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1. 发明申请

US20070188855A1 APPARATUS FOR OBTAINING INFORMATION FOR A STRUCTURE USING SPECTRALLY-ENCODED ENDOSCOPY TEACHNIQUES AND METHODS FOR PRODUCING ONE OR MORE OPTICAL ARRANGEMENTS 有权
标题翻译：用于获得使用分光编码的内窥镜教学结构的信息的装置以及用于生成一个或多个光学装置的方法
公开(公告)号：US20070188855A1
公开(公告)日：2007-08-16
申请号：US11623852
申请日：2007-01-17
申请人： Milen Shishkov , Guillermo Tearney , Brett Bouma , Dvir Yelin , Nicusor Iftimia
发明人： Milen Shishkov , Guillermo Tearney , Brett Bouma , Dvir Yelin , Nicusor Iftimia
IPC分类号： G02B23/24 , A61B1/06
CPC分类号： G02B23/2453 , A61B1/00167 , A61B1/00188 , A61B1/002 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/0086 , B24B9/14 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0218 , G01J3/0256 , G01J3/18 , G02B5/18 , G02B23/2469 , G02B23/26
摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electromagnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can be configured to focus and provide there through the first electromagnetic radiation. Further, the exemplary apparatus can include at least one third dispersive arrangement which is configured to receive a particular radiation which is the first electromagnetic radiation and/or the focused electromagnetic radiation, and forward a dispersed radiation thereof to at least one section of the structure. At least one end of the fiber can be directly connected to the second focusing arrangement and/or the third dispersive arrangement. In addition, an exemplary embodiment of a method for producing an optical arrangement can be provided. For example, a first set of optical elements having a first size in a first configuration and a second set of optical elements in cooperation with the second set and having a second size in a second configuration can be provided. The first and second sets can be clamped into a third set of optical elements. The third set can be polished, and a further set of optical elements may be deposited on the polished set.
摘要翻译：可以提供用于获得结构信息的示例性装置。例如，示例性设备可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。第二布置可以被配置成通过第一电磁辐射聚焦并提供在那里。此外，示例性装置可以包括至少一个第三分散装置，其被配置为接收作为第一电磁辐射和/或聚焦电磁辐射的特定辐射，并将其分散的辐射转发到该结构的至少一个部分。光纤的至少一端可以直接连接到第二聚焦装置和/或第三色散装置。此外，可以提供用于制造光学装置的方法的示例性实施例。例如，可以提供具有第一配置的第一尺寸的第一组光学元件和与第二组配合并具有第二配置的第二尺寸的第二组光学元件。第一组和第二组可以夹紧到第三组光学元件中。可以抛光第三组，并且可以在抛光组上沉积另外的一组光学元件。

2. 发明授权

US08818149B2 Spectrally-encoded endoscopy techniques, apparatus and methods 有权
标题翻译：光谱编码的内窥镜检查技术，仪器和方法
公开(公告)号：US08818149B2
公开(公告)日：2014-08-26
申请号：US13427463
申请日：2012-03-22
申请人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
发明人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
IPC分类号： G02B6/32 , G02B6/34 , G02B6/06
CPC分类号： G02B23/2453 , A61B1/00167 , A61B1/00188 , A61B1/002 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/0086 , B24B9/14 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0218 , G01J3/0256 , G01J3/18 , G02B5/18 , G02B23/2469 , G02B23/26
摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electro-magnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can include a ball lens, and be configured to focus and provide there through the first electro-magnetic radiation to generate the focused electro-magnetic radiation. Further, the exemplary apparatus can include at least at least one dispersive third arrangement which can receive a particular radiation (e.g., the first electro-magnetic radiation(s) and/or the focused electro-magnetic radiation), and forward a dispersed radiation thereof to at least one section of the structure.
摘要翻译：可以提供用于获得结构信息的示例性装置。例如，示例性装置可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。第二布置可以包括球形透镜，并且被配置成通过第一电磁辐射聚焦并提供在其上，以产生聚焦的电磁辐射。此外，示例性装置可以包括至少一个能够接收特定辐射（例如，第一电磁辐射和/或聚焦电磁辐射）的分散第三装置，并且将其分散的辐射到结构的至少一个部分。

