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1. 发明授权

US08552186B2 Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors 有权
标题翻译： 2,4-二氨基嘧啶作为ALK和c-MET抑制剂的稠合双环衍生物
公开(公告)号：US08552186B2
公开(公告)日：2013-10-08
申请号：US13413322
申请日：2012-03-06
申请人： Gulzar Ahmed , Henry J. Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce D. Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph Lisko , Rong-qiang Liu , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
发明人： Gulzar Ahmed , Henry J. Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce D. Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph Lisko , Rong-qiang Liu , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
IPC分类号： C07D403/12
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译：本发明提供式I或II化合物或其药学上可接受的盐形式，其中R1，R2，R3，R4，R5，A1，A2，A3，A4和A5如本文所定义。式I或II的化合物具有ALK和/或c-Met抑制活性，并且可用于治疗增殖性疾病。

2. 发明申请

US20120165519A1 Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors 有权
标题翻译： 2,4-二氨基嘧啶的双酚衍生物作为ALK和c-MET抑制剂
公开(公告)号：US20120165519A1
公开(公告)日：2012-06-28
申请号：US13413322
申请日：2012-03-06
申请人： Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-qiang Liu , Eugen Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
发明人： Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-qiang Liu , Eugen Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
IPC分类号： C07D403/14 , C07D498/04 , C07D413/12 , C07D409/14 , C07D405/12 , C07D417/14 , C07D401/14 , C07D405/14 , C07D403/12 , C07D413/14
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译：本发明提供式I或II化合物或其药学上可接受的盐形式，其中R1，R2，R3，R4，R5，A1，A2，A3，A4和A5如本文所定义。式I或II的化合物具有ALK和/或c-Met抑制活性，并且可用于治疗增殖性疾病。

3. 发明申请

US20090221555A1 FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS 有权
标题翻译： 2,4-二氨基嘧啶作为ALK和c-MET抑制剂的熔融双相衍生物
公开(公告)号：US20090221555A1
公开(公告)日：2009-09-03
申请号：US12162851
申请日：2007-10-23
申请人： Gulzar Ahmed , Adolph Bohnstedt , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Koc-Kan Ho , Keith S. Learn , Joseph G. Lisko , Rong-qiang Liu , Eugen Mesaros , Karen Milkiewicz , Gregory R. Ott , Jonathan Parrish , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Jason C. Wagner , Linda Weinberg , Gregory J. Wells , Ming You , Craig A. Zificsak
发明人： Gulzar Ahmed , Adolph Bohnstedt , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Koc-Kan Ho , Keith S. Learn , Joseph G. Lisko , Rong-qiang Liu , Eugen Mesaros , Karen Milkiewicz , Gregory R. Ott , Jonathan Parrish , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Jason C. Wagner , Linda Weinberg , Gregory J. Wells , Ming You , Craig A. Zificsak
IPC分类号： A61K31/55 , C07D239/02 , A61K31/505 , C07D403/00 , C07D413/14 , A61K31/5377 , C07D413/00 , C07D403/14
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译：本发明提供式I或II化合物或其药学上可接受的盐形式，其中R1，R2，R3，R4，R5，A1，A2，A3，A4和A5如本文所定义。式I或II的化合物具有ALK和/或c-Met抑制活性，并且可用于治疗增殖性疾病。

4. 发明授权

US08148391B2 Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors 有权
标题翻译： 2,4-二氨基嘧啶作为ALK和c-Met抑制剂的稠合双环衍生物
公开(公告)号：US08148391B2
公开(公告)日：2012-04-03
申请号：US12162851
申请日：2007-10-23
申请人： Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-Qiang Liu , Eugen Florin Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
发明人： Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-Qiang Liu , Eugen Florin Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译：本发明提供式I或II化合物或其药学上可接受的盐形式，其中R1，R2，R3，R4，R5，A1，A2，A3，A4和A5如本文所定义。式I或II的化合物具有ALK和/或c-Met抑制活性，并且可用于治疗增殖性疾病。

5. 发明申请

US20080032971A1 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS 有权
标题翻译： 8-HETEROARYLPURINE MNK2用于治疗代谢性疾病的抑制剂
公开(公告)号：US20080032971A1
公开(公告)日：2008-02-07
申请号：US11684262
申请日：2007-03-09
申请人： Andrew Cole , Marc-Raleigh Brescia , Joan Zhang , Zahid Hussain , David Diller , Axel Metzger , Gulzar Ahmed , Ian Henderson
发明人： Andrew Cole , Marc-Raleigh Brescia , Joan Zhang , Zahid Hussain , David Diller , Axel Metzger , Gulzar Ahmed , Ian Henderson
IPC分类号： A61K31/535 , A61K31/519 , A61P25/00 , A61P3/00 , A61P35/00 , C07D413/14 , C07D487/04 , C12N5/06
CPC分类号： C07D473/32
摘要： Compounds of the formula are disclosed as Mnk2 inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.
摘要翻译：公开的化合物作为可用于治疗和预防代谢性疾病如肥胖症和糖尿病的Mnk2抑制剂。

