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1. 发明申请

US20070121196A1 METHOD AND APPARATUS FOR METHOD FOR VIEWING AND ANALYZING OF ONE OR MORE BIOLOGICAL SAMPLES WITH PROGRESSIVELY INCREASING RESOLUTIONS 审中-公开
标题翻译：用于查看和分析一种或多种生物样品以进一步增加决议的方法和装置
公开(公告)号：US20070121196A1
公开(公告)日：2007-05-31
申请号：US11537123
申请日：2006-09-29
申请人： Guillermo Tearney , Dvir Yelin , Benjamin Vakoc , Melissa Suter , Brett Bouma
发明人： Guillermo Tearney , Dvir Yelin , Benjamin Vakoc , Melissa Suter , Brett Bouma
IPC分类号： H01S3/00
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for analyzing and/or illustrating at least one portion of an anatomical structure. For example, light can be forwarded to such portion so as to generate first information which is related to the portion. For example, the light can be provided on or within a subject. The first information can be received, and at least one section of the portion may be selected based on the first information so as to generate second information. A magnification of a display of the portion may be progressively modified as a function of the second information.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和装置，用于分析和/或说明解剖结构的至少一部分。例如，可以将光转发到这样的部分，以便生成与该部分相关的第一信息。例如，光可以提供在被摄体上或内部。可以接收第一信息，并且可以基于第一信息来选择该部分的至少一个部分，以便生成第二信息。可以根据第二信息逐渐地修改该部分的显示的放大率。

2. 发明申请

US20070229801A1 ARRANGEMENTS AND METHODS FOR PROVIDING MULTIMODALITY MICROSCOPIC IMAGING OF ONE OR MORE BIOLOGICAL STRUCTURES 有权
标题翻译：提供一种或多种生物结构的多重微观显微成像的安排和方法
公开(公告)号：US20070229801A1
公开(公告)日：2007-10-04
申请号：US11537343
申请日：2006-09-29
申请人： Guillermo Tearney , Dvir Yelin , Benjamin Vakoc , Wang-Yuhl Oh , Brett Bouma
发明人： Guillermo Tearney , Dvir Yelin , Benjamin Vakoc , Wang-Yuhl Oh , Brett Bouma
IPC分类号： G01N21/00
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method and apparatus according to an exemplary embodiment of the present invention can be provided. For example, first data associated with a first signal received from at least one region of at least one sample can be provided based on a first modality, and second data associated with a second signal received from the at least one sample can be provided based on a second modality which is different from the first modality. Third data associated with a reference can be received. Further data can be generated based on the first, second and third data. In addition, third data associated with a second signal received from the at least one sample can be obtained. Each of the third data can be based on a further modality which is different from the first modality and the second modality, and the further data can be further determined based on the third data. Further, the first modality can be a spectral-encoded modality, and the second modality can be a non-spectral-encoding modality.
摘要翻译：可以提供根据本发明的示例性实施例的方法和装置。例如，可以基于第一模态来提供与从至少一个样本的至少一个区域接收的第一信号相关联的第一数据，并且可以基于从至少一个样本接收的与第二信号相关联的第二数据基于第二种模式与第一种模式不同。可以接收与参考相关联的第三数据。可以基于第一，第二和第三数据生成进一步的数据。此外，可以获得与从至少一个样本接收的第二信号相关联的第三数据。第三数据中的每一个可以基于与第一模态和第二模态不同的另一模态，并且可以基于第三数据进一步确定另外的数据。此外，第一模式可以是频谱编码模式，并且第二模态可以是非频谱编码模式。