3. 发明申请

US20120328241A1 Apparatus for Obtaining Information For A Structure Using Spectrally-Encoded Endoscopy Techniques and Methods for Producing One or More Optical Arrangements 有权
标题翻译：用于使用光谱编码内窥镜技术获得信息的装置和用于产生一个或多个光学布置的方法
公开(公告)号：US20120328241A1
公开(公告)日：2012-12-27
申请号：US13427463
申请日：2012-03-22
申请人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
发明人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
IPC分类号： G02B6/32 , B24B1/00 , G02B6/34
CPC分类号： G02B23/2453 , A61B1/00167 , A61B1/00188 , A61B1/002 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/0086 , B24B9/14 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0218 , G01J3/0256 , G01J3/18 , G02B5/18 , G02B23/2469 , G02B23/26
摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electro-magnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can include a ball lens, and be configured to focus and provide there through the first electro-magnetic radiation to generate focused electro-magnetic radiation. Further, the exemplary apparatus can include at least at least one dispersive third arrangement which can receive a particular radiation (e.g., the first and/or focused electro-magnetic radiation(s), and forward a dispersed radiation thereof to at least one section of the structure. An end of the fiber(s) can be directly connected to the second focusing arrangement and/or the third arrangement(s).
摘要翻译：可以提供用于获得结构信息的示例性装置。例如，示例性装置可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。第二布置可以包括球透镜，并且被配置为通过第一电磁辐射聚焦并提供其中以产生聚焦的电磁辐射。此外，示例性装置可以包括至少一个可接收特定辐射（例如，第一和/或聚焦的电磁辐射）并且将其分散的辐射转发到至少一个部分的分散第三布置纤维的一端可以直接连接到第二聚焦装置和/或第三装置。

4. 发明授权

US08145018B2 Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements 有权
标题翻译：用于使用光谱编码的内窥镜检查技术获得结构信息的装置和用于产生一个或多个光学装置的方法
公开(公告)号：US08145018B2
公开(公告)日：2012-03-27
申请号：US11623852
申请日：2007-01-17
申请人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
发明人： Milen Shishkov , Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin , Nicusor Iftimia
IPC分类号： G02B6/32 , G02B6/34 , G02B6/06
CPC分类号： G02B23/2453 , A61B1/00167 , A61B1/00188 , A61B1/002 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/0086 , B24B9/14 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0218 , G01J3/0256 , G01J3/18 , G02B5/18 , G02B23/2469 , G02B23/26
摘要： Exemplary apparatus for obtaining information for a structure can be provided. For example, first optical fiber arrangement(s) can be provided which transceives at least one first electro-magnetic radiation, and can include at least one fiber. Second focusing arrangement(s) can be provided in optical communication with the optical fiber arrangement. The second arrangement can be configured to focus and provide there through the first electro-magnetic radiation. Third dispersive arrangement(s) can receive a particular radiation which is the first electro-magnetic radiation and/or the focused electro-magnetic radiation, and forward a dispersed radiation thereof to at least one section of the structure. At least one end of the fiber can be directly connected to the second focusing arrangement and/or the third dispersive arrangement.
摘要翻译：可以提供用于获得结构信息的示例性装置。例如，可以提供收发至少一个第一电磁辐射的第一光纤布置，并且可以包括至少一个光纤。可以提供与光纤装置的光通信中的第二聚焦装置。第二布置可以被配置成通过第一电磁辐射聚焦并提供到那里。第三分散布置可以接收作为第一电磁辐射和/或聚焦电磁辐射的特定辐射，并将其分散的辐射转发到结构的至少一个部分。光纤的至少一端可以直接连接到第二聚焦装置和/或第三色散装置。

5. 发明申请

US20080021275A1 METHODS AND SYSTEMS FOR OPTICAL IMAGING OR EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF 有权
标题翻译：通过光束扫描对光学成像或上传光学仪器的方法和系统
公开(公告)号：US20080021275A1
公开(公告)日：2008-01-24
申请号：US11625135
申请日：2007-01-19
申请人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc , Norman Nishioka
发明人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc , Norman Nishioka
IPC分类号： A61B1/00
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.
摘要翻译：提供了布置，装置，系统和系统以获得至少一个管腔或中空样品中的至少一个部分的数据。该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见）第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

