(公告)号：US20070231238A1
公开(公告)日：2007-10-04
申请号：US11694285
申请日：2007-03-30
申请人： Wilhelm Hinsen , Hermann Plate , Gunter Hofmann , Christian Melches
发明人： Wilhelm Hinsen , Hermann Plate , Gunter Hofmann , Christian Melches
IPC分类号： C01B21/093
CPC分类号： C01C3/20
摘要： A method and apparatus are provided for depleting sodium thiocyanate (NaSCN) from washing solutions to obtain pure sodium thiocyanate. By adding an anti-solvent such as ethanol, which acts as anti-solvent for the main part of the accompanying salts in the solution, the major part of these accompanying salts can be separated by precipitation in a crystallization and removed, for example, by filtration, whereas the NaSCN remains in the solution. After separating the anti-solvent from the remaining aqueous solution in a rectification, a very pure crystallized NaSCN is produced in a NaSCN crystallization. After washing in a counterstream washing apparatus, the obtained crystallized NaSCN product has a purity of at least 99%.
摘要翻译：提供了一种从洗涤溶液中消耗硫氰酸钠（NaSCN）以获得纯硫氰酸钠的方法和装置。通过在溶液中加入作为伴随盐的主要部分作为反溶剂的反溶剂如乙醇，这些伴随的盐的主要部分可以通过在结晶中沉淀而分离并除去，例如通过过滤，而NaSCN保留在溶液中。在精馏后从剩余的水溶液中分离出反溶剂后，在NaSCN结晶中产生非常纯的结晶NaSCN。在逆流洗涤装置中洗涤后，得到的结晶NaSCN产物的纯度至少为99％。

10. 发明申请

US20050209548A1 Electroporation-mediated intravascular delivery 审中-公开
标题翻译：电穿孔介导的血管内传递
公开(公告)号：US20050209548A1
公开(公告)日：2005-09-22
申请号：US10804786
申请日：2004-03-19
申请人： Sukhendu Dev , Nasendu Dev , Gunter Hofmann
发明人： Sukhendu Dev , Nasendu Dev , Gunter Hofmann
IPC分类号： A61N1/30
CPC分类号： A61N1/306
摘要： A method for sustained intravascular delivery via electroporation is provided. The method is useful for delivery of therapeutic compositions such as antithrombotic and anticoagulant agents. The invention also provides a catheter apparatus for introducing a composition into at least one cell in a vessel in a subject.
摘要翻译：提供了通过电穿孔持续血管内递送的方法。该方法可用于递送治疗组合物如抗血栓形成剂和抗凝血剂。本发明还提供一种用于将组合物引入受试者的血管中的至少一个细胞的导管装置。

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