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1. 发明授权

US06706004B2 Balloon catheter 有权
标题翻译：气球导管
公开(公告)号：US06706004B2
公开(公告)日：2004-03-16
申请号：US09871771
申请日：2001-05-31
申请人： Guillermo J. Tearney , Brett E. Bouma , S. Eric Ryan , Simon Furnish , Jing Tang , Andres Zuluaga
发明人： Guillermo J. Tearney , Brett E. Bouma , S. Eric Ryan , Simon Furnish , Jing Tang , Andres Zuluaga
IPC分类号： A61B5103
CPC分类号： A61B5/6853 , A61B5/0086 , A61B5/0507 , A61B5/6886
摘要： An apparatus includes a feedback loop for controlling an extent of a gap between a wall of a balloon mounted on a catheter and a wall of a lumen into which the catheter is inserted. The apparatus includes a radiation detector mounted within the balloon for generating a feedback signal having information indicative of whether the extent of the gap is greater than or less than a desired value. The feedback loop receives the feedback signal and controls a size of the balloon to cause the extent of the gap to approach the desired value.
摘要翻译：一种装置包括用于控制安装在导管上的球囊的壁与插入其中的内腔的壁之间的间隙的程度的反馈回路。该装置包括安装在气球内的放射线检测器，用于产生具有指示间隙的程度是否大于或小于期望值的信息的反馈信号。反馈回路接收反馈信号并控制气囊的尺寸以使间隙的程度接近所需值。

2. 发明授权

US06701181B2 Multi-path optical catheter 有权
标题翻译：多路光导管
公开(公告)号：US06701181B2
公开(公告)日：2004-03-02
申请号：US09871770
申请日：2001-05-31
申请人： Jing Tang , Guillermo J. Tearney , Brett E. Bouma , S. Eric Ryan , Simon Furnish , Andres Zuluaga
发明人： Jing Tang , Guillermo J. Tearney , Brett E. Bouma , S. Eric Ryan , Simon Furnish , Andres Zuluaga
IPC分类号： A61B600
CPC分类号： A61B1/0615 , A61B1/00096 , A61B1/00183 , A61B1/3137 , A61B5/0084 , A61B5/6853
摘要： First and second optical-redirectors mounted on a catheter couple radiation to a target along separate first and second paths. Either the first or second optical-redirectors, or both, can include a steering mechanism for selecting the first and/or second path.
摘要翻译：安装在导管上的第一和第二光学重定向器沿着分离的第一和第二路径将辐射耦合到目标。第一或第二光学重定向器或两者都可以包括用于选择第一和/或第二路径的转向机构。

3. 发明授权

US06615062B2 Referencing optical catheters 有权
标题翻译：参考光导管
公开(公告)号：US06615062B2
公开(公告)日：2003-09-02
申请号：US09871759
申请日：2001-05-31
申请人： S. Eric Ryan , Brett Bouma , Guillermo J. Tearney , Simon Furnish , Jing Tang , Andres Zuluaga
发明人： S. Eric Ryan , Brett Bouma , Guillermo J. Tearney , Simon Furnish , Jing Tang , Andres Zuluaga
IPC分类号： A61B500
CPC分类号： A61B5/0084 , A61B5/14535 , A61B2560/0233 , G01N21/4785
摘要： The invention provides methods and apparatus to reference or normalize optical measurements, by removing or accounting for background factors and artifacts, such as motion artifacts, that arise during use of optical catheters.
摘要翻译：本发明提供了通过去除或计算在使用光学导管时出现的背景因素和伪像（诸如运动伪像）来参考或归一化光学测量的方法和装置。

