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1. 发明申请

US20070243270A1 METHODS AND KITS FOR REDUCING CELLULAR DAMAGE, INHIBITING FREE RADICAL PRODUCTION, AND SCAVENGING FREE RADICALS IN MAMMALS 有权
标题翻译：用于减少细胞损伤，抑制自由放射生产的方法和工具，以及在哺乳动物中自由放射自由基
公开(公告)号：US20070243270A1
公开(公告)日：2007-10-18
申请号：US11624687
申请日：2007-01-18
申请人： Gregory Evans , Gregory Grochoski , Russell Randolph , Lynne Connor , John Scimeca , Kevin Gellenbeck , James Mayne , Haeri Roh-Schmidt , Thomas Slaga , Margareth Hanausek-Walaszek , Zbigniew Walaszek
发明人： Gregory Evans , Gregory Grochoski , Russell Randolph , Lynne Connor , John Scimeca , Kevin Gellenbeck , James Mayne , Haeri Roh-Schmidt , Thomas Slaga , Margareth Hanausek-Walaszek , Zbigniew Walaszek
IPC分类号： A61K36/736 , A61K36/82 , A61P17/18
CPC分类号： A61K45/06 , A61K31/015 , A61K31/22 , A61K31/355 , A61K31/375 , A61K36/35 , A61K36/736 , A61K36/82 , A61K36/87 , A61K2300/00
摘要： Methods of reducing cellular damage are described that include (a) administering to the mammal an oral dosage form comprising a therapeutically effective amount of a first antioxidant, and (b) administering to the mammal a topical dosage form comprising a therapeutically effective amount of a second antioxidant, wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate. Methods of inhibiting free radical production, methods of scavenging free radicals, and kits for reducing cellular damage are also described.
摘要翻译：描述了减少细胞损伤的方法，其包括（a）向哺乳动物施用包含治疗有效量的第一抗氧化剂的口服剂型，和（b）向哺乳动物施用包含治疗有效量的第二抗体的局部剂型抗氧化剂，其中所述第一抗氧化剂和所述第二抗氧化剂中的至少一种包含精粉。还描述了抑制自由基产生的方法，清除自由基的方法和用于减少细胞损伤的试剂盒。

2. 发明申请

US20050100537A1 Methods and kits for reducing cellular damage, inhibiting free radical production, and scavenging free radicals in mammals 审中-公开
标题翻译：用于减少细胞损伤，抑制自由基产生和清除哺乳动物自由基的方法和试剂盒
公开(公告)号：US20050100537A1
公开(公告)日：2005-05-12
申请号：US10705081
申请日：2003-11-10
申请人： Gregory Evans , Gregory Grochoski , Keith Randolph , Lynne Connor , John Scimeca , Kevin Gellenbeck , James Mayne , Haeri Roh-Schmidt , Thomas Slaga , Margaret Hanausek-Walaszek , Zbigniew Walaszek
发明人： Gregory Evans , Gregory Grochoski , Keith Randolph , Lynne Connor , John Scimeca , Kevin Gellenbeck , James Mayne , Haeri Roh-Schmidt , Thomas Slaga , Margaret Hanausek-Walaszek , Zbigniew Walaszek
IPC分类号： A61K31/015 , A61K31/22 , A61K31/355 , A61K31/375 , A61K36/35 , A61K36/736 , A61K36/82 , A61K36/87 , A61K45/06 , A61K38/43 , A61K35/78
CPC分类号： A61K45/06 , A61K31/015 , A61K31/22 , A61K31/355 , A61K31/375 , A61K36/35 , A61K36/736 , A61K36/82 , A61K36/87 , A61K2300/00
摘要： Methods of reducing cellular damage are described that include (a) administering to the mammal an oral dosage form comprising a therapeutically effective amount of a first antioxidant, and (b) administering to the mammal a topical dosage form comprising a therapeutically effective amount of a second antioxidant, wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate. Methods of inhibiting free radical production, methods of scavenging free radicals, and kits for reducing cellular damage are also described.
摘要翻译：描述了减少细胞损伤的方法，其包括（a）向哺乳动物施用包含治疗有效量的第一抗氧化剂的口服剂型，和（b）向哺乳动物施用包含治疗有效量的第二抗体的局部剂型抗氧化剂，其中所述第一抗氧化剂和所述第二抗氧化剂中的至少一种包含精粉。还描述了抑制自由基产生的方法，清除自由基的方法和用于减少细胞损伤的试剂盒。