3. 发明申请

US20070087445A1 Arrangements and methods for facilitating photoluminescence imaging 有权
标题翻译：促进光致发光成像的安排和方法
公开(公告)号：US20070087445A1
公开(公告)日：2007-04-19
申请号：US11549397
申请日：2006-10-13
申请人： Guillermo Tearney , Dvir Yelin , Benjamin Vakoc , Brett Bouma , Jason Motz
发明人： Guillermo Tearney , Dvir Yelin , Benjamin Vakoc , Brett Bouma , Jason Motz
IPC分类号： G01N21/76
CPC分类号： A61B5/0071 , A61B1/043 , A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/7257 , G01N21/6408 , G01N21/6456 , G01N21/6458 , G01N2021/6419 , G01N2021/6421
摘要： Exemplary systems and methods for obtaining a photoluminescence radiation from at least one portion of a sample can be provided. For example, using the exemplary embodiment, it is possible to receive a first radiation and disperse the first radiation into at least one second radiation and at least one third radiation. The second and third radiations can be provided to different locations of the portion. In addition, it is possible to receive the photoluminescence radiation from the portion based on the second and third radiations.
摘要翻译：可以提供用于从样品的至少一部分获得光致发光辐射的示例性系统和方法。例如，使用示例性实施例，可以接收第一辐射并将第一辐射分散到至少一个第二辐射和至少一个第三辐射中。第二和第三辐射可以被提供到该部分的不同位置。此外，可以基于第二和第三辐射从该部分接收光致发光辐射。

4. 发明申请

US20060270929A1 System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging 有权
标题翻译：可以使用频谱编码外差干涉测量技术进行成像的系统，方法和布置
公开(公告)号：US20060270929A1
公开(公告)日：2006-11-30
申请号：US11445131
申请日：2006-05-31
申请人： Brett Bouma , Guillermo Tearney , Dvir Yelin , Seok-Hyun Yun
发明人： Brett Bouma , Guillermo Tearney , Dvir Yelin , Seok-Hyun Yun
IPC分类号： A61B5/05
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0084 , A61B5/7257
摘要： Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. The spectrally-encoded line may be scanned over the sample in a direction approximately perpendicular to the line. Image data containing three-dimensional information can then be obtained based on the interference. The exemplary imaging methods and systems can be used in a small fiber optic or endoscopic probe.
摘要翻译：提供了用于获得三维成像数据的系统，布置和方法。例如，宽带光源可以提供特定的辐射。可以将第一电磁辐射聚焦和衍射，然后提供给至少一个样品以产生光谱编码的线。可以将第二电磁辐射提供给参考，其可以包括双遍快速扫描光学延迟，其中第一和第二电磁辐射可以基于特定辐射。可以检测第三电磁辐射（与第一电磁辐射相关联）和第四电磁辐射（与第二电磁辐射相关联）之间的干扰。光谱编码的线可以在大致垂直于线的方向上扫描样品。然后可以基于干扰获得包含三维信息的图像数据。示例性的成像方法和系统可以用于小型光纤或内窥镜探针。

5. 发明申请

US20070263208A1 SYSTEMS AND METHODS FOR GENERATING DATA BASED ON ONE OR MORE SPECTRALLY-ENCODED ENDOSCOPY TECHNIQUES 有权
标题翻译：基于一种或多种频谱编码的内窥镜技术生成数据的系统和方法
公开(公告)号：US20070263208A1
公开(公告)日：2007-11-15
申请号：US11621694
申请日：2007-01-10
申请人： Dvir Yelin , Seok-Hyun Yun , Brett Bouma , Guillermo Tearney
发明人： Dvir Yelin , Seok-Hyun Yun , Brett Bouma , Guillermo Tearney
IPC分类号： G01J3/36 , G06F17/14
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/6852 , A61B5/7257 , A61B5/726 , G01B9/02002 , G01B9/02036 , G01B9/02037 , G01B9/02044 , G01B9/02091 , G01N21/359 , G01N2021/1782 , G01N2021/1787 , G01N2021/3595
摘要： Exemplary systems and methods for generating data associated with at least one portion of a sample can be provided. For example, according to one exemplary embodiment of such systems and methods, it is possible to provide a particular radiation using at least one first arrangement. The particular radiation can include at least one first electro-magnetic radiation directed to at least one sample and at least one second electro-magnetic radiation directed to a reference arrangement. The first radiation and/or the second radiation can comprise a plurality of wavelengths. The first electro-magnetic radiation can be spectrally dispersed along at least one portion of the sample. The second electro-magnetic radiation measured at two or more different lengths of the reference arrangement with respect to the first arrangement. Data can be generated which is associated with the first and second electro-magnetic radiations obtained at the two different lengths using at least one second arrangement which comprises a spectrometer arrangement.
摘要翻译：可以提供用于产生与样品的至少一部分相关联的数据的示例性系统和方法。例如，根据这样的系统和方法的一个示例性实施例，可以使用至少一个第一布置来提供特定的辐射。特定的辐射可以包括被引导至至少一个样品的至少一个第一电磁辐射和指向参考装置的至少一个第二电磁辐射。第一辐射和/或第二辐射可以包括多个波长。第一电磁辐射可沿样品的至少一部分光谱分散。在参考装置的两个或多个不同长度处相对于第一装置测量的第二电磁辐射。可以生成与使用包括光谱仪布置的至少一个第二布置在两个不同长度获得的第一和第二电磁辐射相关联的数据。