4. 发明授权

US06654630B2 Apparatus and method for the optical imaging of tissue samples 有权
公开(公告)号：US06654630B2
公开(公告)日：2003-11-25
申请号：US09871578
申请日：2001-05-31
申请人： Andres F. Zuluaga , Brett Bouma , Simon M. Furnish , Guillermo J. Tearney , S. Eric Ryan , Jing Tang , Mark A. Griffin
发明人： Andres F. Zuluaga , Brett Bouma , Simon M. Furnish , Guillermo J. Tearney , S. Eric Ryan , Jing Tang , Mark A. Griffin
IPC分类号： A61B600
CPC分类号： A61B5/0084
摘要： A catheter based optical system for generating data as to the condition of a tissue sample of a mammalian vessel. The system includes an elongated catheter shaft having a tissue engaging distal end and a coupled proximal end and an elongated optical delivery fiber arrangement disposed through a lumen of said catheter, said optical delivery fiber arrangement having a distal end and a proximal end. The distal end of the delivery fiber arrangement has a re-director light emitter thereon for directing light against mammalian tissues. An elongated optical collection fiber arrangement is disposed through a lumen of the catheter, the optical collection fiber arrangement having a distal end and a proximal most end. The distal end of the collection fiber arrangement has a re-director light receiver thereon for receiving light reflected from the mammalian tissue by the light emitter. The light emitter and the light receiver are longitudinally spaced apart from one another in the distal end of the catheter. The catheter apparatus includes a light source in communication with the delivery fiber and a signal detector in communication with the receiving fiber for receiving and presenting data collected.

5. 发明申请

US20140206989A1 SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR TRACKING VESSEL MOTION DURING THREE-DIMENSIONAL CORONARY ARTERY MICROSCOPY 有权
标题翻译：系统，方法和计算机可访问介质在三维冠状动脉微血管中跟踪血管运动
公开(公告)号：US20140206989A1
公开(公告)日：2014-07-24
申请号：US14088906
申请日：2013-11-25
申请人： Christopher Max Colice , Brett E. Bouma , Guillermo J. Tearney , Jinyong Ha , Milen Shishkov
发明人： Christopher Max Colice , Brett E. Bouma , Guillermo J. Tearney , Jinyong Ha , Milen Shishkov
IPC分类号： A61B5/00 , A61B8/12 , A61B8/08
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0097 , A61B5/1076 , A61B5/1114 , A61B5/489 , A61B5/6844 , A61B5/6852 , A61B8/08 , A61B8/0891 , A61B8/12 , A61B8/488 , A61B90/36 , A61B2090/364 , A61B2090/3782 , G01S15/50 , G01S15/60 , G01S15/87 , G01S17/50 , G01S17/87
摘要： Exemplary embodiments of apparatus, method and computer accessible medium can be provided which can facilitate a determination of at least one characteristic of a structure. For example, it is possible to use at least one first arrangement which can be structured to provide at least one first transmitted radiation along a first axis and at least one second transmitted radiation along a second axis. The first and second transmitted radiations can impact the structure and generate respective first and second returned radiation. The first and second axis can be provided at a predetermined angle with respect with one another which is greater than 0. Further, at least one second arrangement can be provided which can be configured to receive data associated with the first and second returned radiations, and determine at least one relative velocity between the structure and the first arrangement along the first and second axes.
摘要翻译：可以提供装置，方法和计算机可访问介质的示例性实施例，其可以有助于确定结构的至少一个特征。例如，可以使用至少一个第一布置，其可被构造成沿着第一轴线提供至少一个第一透射辐射以及沿着第二轴线提供至少一个第二透射辐射。第一和第二透射辐射可以影响结构并产生相应的第一和第二反射辐射。第一和第二轴线可以彼此相对于预定角度提供，该角度大于0.此外，可以提供至少一个第二布置，其可被配置为接收与第一和第二返回辐射有关的数据，以及确定沿着第一和第二轴线的结构和第一布置之间的至少一个相对速度。