6. 发明申请

US20070282403A1 METHODS AND SYSTEMS FOR PROVIDING ELECTROMAGNETIC RADIATION TO AT LEAST ONE PORTION OF A SAMPLE USING CONFORMAL LASER THERAPY PROCEDURES 审中-公开
标题翻译：使用一致的激光治疗方法提供电镜至少一个样品的电磁辐射的方法和系统
公开(公告)号：US20070282403A1
公开(公告)日：2007-12-06
申请号：US11670043
申请日：2007-02-01
申请人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc
发明人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc
IPC分类号： A61N5/06 , A61B18/18
CPC分类号： A61B18/24 , A61B5/0066 , A61B2017/00066 , A61B2017/22051 , A61B2018/2272
摘要： According one exemplary embodiment of the present invention, method and system can be provided for applying a laser radiation to at least one portion of a biological structure. For example, a beam of the laser radiation can be provided to the portion, whereas a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion. The beam can be applied to the portion (a) based on a predetermined pattern, (b) while modulating a wavelength of the laser radiation, and/or (c) while monitoring a depth of the application of the laser radiation.
摘要翻译：根据本发明的一个示例性实施例，可以提供用于将激光辐射施加到生物结构的至少一部分的方法和系统。例如，可以向该部分提供激光辐射束，而光束的横截面积至多为至少一部分的整个区域的大约1/10。可以基于预定图案将光束施加到部分（a），（b）同时调制激光辐射的波长，和/或（c）同时监视激光辐射的施加深度。

7. 发明申请

US20070274650A1 APPARATUS FOR CONTROLLING AT LEAST ONE OF AT LEAST TWO SECTIONS OF AT LEAST ONE FIBER 有权
标题翻译：用于至少控制至少一个光纤的至少两个部分的装置
公开(公告)号：US20070274650A1
公开(公告)日：2007-11-29
申请号：US11670069
申请日：2007-02-01
申请人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc
发明人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc
IPC分类号： G02B6/04
CPC分类号： A61B18/24 , A61B1/00082 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B5/0066 , A61B5/0084 , A61B5/6852 , A61B2017/00057 , A61B2017/22051 , A61B2018/2211 , A61B2018/2272 , G02B23/2423
摘要： An apparatus for controlling at least one of at least two sections of at least one fiber can be provided. The apparatus can include an arrangement which may be provided between the first and second sections of a particular continuous fiber of the fibers. A particular one of the first and second sections may be provided in a particular orientation that is perpendicular to an extension of the particular fiber. The arrangement is capable of controlling the particular fiber such that the particular one of the sections is capable of being rotated for at least 360° with respect to the particular orientation. The arrangement can include a further arrangement that is capable of at least partially wrapping the particular fiber around the second arrangement, and controlling the particular fiber such that the particular one of the sections is capable of being rotated with respect to the particular orientation during a transmission of the electro-magnetic radiation.
摘要翻译：可以提供一种用于控制至少一个光纤的至少两个部分中的至少一个的装置。该装置可以包括可以设置在纤维的特定连续纤维的第一和第二部分之间的装置。第一和第二部分中的特定一个可以以垂直于特定纤维的延伸部的特定方向设置。该装置能够控制特定光纤，使得特定的一个部分能够相对于特定取向旋转至少360°。该布置可以包括能够至少部分地围绕第二布置包围特定纤维并且控制特定光纤的另外的布置，使得特定的一个部分能够在传输期间相对于特定取向旋转的电磁辐射。

8. 发明申请

US20070179487A1 APPARATUS FOR APPLYING A PLURALITY OF ELECTRO-MAGNETIC RADIATIONS TO A SAMPLE 有权
标题翻译：将大量电磁辐射应用于样品的装置
公开(公告)号：US20070179487A1
公开(公告)日：2007-08-02
申请号：US11670027
申请日：2007-02-01
申请人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc
发明人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc
IPC分类号： A61B18/18
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/6852 , A61B18/24 , A61B2017/00057 , A61B2017/22051 , A61B2018/207 , A61B2090/306 , A61B2090/3614
摘要： An apparatus for applying a plurality of electromagnetic radiations to a sample is provided. In one exemplary embodiment, the apparatus can include an arrangement which has a specific portion with a plurality of channels. One of channels can facilitate a first radiation of the radiations to be forwarded to the sample that is within an anatomical structure, and another one of the channels can facilitate a second radiation of the radiations to be forwarded to the sample. The first radiation may have a first wavelength band, and the second radiation may have a second wavelength band. The first wavelength band may be substantially different from the second wavelength band. According to another exemplary embodiment, the first radiation can be adapted to be delivered to a first area of the sample, and the second radiation may be capable of being delivered to a second area of the sample. The first area may be substantially enclosed by the second area. According to yet another exemplary embodiment of the present invention, each of the channels can facilitate at least one particular radiation of the radiations to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample. Centers of every one of the areas may be provided substantially along a line.
摘要翻译：提供了一种向样品施加多个电磁辐射的装置。在一个示例性实施例中，装置可以包括具有多个通道的特定部分的装置。通道中的一个可以促进要转发到解剖结构内的样品的辐射的第一辐射，并且另一个通道可以促进辐射的第二次辐射以被转发到样品。第一辐射可以具有第一波长带，并且第二辐射可以具有第二波长带。第一波长带可能与第二波长带显着不同。根据另一示例性实施例，第一辐射可以适于被传送到样品的第一区域，并且第二辐射可以能够被传送到样品的第二区域。第一区域可以基本上被第二区域包围。根据本发明的另一个示例性实施例，每个通道可以促进辐射的至少一个特定辐射被转发到样品的解剖结构内的样品，辐射被递送到样品的解剖结构中样品。可以基本沿着一条线提供每个区域的中心。