6. 发明申请

US20070081236A1 METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING 有权
标题翻译：通过光谱编码进行光学成像的方法和装置
公开(公告)号：US20070081236A1
公开(公告)日：2007-04-12
申请号：US11537048
申请日：2006-09-29
申请人： Guillermo Tearney , Dvir Yelin , Brett Bouma
发明人： Guillermo Tearney , Dvir Yelin , Brett Bouma
IPC分类号： G02B21/06
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和装置，用于生成解剖结构的至少一部分的图像。例如，该部分可以具有大于约1mm 2的面积，并且图像可以具有低于约10um的横向分辨率的分辨率。例如，可以在这样的部分上扫描光，以便产生与该部分相关的第一信息，其中可以通过衍射装置提供光以产生光谱分散的线。可以提供根据本发明的另一示例性实施例的方法，装置和装置，用于基于通过使用相同或不同的束扫描结构的一部分而产生的信号来将辐射或光束定位在解剖结构内。

7. 发明申请

US20060013544A1 Imaging system and related techniques 有权
公开(公告)号：US20060013544A1
公开(公告)日：2006-01-19
申请号：US11174425
申请日：2005-07-01
申请人： Brett Bouma , Guillermo Tearney , Dvir Yelin
发明人： Brett Bouma , Guillermo Tearney , Dvir Yelin
IPC分类号： G02B6/06
CPC分类号： G01N21/474 , G01N21/47 , G02B6/02 , G02B6/02042 , G02B6/036 , G02B6/03605 , G02B6/03622 , G02B6/03638 , G02B6/4298 , G02B23/2469 , G02B23/26 , G02B26/10 , G02B27/48
摘要： A method and apparatus for imaging using a double-clad fiber is described.

8. 发明申请

US20050128488A1 Method and apparatus for three-dimensional spectrally encoded imaging 有权
标题翻译：用于三维光谱编码成像的方法和装置
公开(公告)号：US20050128488A1
公开(公告)日：2005-06-16
申请号：US10997789
申请日：2004-11-24
申请人： Dvir Yelin , Brett Bouma , Nicusor Iftimia , Guillermo Tearney
发明人： Dvir Yelin , Brett Bouma , Nicusor Iftimia , Guillermo Tearney
IPC分类号： A61B1/04 , A61B1/07 , A61B5/107 , G01B9/02 , G01B11/24 , G01B11/25 , G01B11/30
CPC分类号： G01B11/2441 , A61B1/042 , A61B5/1077 , G01B9/02027 , G01B9/02044 , G01B11/2509
摘要： A method and apparatus for obtaining three-dimensional surface measurements using phase-sensitive spectrally encoded imaging is described. Both transverse and depth information is transmitted through a single-mode optical fiber, allowing this technique to be incorporated into a miniature probe.
摘要翻译：描述了使用相敏光谱编码成像获得三维表面测量的方法和装置。横向和深度信息均通过单模光纤传输，允许将该技术结合到微型探针中。