6. 发明授权

US08384909B2 Method and apparatus for performing optical imaging using frequency-domain interferometry 有权
标题翻译：使用频域干涉测量进行光学成像的方法和装置
公开(公告)号：US08384909B2
公开(公告)日：2013-02-26
申请号：US12795529
申请日：2010-06-07
申请人： Seok-Hyun Yun , Brett E. Bouma , Guillermo J. Tearney , Johannes Fitzgerald De Boer
发明人： Seok-Hyun Yun , Brett E. Bouma , Guillermo J. Tearney , Johannes Fitzgerald De Boer
IPC分类号： G01B11/02 , G01B9/02
CPC分类号： H01S5/5045 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02002 , G01B9/02004 , G01B9/02043 , G01B9/02075 , G01B9/02081 , G01B9/02083 , G01B9/02084 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/0264 , G01J3/453 , G01J9/0215 , G01N21/4795 , G02B6/3604 , G02B26/12 , G02B27/48 , G02F1/093 , G02F1/11 , H01S3/0071 , H01S3/0078 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S3/1068 , H01S5/0071 , H01S5/0078 , H01S5/1025 , H01S5/14 , H01S5/141 , H01S5/146
摘要： An apparatus and method are provided. In particular, at least one first electro-magnetic radiation may be provided to a sample and at least one second electro-magnetic radiation can be provided to a non-reflective reference. A frequency of the first and/or second radiations varies over time. An interference is detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. Alternatively, the first electro-magnetic radiation and/or second electro-magnetic radiation have a spectrum which changes over time. The spectrum may contain multiple frequencies at a particular time. In addition, it is possible to detect the interference signal between the third radiation and the fourth radiation in a first polarization state. Further, it may be preferable to detect a further interference signal between the third and fourth radiations in a second polarization state which is different from the first polarization state. The first and/or second electro-magnetic radiations may have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond.
摘要翻译：提供了一种装置和方法。特别地，可以向样品提供至少一个第一电磁辐射，并且可以向非反射参考提供至少一个第二电磁辐射。第一和/或第二辐射的频率随时间变化。在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测到干扰。或者，第一电磁辐射和/或第二电磁辐射具有随时间变化的光谱。频谱可以在特定时间包含多个频率。此外，可以在第一偏振状态下检测第三辐射与第四辐射之间的干涉信号。此外，可能优选在与第一偏振状态不同的第二偏振态中检测第三和第四辐射之间的另外的干扰信号。第一和/或第二电磁辐射可以具有在每毫秒大于100Tera赫兹的调谐速度下，其平均频率随时间而基本连续变化的频谱。

7. 发明授权

US08384907B2 Method and apparatus for optical imaging via spectral encoding 有权
标题翻译：通过频谱编码进行光学成像的方法和装置
公开(公告)号：US08384907B2
公开(公告)日：2013-02-26
申请号：US12946635
申请日：2010-11-15
申请人： Guillermo J. Tearney , Dvir Yelin , Brett E. Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Brett E. Bouma
IPC分类号： G01B9/02 , G01J3/45
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和装置，用于生成解剖结构的至少一部分的图像。例如，该部分可以具有大于约1mm 2的面积，并且图像可以具有低于约10μm的横向分辨率的分辨率。例如，可以在这样的部分上扫描光，以便产生与该部分相关的第一信息，其中可以通过衍射装置提供光以产生光谱分散的线。可以提供根据本发明的另一示例性实施例的方法，装置和装置，用于基于通过使用相同或不同的束扫描结构的一部分而产生的信号来将辐射或光束定位在解剖结构内。

8. 发明申请

US20120022381A1 Methods and Systems for Tissue Analysis 有权
标题翻译：组织分析方法与系统
公开(公告)号：US20120022381A1
公开(公告)日：2012-01-26
申请号：US13251594
申请日：2011-10-03
申请人： Guillermo J. Tearney , Brett E. Bouma
发明人： Guillermo J. Tearney , Brett E. Bouma
IPC分类号： A61B6/00
CPC分类号： A61B5/6885 , A61B1/00082 , A61B1/0615 , A61B1/07 , A61B5/0066 , A61B5/0068 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/7207 , A61B5/7257 , G01N21/49
摘要： The invention relates to methods and systems to optically analyze samples such as tissue based on speckle patterns of microscopic motion, such as Brownian motion.
摘要翻译：本发明涉及基于诸如布朗运动的微观运动的斑纹图案光学分析诸如组织的样品的方法和系统。