3. 发明申请

US20060153888A1 Methods for scavenging oxidizing nitrogen and oxygen species with fragrances having antioxidative properties 审中-公开
标题翻译：清除具有抗氧化性能的香料氧化氮和氧的物质的方法
公开(公告)号：US20060153888A1
公开(公告)日：2006-07-13
申请号：US11296799
申请日：2005-12-07
申请人： Jesse Leverett , James Mayne , Stephen Missler , John Scimeca , Richard Roth
发明人： Jesse Leverett , James Mayne , Stephen Missler , John Scimeca , Richard Roth
IPC分类号： A61K36/899 , A61K8/97
CPC分类号： A61K8/922 , A61K8/22 , A61K8/40 , A61K8/97 , A61K2800/522 , A61L9/04 , A61L9/044 , A61Q1/02 , A61Q13/00 , A61Q17/00 , A61Q19/00
摘要： Methods and compositions for scavenging reactive molecules, including free radicals, reactive oxygen and reactive nitrogen species, in the air are described. More specifically, methods and compositions for scavenging reactive molecules in the air before the reactive chemicals contact the skin or other tissue surface are described. The scavenging occurs by topical application of a scavenging agent, such as a volatile antioxidant, to the skin, or by releasing a scavenging agent, such as a volatile antioxidant, into the air near or surrounding the skin. Additionally, the present invention relates to compositions comprising a scavenging agent in combination with a carrier or vehicle, wherein the scavenging agent may include fragrances or fragrance components having antioxidant properties and wherein the scavenging agent scavenges reactive molecules in the air space surrounding a site on the skin where the composition has been applied. The compositions of the invention also may be used in household items such as candles, deodorizers and pet litter to scavenge reactive oxygen and nitrogen species in the home.
摘要翻译：描述了在空气中清除反应性分子的方法和组合物，包括自由基，活性氧和活性氮物质。更具体地，描述了在反应性化学物质接触皮肤或其它组织表面之前清除空气中的反应性分子的方法和组合物。通过局部施用清除剂（例如挥发性抗氧化剂）到皮肤上，或通过将清除剂（例如挥发性抗氧化剂）释放到皮肤附近或周围的空气中而发生清除。另外，本发明涉及包含与载体或载体组合的清除剂的组合物，其中清除剂可以包括具有抗氧化性质的香料或香料组分，并且其中清除剂清除在位于该位置上的空气中的反应性分子已经施用组合物的皮肤。本发明的组合物也可用于诸如蜡烛，除臭剂和宠物垃圾的家居用品中以清除家中的活性氧和氮物质。

4. 发明申请

US20060257509A1 Cosmetic composition and methods 审中-公开
公开(公告)号：US20060257509A1
公开(公告)日：2006-11-16
申请号：US11399728
申请日：2006-04-07
申请人： Amy Zimmerman , John Scimeca
发明人： Amy Zimmerman , John Scimeca
IPC分类号： A61K36/906 , A61K36/53 , A61K36/28
CPC分类号： A61Q19/08 , A61K8/14 , A61K8/645 , A61K8/66 , A61K8/97 , A61K36/23 , A61K36/28 , A61K36/42 , A61K36/47 , A61K36/484 , A61K36/53 , A61K36/752 , A61K36/9062 , A61K2300/00
摘要： A cosmetic composition is provided having ingredients that may prevent signs of aging, improve the aesthetic appearance of skin, and promote recovery from environmental stresses. The composition includes natural ingredients, including at least one ingredient or extract from rosemary; at least one ingredient or extract from Centella, Echinacea, Alpinia or mixtures thereof; a DNA repair enzyme; and at least one pharmaceutically or cosmetically acceptable vehicle.

5. 发明申请

US20080108681A1 Use of allantoin as a pro-collagen synthesis agent in cosmetic compositions 审中-公开
标题翻译：在化妆品组合物中使用尿囊素作为原胶原合成剂
公开(公告)号：US20080108681A1
公开(公告)日：2008-05-08
申请号：US11977926
申请日：2007-10-26
申请人： John Scimeca , David Fast , Amy Zimmerman
发明人： John Scimeca , David Fast , Amy Zimmerman
IPC分类号： A61K31/4164 , A61P17/00 , A61Q19/08
CPC分类号： A61Q19/08 , A61K8/4946 , A61K31/4164 , A61K2800/92
摘要： Compositions comprising allantoin and an acceptable carrier and methods of using such compositions to increase pro-collagen synthesis in skin are disclosed. Compositions of the present invention may be used to decrease the signs of skin aging such as wrinkles and fine lines. Compositions of the present invention may be topically administered, orally administered or parenterally, such as administration by injection. When topically administered, additive ingredients such as penetration enhancers, fragrances, and moisturizers and cosmetic adjuvants may be included in compositions of the present invention.
摘要翻译：公开了包含尿囊素和可接受的载体的组合物和使用这些组合物增加皮肤中原胶原合成的方法。本发明的组合物可用于减少皮肤老化的迹象，例如皱纹和细纹。本发明的组合物可以局部施用，口服给药或肠胃外给药，例如通过注射给药。当局部给药时，可以在本发明的组合物中包括添加成分如渗透促进剂，香料，保湿剂和化妆品佐剂。