6. 发明授权

US5780780A Weighing vibratory apparatus and method 失效
标题翻译：称重振动装置及方法
公开(公告)号：US5780780A
公开(公告)日：1998-07-14
申请号：US782441
申请日：1997-01-17
申请人： Gulzar Ahmed
发明人： Gulzar Ahmed
IPC分类号： G01G11/04 , G01G13/02 , G01G23/10 , G01G21/10
CPC分类号： G01G13/026 , G01G11/04 , G01G23/10
摘要： A weighing vibratory apparatus and method. In one embodiment, an infeed vibratory conveyor element feeds a bulk product to a weighing vibratory conveyor element. In another embodiment, bulk product is fed directly to a weighing vibratory conveyor element and flow rate is determined by measuring the loss of weight therefrom. The weighing vibratory conveyor element includes a weight measuring apparatus that weighs the product at the same time that the product is being dispensed through vibrations. The weight measuring apparatus may be coupled to the vibratory conveyor element through damping mechanisms. An electrical signal output of the weight measuring apparatus may be low-pass filtered to provide an improved signal for feeding to a controller for controlling the flow rate.
摘要翻译：称重振动装置及方法。在一个实施例中，进料振动输送机元件将批量产品送入称重振动输送机元件。在另一个实施例中，大量产品直接供给到称重振动输送机元件，并且通过测量其重量损失来确定流速。称重振动输送机元件包括重量测量装置，其通过振动在产品分配的同时对产品进行称重。重量测量装置可以通过阻尼机构联接到振动输送机元件。重量测量装置的电信号输出可以被低通滤波以提供改进的信号，以供给控制器来控制流量。

7. 发明授权

US10815064B1 Systems and methods for controlling the dispensing of articles 有权
公开(公告)号：US10815064B1
公开(公告)日：2020-10-27
申请号：US16231069
申请日：2018-12-21
申请人： Gulzar Ahmed
发明人： Gulzar Ahmed
IPC分类号： B65G27/34 , B65G27/16 , B65G27/32 , B65G65/20 , B65G27/04
摘要： An article dispensing system and method that has a first and a second vibratory feeder; a rotary trough dispenser having one or more receiving troughs in which counted or weighed articles are dispensed for packaging; while the next trough within the rotary trough dispenser is indexed in a rotational step-wise fashion.

8. 发明申请

US20060276488A1 N-heterocyclic inhibitors of TNF-alpha expression 有权
公开(公告)号：US20060276488A1
公开(公告)日：2006-12-07
申请号：US11485075
申请日：2006-07-12
申请人： Gulzar Ahmed , Axel Metzger , Ian Henderson , David Diller , Jun Wen , Stephen Wrobleski , Katerina Leftheris , Chunjian Liu
发明人： Gulzar Ahmed , Axel Metzger , Ian Henderson , David Diller , Jun Wen , Stephen Wrobleski , Katerina Leftheris , Chunjian Liu
IPC分类号： A61K31/505 , C07D239/48
CPC分类号： C07D239/48 , C07D213/85 , C07D239/47 , C07D239/50 , C07D401/12 , C07D403/12
摘要： N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

9. 发明授权

US06906067B2 N-heterocyclic inhibitors of TNF-α expression 有权
公开(公告)号：US06906067B2
公开(公告)日：2005-06-14
申请号：US09891750
申请日：2001-06-26
申请人： Kevin Joseph Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn David Erickson , Jeffrey John Letourneau , Edward McDonald , Katerina Leftheris , Stephen T. Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John J. Baldwin , Alaric J. Dyckman
发明人： Kevin Joseph Moriarty , Yvonne Shimshock , Gulzar Ahmed , Junjun Wu , James Wen , Wei Li , Shawn David Erickson , Jeffrey John Letourneau , Edward McDonald , Katerina Leftheris , Stephen T. Wrobleski , Zahid Hussain , Ian Henderson , Axel Metzger , John J. Baldwin , Alaric J. Dyckman
IPC分类号： A61K31/40 , A61K31/551 , C07D251/52 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D521/00 , C07D251/40 , A61K31/53 , A61P35/00 , C07D251/48
CPC分类号： C07D251/52 , C07D231/12 , C07D233/56 , C07D249/08 , C07D251/48 , C07D251/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.

10. 发明授权

US10121307B2 Speed checking attachment for use with vibratory conveyors 有权
公开(公告)号：US10121307B2
公开(公告)日：2018-11-06
申请号：US15453704
申请日：2017-03-08
申请人： Gulzar Ahmed
发明人： Gulzar Ahmed
IPC分类号： B65G27/32 , B65G27/34 , G07F13/04
摘要： A product speed checking apparatus for attaching to a vibratory conveying system and a method thereof for dispensing product, including a sample pan mounted to capture flow of product between two vibratory conveyors; a first sensor and a second sensor, each placed separately at a predetermined distance from one another and each capable of independently reading product handled by the sample pan; and, a programmable logic controller operatively arranged to calculate an approximate time between the reading of product by the first sensor and the reading of product by the second sensor and computing product speed by dividing distance between two sensors with the travel time between the two sensors.

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