9. 发明申请

US20110261366A1 SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 有权
标题翻译：系统，方法和计算机可访问介质，提供特定解决方案中至少一个解剖结构的微观图像
公开(公告)号：US20110261366A1
公开(公告)日：2011-10-27
申请号：US13042230
申请日：2011-03-07
申请人： Guillermo J. Tearney , Brett E. Bouma , Joseph A. Gardecki , Linbo Liu
发明人： Guillermo J. Tearney , Brett E. Bouma , Joseph A. Gardecki , Linbo Liu
IPC分类号： G01B9/02
CPC分类号： A61B5/0066 , A61B5/0044 , A61B5/0075 , A61B5/0084 , G01B9/02091 , G02B6/32
摘要： Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through such optical arrangement (or through another optical arrangement), and receive at least one fourth radiation from the portion which is based on the third radiation. Based on an interaction between the optical arrangement (or the other optical arrangement) and the third radiation and/or the fourth radiation, the optical arrangement (or the other optical arrangement) can have a second transfer function. The first transfer function can be at least partially different from the second transfer function. The data can be generated based on the second and fourth radiations.
摘要翻译：可以提供可以生成与样品的至少一部分相关联的数据的系统和方法的示例性实施例。例如，可以通过至少一个光学布置将至少一个第一辐射转发到该部分。可以从基于第一辐射的部分接收至少一个第二辐射。基于光学布置和第一辐射和/或第二辐射之间的相互作用，光学装置可以具有第一传递函数。此外，可以通过这种光学装置（或通过另一种光学装置）将至少一个第三辐射转发到该部分，并且从基于第三辐射的部分接收至少一个第四辐射。基于光学布置（或另一个光学布置）与第三辐射和/或第四辐射之间的相互作用，光学布置（或另一个光学布置）可以具有第二传递函数。第一传递函数可以至少部分地不同于第二传递函数。可以基于第二和第四辐射来生成数据。

10. 发明申请

US20110222563A1 WAVELENGTH TUNING SOURCE BASED ON A ROTATABLE REFLECTOR 审中-公开
标题翻译：基于可旋转反射器的波长调谐源
公开(公告)号：US20110222563A1
公开(公告)日：2011-09-15
申请号：US13112720
申请日：2011-05-20
申请人： Brett E. Bouma , Seok-Yun Yun , Wang-Yuhl Oh , Benjamin J. Vakoc , Guillermo J. Tearney
发明人： Brett E. Bouma , Seok-Yun Yun , Wang-Yuhl Oh , Benjamin J. Vakoc , Guillermo J. Tearney
IPC分类号： H01S3/10
CPC分类号： H01S3/08063 , G01J3/02 , G01J3/021 , G01J3/0229 , G01J3/06 , G01J3/10 , G02B26/002 , G02B26/04 , H01S3/08 , H01S3/08009 , H01S3/0805 , H01S3/10046 , H01S3/105 , H01S3/106
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement, e.g., polygonal scanning mirror and spinning reflector disk scanner, which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.
摘要翻译：可以提供用于过滤电磁辐射的装置和源装置，其可以包括被配置为基于电磁辐射的频率物理地分离电磁辐射的一个或多个部件的至少一个光谱分离装置。设备和源装置还可以具有至少一个连续旋转的光学装置，例如多边形扫描镜和旋转反射器盘扫描器，其被配置为接收与一个或多个部件相关联的至少一个信号。此外，装置和源装置可以包括被配置为接收信号的至少一个波束选择装置。

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