9. 发明申请

US20060245087A1 Microscope objectives 失效
标题翻译：显微镜目标
公开(公告)号：US20060245087A1
公开(公告)日：2006-11-02
申请号：US10542966
申请日：2004-01-21
申请人： Guillermo Tearney , Constantinos Pitris , Milen Shishkov , Brett Bouma
发明人： Guillermo Tearney , Constantinos Pitris , Milen Shishkov , Brett Bouma
IPC分类号： G02B7/02
CPC分类号： G02B21/0072 , G02B21/006 , G02B21/02 , G02B21/33
摘要： A confocal microscope lens arrangement is provided. The confocal microscope lens arrangement includes a lens assembly housing which has a lens assembly, and an exterior housing including a distal end and a proximal end. The exterior housing is configured to allow the lens assembly housing to be placed therein, and translated between the proximal end and the distal end of the exterior housing to focus the lens assembly. The exterior housing has an aperture formed through a distal end thereof. The arrangement also includes an immersion media filling the volume of area between the exterior housing and the lens assembly housing.
摘要翻译：提供共焦显微镜透镜装置。共焦显微镜透镜装置包括具有透镜组件的透镜组件壳体和包括远端和近端的外壳。外部壳体被配置为允许透镜组件壳体放置在其中并且在外部壳体的近端和远端之间平移以聚焦透镜组件。外壳具有通过其远端形成的孔。该布置还包括填充外壳和透镜组件壳体之间的面积的浸没介质。

10. 发明申请

US20070177152A1 METHODS AND SYSTEMS FOR MONITORING AND OBTAINING INFORMATION OF AT LEAST ONE PORTION OF A SAMPLE USING CONFORMAL LASER THERAPY PROCEDURES, AND PROVIDING ELECTROMAGNETIC RADIATION THERETO 有权
标题翻译：用于使用合格激光治疗程序监测和获取至少一个样品的样品的信息的方法和系统，并提供电磁辐射
公开(公告)号：US20070177152A1
公开(公告)日：2007-08-02
申请号：US11670058
申请日：2007-02-01
申请人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc
发明人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc
IPC分类号： G01B9/02
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/6852 , A61B18/24 , A61B2017/00057 , A61B2017/22051 , A61B2018/207 , A61B2090/306 , A61B2090/3614
摘要： In one exemplary embodiment of the present invention, method and system can be provided for obtaining information associated with at least one portion of a sample. For example, a temperature change can be caused in the portion of the sample. At least one first electro-magnetic radiation can be forwarded to a section near or in the portion of the sample. A deformation of the section can be identified at a plurality of depths as a function of (i) a phase of at least one second electro-magnetic radiation provided from the section, and/or (ii) a rate of change of the phase and/or an amplitude of the second electro-magnetic radiation. In another exemplary embodiment of the present invention, method and system can be provided for controlling a temperature distribution in a sample. For example, an electro-magnetic radiation can be provided to the section in the sample at a particular wavelength. The temperature distribution can be controlled by modifying the particular wavelength of the electro-magnetic radiation when the electro-magnetic radiation is provided to the section.
摘要翻译：在本发明的一个示例性实施例中，可以提供方法和系统来获得与样本的至少一部分相关联的信息。例如，可以在样品的部分中引起温度变化。至少一个第一电磁辐射可以转发到样品附近或部分的部分。可以在多个深度处识别该部分的变形作为（i）从该部分提供的至少一个第二电磁辐射的相位和/或（ii）相的变化率和 /或第二电磁辐射的振幅。在本发明的另一示例性实施例中，可以提供方法和系统来控制样品中的温度分布。例如，可以以特定波长向样品中的部分提供电磁辐射。当电磁辐射提供给该部分时，可以通过修改电磁辐射的特定波长来控制温度分布。

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