6. 发明申请

US20070254021A1 Cosmetic treatment system and methods 有权
标题翻译：化妆品治疗系统及方法
公开(公告)号：US20070254021A1
公开(公告)日：2007-11-01
申请号：US11784159
申请日：2007-04-05
申请人： John Scimeca , Amy Zimmerman , Mark Mettler , Akiko Kudo , Yoko Kawasaki
发明人： John Scimeca , Amy Zimmerman , Mark Mettler , Akiko Kudo , Yoko Kawasaki
IPC分类号： A61K36/53 , A61K36/06 , A61K36/535 , A61K36/62 , A61K36/899 , A61K36/9062 , A61K38/47 , A61K38/51 , A61K9/127
CPC分类号： A61K38/51 , A61K8/0208 , A61K8/66 , A61K8/97 , A61K9/0014 , A61K9/7084 , A61K36/07 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/53 , A61K36/535 , A61K36/62 , A61K36/899 , A61K36/9062 , A61K38/46 , A61K38/47 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K2300/00
摘要： A cosmetic treatment system is provided having ingredients that may prevent signs of aging, improve the aesthetic appearance of skin, and promote recovery from environmental stresses. The composition includes natural ingredients, including at least one ingredient or extract from rosemary; at least one ingredient or extract from Centella, Echinacea, Alpinia or mixtures thereof; a DNA repair enzyme; and at least one pharmaceutically or cosmetically acceptable vehicle. The treatment system may further include a patch for applying the cosmetic ingredients and/or a packaging system for holding the components of the cosmetic treatment system.
摘要翻译：提供了具有可以防止老化迹象，改善皮肤美学外观并促进从环境压力恢复的成分的美容治疗系统。该组合物包括天然成分，包括至少一种来自迷迭香的成分或提取物; 至少一种来自Centella，Echinacea，Alpinia或其混合物的成分或提取物; DNA修复酶; 和至少一种药学或化妆品可接受的载体。治疗系统还可以包括用于施加化妆品成分的贴剂和/或用于保持化妆品处理系统的组分的包装系统。

7. 发明申请

US20060257386A1 Cosmetic composition and methods 有权
标题翻译：化妆品成分及方法
公开(公告)号：US20060257386A1
公开(公告)日：2006-11-16
申请号：US11485945
申请日：2006-07-13
申请人： Amy Zimmerman , John Scimeca
发明人： Amy Zimmerman , John Scimeca
IPC分类号： A61K38/46 , A61K36/28 , A61K36/53 , A61K36/906
CPC分类号： A61K8/97 , A61K8/66 , A61Q19/00 , A61Q19/08
摘要： A cosmetic composition is provided having ingredients that may prevent signs of aging, improve the aesthetic appearance of skin, and promote recovery from environmental stresses. The composition includes natural ingredients, including at least one ingredient or extract from rosemary; at least one ingredient or extract from Centella, Echinacea, Alpinia or mixtures thereof; a DNA repair enzyme; and at least one pharmaceutically or cosmetically acceptable vehicle.
摘要翻译：提供具有可以防止老化迹象，改善皮肤美学外观并促进从环境胁迫中恢复的成分的化妆品组合物。该组合物包括天然成分，包括至少一种来自迷迭香的成分或提取物; 至少一种来自Centella，Echinacea，Alpinia或其混合物的成分或提取物; DNA修复酶; 和至少一种药学或化妆品可接受的载体。

8. 发明申请

US20050169860A1 Holistic composition and method for reducing skin pigmentation 有权
标题翻译：整体组合物和减少皮肤色素沉着的方法
公开(公告)号：US20050169860A1
公开(公告)日：2005-08-04
申请号：US10769556
申请日：2004-01-30
申请人： Di Qu , John Scimeca , Louise Schneider , Jay Dittmer , Ronald Sharpe
发明人： Di Qu , John Scimeca , Louise Schneider , Jay Dittmer , Ronald Sharpe
IPC分类号： A61K8/29 , A61K8/34 , A61K8/37 , A61K8/49 , A61K8/60 , A61K8/63 , A61K8/64 , A61K8/67 , A61K8/87 , A61K8/97 , A61Q19/02 , A61K7/135 , A61K7/06 , A61K35/78
CPC分类号： A61Q19/02 , A61K8/29 , A61K8/37 , A61K8/60 , A61K8/63 , A61K8/64 , A61K8/645 , A61K8/676 , A61K8/97 , A61K2800/70 , A61K2800/782
摘要： The present invention provides a holistic composition and method for reducing skin pigmentation.
摘要翻译：本发明提供了减少皮肤色素沉着的整体组合物和方法。

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