9. 发明申请

US20080097225A1 APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S) 有权
标题翻译：用于获取和提供与至少一个样品部分相关的成像信息的装置和方法，以及影响这些部分
公开(公告)号：US20080097225A1
公开(公告)日：2008-04-24
申请号：US11875676
申请日：2007-10-19
申请人： Guillermo Tearney , Brett Bouma , Dvir Yelin
发明人： Guillermo Tearney , Brett Bouma , Dvir Yelin
IPC分类号： A61B1/07 , A61B1/005 , G01B11/00 , A61B1/04
CPC分类号： A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B18/22 , A61B2017/00061
摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) at least two first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) at least two second different wavelengths of at least one second electro-magnetic radiation are provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion. First information of the portion based on the first transverse location and the relative depth location, and second information of the portion based on the second transverse location and the relative depth location can be obtained. The imaging information may include the first and second information.
摘要翻译：可以提供示例性装置和过程用于与样品的至少一部分相关联的成像信息。例如，（i）至少两个第一不同波长的至少一个第一电磁辐射可以在提供在样品部分上的第一波长范围内提供，以便确定该部分的至少一个第一横向位置，和（ii）至少两个第二不同波长的至少一个第二电磁辐射被提供在设置在该部分上的第二波长范围内，以便确定该部分的至少一个第二横向位置。第一和第二范围可以在该部分上部分重叠。此外，可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从基准返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。可以获得基于第一横向位置和相对深度位置的部分的第一信息，以及基于第二横向位置和相对深度位置的部分的第二信息。成像信息可以包括第一和第二信息。

10. 发明申请

US20070188855A1 APPARATUS FOR OBTAINING INFORMATION FOR A STRUCTURE USING SPECTRALLY-ENCODED ENDOSCOPY TEACHNIQUES AND METHODS FOR PRODUCING ONE OR MORE OPTICAL ARRANGEMENTS 有权
标题翻译：用于获得使用分光编码的内窥镜教学结构的信息的装置以及用于生成一个或多个光学装置的方法
公开(公告)号：US20070188855A1
公开(公告)日：2007-08-16
申请号：US11623852
申请日：2007-01-17
申请人： Milen Shishkov , Guillermo Tearney , Brett Bouma , Dvir Yelin , Nicusor Iftimia
发明人： Milen Shishkov , Guillermo Tearney , Brett Bouma , Dvir Yelin , Nicusor Iftimia
IPC分类号： G02B23/24 , A61B1/06
CPC分类号： G02B23/2453 , A61B1/00167 , A61B1/00188 , A61B1/002 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/0086 , B24B9/14 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0218 , G01J3/0256 , G01J3/18 , G02B5/18 , G02B23/2469 , G02B23/26
摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electromagnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can be configured to focus and provide there through the first electromagnetic radiation. Further, the exemplary apparatus can include at least one third dispersive arrangement which is configured to receive a particular radiation which is the first electromagnetic radiation and/or the focused electromagnetic radiation, and forward a dispersed radiation thereof to at least one section of the structure. At least one end of the fiber can be directly connected to the second focusing arrangement and/or the third dispersive arrangement. In addition, an exemplary embodiment of a method for producing an optical arrangement can be provided. For example, a first set of optical elements having a first size in a first configuration and a second set of optical elements in cooperation with the second set and having a second size in a second configuration can be provided. The first and second sets can be clamped into a third set of optical elements. The third set can be polished, and a further set of optical elements may be deposited on the polished set.
摘要翻译：可以提供用于获得结构信息的示例性装置。例如，示例性设备可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。第二布置可以被配置成通过第一电磁辐射聚焦并提供在那里。此外，示例性装置可以包括至少一个第三分散装置，其被配置为接收作为第一电磁辐射和/或聚焦电磁辐射的特定辐射，并将其分散的辐射转发到该结构的至少一个部分。光纤的至少一端可以直接连接到第二聚焦装置和/或第三色散装置。此外，可以提供用于制造光学装置的方法的示例性实施例。例如，可以提供具有第一配置的第一尺寸的第一组光学元件和与第二组配合并具有第二配置的第二尺寸的第二组光学元件。第一组和第二组可以夹紧到第三组光学元件中。可以抛光第三组，并且可以在抛光组上沉积另外的一组光学元件。

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